Bistability in the Bacillus subtilis K-state (competence) system requires a positive feedback loop

scientific article published on May 2005

Bistability in the Bacillus subtilis K-state (competence) system requires a positive feedback loop is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1365-2958.2005.04592.X
P932PMC publication ID3831615
P698PubMed publication ID15819619
P5875ResearchGate publication ID7916416

P2093author name stringDavid Dubnau
Hédia Maamar
P2860cites workcomK encodes the competence transcription factor, the key regulatory protein for competence development in Bacillus subtilisQ72318915
Biochemical characterization of a molecular switch involving the heat shock protein ClpC, which controls the activity of ComK, the competence transcription factor of Bacillus subtilisQ72988435
The Bacillus subtilis transition state regulator AbrB binds to the -35 promoter region of comKQ72998152
Competence in Bacillus subtilis is controlled by regulated proteolysis of a transcription factorQ24533414
Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversionQ24535235
Stochastic gene expression in a single cellQ28131784
Construction of a genetic toggle switch in Escherichia coliQ28144086
Intrinsic and extrinsic contributions to stochasticity in gene expressionQ29615956
Bacterial persistence as a phenotypic switchQ29618111
Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistabilityQ29619706
Convergent sensing pathways mediate response to two extracellular competence factors in Bacillus subtilisQ34307215
Control, exploitation and tolerance of intracellular noiseQ34997459
Controlling competence in Bacillus subtilis: shared use of regulatorsQ35063306
The competence transcription factor of Bacillus subtilis recognizes short A/T-rich sequences arranged in a unique, flexible pattern along the DNA helixQ35200591
The pleiotropic response regulator DegU functions as a priming protein in competence development in Bacillus subtilisQ35202131
CodY is required for nutritional repression of Bacillus subtilis genetic competence.Q35614237
Expression of competence genes in Bacillus subtilisQ36240080
Fractionation of transformable bacteria from ocompetent cultures of Bacillus subtilis on renografin gradientsQ36847719
Purification of competent cells in the Bacillus subtilis transformation systemQ36847724
BIOSYNTHETIC LATENCY IN EARLY STAGES OF DEOXYRIBONUCLEIC ACIDTRANSFORMATION IN BACILLUS SUBTILISQ37446077
ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENONQ37617203
The SpoOA protein of Bacillus subtilis is a repressor of the abrB geneQ37709796
A ComGA-dependent checkpoint limits growth during the escape from competenceQ38302079
Whole-genome analysis of genes regulated by the Bacillus subtilis competence transcription factor ComK.Q39678911
Postexponential regulation of sin operon expression in Bacillus subtilisQ39694611
Improving the predictive value of the competence transcription factor (ComK) binding site in Bacillus subtilis using a genomic approachQ39696580
The major role of Spo0A in genetic competence is to downregulate abrB, an essential competence geneQ39837315
The regulation of competence transcription factor synthesis constitutes a critical control point in the regulation of competence in Bacillus subtilisQ39897999
comK acts as an autoregulatory control switch in the signal transduction route to competence in Bacillus subtilisQ39898005
Stripping Bacillus: ComK auto-stimulation is responsible for the bistable response in competence developmentQ42476733
Microarray analysis of the Bacillus subtilis K-state: genome-wide expression changes dependent on ComK.Q42673179
Rok (YkuW) regulates genetic competence in Bacillus subtilis by directly repressing comKQ59398620
Inactivation of mecA prevents recovery from the competent state and interferes with cell division and the partitioning of nucleoids in Bacillus subtilisQ71558738
Regulatory inputs for the synthesis of ComK, the competence transcription factor of Bacillus subtilisQ71699782
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectBacillus subtilisQ131238
P304page(s)615-624
P577publication date2005-05-01
P1433published inMolecular MicrobiologyQ6895967
P1476titleBistability in the Bacillus subtilis K-state (competence) system requires a positive feedback loop
P478volume56

Reverse relations

cites work (P2860)
Q38786789A DegU-P and DegQ-Dependent Regulatory Pathway for the K-state in Bacillus subtilis
Q34228474A GFP-lacZ bicistronic reporter system for promoter analysis in environmental gram-negative bacteria
Q35673947A Novel Feedback Loop That Controls Bimodal Expression of Genetic Competence
Q89282021A bacterial signaling system regulates noise to enable bet hedging
Q33352019A bistable gene switch for antibiotic biosynthesis: the butyrolactone regulon in Streptomyces coelicolor
Q21559407A bistable switch and anatomical site control Vibrio cholerae virulence gene expression in the intestine
Q33947564A delay model for noise-induced bi-directional switching
Q36091886A peptide signal for adapter protein-mediated degradation by the AAA+ protease ClpCP
Q30539650Agent-based modeling of competence phenotype switching in Bacillus subtilis
Q33788495An epigenetic switch governing daughter cell separation in Bacillus subtilis
Q28303335An excitable gene regulatory circuit induces transient cellular differentiation
Q28476076Analysis of stochastic strategies in bacterial competence: a master equation approach
Q37318351Antirepression as a second mechanism of transcriptional activation by a minor groove binding protein
Q35761247Are Quasi-Steady-State Approximated Models Suitable for Quantifying Intrinsic Noise Accurately?
Q47839275Autocatalytic genetic networks modeled by piecewise-deterministic Markov processes.
Q33815417Bacillus subtilis two-component system sensory kinase DegS is regulated by serine phosphorylation in its input domain.
Q34068147Bacteria determine fate by playing dice with controlled odds
Q90007875Bacterial Transformation Buffers Environmental Fluctuations through the Reversible Integration of Mobile Genetic Elements
Q34932825Bacterial persistence: some new insights into an old phenomenon
Q34403233Bacterial transformation: distribution, shared mechanisms and divergent control
Q27319462Bet hedging in yeast by heterogeneous, age-correlated expression of a stress protectant
Q34552788Bistability in bacteria
Q42683279Bistability in myo-inositol utilization by Salmonella enterica serovar Typhimurium.
Q34013576Bistability versus bimodal distributions in gene regulatory processes from population balance
Q34976954Bistable expression of WOR1, a master regulator of white-opaque switching in Candida albicans
Q59800394Buffering and Amplifying Transcriptional Noise During Cell Fate Specification
Q41710433CRP-dependent positive autoregulation and proteolytic degradation regulate competence activator Sxy of Escherichia coli
Q36727995Cannibalism and fratricide: mechanisms and raisons d'être
Q37425573Capacity for stochastic self-renewal and differentiation in mammalian spermatogonial stem cells
Q40053085Cell differentiation defines acute and chronic infection cell types in Staphylococcus aureus.
Q34227105Cell population heterogeneity during growth of Bacillus subtilis
Q47591124Cell-cell recognition and social networking in bacteria.
Q33809149Cell-to-cell transformation in Escherichia coli: a novel type of natural transformation involving cell-derived DNA and a putative promoting pheromone
Q40726120Chance and Necessity in Bacillus subtilis Development
Q38358228Characterization of YvcJ, a conserved P-loop-containing protein, and its implication in competence in Bacillus subtilis
Q39950708Chromosomal transformation in Bacillus subtilis is a non-polar recombination reaction
Q41768599Construction of a Super-Competent Bacillus subtilis 168 Using the P mtlA -comKS Inducible Cassette
Q35035108Convergent transcription confers a bistable switch in Enterococcus faecalis conjugation.
Q33963878Convergent transcription in the butyrolactone regulon in Streptomyces coelicolor confers a bistable genetic switch for antibiotic biosynthesis
Q43720941Correlated phenotypic transitions to competence in bacterial colonies
Q30492401Deciding fate in adverse times: sporulation and competence in Bacillus subtilis
Q40248467Density-Dependent Differentiation of Bacteria in Spatially Structured Open Systems
Q38746502Determining the Limitations and Benefits of Noise in Gene Regulation and Signal Transduction through Single Cell, Microscopy-Based Analysis
Q36552166Different genetic programmes within identical bacteria under identical conditions: the phenomenon of bistability greatly modifies our view on bacterial populations
Q36692930Direct involvement of DprA, the transformation-dedicated RecA loader, in the shut-off of pneumococcal competence.
Q33958123Distinct roles of ComK1 and ComK2 in gene regulation in Bacillus cereus.
Q33307620DprA/Smf protein localizes at the DNA uptake machinery in competent Bacillus subtilis cells
Q28554777Driving Cells to the Desired State in a Bimodal Distribution through Manipulation of Internal Noise with Biologically Practicable Approaches
Q44462601Effects of cell cycle noise on excitable gene circuits
Q28492966Epigenetic control of virulence gene expression in Pseudomonas aeruginosa by a LysR-type transcription regulator
Q38944454Epigenetic mechanisms in microbial members of the human microbiota: current knowledge and perspectives
Q36009570Epitope-Tagged Autotransporters as Single-Cell Reporters for Gene Expression by a Salmonella Typhimurium wbaP Mutant
Q34438161Evidence for phenotypic bistability resulting from transcriptional interference of bvgAS in Bordetella bronchiseptica
Q38754752Exploring the diversity of protein modifications: special bacterial phosphorylation systems
Q34310354Expression of a cryptic secondary sigma factor gene unveils natural competence for DNA transformation in Staphylococcus aureus.
Q33520521Extracellular signals that define distinct and coexisting cell fates in Bacillus subtilis
Q41958429Facilitation of direct conditional knockout of essential genes in Bacillus licheniformis DSM13 by comparative genetic analysis and manipulation of genetic competence
Q27324582Fitness Trade-Offs in Competence Differentiation of Bacillus subtilis
Q34542515Functional analysis of the ComK protein of Bacillus coagulans
Q29616625Functional roles for noise in genetic circuits
Q34027203Gene position in a long operon governs motility development in Bacillus subtilis.
Q34894210Generation of multiple cell types in Bacillus subtilis
Q49369697Genetic Competence Drives Genome Diversity in Bacillus subtilis.
Q30493959Heterochronic phosphorelay gene expression as a source of heterogeneity in Bacillus subtilis spore formation
Q42506677Heterogeneity in expression of the Escherichia coli colicin K activity gene cka is controlled by the SOS system and stochastic factors.
Q36970921High stimulus unmasks positive feedback in an autoregulated bacterial signaling circuit
Q91638434High-resolution studies of lysis-lysogeny decision-making in bacteriophage lambda
Q51700211Horizontal gene transfer between bacteria.
Q43191527Hysteretic and graded responses in bacterial two-component signal transduction
Q37115797Identification by genomic and genetic analysis of two new genes playing a key role in intermediate glycopeptide resistance in Staphylococcus aureus
Q41893581Identity gene expression in Proteus mirabilis.
Q46264140Impaired competence in flagellar mutants of Bacillus subtilis is connected to the regulatory network governed by DegU.
Q27303488Improved statistical analysis of low abundance phenomena in bimodal bacterial populations
Q42755406Induction of natural competence in Bacillus cereus ATCC14579.
Q33860800Inhibitors Alter the Stochasticity of Regulatory Proteins to Force Cells to Switch to the Other State in the Bistable System.
Q58090057Intracellular Signaling by the comRS System in Streptococcus mutans Genetic Competence.
Q37277342Kinetics of genetic switching into the state of bacterial competence.
Q38115631Lessons about terminal differentiation from the specification of color-detecting photoreceptors in the Drosophila retina
Q28541592Loads bias genetic and signaling switches in synthetic and natural systems
Q34372375MG428 is a novel positive regulator of recombination that triggers mgpB and mgpC gene variation in Mycoplasma genitalium
Q41809162Maf acts downstream of ComGA to arrest cell division in competent cells of B. subtilis
Q38364442Maintaining a stochastic neuronal cell fate decision
Q41126069Mechanisms and Regulation of Extracellular DNA Release and Its Biological Roles in Microbial Communities
Q28252446Microbial cell individuality and the underlying sources of heterogeneity
Q42027974Microbial scout hypothesis, stochastic exit from dormancy, and the nature of slow growers
Q42136220Microfluidic study of competence regulation in Streptococcus mutans: environmental inputs modulate bimodal and unimodal expression of comX.
Q41913650Modeling of the ComRS Signaling Pathway Reveals the Limiting Factors Controlling Competence in Streptococcus thermophilus
Q36497703Molecular control of bacterial death and lysis
Q36140843Molecular level stochastic model for competence cycles in Bacillus subtilis
Q37747858Multiple roles for a novel RND-type efflux system in Acinetobacter baumannii AB5075.
Q24610764Nature, nurture, or chance: stochastic gene expression and its consequences
Q28659275Noise in biology
Q30557299Noise in gene expression determines cell fate in Bacillus subtilis
Q41970431Novel mechanisms of controlling the activities of the transcription factors Spo0A and ComA by the plasmid-encoded quorum sensing regulators Rap60-Phr60 in Bacillus subtilis
Q41811250Novel methods for genetic transformation of natural Bacillus subtilis isolates used to study the regulation of the mycosubtilin and surfactin synthetases
Q42565750Paracrine signaling in a bacterium
Q55402036Phenotypic Switching Can Speed up Microbial Evolution.
Q34502643Phenotypic variation in bacteria: the role of feedback regulation
Q41772010Plasmid-encoded ComI inhibits competence in the ancestral 3610 strain of Bacillus subtilis
Q36793610Positive feedback in cellular control systems.
Q42106817Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence
Q36895178Recent Progress on Systems and Synthetic Biology Approaches to Engineer Fungi As Microbial Cell Factories.
Q53035308Reconstructing the single-cell-level behavior of a toggle switch from population-level measurements.
Q36483729Regulation of type IV secretion apparatus genes during Ehrlichia chaffeensis intracellular development by a previously unidentified protein
Q21144990SOS response induces persistence to fluoroquinolones in Escherichia coli
Q45210502Screening of rhizosphere and soil bacteria for transformability
Q33799875Simple, fast and high-efficiency transformation system for directed evolution of cellulase in Bacillus subtilis
Q36565136Single cell analysis of gene expression patterns of competence development and initiation of sporulation in Bacillus subtilis grown on chemically defined media.
Q35036361Single gene control of a complex phenotype hangs in the balance
Q50674650Single-cell analysis of gene expression by fluorescence microscopy.
Q35830779SlrA/SinR/SlrR inhibits motility gene expression upstream of a hypersensitive and hysteretic switch at the level of σ(D) in Bacillus subtilis
Q34192919Spo0A~P imposes a temporal gate for the bimodal expression of competence in Bacillus subtilis.
Q36961669Stationary phase mutagenesis in B. subtilis: a paradigm to study genetic diversity programs in cells under stress
Q90840702Stem cell bioengineering: building from stem cell biology
Q21146037Stochastic mRNA synthesis in mammalian cells
Q34767687Stochasticity and cell fate
Q47325767Stochasticity of TOL plasmid catabolic promoters sets a bimodal expression regime in Pseudomonas putida mt-2 exposed to m-xylene
Q37634302Strategies for cellular decision-making
Q39206961Synthetic Biology: Engineering Living Systems from Biophysical Principles
Q38805497Synthetic biology approaches in cancer immunotherapy, genetic network engineering, and genome editing
Q89697204The Bacillus Subtilis K-State Promotes Stationary-Phase Mutagenesis via Oxidative Damage
Q43192532The Bacillus subtilis late competence operon comE is transcriptionally regulated by yutB and under post-transcription initiation control by comN (yrzD).
Q35052616The Vibrio harveyi quorum-sensing system uses shared regulatory components to discriminate between multiple autoinducers
Q27013056The cell pole: the site of cross talk between the DNA uptake and genetic recombination machinery
Q49911608The expression of bacteriocin production and self-resistance in Lactobacillus brevis 174A is mediated by two regulatory proteins.
Q36678612The impact of the neisserial DNA uptake sequences on genome evolution and stability
Q38268675The physics of bacterial decision making
Q38171535The private life of environmental bacteria: pollutant biodegradation at the single cell level
Q34318274The regulatory network of natural competence and transformation of Vibrio cholerae
Q42969960The secretion ATPase ComGA is required for the binding and transport of transforming DNA.
Q52656028The two putative comS homologs of the biotechnologically important Bacillus licheniformis do not contribute to competence development.
Q21145327To lyse or not to lyse: transient-mediated stochastic fate determination in cells infected by bacteriophages
Q37268254Transcription factor levels enable metabolic diversification of single cells of environmental bacteria
Q33593152Transcriptional and post-transcriptional regulation of the GmaR antirepressor governs temperature-dependent control of flagellar motility in Listeria monocytogenes
Q40168881Transient Thresholding: A Mechanism Enabling Noncooperative Transcriptional Circuitry to Form a Switch
Q30481955Transient heterogeneity in extracellular protease production by Bacillus subtilis
Q30538921Turning oscillations into opportunities: lessons from a bacterial decision gate
Q39083061Two regulatory RNA elements affect TisB-dependent depolarization and persister formation.
Q99611763Unbiased homeologous recombination during pneumococcal transformation allows for multiple chromosomal integration events
Q21267223Understanding the evolutionary relationships and major traits of Bacillus through comparative genomics
Q30494072Using movies to analyse gene circuit dynamics in single cells
Q42513571Viscous drag on the flagellum activates Bacillus subtilis entry into the K-state
Q38303308What renders Bacilli genetically competent? A gaze beyond the model organism
Q27318083When Phase Contrast Fails: ChainTracer and NucTracer, Two ImageJ Methods for Semi-Automated Single Cell Analysis Using Membrane or DNA Staining

Search more.