| scholarly article | Q13442814 |
| P2093 | author name string | Michael S Y Huen | |
| Junjie Chen | |||
| Katherine Minter-Dykhouse | |||
| Zhenkun Lou | |||
| Irene Ward | |||
| P2860 | cites work | MDC1 is a mediator of the mammalian DNA damage checkpoint | Q24296229 |
| MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks | Q24299852 | ||
| RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins | Q24300411 | ||
| RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly | Q24300428 | ||
| Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response | Q24306765 | ||
| RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites | Q24306789 | ||
| Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response | Q24306807 | ||
| Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage | Q24337134 | ||
| Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase | Q24653776 | ||
| NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage | Q28205262 | ||
| MDC1 is required for the intra-S-phase DNA damage checkpoint | Q28212500 | ||
| DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1 | Q28215916 | ||
| 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage | Q28236024 | ||
| MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes | Q28274268 | ||
| MDC1 regulates DNA-PK autophosphorylation in response to DNA damage | Q28282983 | ||
| Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks | Q28291639 | ||
| MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals | Q28292900 | ||
| DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours | Q28304920 | ||
| Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma | Q28509780 | ||
| 53BP1 is required for class switch recombination | Q29465541 | ||
| 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. | Q29465548 | ||
| ATM and related protein kinases: safeguarding genome integrity | Q29547735 | ||
| Cell cycle checkpoint signaling through the ATM and ATR kinases | Q29617837 | ||
| p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks | Q30014828 | ||
| 53BP1, a mediator of the DNA damage checkpoint | Q34153067 | ||
| MDC1 interacts with Rad51 and facilitates homologous recombination | Q34454221 | ||
| 53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis. | Q34480292 | ||
| p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice | Q34784963 | ||
| Homologous and non-homologous recombination differentially affect DNA damage repair in mice | Q35008336 | ||
| Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1 | Q36320732 | ||
| Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair | Q36510700 | ||
| Analysis of DNA double-strand break repair pathways in mice | Q36517406 | ||
| Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage | Q36696336 | ||
| Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage | Q39457941 | ||
| Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways | Q41861185 | ||
| Dual roles of ATM in the cellular response to radiation and in cell growth control. | Q52521591 | ||
| Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability | Q78960906 | ||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cell biology | Q7141 |
| DNA damage | Q5205747 | ||
| P304 | page(s) | 727-35 | |
| P577 | publication date | 2008-06-02 | |
| P1433 | published in | Journal of Cell Biology | Q1524550 |
| P1476 | title | Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis | |
| P478 | volume | 181 |
| Q35238504 | A novel antisense long noncoding RNA regulates the expression of MDC1 in bladder cancer |
| Q28118543 | A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses |
| Q45068235 | ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks |
| Q39921855 | ATM activation and signaling under hypoxic conditions. |
| Q33725435 | ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination. |
| Q41472052 | Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis |
| Q36063107 | BAZ1B is dispensable for H2AX phosphorylation on Tyrosine 142 during spermatogenesis |
| Q24632998 | BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair |
| Q90195204 | Cellular Stress Responses in Radiotherapy |
| Q38716604 | DNA Damage Response-Independent Role for MDC1 in Maintaining Genomic Stability |
| Q26776513 | DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer |
| Q28301859 | DNA damage response pathways in tumor suppression and cancer treatment |
| Q37528773 | Defective chromatin recruitment and retention of NHEJ core components in human tumor cells expressing a Cyclin E fragment |
| Q37393820 | Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications |
| Q34585782 | Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. |
| Q28482558 | Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine |
| Q34482867 | FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis |
| Q37261069 | Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin |
| Q33892356 | Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome |
| Q34089263 | H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy. |
| Q28506770 | Histone ubiquitination associates with BRCA1-dependent DNA damage response |
| Q27325197 | Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks |
| Q43871340 | Human genetic variants of homologous recombination repair genes first found to be associated with Epstein-Barr virus antibody titers in healthy Cantonese |
| Q42376094 | ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability |
| Q35615685 | Increased sensitivity of DNA damage response-deficient cells to stimulated microgravity-induced DNA lesions |
| Q90306076 | LMX1A inhibits C-Myc expression through ANGPTL4 to exert tumor suppressive role in gastric cancer |
| Q92689026 | Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner |
| Q35891320 | MDC1 Enhances Estrogen Receptor-mediated Transactivation and Contributes to Breast Cancer Suppression |
| Q91291695 | MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance |
| Q35656832 | MDC1 functionally identified as an androgen receptor co-activator participates in suppression of prostate cancer. |
| Q28275795 | MDC1: The art of keeping things in focus |
| Q38982264 | MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice. |
| Q26826949 | Modeling the study of DNA damage responses in mice |
| Q37727114 | Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression |
| Q35070481 | NFBD1/MDC1 is phosphorylated by PLK1 and controls G2/M transition through the regulation of a TOPOIIα-mediated decatenation checkpoint |
| Q39918729 | NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway |
| Q35042146 | OsSDS is essential for DSB formation in rice meiosis |
| Q37258492 | PTIP regulates 53BP1 and SMC1 at the DNA damage sites |
| Q35703913 | Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germline. |
| Q34515173 | RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment |
| Q50422500 | RNF8 and SCML2 cooperate to regulate ubiquitination and H3K27 acetylation for escape gene activation on the sex chromosomes. |
| Q33782442 | Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM). |
| Q35338785 | SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination. |
| Q33812604 | SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression. |
| Q27676675 | Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain |
| Q37497709 | Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response |
| Q34718519 | The 53BP1 homolog in C. elegans influences DNA repair and promotes apoptosis in response to ionizing radiation |
| Q35930506 | The TMPRSS2-ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition |
| Q34915507 | The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks |
| Q33941037 | The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0. |
| Q39411463 | The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response. |
| Q34236779 | The viral oncoprotein tax sequesters DNA damage response factors by tethering MDC1 to chromatin |
| Q41471528 | c-Fos-dependent miR-22 targets MDC1 and regulates DNA repair in terminally differentiated cells |
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