A bistable switch and anatomical site control Vibrio cholerae virulence gene expression in the intestine

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A bistable switch and anatomical site control Vibrio cholerae virulence gene expression in the intestine is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1001102
P8608Fatcat IDrelease_5ysuc46nqjcmtoyggmfyamaufa
P932PMC publication ID2940755
P698PubMed publication ID20862321
P5875ResearchGate publication ID46404352

P50authorAlex Toftgaard NielsenQ30511940
Gary K SchoolnikQ114419730
P2093author name stringStephen A Felt
Glen Otto
Thomas Rasmussen
Stéphanie Torreilles
Michael C Miller
Nadia A Dolganov
P2860cites workRpoS controls the Vibrio cholerae mucosal escape responseQ21559520
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Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonizationQ28276944
Transmission of Vibrio cholerae is antagonized by lytic phage and entry into the aquatic environmentQ28473809
TcpP protein is a positive regulator of virulence gene expression in Vibrio choleraeQ28485708
Overlapping binding sites for the virulence gene regulators AphA, AphB and cAMP-CRP at the Vibrio cholerae tcpPH promoterQ29346608
The virulence activator AphA links quorum sensing to pathogenesis and physiology in Vibrio cholerae by repressing the expression of a penicillin amidase gene on the small chromosomeQ29346614
Carbon catabolite repression in bacteria: many ways to make the most out of nutrientsQ29615329
Bacterial persistence as a phenotypic switchQ29618111
Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistabilityQ29619706
Role of commensal relationships on the spatial structure of a surface-attached microbial consortiumQ30657913
Quorum-regulated biofilms enhance the development of conditionally viable, environmental Vibrio choleraeQ33667813
Vibrio cholerae phosphoenolpyruvate phosphotransferase system control of carbohydrate transport, biofilm formation, and colonization of the germfree mouse intestineQ33768976
Transient transcriptional activation of the Vibrio cholerae El Tor virulence regulator toxT in response to culture conditionsQ33866926
The suckling mouse model of choleraQ33885499
Analysis of an autoregulatory loop controlling ToxT, cholera toxin, and toxin-coregulated pilus production in Vibrio choleraeQ33991807
Genetic characterization of a new type IV-A pilus gene cluster found in both classical and El Tor biotypes of Vibrio choleraeQ34000690
Determination of the transcriptome of Vibrio cholerae during intraintestinal growth and midexponential phase in vitroQ34330409
Bistability in bacteriaQ34552788
Transmissibility of cholera: in vivo-formed biofilms and their relationship to infectivity and persistence in the environmentQ34597519
Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxinQ34618561
ToxR regulon of Vibrio cholerae and its expression in vibrios shed by cholera patients.Q34808623
Virstatin inhibits dimerization of the transcriptional activator ToxTQ35844578
Cyclic AMP and its receptor protein negatively regulate the coordinate expression of cholera toxin and toxin-coregulated pilus in Vibrio choleraeQ35909962
Growth rate-dependent control of the rrnB P1 core promoter in Escherichia coliQ35974981
Co-ordinate expression of virulence genes by ToxR in Vibrio choleraeQ35988328
The virulence gene activator ToxT from Vibrio cholerae is a member of the AraC family of transcriptional activatorsQ36132704
Pathogenesis of experimental cholera. Preparation and isolation of choleragen and choleragenoidQ36269786
Synthesis of cholera toxin is positively regulated at the transcriptional level by toxRQ36269897
Complexity of rice-water stool from patients with Vibrio cholerae plays a role in the transmission of infectious diarrheaQ36277234
Regulatory networks controlling Vibrio cholerae virulence gene expressionQ36313974
Toxin, toxin-coregulated pili, and the toxR regulon are essential for Vibrio cholerae pathogenesis in humansQ36355455
Regulation of tcp genes in classical and El Tor strains of Vibrio cholerae O1.Q51048192
Phosphatases modulate the bistable sporulation gene expression pattern in Bacillus subtilis.Q51454060
Differential rate of ribosomal protein synthesis in Escherichia coli B/rQ52910495
Single amino acid substitutions in the N-terminus of Vibrio cholerae TcpA affect colonization, autoagglutination, and serum resistance.Q54162990
Regulatory interplay between pap operons in uropathogenic Escherichia coli.Q54427805
CholeraQ57119004
Stochastic protein expression in individual cells at the single molecule levelQ57534158
Regulation of virulence gene expression in Vibrio cholerae by quorum sensing: HapR functions at the aphA promoterQ64449466
Regulation of gene expression in Vibrio cholerae by ToxT involves both antirepression and RNA polymerase stimulationQ64449517
Delineation of pilin domains required for bacterial association into microcolonies and intestinal colonization by Vibrio choleraeQ64449713
Regulation and temporal expression patterns of Vibrio cholerae virulence genes during infectionQ64449734
Culture conditions for stimulating cholera toxin production by Vibrio cholerae O1 El TorQ68930307
Cholera toxin stimulates secretion of immunoreactive intestinal mucinQ71462366
comK encodes the competence transcription factor, the key regulatory protein for competence development in Bacillus subtilisQ72318915
Cholera Infection and Toxin in the Rabbit Ileal LoopQ72777270
Ionic constituents and osmolality of gastric and small-intestinal fluids after eatingQ72849129
An experimental study of the mechanism of action of Vibriod cholerae on the intestinal mucous membraneQ73363678
The cyclic AMP receptor protein modulates quorum sensing, motility and multiple genes that affect intestinal colonization in Vibrio choleraeQ80984652
The Vibrio cholerae chitin utilization programQ36602658
Bacterial contingency loci: the role of simple sequence DNA repeats in bacterial adaptationQ36649037
Mucosal penetration primes Vibrio cholerae for host colonization by repressing quorum sensingQ36775203
Bistability, epigenetics, and bet-hedging in bacteriaQ37184651
Individuality in bacteriaQ37225852
Bicarbonate Induces Vibrio cholerae virulence gene expression by enhancing ToxT activity.Q37333396
Cholera transmission: the host, pathogen and bacteriophage dynamicQ37346626
Transcriptional regulation of Vibrio cholerae hemagglutinin/protease by the cyclic AMP receptor protein and RpoSQ37513677
Vibrio cholerae interactions with the gastrointestinal tract: lessons from animal studies.Q37610832
Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coliQ37663571
The Vibrio cholerae ToxR/TcpP/ToxT virulence cascade: distinct roles for two membrane-localized transcriptional activators on a single promoterQ38307608
Binding of Yersinia enterocolitica to purified, native small intestinal mucins from rabbits and humans involves interactions with the mucin carbohydrate moiety.Q38309622
Bistability and biofilm formation in Bacillus subtilisQ39257013
A Vibrio cholerae LysR homolog, AphB, cooperates with AphA at the tcpPH promoter to activate expression of the ToxR virulence cascade.Q39496555
Distribution of bacterial growth activity in flow-chamber biofilmsQ39527850
New unstable variants of green fluorescent protein for studies of transient gene expression in bacteriaQ39561041
Mechanism of ToxT-dependent transcriptional activation at the Vibrio cholerae tcpA promoterQ39694798
Gene expression in single cells of Bacillus subtilis: evidence that a threshold mechanism controls the initiation of sporulationQ39931223
New medium for the production of cholera toxin by Vibrio cholerae O1 biotype El Tor.Q40204162
Global climate and infectious disease: the cholera paradigmQ41254076
TcpF is a soluble colonization factor and protective antigen secreted by El Tor and classical O1 and O139 Vibrio cholerae serogroupsQ42062729
Hyperinfectivity of human-passaged Vibrio cholerae can be modeled by growth in the infant mouseQ42108617
Cholera stool bacteria repress chemotaxis to increase infectivity.Q42225367
Genes induced late in infection increase fitness of Vibrio cholerae after release into the environmentQ42234800
Kinetic properties of rrn promoters in Escherichia coliQ42435170
Bistability in the Bacillus subtilis K-state (competence) system requires a positive feedback loopQ42882124
Transcriptional profiling of Vibrio cholerae recovered directly from patient specimens during early and late stages of human infectionQ42957120
A panel of Tn7-based vectors for insertion of the gfp marker gene or for delivery of cloned DNA into Gram-negative bacteria at a neutral chromosomal siteQ43604598
The toxbox: specific DNA sequence requirements for activation of Vibrio cholerae virulence genes by ToxT.Q44245560
Cannibalism by sporulating bacteriaQ44484604
Ion transport in rabbit ileal mucosa. IV. Bicarbonate secretionQ45180444
Whole genome DNA microarray expression analysis of biofilm development by Vibrio cholerae O1 E1 Tor.Q46409550
Characterization of functional domains of the Vibrio cholerae virulence regulator ToxT.Q46785725
Mini-Tn7 transposons for site-specific tagging of bacteria with fluorescent proteinsQ47373670
Dependency on medium and temperature of cell size and chemical composition during balanced grown of Salmonella typhimuriumQ47434584
Comparison of the promoter proximal regions of the toxin-co-regulated tcp gene cluster in classical and El Tor strains of Vibrio cholerae O1.Q48064785
Cholera toxin transcriptional activator toxR is a transmembrane DNA binding proteinQ48350458
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectVibrio choleraeQ160821
virulenceQ1460232
P304page(s)e1001102
P577publication date2010-09-16
P1433published inPLOS PathogensQ283209
P1476titleA bistable switch and anatomical site control Vibrio cholerae virulence gene expression in the intestine
P478volume6

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