Pathogenic Hijacking of ER-Associated Degradation: Is ERAD Flexible?

scientific article (publication date: 6 August 2015)

Pathogenic Hijacking of ER-Associated Degradation: Is ERAD Flexible? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.MOLCEL.2015.06.010
P8608Fatcat IDrelease_kbovlr4urvhrthj7oxwf5lsy6a
P698PubMed publication ID26253026

P50authorKazuhiro NagataQ11550232
Daisuke MoritoQ59683777
P2860cites workBAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosolQ84985437
Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting stepsQ21131559
Retrograde transport pathways utilised by viruses and protein toxinsQ21245139
A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradationQ24297209
A membrane protein required for dislocation of misfolded proteins from the ERQ24297703
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosolQ24297732
Defining human ERAD networks through an integrative mapping strategyQ24298439
Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulumQ24298901
EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming stepQ24301651
Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradationQ24302539
The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ERQ24311488
Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ERQ24311975
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERADQ24312778
Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradationQ24322026
Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destructionQ24324602
Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membraneQ24336904
HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradationQ24337606
Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membraneQ24530318
A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromisedQ24535941
The human protein disulphide isomerase family: substrate interactions and functional propertiesQ24537186
EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosolQ24541550
Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulumQ24600792
Two translocating hydrophilic segments of a nascent chain span the ER membrane during multispanning protein topogenesisQ24645170
One step at a time: endoplasmic reticulum-associated degradationQ24658302
Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infectionQ24674111
Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3Q24683139
Ubiquitylation of an ERAD substrate occurs on multiple types of amino acidsQ26781978
Protein folding and quality control in the ERQ26823157
Structural basis of an ERAD pathway mediated by the ER-resident protein disulfide reductase ERdj5Q27666741
The ubiquitin systemQ27860803
Key steps in ERAD of luminal ER proteins reconstituted with purified componentsQ27929992
A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradationQ27930372
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteinsQ27931299
The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosolQ27936514
Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membraneQ27938831
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1pQ27938951
AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradationQ27939982
Molecular chaperones in the cytosol: from nascent chain to folded proteinQ28205903
EDEM as an acceptor of terminally misfolded glycoproteins released from calnexinQ28212764
Cleaning up in the endoplasmic reticulum: ubiquitin in chargeQ28237362
Signal peptide peptidase is required for dislocation from the endoplasmic reticulumQ28243253
A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motifQ28276184
How viruses and toxins disassemble to enter host cellsQ37891079
Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulumQ37954281
Quality control: ER-associated degradation: protein quality control and beyondQ38196654
A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum.Q38542913
Role of the RING-CH domain of viral ligase mK3 in ubiquitination of non-lysine and lysine MHC I residuesQ39837294
The role of BiP in endoplasmic reticulum-associated degradation of major histocompatibility complex class I heavy chain induced by cytomegalovirus proteins.Q40274580
The viral E3 ubiquitin ligase mK3 uses the Derlin/p97 endoplasmic reticulum-associated degradation pathway to mediate down-regulation of major histocompatibility complex class I proteinsQ40323216
Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrateQ40414043
Virus subversion of the MHC class I peptide-loading complexQ40677035
MHC class I ubiquitination by a viral PHD/LAP finger protein.Q40773241
Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cellsQ41623826
Real-time fluorescence detection of ERAD substrate retrotranslocation in a mammalian in vitro system.Q41785201
Cholera toxin is exported from microsomes by the Sec61p complexQ41861735
Transcriptome profile of murine gammaherpesvirus-68 lytic infectionQ44281971
Vpu-mediated degradation of CD4 reconstituted in yeast reveals mechanistic differences to cellular ER-associated protein degradationQ44852706
p97 Is in a Complex with Cholera Toxin and Influences the Transport of Cholera Toxin and Related Toxins to the CytoplasmQ57372274
The peroxisomal importomer constitutes a large and highly dynamic poreQ57856741
Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeastQ73047414
Navigating the ERAD interaction networkQ83114417
ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ERQ28512215
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
Roles of N-linked glycans in the endoplasmic reticulumQ29616458
Intracellular functions of N-linked glycansQ29617165
The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosolQ29618773
Virus entry: open sesameQ29619349
TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.Q29871423
An interaction between ricin and calreticulin that may have implications for toxin traffickingQ31672834
The E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin retro-translocationQ33571592
Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteinsQ33797023
A role for N-glycanase in the cytosolic turnover of glycoproteinsQ34179944
Hsp90 is required for transfer of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosolQ34181280
The p97 ATPase dislocates MHC class I heavy chain in US2-expressing cells via a Ufd1-Npl4-independent mechanismQ34186527
Ricin trafficking in cellsQ34457972
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranesQ34719604
Establishment of an in vitro transport assay that reveals mechanistic differences in cytosolic events controlling cholera toxin and T-cell receptor α retro-translocationQ35022480
Dislocation of ricin toxin A chains in human cells utilizes selective cellular factorsQ35065140
Cytolethal distending toxins require components of the ER-associated degradation pathway for host cell entryQ35215974
Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulumQ35381401
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.Q35665886
SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.Q36119119
TorsinA participates in endoplasmic reticulum-associated degradationQ36487761
Derlin-1 facilitates the retro-translocation of cholera toxinQ36488986
Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactionsQ36673300
The ERdj5-Sel1L complex facilitates cholera toxin retrotranslocationQ36680557
Mechanisms of CD4 downregulation by the Nef and Vpu proteins of primate immunodeficiency virusesQ36754608
A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradationQ36887431
Immunobiology of human cytomegalovirus: from bench to bedside.Q37050965
Early events during BK virus entry and disassemblyQ37051570
MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation.Q37143424
Regulation of MHC class I assembly and peptide bindingQ37253085
HIV accessory proteins versus host restriction factorsQ37375080
CD4 and BST-2/tetherin proteins retro-translocate from endoplasmic reticulum to cytosol as partially folded and multimeric moleculesQ37428581
Life and death of a BiP substrateQ37660656
ERAD substrates: which way out?Q37660718
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)335-344
P577publication date2015-08-06
P1433published inMolecular CellQ3319468
P1476titlePathogenic Hijacking of ER-Associated Degradation: Is ERAD Flexible?
P478volume59

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cites work (P2860)
Q93081075A Transcriptomics Approach Reveals Putative Interaction of Candidatus Liberibacter Solanacearum with the Endoplasmic Reticulum of Its Psyllid Vector
Q89683056Alternative Mechanisms of p53 Action During the Unfolded Protein Response
Q91894003Contribution of the Unfolded Protein Response (UPR) to the Pathogenesis of Proteasome-Associated Autoinflammatory Syndromes (PRAAS)
Q40080379Emerging roles of rhomboid-like pseudoproteases in inflammatory and innate immune responses
Q30234505Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell Fate
Q41922848Enterovirus 71 protease 2Apro and 3Cpro differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication.
Q92255602Herpesviruses and the Unfolded Protein Response
Q92055431Identification of proteins regulated by the proteasome following induction of endoplasmic reticulum stress
Q90418737Mammalian membrane trafficking as seen through the lens of bacterial toxins
Q31031297Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.
Q37727169Mouse Mammary Tumor Virus Signal Peptide Uses a Novel p97-Dependent and Derlin-Independent Retrotranslocation Mechanism To Escape Proteasomal Degradation
Q56562738Nitazoxanide inhibits paramyxovirus replication by targeting the Fusion protein folding: role of glycoprotein-specific thiol oxidoreductase ERp57
Q52318700Nuclear export of ubiquitinated proteins via the UBIN-POST system.
Q96306487Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8+ T cell response in tumor
Q40603885Posttranscriptional Regulation of Glycoprotein Quality Control in the Endoplasmic Reticulum Is Controlled by the E2 Ub-Conjugating Enzyme UBC6e.
Q57036995Protein Quality Control in the Endoplasmic Reticulum and Cancer
Q41123201The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond
Q64087546Toxins Utilize the Endoplasmic Reticulum-Associated Protein Degradation Pathway in Their Intoxication Process
Q50073383Unfolded Protein Response of the Endoplasmic Reticulum in Tumor Progression and Immunogenicity.
Q41636911p53-mediated suppression of BiP triggers BIK-induced apoptosis during prolonged endoplasmic reticulum stress

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