| scholarly article | Q13442814 |
| P50 | author | Piero Marchetti | Q37382607 |
| Miriam Cnop | Q44930881 | ||
| Alessandra K. Cardozo | Q61784241 | ||
| P2093 | author name string | Fabrice Moore | |
| Daniel A Cunha | |||
| Marco Bugliani | |||
| Décio L Eizirik | |||
| Maikel L Colli | |||
| Mariana Igoillo Esteve | |||
| P2860 | cites work | Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP | Q24296501 |
| Identification of a nuclear Stat1 protein tyrosine phosphatase | Q24302061 | ||
| T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6 | Q24338883 | ||
| Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase | Q24522441 | ||
| Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls | Q24550675 | ||
| Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase | Q24563410 | ||
| cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family | Q24611364 | ||
| Shared and distinct genetic variants in type 1 diabetes and celiac disease | Q24623113 | ||
| Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes | Q24652324 | ||
| A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis | Q28216420 | ||
| Role of PTPN22 in type 1 diabetes and other autoimmune diseases | Q28239964 | ||
| Regulation of gene-activation pathways by PIAS proteins in the immune system | Q28264801 | ||
| T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease | Q28511860 | ||
| A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells | Q28572940 | ||
| Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells | Q28574877 | ||
| Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis | Q28576685 | ||
| T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation | Q28590621 | ||
| Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids | Q29616817 | ||
| Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines | Q29619317 | ||
| T1DBase: integration and presentation of complex data for type 1 diabetes research | Q31085600 | ||
| Structural and evolutionary relationships among protein tyrosine phosphatase domains | Q34012560 | ||
| A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis | Q34495385 | ||
| Genome-wide association studies: theoretical and practical concerns | Q34555195 | ||
| Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP. | Q36076075 | ||
| PTP1B and TC-PTP: novel roles in immune-cell signaling | Q36602604 | ||
| The central role of T cells in rheumatoid arthritis | Q36988984 | ||
| STAT3 as a target for inducing apoptosis in solid and hematological tumors | Q37029162 | ||
| PTP1B and TC-PTP: regulators of transformation and tumorigenesis | Q37072449 | ||
| The CVB and etiology of type 1 diabetes | Q37115640 | ||
| EGF receptor in pancreatic beta-cell mass regulation | Q37164483 | ||
| Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes | Q37164503 | ||
| Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes? | Q37173779 | ||
| Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program | Q37360298 | ||
| Toll-like receptor 4 suppression leads to islet allograft survival | Q40137830 | ||
| Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells | Q40623131 | ||
| Insulin receptor signaling in the beta-cell influences insulin gene expression and insulin content: evidence for autocrine beta-cell regulation | Q41016896 | ||
| Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells | Q43585447 | ||
| Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. | Q43972538 | ||
| Diabetogenic potential of human pathogens uncovered in experimentally permissive beta-cells. | Q46038754 | ||
| The transcription factor Stat3 is dispensable for pancreatic beta-cell development and function. | Q46606422 | ||
| Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells | Q46620665 | ||
| Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis | Q46625501 | ||
| IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice. | Q54449054 | ||
| Essential Role for Signal Transducer and Activator of Transcription-1 in Pancreatic -Cell Death and Autoimmune Type 1 Diabetes of Nonobese Diabetic Mice | Q59302409 | ||
| Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in ty | Q64379014 | ||
| A new in vitro model for the study of pancreatic A and B cells | Q69866352 | ||
| Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture | Q71617439 | ||
| Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on "substrate-trapping" mutants | Q73586208 | ||
| Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays | Q73831600 | ||
| Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR | Q77753107 | ||
| Global profiling of double stranded RNA- and IFN-?-induced genes in rat pancreatic beta cells | Q79255376 | ||
| TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma} | Q79598045 | ||
| Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection | Q80249480 | ||
| Islet beta-cell death - fuel to sustain autoimmunity? | Q80851772 | ||
| Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets | Q81914032 | ||
| Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation | Q82927575 | ||
| P275 | copyright license | Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported | Q19125045 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | type-1 diabetes | Q124407 |
| apoptotic process | Q14599311 | ||
| P304 | page(s) | 1283-1291 | |
| P577 | publication date | 2009-03-31 | |
| P1433 | published in | Diabetes | Q895262 |
| P1476 | title | PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis | |
| P478 | volume | 58 |
| Q36465629 | A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly |
| Q33947078 | A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells |
| Q83233518 | A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes |
| Q33631445 | A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes |
| Q90745613 | Advances in Knowledge of Candidate Genes Acting at the Beta-Cell Level in the Pathogenesis of T1DM |
| Q34682216 | An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells |
| Q36229769 | Both baseline clinical factors and genetic polymorphisms influence the development of severe functional status in ankylosing spondylitis |
| Q36311167 | C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells |
| Q33925780 | CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients |
| Q38127357 | Candidate genes expressed in human islets and their role in the pathogenesis of type 1 diabetes. |
| Q38134106 | Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and β-cell apoptosis |
| Q40739094 | Clinical Case of Immune Dysregulation, Polyendocrinopaty, Enteropathy, X-Linked (IPEX) Syndrome with Severe Immune Deficiency and Late Onset of Endocrinopathy and Enteropathy |
| Q36884595 | Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways |
| Q38861124 | Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms |
| Q33604490 | Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells |
| Q28579310 | Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation |
| Q33604570 | Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects |
| Q35779845 | Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells |
| Q24336003 | Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase |
| Q39351883 | Differential usage of NF-κB activating signals by IL-1β and TNF-α in pancreatic beta cells |
| Q28574313 | Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance |
| Q34041550 | Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance |
| Q28571413 | GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim |
| Q33847195 | Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells |
| Q38590582 | Genes affecting β-cell function in type 1 diabetes |
| Q36051516 | Genetic Variants of PTPN2 Gene in Chinese Children with Type 1 Diabetes Mellitus |
| Q30431554 | Genetics of type 1 diabetes: what's next? |
| Q34464568 | Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets |
| Q38325456 | How apoptotic β-cells direct immune response to tolerance or to autoimmune diabetes: a review. |
| Q35217022 | Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis |
| Q45344831 | IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets |
| Q37996976 | Inflammation and type one diabetes |
| Q34921610 | Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells |
| Q28507344 | Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets |
| Q37471784 | MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA. |
| Q26775510 | MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes research |
| Q28571868 | Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis |
| Q35138365 | Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels |
| Q36163240 | MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells. |
| Q38721830 | Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival. |
| Q34313109 | Nova1 is a master regulator of alternative splicing in pancreatic beta cells. |
| Q36047614 | On the immense variety and complexity of circumstances conditioning pancreatic β-cell apoptosis in type 1 diabetes |
| Q91671317 | PTPN2 Downregulation Is Associated with Albuminuria and Vitamin D Receptor Deficiency in Type 2 Diabetes Mellitus |
| Q34211942 | PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background |
| Q64950663 | PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy. |
| Q90726163 | PTPN2 improves implant osseointegration in T2DM via inducing the dephosphorylation of ERK |
| Q34044630 | PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim. |
| Q53217400 | Pancreatic Beta Cell Survival and Signaling Pathways: Effects of Type 1 Diabetes-Associated Genetic Variants. |
| Q34644615 | Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice |
| Q33592510 | Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis |
| Q58702444 | Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes |
| Q57503330 | Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation |
| Q28582005 | Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death |
| Q92405630 | Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells |
| Q38200472 | Protein phosphatases in pancreatic islets. |
| Q37088189 | Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22 |
| Q27317203 | Reduction of connexin36 content by ICER-1 contributes to insulin-secreting cells apoptosis induced by oxidized LDL particles |
| Q28575333 | STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation |
| Q46115480 | T cell protein tyrosine phosphatase prevents STAT1 induction of claudin-2 expression in intestinal epithelial cells. |
| Q64108040 | The Association between Depression and Type 1 Diabetes Mellitus: Inflammatory Cytokines as Ferrymen in between? |
| Q64091915 | The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives |
| Q34192894 | The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines |
| Q26822824 | The impact of anti-inflammatory cytokines on the pancreatic β-cell |
| Q37537864 | The pancreatic β cell and type 1 diabetes: innocent bystander or active participant? |
| Q34162699 | The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells |
| Q39140831 | Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis |
| Q49200841 | Type 1 diabetes genome-wide association studies: not to be lost in translation |
| Q36525107 | USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis |
| Q37065973 | Ubiquitin D Regulates IRE1α/c-Jun N-terminal Kinase (JNK) Protein-dependent Apoptosis in Pancreatic Beta Cells |
| Q38924043 | Unveiling a common mechanism of apoptosis in β-cells and neurons in Friedreich's ataxia |
| Q37697741 | Viral infections in type 1 diabetes mellitus--why the β cells? |
| Q28580759 | p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress |
| Q24339464 | tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans |
| Q92217601 | β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes |
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