Slfn2 mutation-induced loss of T-cell quiescence leads to elevated de novo sterol synthesis.

scientific article published on 3 July 2017

Slfn2 mutation-induced loss of T-cell quiescence leads to elevated de novo sterol synthesis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/IMM.12785
P932PMC publication ID5629436
P698PubMed publication ID28672048

P50authorMichael BergerQ86559023
P2093author name stringOren Rom
John S Parks
Abraham K Gebre
Michael Aviram
Ibrahim Omar
Leonor Cohen-Daniel
P2860cites workSterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunityQ36839721
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CD8 T cell quiescence revisitedQ37987729
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Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and aQ40542044
Loss of T-cell quiescence by targeting Slfn2 prevents the development and progression of T-ALL.Q40857983
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Adipocyte Metrnl Antagonizes Insulin Resistance Through PPARγ Signaling.Q42823688
Liver X receptors interfere with cytokine-induced proliferation and cell survival in normal and leukemic lymphocytes.Q43293820
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophagesQ44542540
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Dietary monounsaturated fatty acids promote aortic atherosclerosis in LDL receptor-null, human ApoB100-overexpressing transgenic mice.Q55068119
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LKLF: A transcriptional regulator of single-positive T cell quiescence and survivalQ73709468
ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterizationQ22003885
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesisQ24336781
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Tob is a negative regulator of activation that is expressed in anergic and quiescent T cellsQ28203889
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Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Schlafen, a new family of growth regulatory genes that affect thymocyte developmentQ28592251
Regulation of the mevalonate pathwayQ29547763
ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferationQ30427703
12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1.Q30438268
Molecular signature of cell cycle exit induced in human T lymphoblasts by IL-2 withdrawalQ33463820
Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.Q33608726
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.Q33797113
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescenceQ33819643
The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolismQ33846421
Relationship between sterol synthesis and DNA synthesis in phytohemagglutinin-stimulated mouse lymphocytesQ35079778
Liver X Receptor Signaling Pathways in Cardiovascular DiseaseQ35104848
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and functionQ35172754
Regulation of quiescence in lymphocytesQ35177712
Regulation of T-cell survival and mitochondrial homeostasis by TSC1Q35621065
mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiationQ35719914
Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.Q36433762
Metabolic regulation of T lymphocytesQ36711431
Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cellsQ36780944
P433issue3
P304page(s)484-493
P577publication date2017-08-02
P1433published inImmunologyQ15754984
P1476titleSlfn2 mutation-induced loss of T-cell quiescence leads to elevated de novo sterol synthesis
P478volume152

Reverse relations

Q88984029Slfn2 Regulates Type I Interferon Responses by Modulating the NF-κB Pathwaycites workP2860

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