| scholarly article | Q13442814 |
| P50 | author | Francesco Dotta | Q52573918 |
| Carmela Santangelo | Q57046605 | ||
| Salvatore Piro | Q59684683 | ||
| P2093 | author name string | Lorella Marselli | |
| Umberto Di Mario | |||
| Piero Marchetti | |||
| Roberto Lupi | |||
| Silvia Del Guerra | |||
| Stefano Del Prato | |||
| Matilde Masini | |||
| Ettore Bergamini | |||
| Ugo Boggi | |||
| Franco Mosca | |||
| Giovanni Patané | |||
| Marcello Anello | |||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | fatty acid | Q61476 |
| apoptotic process | Q14599311 | ||
| ceramides | Q424213 | ||
| P304 | page(s) | 1437-1442 | |
| P577 | publication date | 2002-05-01 | |
| P1433 | published in | Diabetes | Q895262 |
| P1476 | title | Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated | |
| P478 | volume | 51 |
| Q58803992 | A PDX1-ATF transcriptional complex governs β cell survival during stress |
| Q51039651 | A novel mechanism regulating insulin secretion involving Herpud1 in mice. |
| Q36041872 | A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death |
| Q35942505 | A simple matter of life and death-the trials of postnatal Beta-cell mass regulation |
| Q36800711 | A systematic review of oxidative stress and safety of antioxidants in diabetes: focus on islets and their defense |
| Q39669833 | ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta cells |
| Q40599426 | Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1. |
| Q57503065 | Adiponectin increases glucose-induced insulin secretion through the activation of lipid oxidation |
| Q34492575 | Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration |
| Q36325762 | Adipose Tissue: A Metabolic Regulator. Potential Implications for the Metabolic Outcome of Subjects Born Small for Gestational Age (SGA) |
| Q40386417 | Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro |
| Q37168389 | Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells |
| Q36906371 | Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction |
| Q36112058 | An immune origin of type 2 diabetes? |
| Q33558360 | An islet in distress: β cell failure in type 2 diabetes |
| Q37667018 | Anti-diabetic effects of CTB-APSL fusion protein in type 2 diabetic mice |
| Q35557601 | Apoptotic signal transduction pathways in diabetes |
| Q42798556 | Aqueous extracts of husks of Plantago ovata reduce hyperglycaemia in type 1 and type 2 diabetes by inhibition of intestinal glucose absorption. |
| Q39656062 | Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line |
| Q49687928 | Autophagy Dysregulation and Obesity-Associated Pathologies. |
| Q37748303 | Autophagy in health and disease. 4. The role of pancreatic beta-cell autophagy in health and diabetes. |
| Q46050859 | Autophagy in human type 2 diabetes pancreatic beta cells. |
| Q39284913 | Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death |
| Q37566231 | BAD: undertaker by night, candyman by day. |
| Q37141727 | Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus |
| Q97069779 | Bax and Bak jointly control survival and dampen the early unfolded protein response in pancreatic β-cells under glucolipotoxic stress |
| Q38952228 | Bcl-2 maintains the mitochondrial membrane potential, but fails to affect production of reactive oxygen species and endoplasmic reticulum stress, in sodium palmitate-induced β-cell death |
| Q35947844 | Beta-Cell Injury in Ncb5or-null Mice is Exacerbated by Consumption of a High-Fat Diet |
| Q37221767 | Beta-cell apoptosis in type 2 diabetes: quantitative and functional consequences. |
| Q37262812 | Beta-cell failure as a complication of diabetes |
| Q37215420 | Beta-cell failure in type 2 diabetes mellitus |
| Q28582648 | Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis |
| Q43053240 | Cannabinoid receptor 1 mediates palmitic acid-induced apoptosis via endoplasmic reticulum stress in human renal proximal tubular cells. |
| Q24645884 | Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis |
| Q37884074 | Ceramide formation as a target in beta-cell survival and function |
| Q54372459 | Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells. |
| Q43297024 | Characterization of beta-cell mass and insulin resistance in diet-induced obese and diet-resistant rats |
| Q83171009 | Chronic effects of different non-esterified fatty acids on pancreatic islets of rats |
| Q27316876 | Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells |
| Q46397532 | Chronic inhibition of dipeptidyl peptidase-IV with ASP8497 improved the HbA(1c) level, glucose intolerance, and lipid parameter level in streptozotocin-nicotinamide-induced diabetic mice |
| Q39255963 | Combination therapy with GLP-1 receptor agonist and SGLT2 inhibitor |
| Q39182810 | Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity |
| Q35691070 | Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients |
| Q38838774 | Curcumin attenuates palmitate-induced apoptosis in MIN6 pancreatic β-cells through PI3K/Akt/FoxO1 and mitochondrial survival pathways |
| Q78419821 | Current literature in diabetes |
| Q40658019 | Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cells |
| Q28579310 | Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation |
| Q38892542 | Cytoprotective effect of hispidin against palmitate-induced lipotoxicity in C2C12 myotubes |
| Q27690875 | Defect of insulin signal in peripheral tissues: Important role of ceramide |
| Q41630494 | Deficiency of stearoyl-CoA desaturase-1 aggravates colitogenic potential of adoptively transferred effector T cells |
| Q41478915 | Deletion of Pten in pancreatic ß-cells protects against deficient ß-cell mass and function in mouse models of type 2 diabetes. |
| Q37186774 | Diabetes: 1 and 2, or one and the same? Progress with the accelerator hypothesis |
| Q35896359 | Diabetes: insulin resistance and derangements in lipid metabolism. Cure through intervention in fat transport and storage |
| Q35103998 | Diabetes: mellitus or lipidus? |
| Q44241620 | Different role of saturated and unsaturated fatty acids in beta-cell apoptosis |
| Q40024663 | Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells |
| Q34998652 | Differential protective effects of exenatide, an agonist of GLP-1 receptor and Piragliatin, a glucokinase activator in beta cell response to streptozotocin-induced and endoplasmic reticulum stresses |
| Q38994824 | Downregulation of Bcl-2 expression by miR-34a mediates palmitate-induced Min6 cells apoptosis. |
| Q30489415 | Dynamics of beta-cell turnover: evidence for beta-cell turnover and regeneration from sources of beta-cells other than beta-cell replication in the HIP rat |
| Q51386809 | Ectopic Fat Storage in the Pancreas, Liver, and Abdominal Fat Depots: Impact on β-Cell Function in Individuals with Impaired Glucose Metabolism |
| Q47134884 | Effect of Saturated Stearic Acid on MAP Kinase and ER Stress Signaling Pathways during Apoptosis Induction in Human Pancreatic β-Cells Is Inhibited by Unsaturated Oleic Acid. |
| Q51175463 | Effect of exposure to non-esterified fatty acid on progressive deterioration of insulin secretion in patients with Type 2 diabetes: a long-term follow-up study. |
| Q52346335 | Effects of Dietary Fatty Acids in Pancreatic Beta Cell Metabolism, Implications in Homeostasis. |
| Q57503692 | Effects of exendin-4 on islets from type 2 diabetes patients |
| Q34810392 | Effects of glucagon-like peptide 1 on glycemia control and its metabolic consequence after severe thermal injury--studies in an animal model |
| Q44184962 | Effects of metformin on oxidative stress, adenine nucleotides balance, and glucose-induced insulin release impaired by chronic free fatty acids exposure in rat pancreatic islets. |
| Q46164585 | Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells |
| Q37138709 | Effects of prolonged fasting and sustained lipolysis on insulin secretion and insulin sensitivity in normal subjects |
| Q40329949 | Efficient delivery of siRNA into cytokine-stimulated insulinoma cells silences Fas expression and inhibits Fas-mediated apoptosis. |
| Q42463130 | Elevated circulating free fatty acids levels causing pancreatic islet cell dysfunction through oxidative stress |
| Q90664827 | Elevated serum ceramides are linked with obesity-associated gut dysbiosis and impaired glucose metabolism |
| Q37277467 | Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic beta-cells |
| Q59355625 | Emricasan (IDN-6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension |
| Q26864238 | Endoplasmic reticulum stress and type 2 diabetes |
| Q88349798 | Enzyme Development for Human Islet Isolation: Five Decades of Progress or Stagnation? |
| Q37253148 | Exendin-4 Promotes Survival of Mouse Pancreatic β-Cell Line in Lipotoxic Conditions, through the Extracellular Signal-Related Kinase 1/2 Pathway |
| Q35034582 | Exendin-4 protects mitochondria from reactive oxygen species induced apoptosis in pancreatic Beta cells |
| Q39101720 | Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway |
| Q33373177 | Exercise training in the aerobic/anaerobic metabolic transition prevents glucose intolerance in alloxan-treated rats |
| Q33869030 | Expression of p53, Bax and Bcl-2 proteins in hepatocytes in non-alcoholic fatty liver disease |
| Q41952935 | Fasting plasma triglycerides predict the glycaemic response to treatment of type 2 diabetes by gastric electrical stimulation. A novel lipotoxicity paradigm |
| Q64911734 | Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity. |
| Q35604849 | Fatty acids suppress autophagic turnover in β-cells |
| Q34635587 | Free fatty acid induces endoplasmic reticulum stress and apoptosis of β-cells by Ca2+/calpain-2 pathways |
| Q80398431 | Frequency of feline diabetes mellitus and breed predisposition in domestic cats in Australia |
| Q57503539 | Functional and Survival Analysis of Isolated Human Islets |
| Q45227245 | Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. |
| Q53327603 | GGPPS-mediated Rab27A geranylgeranylation regulates β cell dysfunction during type 2 diabetes development by affecting insulin granule docked pool formation. |
| Q28571413 | GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim |
| Q33759896 | Gene expression profiling in whole blood identifies distinct biological pathways associated with obesity |
| Q46209001 | Gene expression regulated by pioglitazone and exenatide in normal and diabetic rat islets exposed to lipotoxicity |
| Q40197386 | Generation and expansion of multipotent mesenchymal progenitor cells from cultured human pancreatic islets |
| Q44853988 | Genetic disruption of protein phosphatase 5 in mice prevents high-fat diet feeding-induced weight gain |
| Q38328035 | Genome-wide identification of palmitate-regulated immediate early genes and target genes in pancreatic beta-cells reveals a central role of NF-κB. |
| Q42941644 | Ginsenoside Rg3 Suppresses Palmitate-Induced Apoptosis in MIN6N8 Pancreatic beta-Cells |
| Q28261829 | Gliclazide protects human islet beta-cells from apoptosis induced by intermittent high glucose |
| Q40565084 | Glucagon-like peptide-1 prevents beta cell glucolipotoxicity |
| Q34163947 | Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass |
| Q37921903 | Glucolipotoxicity and beta cells in type 2 diabetes mellitus: target for durable therapy? |
| Q33665283 | Glucolipotoxicity of the pancreatic beta cell. |
| Q36861036 | Glucolipotoxicity: fuel excess and beta-cell dysfunction. |
| Q33886495 | Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death |
| Q33619491 | Group VIA phospholipase A2 mitigates palmitate-induced β-cell mitochondrial injury and apoptosis |
| Q26992217 | Guards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetes |
| Q33616618 | High Dietary Fructose: Direct or Indirect Dangerous Factors Disturbing Tissue and Organ Functions |
| Q28584125 | High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 β-cells by increasing the posttranslational carboxylmethylation of its catalytic subunit |
| Q40639986 | High glucose potentiates palmitate-induced NO-mediated cytotoxicity through generation of superoxide in clonal beta-cell HIT-T15. |
| Q35062610 | Hip circumference and the risk of type 2 diabetes in middle-aged and elderly men and women: the Shanghai women and Shanghai men's health studies |
| Q37425106 | Histopathology of type 1 diabetes: old paradigms and new insights |
| Q40450700 | Human triglyceride-rich lipoproteins impair glucose metabolism and insulin signalling in L6 skeletal muscle cells independently of non-esterified fatty acid levels. |
| Q42159827 | Hyperglycemia magnifies Schwann cell dysfunction and cell death triggered by PA-induced lipotoxicity |
| Q40036683 | ICER-1gamma overexpression drives palmitate-mediated connexin36 down-regulation in insulin-secreting cells. |
| Q45344831 | IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets |
| Q46082371 | Identification of Gene Expression Changes in the Aorta of ApoE Null Mice Fed a High-Fat Diet |
| Q39312165 | Identification of direct forkhead box O1 targets involved in palmitate-induced apoptosis in clonal insulin-secreting cells using chromatin immunoprecipitation coupled to DNA selection and ligation |
| Q58720604 | Identification of early biological changes in palmitate-treated isolated human islets |
| Q36390892 | Implications of rosiglitazone and pioglitazone on cardiovascular risk in patients with type 2 diabetes mellitus |
| Q54384891 | Improved survival and function of rat cryopreserved islets by coculture with sertoli cells. |
| Q38693422 | In Vitro Effect of Fatty Acids Identified in the Plasma of Obese Adolescents on the Function of Pancreatic β-Cells |
| Q39411365 | In vitro effects of mycophenolic acid on survival, function, and gene expression of pancreatic beta-cells. |
| Q41646644 | Increased Frequency of Hormone Negative and Polyhormonal Endocrine Cells in Lean Individuals With Type 2 Diabetes |
| Q64069791 | Influences of sterol regulatory element binding protein-1c silencing on glucose production in HepG2 cells treated with free fatty acid |
| Q36910693 | Initiation and execution of lipotoxic ER stress in pancreatic beta-cells |
| Q35871387 | Insulin resistance, metabolic stress, and atherosclerosis |
| Q46542315 | Insulin secretion in metabolically obese, but normal weight, and in metabolically healthy but obese individuals. |
| Q73531395 | Insulin therapy in type 2 diabetes |
| Q51203936 | Interleukin-22 restored mitochondrial damage and impaired glucose-stimulated insulin secretion through down-regulation of uncoupling protein-2 in INS-1 cells. |
| Q39616452 | Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells |
| Q26830871 | Interventions to preserve beta-cell function in the management and prevention of type 2 diabetes |
| Q42166780 | Intra-islet PACAP protects pancreatic β-cells against glucotoxicity and lipotoxicity |
| Q47616793 | Involvement of dying beta cell originated messenger molecules in differentiation of pancreatic mesenchymal stem cells under glucotoxic and glucolipotoxic conditions. |
| Q39556492 | Involvement of the TLR4 (Toll-like receptor4) signaling pathway in palmitate-induced INS-1 beta cell death |
| Q34698810 | Islet beta cell failure in type 2 diabetes |
| Q33858456 | JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway |
| Q28079845 | Kinase Signaling in Apoptosis Induced by Saturated Fatty Acids in Pancreatic β-Cells |
| Q35580023 | L-carnitine ameliorated fatty liver in high-calorie diet/STZ-induced type 2 diabetic mice by improving mitochondrial function |
| Q50927857 | Late gestation over- and undernutrition predispose for visceral adiposity in response to a post-natal obesogenic diet, but with differential impacts on glucose-insulin adaptations during fasting in lambs. |
| Q51316037 | Late gestation under- and overnutrition have differential impacts when combined with a post-natal obesogenic diet on glucose-lactate-insulin adaptations during metabolic challenges in adolescent sheep. |
| Q36700877 | Leptin therapy, insulin sensitivity, and glucose homeostasis. |
| Q34658250 | Linoleic acid stimulates [Ca2+]i increase in rat pancreatic beta-cells through both membrane receptor- and intracellular metabolite-mediated pathways |
| Q42451513 | Lipodystrophy in human immunodeficiency virus patients impairs insulin action and induces defects in beta-cell function |
| Q64230296 | Lipotoxicity and Cell Maintenance in Obesity and Type 2 Diabetes |
| Q39509041 | Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells |
| Q40627561 | LysB3, GluB29 insulin: a novel insulin analog with enhanced β-cell protective action |
| Q39247779 | Macrophage migration inhibitory factor (MIF) enhances palmitic acid- and glucose-induced murine beta cell dysfunction and destruction in vitro |
| Q39446700 | Macrophage migration inhibitory factor deficiency protects pancreatic islets from palmitic acid-induced apoptosis |
| Q46373924 | Mechanism of Generation of Oxidative Stress and Pathophysiology of Type 2 Diabetes Mellitus: How Are They Interlinked? |
| Q40104537 | Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells |
| Q36846978 | Mesenchymal Stem Cells Ameliorated Glucolipotoxicity in HUVECs through TSG-6 |
| Q36850355 | Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis |
| Q38336639 | Minireview: Autophagy in pancreatic β-cells and its implication in diabetes |
| Q40663264 | Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids |
| Q50516646 | Mitochondrial reactive oxygen species (ROS) inhibition ameliorates palmitate-induced INS-1 beta cell death |
| Q35250813 | Mitochondrial vulnerability and increased susceptibility to nutrient-induced cytotoxicity in fibroblasts from leigh syndrome French canadian patients. |
| Q43760976 | Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis |
| Q44779071 | Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure |
| Q30994890 | NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways |
| Q37959319 | Nanospaces between endoplasmic reticulum and mitochondria as control centres of pancreatic β-cell metabolism and survival. |
| Q44403757 | Necrosis Is the Predominant Type of Islet Cell Death During Development of Insulin-Dependent Diabetes Mellitus in BB Rats |
| Q38721830 | Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival. |
| Q28574983 | Neuronal nitric oxide synthase protects the pancreatic beta cell from glucolipotoxicity-induced endoplasmic reticulum stress and apoptosis |
| Q36400258 | New insights into fatty acid modulation of pancreatic beta-cell function. |
| Q35600131 | Nifedipine protects INS-1 β-cell from high glucose-induced ER stress and apoptosis |
| Q33772298 | Novel proapoptotic effect of hepatocyte growth factor: synergy with palmitate to cause pancreatic {beta}-cell apoptosis |
| Q38038651 | Nutrition-/diet-induced changes in gene expression in pancreatic β-cells. |
| Q42079508 | Oleate inhibits steryl ester synthesis and causes liposensitivity in yeast. |
| Q33283063 | PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism |
| Q37193767 | PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis |
| Q34044630 | PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim. |
| Q28483101 | Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets |
| Q33549736 | Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes |
| Q44456467 | Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis |
| Q42658904 | Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets |
| Q92705363 | Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells |
| Q58702444 | Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes |
| Q57503330 | Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation |
| Q46923599 | Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity |
| Q36051530 | Phenylpropenoic Acid Glucoside from Rooibos Protects Pancreatic Beta Cells against Cell Death Induced by Acute Injury |
| Q35537840 | Plasma phospholipid very-long-chain saturated fatty acids and incident diabetes in older adults: the Cardiovascular Health Study |
| Q90230665 | Polysiphonia japonica Extract Attenuates Palmitate-Induced Toxicity and Enhances Insulin Secretion in Pancreatic Beta-Cells |
| Q40294764 | Polyunsaturated fatty acids mobilize intracellular Ca2+ in NT2 human teratocarcinoma cells by causing release of Ca2+ from mitochondria |
| Q35989381 | Potential role of oral thiazolidinedione therapy in preserving beta-cell function in type 2 diabetes mellitus |
| Q47133871 | Prediction aided in vitro analysis of octa-decanoic acid from Cyanobacterium Lyngbya sp. as a proapoptotic factor in eliciting anti-inflammatory properties |
| Q38308272 | Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice |
| Q90316976 | Protection from β-cell apoptosis by inhibition of TGF-β/Smad3 signaling |
| Q36134154 | Protective Role of PPARdelta in Lipoapoptosis of Pancreatic β Cells |
| Q37320446 | Proteins altered by elevated levels of palmitate or glucose implicated in impaired glucose-stimulated insulin secretion |
| Q44203320 | Reproducibility of targeted gene expression measurements in human islets of Langerhans |
| Q61046250 | Role of Apoptosis in Autoimmunity |
| Q30351934 | Role of ceramide in diabetes mellitus: evidence and mechanisms. |
| Q37650996 | Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies |
| Q35667288 | Roles of Sphingolipid Metabolism in Pancreatic β Cell Dysfunction Induced by Lipotoxicity |
| Q38030857 | Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction. |
| Q44660894 | Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion. |
| Q37119316 | SLipid-induced cell dysfunction and cell death: lessons from yeast |
| Q51357843 | Serine/threonine protein phosphatase 5 regulates glucose homeostasis in vivo and apoptosis signalling in mouse pancreatic islets and clonal MIN6 cells. |
| Q55278796 | Sphingolipid regulators of cellular dysfunction in Type 2 diabetes mellitus: a systems overview. |
| Q38809404 | Sphingolipids in mitochondria. |
| Q33880588 | Sphingolipids in obesity, type 2 diabetes, and metabolic disease |
| Q36861002 | Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism |
| Q37972614 | Stearoyl CoA desaturase 1: role in cellular inflammation and stress |
| Q91658255 | Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity |
| Q34997512 | Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discovery |
| Q42984798 | Steatosis and liver cell apoptosis in chronic hepatitis C: a mechanism for increased liver injury |
| Q39842274 | Stereological assessment of pancreatic beta‐cell mass development in male Zucker Diabetic Fatty (ZDF) rats: correlation with pancreatic beta‐cell function |
| Q36867289 | Stress-impaired transcription factor expression and insulin secretion in transplanted human islets. |
| Q37798716 | Systemic effects of white adipose tissue dysregulation and obesity-related inflammation |
| Q31161182 | TRB3 is involved in free fatty acid-induced INS-1-derived cell apoptosis via the protein kinase C δ pathway |
| Q48159452 | The Dynamic Effects of Isosteviol on Insulin Secretion and Its Inability to Counteract the Impaired β-Cell Function during Gluco-, Lipo-, and Aminoacidotoxicity: Studies In Vitro. |
| Q38415589 | The Glucotoxicity Protecting Effect of Ezetimibe in Pancreatic Beta Cells via Inhibition of CD36. |
| Q94454413 | The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond |
| Q36329899 | The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis |
| Q36477263 | The apoptosis inhibitor ARC alleviates the ER stress response to promote β-cell survival |
| Q41689708 | The dynamic plasticity of insulin production in β-cells. |
| Q33300966 | The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. |
| Q37704600 | The endoplasmic reticulum stress/autophagy pathway is involved in cholesterol-induced pancreatic β-cell injury |
| Q45457722 | The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum |
| Q36864864 | The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase. |
| Q36921672 | The importance of free fatty acids in the development of Type 2 diabetes. |
| Q37618278 | The natural PPAR agonist linoleic acid stimulated insulin release in the rat pancreas |
| Q37606940 | The p21-activated kinase (PAK1) is involved in diet-induced beta cell mass expansion and survival in mice and human islets |
| Q92759314 | The role of elevated alanine aminotransferase (ALT), FasL and atherogenic dyslipidemia in type II diabetes mellitus |
| Q37868424 | The role of nitric oxide synthase in post-operative hyperglycaemia |
| Q37711953 | The role of sphingolipid signalling in diabetes‑associated pathologies (Review). |
| Q34162699 | The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells |
| Q51485541 | Thiazolidinediones improve beta-cell function in type 2 diabetic patients. |
| Q39620625 | Thiazolidinediones protect mouse pancreatic β-cells directly from cytokine-induced cytotoxicity through PPARγ-dependent mechanisms |
| Q24803245 | Transcriptional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic beta-cell function |
| Q54393261 | Transcriptional regulation of Δ6-desaturase by peroxisome proliferative-activated receptor δ agonist in human pancreatic cancer cells: role of MEK/ERK1/2 pathway. |
| Q33312956 | UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells |
| Q36525107 | USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis |
| Q57503376 | Ultrastructural morphometric analysis of insulin secretory granules in human type 2 diabetes |
| Q38924043 | Unveiling a common mechanism of apoptosis in β-cells and neurons in Friedreich's ataxia |
| Q37694420 | miR-31 Links Lipid Metabolism and Cell Apoptosis in Bacteria-Challenged Apostichopus japonicus via Targeting CTRP9. |
| Q35918941 | p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells. |
| Q28580759 | p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress |
| Q24339464 | tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans |
| Q33558395 | β-cell mass in people with type 2 diabetes |
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