Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress

scientific article published on 16 January 2013

Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.411603
P932PMC publication ID3585069
P698PubMed publication ID23329831

P2093author name stringLei Li
Jiadong Wang
Junjie Chen
Wenqi Wang
Gargi Ghosal
Xi Shen
Justin Wai-Chung Leung
P2860cites workChk1 inhibits replication factory activation but allows dormant origin firing in existing factories.Q39617777
Loss of ATRX leads to chromosome cohesion and congression defectsQ41825660
The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stressQ43125340
ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.Q47407852
Synchronization of HeLa cells.Q53213847
Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the α-thalassemia myelodysplasia syndrome (ATMDS)Q63248767
Promyelocytic leukemia nuclear bodies are predetermined processing sites for damaged DNAQ79988209
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeresQ24292850
Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesisQ24296912
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assemblyQ24300428
Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repairQ24306790
Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome)Q24311995
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3Q24315621
CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombinationQ24318939
The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPAQ24319860
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stressQ24338351
The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stressQ24338440
ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress responseQ24339475
Loss of maternal ATRX results in centromere instability and aneuploidy in the mammalian oocyte and pre-implantation embryoQ27345576
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndromeQ27670417
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexesQ27860662
ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cellsQ28114801
Distinct factors control histone variant H3.3 localization at specific genomic regionsQ28275277
ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndromeQ28299644
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpointsQ29617405
Cell cycle checkpoint signaling through the ATM and ATR kinasesQ29617837
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replicationQ29617915
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forksQ33507753
The annealing helicase HARP protects stalled replication forksQ33507756
Altered telomeres in tumors with ATRX and DAXX mutationsQ34196696
Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.Q34218130
Involvement of a chromatin remodeling complex in damage tolerance during DNA replicationQ34280451
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathwayQ34350929
ATR-X mutations cause impaired nuclear location and altered DNA binding properties of the XNP/ATR-X proteinQ35559646
Role of ATRX in chromatin structure and function: implications for chromosome instability and human diseaseQ35661042
Replicon clusters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cellsQ36255115
Understanding alpha-globin gene regulation: Aiming to improve the management of thalassemiaQ36337001
Compromised genomic integrity impedes muscle growth after Atrx inactivation.Q36498031
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.Q37334922
Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombinationQ37354145
SWI/SNF nucleosome remodellers and cancer.Q37886668
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectAlpha-thalassemia mental retardation syndromeQ2613277
P304page(s)6342-6350
P577publication date2013-01-16
P1433published inJournal of Biological ChemistryQ867727
P1476titleAlpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress
P478volume288

Reverse relations

cites work (P2860)
Q92375621ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity
Q39071428ATRX and DAXX: Mechanisms and Mutations
Q28116488ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment
Q24339453ATRX dysfunction induces replication defects in primary mouse cells
Q41565938ATRX is a regulator of therapy induced senescence in human cells.
Q37738658ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma
Q37008597ATRX mutations and glioblastoma: Impaired DNA damage repair, alternative lengthening of telomeres, and genetic instability.
Q50302756ATRX promotes gene expression by facilitating transcriptional elongation through guanine-rich coding regions
Q36140856ATRX represses alternative lengthening of telomeres
Q47552952Alpha Thalassemia/Mental Retardation Syndrome X-Linked, the Alternative Lengthening of Telomere Phenotype, and Gliomagenesis: Current Understandings and Future Potential
Q89622479Alternative Lengthening of Telomeres in Pediatric Cancer: Mechanisms to Therapies
Q33558285Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands
Q90346173Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks
Q33983659Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping
Q38690384Arabidopsis ATRX Modulates H3.3 Occupancy and Fine-Tunes Gene Expression.
Q35171587CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells
Q38240348Chromatin regulation of DNA damage repair and genome integrity in the central nervous system
Q47095909Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?
Q38662646Emerging roles of ATRX in cancer
Q64102392G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma
Q40292496Identification of epigenetic signature associated with alpha thalassemia/mental retardation X-linked syndrome
Q90224942Mechanisms of DNA Replication and Repair: Insights from the Study of G-Quadruplexes
Q37644439Mosaic expression of Atrx in the mouse central nervous system causes memory deficits.
Q55456861Mutant ATRX: uncovering a new therapeutic target for glioma.
Q98735817Neurodevelopmental Disorders Caused by Defective Chromatin Remodeling: Phenotypic Complexity Is Highlighted by a Review of ATRX Function
Q91843058PML is recruited to heterochromatin during S phase and represses DAXX-mediated histone H3.3 chromatin assembly
Q94048487Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability
Q26785908Replication Stress: A Lifetime of Epigenetic Change
Q64266001Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage
Q47806032Retinal interneuron survival requires non-cell-autonomous Atrx activity
Q41924768Stalled replication forks within heterochromatin require ATRX for protection
Q38856558Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX.
Q26751191The DNA fibre technique - tracking helicases at work
Q42369808The Role of ATRX in Glioma Biology
Q28071562The Role of ATRX in the Alternative Lengthening of Telomeres (ALT) Phenotype
Q38795281The chromatin remodelling factor ATRX suppresses R-loops in transcribed telomeric repeats
Q64387662The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening

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