Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.

scientific article

Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/CB500956G
P932PMC publication ID4402254
P698PubMed publication ID25590533
P5875ResearchGate publication ID270963944

P50authorCheryl ArrowsmithQ5092682
Brian D StrahlQ41544665
Peter J. BrownQ42713845
Yunxiang MuQ55175819
Scott B RothbartQ62070938
Pavel MaderQ92749368
P2093author name stringAiping Dong
Gaofeng Cui
Georges Mer
Kevin M McBride
Stephen V Frye
Jacqueline L Norris
William P Janzen
Bradley M Dickson
Lindsey I James
Brandi M Baughman
Michael T Perfetti
P2860cites workTranslating the Histone CodeQ22065840
MDC1 is a mediator of the mammalian DNA damage checkpointQ24296229
The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaksQ24298486
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assemblyQ24300428
Tudor, MBT and chromo domains gauge the degree of lysine methylationQ24301294
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sitesQ24306486
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteinsQ24309287
The DNA-damage response in human biology and diseaseQ24606586
Human CtIP promotes DNA end resectionQ24646062
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repairQ24669691
Small-Molecule Ligands of Methyl-Lysine Binding ProteinsQ27667285
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombinationQ27676128
The language of covalent histone modificationsQ27860931
53BP1 regulates DSB repair using Rif1 to control 5' end resectionQ28000120
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choiceQ28000121
53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damageQ28236024
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiencyQ28256846
The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombinationQ28592784
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaksQ29465538
53BP1 is required for class switch recombinationQ29465541
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.Q29465548
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switchingQ29465549
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin markQ29465773
The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouseQ29618622
Epigenetic modifications and human diseaseQ29619753
The emerging field of dynamic lysine methylation of non-histone proteins.Q30368231
Identification of non-peptide malignant brain tumor (MBT) repeat antagonists by virtual screening of commercially available compoundsQ30497277
Screening for inhibitors of low-affinity epigenetic peptide-protein interactions: an AlphaScreen-based assay for antagonists of methyl-lysine binding proteinsQ33518291
Preparation of recombinant peptides with site- and degree-specific lysine (13)C-methylationQ33805946
The art of the chemical probeQ34098693
Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parametersQ34369771
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.Q34503454
p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in miceQ34784963
Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3.Q34990803
Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.Q35125130
CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation.Q36062092
Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1Q36320732
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domainQ36625174
Role for 53BP1 Tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signalingQ37000240
BRCA1 and BRCA2: different roles in a common pathway of genome protectionQ37149848
Epigenetic modifications as therapeutic targetsQ37800011
BRCA mutations in the management of breast cancer: the state of the artQ37801266
gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repairQ40347113
Amino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocationQ42582794
Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrestQ42738049
Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA.Q44489693
Using halogen bonds to address the protein backbone: a systematic evaluationQ47301557
Ligand binding efficiency: trends, physical basis, and implicationsQ80992297
P433issue4
P304page(s)1072-1081
P577publication date2015-01-28
P1433published inACS Chemical BiologyQ165583
P1476titleIdentification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.
P478volume10

Reverse relations

cites work (P2860)
Q30378316A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1
Q39423291Chemical modulators for epigenome reader domains as emerging epigenetic therapies for cancer and inflammation
Q38878310Chemical probes for methyl lysine reader domains
Q36371775Developing Spindlin1 small-molecule inhibitors by using protein microarrays
Q48273323Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.
Q36135192Identification and Structure-Activity Relationship Studies of Small-Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1.
Q36914593Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform.
Q99548779Inhibition of DNA Repair in Cancer Therapy: Toward a Multi-Target Approach
Q47419320Phosphorylation promotes activation-induced cytidine deaminase activity at the Myc oncogene
Q93119673Rational Adaptation of L3MBTL1 Inhibitors to Create Small-Molecule Cbx7 Antagonists
Q52767723Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin.
Q38434032Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family
Q89511226Small Molecules Targeting the Specific Domains of Histone-Mark Readers in Cancer Therapy
Q38826160Structural aspects of small-molecule inhibition of methyllysine reader proteins
Q38749422Structure-Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains
Q90468310Targeting non-bromodomain chromatin readers
Q48379350Unlocking the potential of chemical probes for methyl-lysine reader proteins

Search more.