Structural and functional implication of RAP80 ΔGlu81 mutation

scientific article

Structural and functional implication of RAP80 ΔGlu81 mutation is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...872707V
P356DOI10.1371/JOURNAL.PONE.0072707
P932PMC publication ID3767628
P698PubMed publication ID24039796
P5875ResearchGate publication ID256614158

P2093author name stringVikrant
Ashok K Varma
Peyush Goyal
Sanjeev K Waghmare
Rajan Kumar
Pallavi Nakhwa
Lumbini R Yadav
P2860cites workRAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptorQ24300133
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteinsQ24300411
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assemblyQ24300428
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage responseQ24306765
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sitesQ24306789
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage responseQ24306807
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint controlQ24317325
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligaseQ24653776
The SWISS-MODEL Repository and associated resourcesQ24656047
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3Q27658279
The SWISS-MODEL workspace: a web-based environment for protein structure homology modellingQ27860637
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1Q28115843
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139Q28131715
Genetic analysis of BRCA1 function in a defined tumor cell lineQ28142643
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damageQ28144576
Stereochemistry of polypeptide chain configurationsQ28190300
The DNA damage response: ten years afterQ28261230
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signalsQ28292900
Optimized Hydrophobic Interactions and Hydrogen Bonding at the Target-Ligand Interface Leads the Pathways of Drug-DesigningQ28475117
Ubiquitin-binding domainsQ29616461
DICHROWEB: an interactive website for the analysis of protein secondary structure from circular dichroism spectra.Q52046718
Breast cancer genes and DNA repair.Q55033520
The cellular response to DNA double-strand breaks: defining the sensors and mediatorsQ63383934
Circular dichroism and magnetic circular dichroism of reduced molybdenum-iron protein of Azotobacter vinelandii nitrogenaseQ72011071
Estimation of protein secondary structure from circular dichroism spectra: inclusion of denatured proteins with native proteins in the analysisQ73286669
Activation of transcription in vitro by the BRCA1 carboxyl-terminal domainQ77801019
Mechanism for recognition of polyubiquitin chains: balancing affinity through interplay between multivalent binding and dynamicsQ84711571
Determination and analysis of urea and guanidine hydrochloride denaturation curvesQ29616644
DICHROWEB, an online server for protein secondary structure analyses from circular dichroism spectroscopic dataQ29617363
Protein secondary structure analyses from circular dichroism spectroscopy: methods and reference databasesQ29617578
Conformation of Polypeptides and ProteinsQ29617878
Fast-response proteomics by accelerated in-gel digestion of proteinsQ30906200
In-gel digestion of proteins for MALDI-MS fingerprint mappingQ33330016
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AXQ34031720
Loss of BRCA1-A complex function in RAP80 null tumor cellsQ34336205
BRCA1 and BRCA2: 1994 and beyondQ34345297
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cellsQ34503003
Evidence for a transcriptional activation function of BRCA1 C-terminal regionQ34736712
The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resectionQ34787446
BRCA1 functions as a breast stem cell regulatorQ35559914
H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximityQ35623763
Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor alpha.Q35781803
RAP80 is critical in maintaining genomic stability and suppressing tumor developmentQ36352398
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomesQ36418967
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damageQ36696336
Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response functionQ37217527
A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage.Q37339272
Quantitation of proteinQ37628067
CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage responseQ40104298
ATR signaling at a glanceQ41971846
Practical approaches to protein folding and assembly: spectroscopic strategies in thermodynamics and kineticsQ42641148
NMR analysis of Lys63-linked polyubiquitin recognition by the tandem ubiquitin-interacting motifs of Rap80.Q44104911
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)e72707
P577publication date2013-09-09
P1433published inPLOS OneQ564954
P1476titleStructural and functional implication of RAP80 ΔGlu81 mutation
P478volume8

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cites work (P2860)
Q58983922Multimodal approach to explore the pathogenicity of BARD1, ARG 658 CYS, and ILE 738 VAL mutants
Q44084623Structural and functional characterization of the MERIT40 to understand its role in DNA repair

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