Mitochondrial fatty acid oxidation in obesity

scientific article

Mitochondrial fatty acid oxidation in obesity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1089/ARS.2012.4875
P3181OpenCitations bibliographic resource ID2657128
P932PMC publication ID3691913
P698PubMed publication ID22900819
P5875ResearchGate publication ID230695995

P50authorLaura HerreroQ31229237
Joan Francesc MirQ41464635
Dolors Serra CucurullQ41464641
Paula MeraQ84817655
Maria Ida MalandrinoQ114438455
P2860cites workRole of AMP-activated protein kinase in mechanism of metformin actionQ22241898
Obesity, Inflammation, and Insulin ResistanceQ22250939
Positional cloning of the mouse obese gene and its human homologueQ22251285
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actionsQ24321265
SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activationQ24321658
Nuclear receptor corepressor RIP140 regulates fat accumulationQ24561531
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activityQ24595845
Identification and importance of brown adipose tissue in adult humansQ24632425
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
How mitochondria produce reactive oxygen speciesQ24643882
Identification of a physiologically relevant endogenous ligand for PPARalpha in liverQ24653691
Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate dietsQ24683319
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiologyQ27860991
A novel brain-expressed protein related to carnitine palmitoyltransferase IQ28206878
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamusQ28254114
Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathwayQ28348167
Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimersQ28378616
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obeseQ28510931
UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutralityQ28513102
Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose productionQ28566853
Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animalsQ28568642
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibitionQ28579126
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesisQ28588558
Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistanceQ37105295
ATF6 modulates SREBP2-mediated lipogenesis.Q37260315
Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women.Q37271487
Characteristics and mechanisms of hypothalamic neuronal fatty acid sensingQ37337599
Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen speciesQ37363614
Acetylation of mitochondrial proteinsQ37475301
Role of lipid-derived mediators in skeletal muscle insulin resistance.Q37551374
Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspectiveQ37670371
Nonalcoholic fatty liver disease: pathology and pathogenesisQ37676210
JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunctionQ37725556
Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connectionQ37739949
LKB1 is the upstream kinase in the AMP-activated protein kinase cascadeQ28610414
Increased oxidative stress in obesity and its impact on metabolic syndromeQ29012150
Cold-activated brown adipose tissue in healthy menQ29547382
Brown adipose tissue: function and physiological significanceQ29547448
Obesity induces a phenotypic switch in adipose tissue macrophage polarizationQ29547686
Functional brown adipose tissue in healthy adultsQ29547687
Steatohepatitis: a tale of two "hits"?Q29547771
Hydroperoxide metabolism in mammalian organsQ29614205
Macrophages, inflammation, and insulin resistanceQ29614351
Sirtuins in mammals: insights into their biological functionQ29615248
High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposityQ29615454
Mitochondrial dysfunction and type 2 diabetesQ29617913
The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysisQ29618429
Unexpected evidence for active brown adipose tissue in adult humansQ29619030
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver diseaseQ29619334
Adipocytes as regulators of energy balance and glucose homeostasisQ29619448
Reactive oxygen species have a causal role in multiple forms of insulin resistanceQ29619831
Mechanisms for insulin resistance: common threads and missing linksQ29620447
Lipid content in the musculature of the lower leg assessed by fat selective MRI: intra- and interindividual differences and correlation with anthropometric and metabolic dataQ30770149
A potent PPARalpha agonist stimulates mitochondrial fatty acid beta-oxidation in liver and skeletal muscleQ31833512
Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidationQ33238478
Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesityQ33589062
Inflammation and adipose tissue macrophages in lipodystrophic miceQ33591836
Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathwayQ33661644
Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat.Q33762194
Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic miceQ33782682
Cellular bioenergetics as a target for obesity therapyQ33894407
Oxidative stress stimulates skeletal muscle glucose uptake through a phosphatidylinositol 3-kinase-dependent pathwayQ33901770
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetesQ33918445
Reactive oxygen species enhance insulin sensitivityQ33941647
Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient dietQ34016567
Autophagy in hypothalamic AgRP neurons regulates food intake and energy balanceQ34204941
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndromeQ34209480
Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat dietQ34275922
Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosisQ34299225
Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxideQ34367006
Lipid-induced insulin resistance: unravelling the mechanismQ34370958
Forkhead box o as a sensor, mediator, and regulator of redox signaling.Q37772177
Redox Balance in the Pathogenesis of Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic OpportunitiesQ37802379
Brain lipid sensing and nervous control of energy balanceQ37824009
Uncoupling proteins and the control of mitochondrial reactive oxygen species productionQ37901603
Endoplasmic reticulum stress, obesity and diabetesQ37926034
Current updates in the medical management of obesity.Q37995649
Anti-obesity drugs: a review about their effects and their safetyQ37996099
Biological role, clinical significance, and therapeutic possibilities of the recently discovered metabolic hormone fibroblastic growth factor 21.Q38022223
Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulationQ38303256
Elevated hepatic mitochondrial and peroxisomal oxidative capacities in fed and starved adult obese (ob/ob) miceQ38351927
Immunometabolism: an emerging frontierQ38876919
Mechanism responsible for 5-(tetradecyloxy)-2-furoic acid inhibition of hepatic lipogenesisQ39275872
More than satiety: central serotonin signaling and glucose homeostasisQ39676645
Interactions between ROS and AMP kinase activity in the regulation of PGC-1alpha transcription in skeletal muscle cellsQ39917673
The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue.Q39982206
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistanceQ40028148
CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistanceQ40216131
Fatty acids induce L-CPT I gene expression through a PPARalpha-independent mechanism in rat hepatoma cellsQ40370246
Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicityQ40379756
Redox regulation of protein tyrosine phosphatases by hydrogen peroxide: detecting sulfenic acid intermediates and examining reversible inactivationQ40745756
Insulin regulates enzyme activity, malonyl-CoA sensitivity and mRNA abundance of hepatic carnitine palmitoyltransferase-I.Q41295267
The insulinomimetic agents H2O2 and vanadate stimulate protein tyrosine phosphorylation in intact cellsQ41743893
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.Q41807977
Characterization of rat liver malonyl-CoA decarboxylase and the study of its role in regulating fatty acid metabolismQ41857449
Peroxisome proliferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype.Q41913346
Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.Q42033681
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicalsQ42065664
Flux control exerted by mitochondrial outer membrane carnitine palmitoyltransferase over beta-oxidation, ketogenesis and tricarboxylic acid cycle activity in hepatocytes isolated from rats in different metabolic statesQ42081081
Oxidant stress and skeletal muscle glucose transport: roles of insulin signaling and p38 MAPK.Q42499381
Digging deeper into obesityQ42741873
Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinaseQ42814174
Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanismQ43288025
Regulation of carnitine palmitoyltransferase by insulin results in decreased activity and decreased apparent Ki values for malonyl-CoA.Q43413499
Central administration of oleic acid inhibits glucose production and food intakeQ43867506
The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.Q43940116
AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed ratsQ44155454
Discovery of a long-chain carbamoyl aminocarnitine derivative, a reversible carnitine palmitoyltransferase inhibitor with antiketotic and antidiabetic activity.Q44272716
Hepatic mitochondrial beta-oxidation in patients with nonalcoholic steatohepatitis assessed by 13C-octanoate breath testQ44627897
UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunctionQ44653224
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistanceQ44760628
Insulin resistance. Prosperity's plague.Q45927417
Liver fat and lipid oxidation in humans.Q45929386
C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weightQ46191269
Selective reversible inhibition of liver carnitine palmitoyl-transferase 1 by teglicar reduces gluconeogenesis and improves glucose homeostasisQ34527222
Developmental origin of fat: tracking obesity to its source.Q34705822
Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intakeQ34706061
The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelinQ34718745
Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance.Q34733232
Metabolic sensors: viewing glucosensing neurons from a broader perspectiveQ34738773
Oxidative stress and the etiology of insulin resistance and type 2 diabetesQ34768229
Adipose tissue remodeling and obesityQ35015740
Sixteen years and counting: an update on leptin in energy balanceQ35015746
Circadian rhythms, sleep, and metabolismQ35015762
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species productionQ35197888
Sirtuin 1 in lipid metabolism and obesityQ35214969
Therapeutic approaches to target inflammation in type 2 diabetesQ35581498
Human fatty liver disease: old questions and new insightsQ35588477
Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on genderQ35592126
Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused?Q35596985
Patients with type 2 diabetes have normal mitochondrial function in skeletal muscleQ35676919
Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesityQ35768964
Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytesQ35780260
The ins and outs of mitochondrial dysfunction in NASH.Q35821156
NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytesQ35879950
Lipid-induced mitochondrial stress and insulin action in muscleQ35947486
Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivityQ36082167
Hypothalamic sensing of fatty acidsQ36108719
Regulation of hypothalamic malonyl-CoA by central glucose and leptin.Q36288540
Ins and outs modulating hepatic triglyceride and development of nonalcoholic fatty liver diseaseQ36450812
Modulation of glucose transport in skeletal muscle by reactive oxygen speciesQ36643399
High expression of a novel carnitine palmitoyltransferase I like protein in rat brown adipose tissue and heart: isolation and characterization of its cDNA cloneQ36701696
Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic functionQ36777865
Neurobiology of feeding and energy expenditureQ36824059
Insulin sensitivity: modulation by nutrients and inflammationQ36848937
Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver diseaseQ36856713
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic diseaseQ36910684
Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic diseaseQ37024621
Sites of generation of reactive oxygen species in homogenates of brain tissue determined with the use of respiratory substrates and inhibitors.Q46568844
"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasisQ46626411
Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid contentQ46933158
Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight lossQ47254568
Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: the BLOOM-DM studyQ47321369
Effects of high fat-feeding to rats on the interrelationship of body weight, plasma insulin, and fatty acyl-coenzyme A esters in liver and skeletal muscleQ47412626
Lipid sensing and insulin resistance in the brainQ48531280
Differential effects of short- and long-term high-fat diet feeding on hepatic fatty acid metabolism in rats.Q50534857
GH does not modulate the early fasting-induced release of free fatty acids in mice.Q51364932
Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation.Q51379331
Control of hepatic fatty acid oxidation by 5'-AMP-activated protein kinase involves a malonyl-CoA-dependent and a malonyl-CoA-independent mechanism.Q52523762
Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.Q54332121
Type I iodothyronine 5'-deiodinase mRNA and activity is increased in adipose tissue of obese subjects.Q54369689
Role of reactive oxygen species-related enzymes in neuropeptide y and proopiomelanocortin-mediated appetite control: a study using atypical protein kinase C knockdown.Q54380190
Maximal perfusion of skeletal muscle in man.Q54444608
Evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease.Q54645541
Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in MuscleQ54986901
Adipose tissue as an endocrine organQ57257904
Setting the Tone: Reactive Oxygen Species and the Control of Appetitive Melanocortin NeuronsQ57912919
T-ing up inflammation in fatQ58197131
Free radicals and tissue damage produced by exerciseQ67231917
The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterizationQ70196543
Cyclic AMP and fatty acids increase carnitine palmitoyltransferase I gene transcription in cultured fetal rat hepatocytesQ71130146
Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cellsQ71148397
Free radical-mediated lipid peroxidation in cells: oxidizability is a function of cell lipid bis-allylic hydrogen contentQ72371468
Regulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl-CoA carboxylase by the adenylate energy chargeQ72420028
Exercise training increases lipid metabolism gene expression in human skeletal muscleQ74308831
Steady state changes in mitochondrial electrical potential and proton gradient in perfused liver from rats fed a high fat dietQ74453044
UCP1 deficiency increases susceptibility to diet-induced obesity with ageQ81797596
Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosisQ82254642
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
mitochondrionQ39572
fatty acidQ61476
P304page(s)269-284
P577publication date2012-10-05
P1433published inAntioxidants & Redox SignalingQ4775078
P1476titleMitochondrial fatty acid oxidation in obesity
P478volume19

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