Chromatin modifications and DNA repair: beyond double-strand breaks

scientific article published on 05 September 2014

Chromatin modifications and DNA repair: beyond double-strand breaks is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FGENE.2014.00296
P8608Fatcat IDrelease_jaxzytqq45dudiqqct3bh3qypu
P932PMC publication ID4155812
P698PubMed publication ID25250043
P5875ResearchGate publication ID266086312

P50authorNealia C M HouseQ86572927
P2093author name stringMelissa R Koch
Catherine H Freudenreich
P2860cites workInvolvement of the TIP60 histone acetylase complex in DNA repair and apoptosisQ24290159
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilizationQ24292930
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complexQ24298863
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaksQ24299852
Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivoQ24300037
INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathwayQ24300346
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteinsQ24300411
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assemblyQ24300428
A YY1-INO80 complex regulates genomic stability through homologous recombination-based repairQ24300998
A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repairQ24302261
Roles of human INO80 chromatin remodeling enzyme in DNA replication and chromosome segregation suppress genome instabilityQ24303693
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activityQ24309061
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteinsQ24309287
UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repairQ24310704
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisionsQ24313501
USP7/HAUSP stimulates repair of oxidative DNA lesionsQ42714232
The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stabilityQ42853694
RSC mobilizes nucleosomes to improve accessibility of repair machinery to the damaged chromatinQ42924860
Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repairQ43217577
ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.Q44079733
Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.Q44094473
The Ino80 chromatin-remodeling enzyme regulates replisome function and stability.Q45739139
Structure of replicating simian virus 40 minichromosomes. The replication fork, core histone segregation and terminal structuresQ45835765
Phosphorylation of histone H4 serine 1 during DNA damage requires casein kinase II in S. cerevisiaeQ46432359
Ino80 chromatin remodeling complex promotes recovery of stalled replication forksQ46649401
UV sensitive mutations in histone H3 in Saccharomyces cerevisiae that alter specific K79 methylation states genetically act through distinct DNA repair pathwaysQ46713104
Methylations of histone H3 lysine 9 and lysine 36 are functionally linked to DNA replication checkpoint control in fission yeastQ46770435
The ACF1 complex is required for DNA double-strand break repair in human cells.Q50530840
Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation.Q50731881
Docking onto chromatin via the Saccharomyces cerevisiae Rad9 Tudor domain.Q51081692
Changes in nuclear protein acetylation in u.v.-damaged human cells.Q53535802
Deposition of newly synthesized histones: hybrid nucleosomes are not tandemly arranged on daughter DNA strandsQ68389220
Preferential nucleosome assembly at DNA triplet repeats from the myotonic dystrophy geneQ72073093
Expanded CTG triplet blocks from the myotonic dystrophy gene create the strongest known natural nucleosome positioning elementsQ72333265
Trinucleotide repeats affect DNA replication in vivoQ73839003
Expansion and length-dependent fragility of CTG repeats in yeastQ74128701
Expanded CAG repeats activate the DNA damage checkpoint pathwayQ80354669
Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase IIQ24314310
Cockayne syndrome group B protein enhances elongation by RNA polymerase IIQ24317053
ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaksQ24321489
The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSαQ24339204
DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2AQ24546161
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retentionQ24563397
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during agingQ24595900
Histone H3 lysine 56 acetylation and the response to DNA replication fork damageQ24612284
A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replicationQ24626425
The Dot1 histone methyltransferase and the Rad9 checkpoint adaptor contribute to cohesin-dependent double-strand break repair by sister chromatid recombination in Saccharomyces cerevisiaeQ24650576
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligaseQ24653776
DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamicsQ24681614
The balancing act of DNA repeat expansionsQ27001959
Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaksQ27337186
Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during developmentQ27347595
Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1Q27671621
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombinationQ27676128
The ctf13-30/CTF13 genomic haploinsufficiency modifier screen identifies the yeast chromatin remodeling complex RSC, which is required for the establishment of sister chromatid cohesionQ27930793
COMPASS: a complex of proteins associated with a trithorax-related SET domain proteinQ27931344
Regulation of NuA4 histone acetyltransferase activity in transcription and DNA repair by phosphorylation of histone H4.Q27931428
Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sitesQ27931488
Dephosphorylation of gamma H2A by Glc7/protein phosphatase 1 promotes recovery from inhibition of DNA replication.Q27932022
Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assemblyQ27932260
A chromatin remodelling complex involved in transcription and DNA processing.Q27932458
Rad4-Rad23 interaction with SWI/SNF links ATP-dependent chromatin remodeling with nucleotide excision repairQ27932672
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recoveryQ27933727
Chromatin remodelling complex RSC promotes base excision repair in chromatin of Saccharomyces cerevisiaeQ27933831
INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.Q27933934
The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1.Q27934025
Histone variant Htz1 promotes histone H3 acetylation to enhance nucleotide excision repair in Htz1 nucleosomesQ27934483
Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks.Q27934708
The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repairQ34191583
NuA4 initiates dynamic histone H4 acetylation to promote high-fidelity sister chromatid recombination at postreplication gaps.Q34216700
Involvement of a chromatin remodeling complex in damage tolerance during DNA replicationQ34280451
Yeast RAD26, a homolog of the human CSB gene, functions independently of nucleotide excision repair and base excision repair in promoting transcription through damaged basesQ34280857
PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1Q34304600
H2AX post-translational modifications in the ionizing radiation response and homologous recombinationQ34306825
Distribution and dynamics of chromatin modification induced by a defined DNA double-strand breakQ34354650
Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair.Q34422309
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sitesQ34479820
The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcriptionQ34512121
X-ray survival characteristics and genetic analysis for nine Saccharomyces deletion mutants that show altered radiation sensitivityQ34570137
CAF-I-dependent control of degradation of the discontinuous strands during mismatch repairQ34582950
GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage.Q34609350
The structural determinants of checkpoint activationQ34619662
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stallingQ34653133
An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiaeQ34659849
30 nm chromatin fibre decompaction requires both H4-K16 acetylation and linker histone evictionQ34800325
Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX.Q34841266
Replication stress induces 53BP1-containing OPT domains in G1 cellsQ34854577
Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage responseQ35006034
Meiotic instability of CAG repeat tracts occurs by double-strand break repair in yeastQ35049665
Analysis of protein dynamics at active, stalled, and collapsed replication forks.Q35080080
Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient miceQ35134204
Mechanisms of trinucleotide repeat instability during human developmentQ35219284
SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombinationQ35680031
Overcoming natural replication barriers: differential helicase requirementsQ35740570
ATP-dependent chromatin remodeling in the DNA-damage response.Q35744850
Interplay between mismatch repair and chromatin assemblyQ35750965
Different structural states in oligonucleosomes are required for early versus late steps of base excision repair.Q35917003
ATP-dependent chromatin remodeling is required for base excision repair in conventional but not in variant H2A.Bbd nucleosomes.Q35950275
Chromatin dynamics in DNA double-strand break repairQ36012981
Chromatin changes in the development and pathology of the Fragile X-associated disorders and Friedreich ataxiaQ36016607
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaksQ36095690
Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair.Q27935926
The NEF4 complex regulates Rad4 levels and utilizes Snf2/Swi2-related ATPase activity for nucleotide excision repairQ27936146
NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex.Q27936275
The RAD6/BRE1 histone modification pathway in Saccharomyces confers radiation resistance through a RAD51-dependent process that is independent of RAD18Q27936359
RAD26, the yeast homolog of human Cockayne's syndrome group B gene, encodes a DNA-dependent ATPaseQ27936827
Methylation of histone H3 lysine-79 by Dot1p plays multiple roles in the response to UV damage in Saccharomyces cerevisiae.Q27937420
Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79.Q27938606
A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzymeQ27940293
PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpointQ28117742
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139Q28131715
CGG/CCG repeats exhibit orientation-dependent instability and orientation-independent fragility in Saccharomyces cerevisiaeQ28139592
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damageQ28144576
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndromeQ28183834
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stressQ28201846
Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcriptionQ28203698
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damageQ28238604
Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaksQ28286203
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signalsQ28292900
Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiaeQ28343956
ATP-dependent chromatin remodeling facilitates nucleotide excision repair of UV-induced DNA lesions in synthetic dinucleosomesQ28362241
A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stabilityQ28534685
Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphomaQ28534761
Histone H3K56 acetylation, Rad52, and non-DNA repair factors control double-strand break repair choice with the sister chromatidQ28563892
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigenQ28608938
Double strand break repair functions of histone H2AXQ28661754
DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiaeQ28709604
ATP-dependent chromatin remodeling shapes the DNA replication landscapeQ28754502
Histone H4-K16 acetylation controls chromatin structure and protein interactionsQ29614521
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaksQ29617463
Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repairQ29620305
Gene silencing: trans-histone regulatory pathway in chromatinQ30309681
Histone H3 Thr 45 phosphorylation is a replication-associated post-translational modification in S. cerevisiaeQ30436419
The Rtt109 histone acetyltransferase facilitates error-free replication to prevent CAG/CTG repeat contractionsQ30493921
Histone H2B ubiquitylation controls processive methylation but not monomethylation by Dot1 and Set1.Q33220208
Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutationsQ33229596
Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cellsQ33275895
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaksQ33286997
Requirement for yeast RAD26, a homolog of the human CSB gene, in elongation by RNA polymerase IIQ33551567
Double-strand break repair pathways protect against CAG/CTG repeat expansions, contractions and repeat-mediated chromosomal fragility in Saccharomyces cerevisiaeQ33628502
Methylated H3K4, a Transcription-Associated Histone Modification, Is Involved in the DNA Damage Response PathwayQ33701701
Rad26p, a transcription-coupled repair factor, is recruited to the site of DNA lesion in an elongating RNA polymerase II-dependent manner in vivoQ33719420
DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatinQ33834990
UV irradiation stimulates histone acetylation and chromatin remodeling at a repressed yeast locusQ33853904
Expanded CAG/CTG repeat DNA induces a checkpoint response that impacts cell proliferation in Saccharomyces cerevisiaeQ33855685
Deletion of the CSB homolog, RAD26, yields Spt(-) strains with proficient transcription-coupled repairQ33940642
How chromatin is remodelled during DNA repair of UV-induced DNA damage in Saccharomyces cerevisiaeQ33940737
Role for hACF1 in the G2/M damage checkpointQ33957455
MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repairQ33963853
ATP-dependent chromatin remodeling factors tune S phase checkpoint activityQ34022692
The mammalian INO80 chromatin remodeling complex is required for replication stress recoveryQ34044332
Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.Q34133875
Requirement of the MRN complex for ATM activation by DNA damageQ36267304
MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cellsQ36368825
ATR protects the genome against CGG.CCG-repeat expansion in Fragile X premutation miceQ36457201
H2AX haploinsufficiency modifies genomic stability and tumor susceptibilityQ36533572
Five repair pathways in one context: chromatin modification during DNA repairQ36579359
CAG/CTG repeats alter the affinity for the histone core and the positioning of DNA in the nucleosomeQ36594935
Chromatin structure of repeating CTG/CAG and CGG/CCG sequences in human diseaseQ36814097
Chromosome fragility: molecular mechanisms and cellular consequencesQ36849639
Expandable DNA repeats and human disease.Q36854284
Regulation of DNA repair throughout the cell cycleQ37088926
Histone H3 Lys79 methylation is required for efficient nucleotide excision repair in a silenced locus of Saccharomyces cerevisiaeQ37128155
Chromatin remodeling in the noncoding repeat expansion diseasesQ37134343
The biological effects of simple tandem repeats: lessons from the repeat expansion diseasesQ37204533
Regulation of H3K4 trimethylation via Cps40 (Spp1) of COMPASS is monoubiquitination independent: implication for a Phe/Tyr switch by the catalytic domain of Set1.Q37233447
Protein modifications in transcription elongationQ37249177
Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1.Q37309152
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.Q37347174
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joiningQ37365625
The role of RAD6 in recombinational repair, checkpoints and meiosis via histone modificationQ37397286
Marks to stop the clock: histone modifications and checkpoint regulation in the DNA damage responseQ37398637
Checkpoint responses to unusual structures formed by DNA repeats.Q37420602
Modulation of nucleotide excision repair by mammalian SWI/SNF chromatin-remodeling complexQ37431761
Evidence that nucleosomes inhibit mismatch repair in eukaryotic cellsQ37446019
Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylationQ37451917
Core and linker histone modifications involved in the DNA damage responseQ37655471
Histone modifications: crucial elements for damage response and chromatin restorationQ37683656
Chromatin dynamics and the repair of DNA double strand breaksQ37826623
Nucleotide excision repair in chromatin: damage removal at the drop of a HAT.Q37877924
Histone tails: Directing the chromatin response to DNA damageQ37881417
Chromatin response to DNA double-strand break damageQ37961878
Histone marks: repairing DNA breaks within the context of chromatinQ37995722
The complex basis underlying common fragile site instability in cancerQ37998801
Nucleosome remodelers in double-strand break repair.Q38076899
Chromatin remodeling at DNA double-strand breaksQ38090114
Chromatin movement in the maintenance of genome stability.Q38090115
Chromatin modifications and chromatin remodeling during DNA repair in budding yeastQ38100439
Saccharomyces cerevisiae Rad16 mediates ultraviolet-dependent histone H3 acetylation required for efficient global genome nucleotide-excision repairQ38296363
The RAD7 and RAD16 genes, which are essential for pyrimidine dimer removal from the silent mating type loci, are also required for repair of the nontranscribed strand of an active gene in Saccharomyces cerevisiaeQ38304692
The chromatin remodeling factor BRG1 stimulates nucleotide excision repair by facilitating recruitment of XPC to sites of DNA damageQ38349017
RSC facilitates Rad59-dependent homologous recombination between sister chromatids by promoting cohesin loading at DNA double-strand breaks.Q38630544
Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcriptionQ38978584
Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repairQ39208600
GCN5 protects vertebrate cells against UV-irradiation via controlling gene expression of DNA polymerase η.Q39266637
A role for chromatin remodellers in replication of damaged DNA.Q39341270
Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phasesQ39388766
ATP-dependent chromatin remodeling by the Cockayne syndrome B DNA repair-transcription-coupling factor.Q39455992
Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragilityQ39592950
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stressQ39593027
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joiningQ39662092
Slipped-strand DNAs formed by long (CAG)*(CTG) repeats: slipped-out repeats and slip-out junctionsQ39687235
p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damageQ39714641
Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex.Q39752528
Mutations in Yeast Replication Proteins That Increase CAG/CTG Expansions Also Increase Repeat FragilityQ39940361
gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repairQ40347113
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiationQ40570996
The Ino80 chromatin-remodeling complex restores chromatin structure during UV DNA damage repairQ41157072
Nucleosome remodeling by hMSH2-hMSH6.Q41479268
Monitoring the spatiotemporal dynamics of proteins at replication forks and in assembled chromatin using isolation of proteins on nascent DNA.Q41490747
Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progressionQ41772663
Rad26p, a transcription-coupled repair factor, promotes the eviction and prevents the reassociation of histone H2A-H2B dimer during transcriptional elongation in vivoQ41786276
Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesisQ42132322
DNA repair choice defines a common pathway for recruitment of chromatin regulatorsQ42144432
Phosphorylation of histone H3(T118) alters nucleosome dynamics and remodelingQ42230215
Drosophila p53 Is Required to Increase the Levels of the dKDM4B Demethylase after UV-induced DNA Damage to Demethylate Histone H3 Lysine 9Q42274730
MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1.Q42375517
Histone H2A.Z controls a critical chromatin remodeling step required for DNA double-strand break repairQ42418108
Dual chromatin remodeling roles for RSC during DNA double strand break induction and repair at the yeast MAT locusQ42516363
P304page(s)296
P577publication date2014-09-05
P1433published inFrontiers in GeneticsQ2499875
P1476titleChromatin modifications and DNA repair: beyond double-strand breaks
P478volume5

Reverse relations

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