Construction of a genetic toggle switch in Escherichia coli

scientific article (publication date: 20 January 2000)

Construction of a genetic toggle switch in Escherichia coli is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1002786107
P356DOI10.1038/35002131
P3181OpenCitations bibliographic resource ID1011640
P698PubMed publication ID10659857
P5875ResearchGate publication ID12654725

P2093author name stringC R Cantor
J J Collins
T S Gardner
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P433issue6767
P407language of work or nameEnglishQ1860
P921main subjectEscherichia coliQ25419
P304page(s)339-42
P577publication date2000-01-20
P1433published inNatureQ180445
P1476titleConstruction of a genetic toggle switch in Escherichia coli
P478volume403

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Q30870894Directed evolution of a genetic circuit
Q50221591Dissipative structures and biological rhythms.
Q89068414Dissipative structures in biological systems: bistability, oscillations, spatial patterns and waves
Q33768677Distributed biological computation with multicellular engineered networks
Q64264203Diversity, versatility and complexity of bacterial gene regulation mechanisms: opportunities and drawbacks for applications in synthetic biology
Q33431823Diversity-based, model-guided construction of synthetic gene networks with predicted functions
Q52320838Division rate, cell size and proteome allocation: impact on gene expression noise and implications for the dynamics of genetic circuits.
Q28554777Driving Cells to the Desired State in a Bimodal Distribution through Manipulation of Internal Noise with Biologically Practicable Approaches
Q58730713Drug treatment efficiency depends on the initial state of activation in nonlinear pathways
Q35978503Dual control system - A novel scaffolding architecture of an inducible regulatory device for the precise regulation of gene expression
Q38309176Dynamic membrane patterning, signal localization and polarity in living cells.
Q47590195Dynamic metabolic engineering for increasing bioprocess productivity
Q36238821Dynamic metabolic engineering: New strategies for developing responsive cell factories
Q34314357Dynamic regulation of myosin light chain phosphorylation by Rho-kinase.
Q51617010Dynamic stabilization in the PU1-GATA1 circuit using a model with time-dependent kinetic change.
Q51949944Dynamical advantages of scale-free networks.
Q51657216Dynamical properties of the repressilator model.
Q36104888Dynamical systems approach to endothelial heterogeneity
Q35102173Dynamical systems theory in physiology
Q57942506Dynamics in high-dimensional model gene networks
Q37814778Dynamics in the mixed microbial concourse
Q58049367Dynamics of a genetic toggle switch at the nucleotide and codon levels
Q51895646Dynamics of a two-dimensional model of cell tissues with coupled stochastic gene networks.
Q51575790Dynamics of coupled repressilators: the role of mRNA kinetics and transcription cooperativity.
Q51628719Dynamics of gene regulatory networks with cell division cycle.
Q35194039Dynamics of single-cell gene expression
Q42624814Dynamics of transcription driven by the tetA promoter, one event at a time, in live Escherichia coli cells
Q39264523Early gene regulation of osteogenesis in embryonic stem cells.
Q35694371Effect of Intrinsic Noise on the Phenotype of Cell Populations Featuring Solution Multiplicity: An Artificial lac Operon Network Paradigm
Q28584416Effects of cell-cycle-dependent expression on random fluctuations in protein levels
Q51908864Effects of coupling strength and space on the dynamics of coupled toggle switches in stochastic gene networks with multiple-delayed reactions.
Q35529184Effects of downstream genes on synthetic genetic circuits.
Q35051451Effects of multimerization on the temporal variability of protein complex abundance
Q50471371Effects of temperature on the dynamics of the LacI-TetR-CI repressilator.
Q36240474Efficient Switches in Biology and Computer Science
Q33649936Efficient computation of parameter sensitivities of discrete stochastic chemical reaction networks
Q47107934Efflux Pump Control Alters Synthetic Gene Circuit Function.
Q37658992Emergence of function from coordinated cells in a tissue
Q21145326Emergence of switch-like behavior in a large family of simple biochemical networks
Q43760764Emergence of synthetic biology: characterization by a scientometric approach
Q30495631Emergent bistability by a growth-modulating positive feedback circuit
Q51418749Emergent bistability: effects of additive and multiplicative noise.
Q37962354Emerging biomedical applications of synthetic biology
Q41976051Enabling the new biology of the 21(st) century
Q59336021Encryption and steganography of synthetic gene circuits
Q44924015Endowing cells with logic and memory
Q40195519Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation
Q47588261Engineered bacteria self-organize to sense pressure
Q56984534Engineered dCas9 with reduced toxicity in bacteria: implications for genetic circuit design
Q34997456Engineered gene circuits.
Q38084923Engineered genetic information processing circuits
Q33564662Engineered microbial biosensors based on bacterial two-component systems as synthetic biotechnology platforms in bioremediation and biorefinery
Q89685405Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies
Q99207479Engineered systems of inducible anti-repressors for the next generation of biological programming
Q37519764Engineered temperature compensation in a synthetic genetic clock.
Q21131321Engineered transcriptional systems for cyanobacterial biotechnology
Q92488848Engineering DNA recognition and allosteric response properties of TetR family proteins by using a module-swapping strategy
Q90352644Engineering Epigenetic Regulation Using Synthetic Read-Write Modules
Q38009596Engineering and control of biological systems: A new way to tackle complex diseases.
Q49339110Engineering bacteria for diagnostic and therapeutic applications.
Q36304169Engineering dynamic cell cycle control with synthetic small molecule-responsive RNA devices
Q37450926Engineering dynamical control of cell fate switching using synthetic phospho-regulons
Q24794656Engineering gene networks to emulate Drosophila embryonic pattern formation
Q50849632Engineering genetic circuits that compute and remember.
Q35088032Engineering ligand-responsive RNA controllers in yeast through the assembly of RNase III tuning modules
Q37185202Engineering microbial consortia for controllable outputs
Q35974660Engineering microbial systems to explore ecological and evolutionary dynamics
Q38924442Engineering modular and orthogonal genetic logic gates for robust digital-like synthetic biology
Q34320464Engineering of a synthetic electron conduit in living cells
Q33554618Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination.
Q36967848Engineering of regulated stochastic cell fate determination
Q38876131Engineering of synthetic gene circuits for (re-)balancing physiological processes in chronic diseases
Q38067993Engineering of synthetic intercellular communication systems
Q37328414Engineering prokaryotic gene circuits
Q57804750Engineering protein-protein devices for multilayered regulation of mRNA translation using orthogonal proteases in mammalian cells
Q92513208Engineering repressors with coevolutionary cues facilitates toggle switches with a master reset
Q42092679Engineering scalable biological systems
Q29615326Engineering stability in gene networks by autoregulation
Q43194801Engineering stochasticity in gene expression
Q38205343Engineering synergy in biotechnology
Q37181492Engineering transcription factors with novel DNA-binding specificity using comparative genomics
Q28606753Enhancement of 3-hydroxypropionic acid production from glycerol by using a metabolic toggle switch
Q34418258Enhancement of cellular memory by reducing stochastic transitions
Q58915434Entrained Collective Rhythms of Multicellular Systems: Partial Impulsive Control Strategy
Q51788965Entraining synthetic genetic oscillators.
Q27332166Entrainment of a population of synthetic genetic oscillators
Q43129547Environmentally-modulated changes in fluorescence distribution in cells with oscillatory genetic network dynamics
Q28551936Enzyme Sequestration as a Tuning Point in Controlling Response Dynamics of Signalling Networks
Q54978867Enzyme sequestration by the substrate: An analysis in the deterministic and stochastic domains.
Q46489955Enzyme-free nucleic acid dynamical systems.
Q73303420Epigenes: design and construction of new hereditary units
Q27348976Epigenetic and conventional regulation is distributed among activators of FLO11 allowing tuning of population-level heterogeneity in its expression
Q34712052Epigenetic chromatin silencing: bistability and front propagation
Q41023328Epigenetics knocks on synthetic biology's door.
Q93382220Escherichia coli "Marionette" strains with 12 highly optimized small-molecule sensors
Q83161962Essential information for synthetic DNA sequences
Q21563494Estimating the stochastic bifurcation structure of cellular networks
Q33327043Estimation of the source-by-source effect of autorepression on genetic noise
Q33895303Eugene--a domain specific language for specifying and constraining synthetic biological parts, devices, and systems
Q33590931Eukaryotic systems broaden the scope of synthetic biology
Q51904098Evaluation of the multiplane method for efficient simulations of reaction networks.
Q51861603Evolution of complex dynamics.
Q35107362Evolution of complexity in signaling pathways
Q50281938Evolution of extrema features reveals optimal stimuli for biological state transitions.
Q46774328Evolution of gene network activity by tuning the strength of negative-feedback regulation
Q42574966Evolution of opinions on social networks in the presence of competing committed groups
Q35673851Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations
Q41811505Evolutionary design of non-frustrated networks of phase-repulsive oscillators
Q58030943Evolutionary mechanisms of circadian clocks
Q33304212Evolutionary models for formation of network motifs and modularity in the Saccharomyces transcription factor network
Q28535196Evolutionary tradeoffs between economy and effectiveness in biological homeostasis systems
Q43148797Evolvability and hierarchy in rewired bacterial gene networks
Q51609873Evolving complex dynamics in electronic models of genetic networks.
Q35548103Evolving robust gene regulatory networks
Q30581754Exocytosis of serotonin from the neuronal soma is sustained by a serotonin and calcium-dependent feedback loop
Q37081637Expanding metabolism for biosynthesis of nonnatural alcohols
Q36119863Experimental Design for Stochastic Models of Nonlinear Signaling Pathways Using an Interval-Wise Linear Noise Approximation and State Estimation
Q33306135Experimental design for efficient identification of gene regulatory networks using sparse Bayesian models
Q38899793Experimental verification of a conserved intronic microRNA located in the human TrkC gene with a cell type-dependent apoptotic function.
Q35692901Exploring Host-Microbiome Interactions using an in Silico Model of Biomimetic Robots and Engineered Living Cells
Q35906061Expression optimization and synthetic gene networks in cell-free systems.
Q33895020External control of the GAL network in S. cerevisiae: a view from control theory
Q37039455Extinction and resurrection in gene networks
Q42661785FGF/MAPK signaling sets the switching threshold of a bistable circuit controlling cell fate decisions in embryonic stem cells
Q40086009Fate-Regulating Circuits in Viruses: From Discovery to New Therapy Targets
Q55922764Feedback for physicists: A tutorial essay on control
Q27021741Feedback loops and reciprocal regulation: recurring motifs in the systems biology of the cell cycle
Q35208715Fez function is required to maintain the size of the animal plate in the sea urchin embryo
Q42709833Field Hypothesis on the Self-regulation of Gene Expression
Q34395078Fine-tuning gene networks using simple sequence repeats.
Q31122657Finite state projection based bounds to compare chemical master equation models using single-cell data
Q51957027First passage and cooperativity of queuing kinetics.
Q43187919Five hard truths for synthetic biology
Q51701794Fluctuations in gene regulatory networks as Gaussian colored noise.
Q51634875Fluctuations-induced switch in the gene transcriptional regulatory system.
Q37305086Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression
Q96817183Formation and functionalization of membraneless compartments in Escherichia coli
Q30482962Foundations for engineering biology
Q38182184Foundations for modeling the dynamics of gene regulatory networks: a multilevel-perspective review
Q34273084Foundations for the design and implementation of synthetic genetic circuits
Q33716718Frequency domain analysis of noise in autoregulated gene circuits.
Q36527652Frequency domain analysis of noise in simple gene circuits.
Q50548913Frequency modulation of stochastic gene expression bursts by strongly interacting small RNAs.
Q35659587From Boolean Network Model to Continuous Model Helps in Design of Functional Circuits
Q36682037From Cellular Attractor Selection to Adaptive Signal Control for Traffic Networks
Q24650577From DNA nanotechnology to synthetic biology
Q98466542From Microbial Communities to Distributed Computing Systems
Q36615907From in vivo to in silico biology and back
Q74313658From molecular biology to nanotechnology and nanomedicine
Q38692135From noise to synthetic nucleoli: can synthetic biology achieve new insights?
Q38034935Frontiers of optofluidics in synthetic biology.
Q37171591Functional characteristics of a double negative feedback loop mediated by microRNAs
Q35217099Functional characterization of bacterial sRNAs using a network biology approach
Q37670151Functional motifs in biochemical reaction networks.
Q29616625Functional roles for noise in genetic circuits
Q36207933Functional roles of slow enzyme conformational changes in network dynamics.
Q33896779GA-based Design Algorithms for the Robust Synthetic Genetic Oscillators with Prescribed Amplitude, Period and Phase
Q40500403Gas-inducible transgene expression in mammalian cells and mice
Q42921721Gene dosage balance in cellular pathways: implications for dominance and gene duplicability
Q38686945Gene expression variability in clonal populations: Causes and consequences
Q42787778Gene networks and liar paradoxes
Q27318486Gene networks of fully connected triads with complete auto-activation enable multistability and stepwise stochastic transitions
Q47610427Gene regulatory network growth by duplication
Q46972144Gene regulatory networks: a coarse-grained, equation-free approach to multiscale computation
Q24658502Gene switching rate determines response to extrinsic perturbations in the self-activation transcriptional network motif
Q37263722Gene-gene cooperativity in small networks
Q36335163Genetic Circuits in Salmonella typhimurium
Q50238363Genetic Toggle Switch in the Absence of Cooperative Binding: Exact Results.
Q34520533Genetic circuit design automation
Q64068600Genetic circuits to engineer tissues with alternative functions
Q37189975Genetic design automation: engineering fantasy or scientific renewal?
Q33382294Genetic noise control via protein oligomerization
Q47352291Genetic programs can be compressed and autonomously decompressed in live cells.
Q47163085Genetic toggle switch controlled by bacterial growth rate
Q55345251Genetic tool development and systemic regulation in biosynthetic technology.
Q54334788Genetically switched D-lactate production in Escherichia coli.
Q33532340GenoCAD for iGEM: a grammatical approach to the design of standard-compliant constructs
Q42278257Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs
Q92889687Genome-scale transcriptional dynamics and environmental biosensing
Q37330215Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture
Q34194331Genomic mining of prokaryotic repressors for orthogonal logic gates
Q36409912GillesPy: A Python Package for Stochastic Model Building and Simulation
Q33296323Global analysis of host response to induction of a latent bacteriophage
Q48159904Global convergence of quorum-sensing networks
Q33651556Global parameter estimation methods for stochastic biochemical systems
Q33723464Global robust power-rate stability of delayed genetic regulatory networks with noise perturbations
Q33878009Grand Challenges in Synthetic Biology to be Accomplished
Q42062295Growth rate-dependent global effects on gene expression in bacteria
Q37691431HIC1 and miR-23~27~24 clusters form a double-negative feedback loop in breast cancer
Q41992077Half-life measurements of chemical inducers for recombinant gene expression
Q35130336Hardware (DNA) circuits
Q33747160Harnessing nature's toolbox: regulatory elements for synthetic biology
Q27321679Heritable change caused by transient transcription errors
Q51887731Hierarchical analysis of piecewise affine models of gene regulatory networks.
Q33996801Hierarchical differentiation of myeloid progenitors is encoded in the transcription factor network
Q64107147High-Performance Biocomputing in Synthetic Biology-Integrated Transcriptional and Metabolic Circuits
Q29036647High-Yield, Zero-Leakage Expression System with a Translational Switch Using Site-Specific Unnatural Amino Acid Incorporation
Q91917183High-order interactions distort the functional landscape of microbial consortia
Q28477385High-precision, in vitro validation of the sequestration mechanism for generating ultrasensitive dose-response curves in regulatory networks
Q39576497High-resolution mapping of bifurcations in nonlinear biochemical circuits.
Q34340886Highly modular bow-tie gene circuits with programmable dynamic behaviour
Q30974536How to turn a genetic circuit into a synthetic tunable oscillator, or a bistable switch
Q74440565How to turn living cells into computers
Q34970086Hybrid T-helper cells: stabilizing the moderate center in a polarized system
Q28828779Hypothetical biomolecular probe based on a genetic switch with tunable symmetry and stability
Q40319558Hysteresis and cell cycle transitions: how crucial is it?
Q35214046Hysteresis can grant fitness in stochastically varying environment
Q33892242Hysteresis in a synthetic mammalian gene network
Q35770823Hysteresis vs. graded responses: the connections make all the difference
Q43191527Hysteretic and graded responses in bacterial two-component signal transduction
Q46841056Identifiability and inference of pathway motifs by epistasis analysis
Q34110410Identification of important nodes in directed biological networks: a network motif approach
Q34067222Identification of novel targets for breast cancer by exploring gene switches on a genome scale
Q34101667Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis
Q33266433Identification of the proliferation/differentiation switch in the cellular network of multicellular organisms
Q93009232Identifying critical state of complex diseases by single-sample Kullback-Leibler divergence
Q95328049Identifying inhibitors of epithelial-mesenchymal plasticity using a network topology-based approach
Q42369473Identifying parameter regions for multistationarity
Q52570105Identifying robust hysteresis in networks.
Q51129704Impact of RNA interference on gene networks.
Q50534237Impact of time delays on oscillatory dynamics of interlinked positive and negative feedback loops.
Q35909908Implementation of Complex Biological Logic Circuits Using Spatially Distributed Multicellular Consortia
Q36396573Implementation of a genetic logic circuit: bio-register
Q48668624Implementing an OR-NOT (ORN) logic gate with components of the SOS regulatory network of Escherichia coli.
Q28472646Implementing arithmetic and other analytic operations by transcriptional regulation
Q36420995Implications of rewiring bacterial quorum sensing
Q26799987Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis
Q40830283Importance of input perturbations and stochastic gene expression in the reverse engineering of genetic regulatory networks: insights from an identifiability analysis of an in silico network
Q92283882Improvement of the memory function of a mutual repression network in a stochastic environment by negative autoregulation
Q37660070Incorporation of unnatural amino acids for synthetic biology
Q37847611Increasing the dynamic control space of mammalian transcription devices by combinatorial assembly of homologous regulatory elements from different bacterial species
Q35172171Inducible suppression of global translation by overuse of rare codons
Q44597467Information recovery in molecular biology: causal modelling of regulated promoter switching experiments.
Q52687617Information transmission in microbial and fungal communication: from classical to quantum.
Q47777229Information-based measures for logical stochastic resonance in a synthetic gene network under Lévy flight superdiffusion
Q29307507Informing Biological Design by Integration of Systems and Synthetic Biology
Q50528595Inhibition of gene expression in Escherichia coli under hypergravity.
Q33860800Inhibitors Alter the Stochasticity of Regulatory Proteins to Force Cells to Switch to the Other State in the Bistable System.
Q31034422Inner Workings: DNA for data storage and computing
Q40971962Insulated transcriptional elements enable precise design of genetic circuits.
Q36247937Integrated analysis of tumor samples sheds light on tumor heterogeneity
Q35966355Integrated analysis reveals that STAT3 is central to the crosstalk between HER/ErbB receptor signaling pathways in human mammary epithelial cells
Q26830304Integrating biological redesign: where synthetic biology came from and where it needs to go
Q51543749Integrating cell-level kinetic modeling into the design of engineered protein therapeutics.
Q95318850Integrative Circuit-Host Modeling of a Genetic Switch in Varying Environments
Q30496545Integrative multicellular biological modeling: a case study of 3D epidermal development using GPU algorithms
Q37361255Intelligent medical diagnostics via molecular logic
Q34461517Interlinked fast and slow positive feedback loops drive reliable cell decisions
Q50905118Interlinked mutual inhibitory positive feedbacks induce robust cellular memory effects.
Q51004530Intermediate Filaments Supporting Cell Shape and Growth in Bacteria.
Q41895297Interplay of microRNA and epigenetic regulation in the human regulatory network
Q101165910Interpretation of morphogen gradients by a synthetic bistable circuit
Q36329954Interrogating the topological robustness of gene regulatory circuits by randomization.
Q36124322Intracellular signaling: spatial and temporal control
Q24630461Intrinsic noise in gene regulatory networks
Q34498475Introduction of customized inserts for s-treamlined assembly and optimization of BioBrick synthetic genetic circuits.
Q44717284Introduction to focus issue: quantitative approaches to genetic networks
Q41899660Inverse bifurcation analysis: application to simple gene systems
Q41369640Iterative plug-and-play methodology for constructing and modifying synthetic gene networks
Q52585319Kinetic models of hematopoietic differentiation.
Q40681530Kinetics of the cellular intake of a gene expression inducer at high concentrations
Q28474801Large-scale analysis of network bistability for human cancers
Q41686631Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells
Q35664673Layering genetic circuits to build a single cell, bacterial half adder
Q99402094Limit cycles in models of circular gene networks regulated by negative feedback loops
Q33681660Limitations of quantitative gene regulation models: a case study.
Q58770977Linear mapping approximation of gene regulatory networks with stochastic dynamics
Q35228707Linear population allocation by bistable switches in response to transient stimulation
Q35165190Linear superposition and prediction of bacterial promoter activity dynamics in complex conditions
Q21563740Linking fast and slow positive feedback loops creates an optimal bistable switch in cell signaling
Q37425287Listening to the noise: random fluctuations reveal gene network parameters.
Q28541592Loads bias genetic and signaling switches in synthetic and natural systems
Q42373949Logic Synthesis of Recombinase-Based Genetic Circuits.
Q33812404Logic integration of mRNA signals by an RNAi-based molecular computer
Q90704156Long-range temporal coordination of gene expression in synthetic microbial consortia
Q34042604LsrR quorum sensing "switch" is revealed by a bottom-up approach
Q51063630MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast.
Q41978496MODELING OF GENE REGULATORY PROCESSES BY POPULATION MEDIATED SIGNALING. NEW APPLICATIONS OF POPULATION BALANCES
Q97643279Majority sensing in synthetic microbial consortia
Q33899356Making cellular memories
Q36342438Making gene circuits sing
Q88513495Making lineage decisions with biological noise: Lessons from the early mouse embryo
Q38390803Mammalian synthetic biology: emerging medical applications.
Q38847010Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery.
Q64243889Mapping DNA sequence to transcription factor binding energy in vivo
Q36128011Mapping the Emergence of Synthetic Biology
Q27331437Mapping the environmental fitness landscape of a synthetic gene circuit
Q28817353Markov State Models of gene regulatory networks
Q36481458Mathematical analysis and quantification of fluorescent proteins as transcriptional reporters.
Q52069458Mathematical biology. Life is a game of numbers.
Q89013799Mathematical model of a serine integrase-controlled toggle switch with a single input
Q37403978Mathematical modeling and synthetic biology.
Q38423902Mathematical modeling in neuroendocrinology
Q33840296Mathematical modeling of GATA-switching for regulating the differentiation of hematopoietic stem cell.
Q33969404Mathematical modeling of gene networks
Q38851598Mathematical modeling reveals a critical role for cyclin D1 dynamics in phenotype switching during glioma differentiation
Q37768672Mathematical modeling: bridging the gap between concept and realization in synthetic biology
Q51582440Mathematical modelling of stem cell differentiation: the PU.1-GATA-1 interaction.
Q34776635Mathematical models in biology: from molecules to life
Q50737128Mathematical models of morphogen gradients and their effects on gene expression.
Q38332781Mechanism of transcriptional repression at a bacterial promoter by analysis of single molecules
Q36824562Mechanistically consistent reduced models of synthetic gene networks.
Q38769967Mechanosensing of shear by Pseudomonas aeruginosa leads to increased levels of the cyclic-di-GMP signal initiating biofilm development
Q42905903Meeting report: synthetic biology Jamboree for undergraduates
Q90414193Membrane Modulation of Super-Secreting "midiBacillus" Expressing the Major Staphylococcus aureus Antigen - A Mass-Spectrometry-Based Absolute Quantification Approach
Q33322890Memory in microbes: quantifying history-dependent behavior in a bacterium
Q54294212Metabolic flux redirection from a central metabolic pathway toward a synthetic pathway using a metabolic toggle switch.
Q34282268Methods and applications for assembling large DNA constructs
Q37331613MiRNAs confer phenotypic robustness to gene networks by suppressing biological noise.
Q24598602MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination
Q57062283Microbial population dynamics and evolution: a statistical physicist's guide
Q38829360Microbiome therapeutics - Advances and challenges
Q90006144Microfluidic cap-to-dispense (μCD): a universal microfluidic-robotic interface for automated pipette-free high-precision liquid handling
Q34098336Microfluidic devices for measuring gene network dynamics in single cells
Q91741441Microfluidics for Artificial Life: Techniques for Bottom-Up Synthetic Biology
Q42877353Minimal genetic device with multiple tunable functions
Q34105707Model transcriptional networks with continuously varying expression levels
Q37255911Model-driven optimization of multicomponent self-assembly processes
Q36235112Model-guided combinatorial optimization of complex synthetic gene networks.
Q36973028Model-guided design of ligand-regulated RNAi for programmable control of gene expression
Q41281433Modeling and simulation of biological systems using SPICE language
Q34122241Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives
Q33690994Modeling delay in genetic networks: from delay birth-death processes to delay stochastic differential equations.
Q26801236Modeling for (physical) biologists: an introduction to the rule-based approach
Q58698875Modeling of mesenchymal hybrid epithelial state and phenotypic transitions in EMT and MET processes of cancer cells
Q38056561Modeling regulatory networks to understand plant development: small is beautiful.
Q41959735Modeling stochastic dynamics in biochemical systems with feedback using maximum caliber
Q51914170Modeling stochastic gene expression under repression.
Q38336312Modeling stochastic noise in gene regulatory systems
Q21145352Modeling structure-function relationships in synthetic DNA sequences using attribute grammars
Q33934640Modelling cellular behaviour
Q30534748Modelling emergence of oscillations in communicating bacteria: a structured approach from one to many cells
Q36069239Modelling gene networks at different organisational levels
Q28767107Modelling in molecular biology: describing transcription regulatory networks at different scales
Q21202797Models for synthetic biology
Q35926371Modular Synthetic Inverters from Zinc Finger Proteins and Small RNAs
Q36482527Modular approaches to expanding the functions of living matter
Q35120083Modular composition of gene transcription networks
Q35096976Modular construction of mammalian gene circuits using TALE transcriptional repressors.
Q36280671Modular control of multiple pathways using engineered orthogonal T7 polymerases
Q28481407Modular design of artificial tissue homeostasis: robust control through synthetic cellular heterogeneity
Q41784461Modular electron transfer circuits for synthetic biology: insulation of an engineered biohydrogen pathway
Q85375641Modular gene-circuit design takes two steps forward
Q34258562Molecular characterization of duck enteritis virus CHv strain UL49.5 protein and its colocalization with glycoprotein M
Q30484516Molecular circuits for associative learning in single-celled organisms
Q50528466Molecular computing with plant cell phenotype serving as quality controlled output.
Q38259273Molecular crowding shapes gene expression in synthetic cellular nanosystems
Q37371719Molecular flip-flops formed by overlapping Fis sites.
Q39941055Molecular implementation of simple logic programs
Q48119442Molecular level dynamics of genetic oscillator--the effect of protein-protein interaction
Q37197570Molecular recordings by directed CRISPR spacer acquisition
Q33436717Monomeric bistability and the role of autoloops in gene regulation
Q42087577Monotone and near-monotone biochemical networks
Q42716577Monotone bifurcation graphs
Q35226041Morphisms of reaction networks that couple structure to function
Q37640975Morphogenesis at criticality
Q33272715Motif programming: a microgene-based method for creating synthetic proteins containing multiple functional motifs
Q35408902Motifs emerge from function in model gene regulatory networks
Q35121904Motifs, modules and games in bacteria
Q35623314Multi-input distributed classifiers for synthetic genetic circuits
Q64234963Multi-modality in gene regulatory networks with slow promoter kinetics
Q64057671Multi-rhythmicity generated by coupling two cellular rhythms
Q51579443Multi-scale genetic dynamic modelling I : an algorithm to compute generators.
Q38410699Multi-scale genetic dynamic modelling II: application to synthetic biology: an algorithmic Markov chain based approach
Q37894287Multi-scale modeling in biology: how to bridge the gaps between scales?
Q38802489Multi-stability and the origin of microbial community types
Q43169274Multi-stable dynamics of the non-adiabatic repressilator
Q27315853Multicellular computing using conjugation for wiring
Q35271606Multicriteria global optimization for biocircuit design
Q51150465Multimodality and flexibility of stochastic gene expression.
Q35058171Multiple sequence-specific factors generate the nucleosome-depleted region on CLN2 promoter.
Q51887476Multiscale analysis of reaction networks.
Q57811248Multiscale effects of heating and cooling on genes and gene networks
Q44770275Multistability in the lactose utilization network of Escherichia coli
Q46319267Multistability of synthetic genetic networks with repressive cell-to-cell communication
Q96127357Multistable and dynamic CRISPRi-based synthetic circuits
Q25256691Multistable and multistep dynamics in neutrophil differentiation
Q33388197Multistable decision switches for flexible control of epigenetic differentiation
Q21284297Multistable switches and their role in cellular differentiation networks
Q46080347NOT Gate Genetic Circuits to Control Gene Expression in Cyanobacteria
Q37098224Napoleon Is in Equilibrium
Q24610764Nature, nurture, or chance: stochastic gene expression and its consequences
Q24537594Near-critical phenomena in intracellular metabolite pools
Q56698274Necessary conditions for multistationarity in discrete dynamical systems
Q88651426Negative Regulation Gene Circuits for Efflux Pump Control
Q37125162Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression
Q33962256Negative autoregulation speeds the response times of transcription networks
Q90201856Network Topologies That Can Achieve Dual Function of Adaptation and Noise Attenuation
Q37452948Network dynamics
Q34457189Network dynamics and cell physiology
Q33533378Network inference and network response identification: moving genome-scale data to the next level of biological discovery
Q29615325Network motifs: theory and experimental approaches
Q38112371Network nonlinearities in drug treatment
Q37519797Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions
Q50986545Networks of coupled circuits: from a versatile toggle switch to collective coherent behavior.
Q73887486Neutralizing noise in gene networks
Q39919274Next-generation synthetic gene networks
Q30708248Noise Reduction in Complex Biological Switches.
Q89574815Noise control for molecular computing
Q28659275Noise in biology
Q30557299Noise in gene expression determines cell fate in Bacillus subtilis
Q34528937Noise in protein expression scales with natural protein abundance
Q24672369Noise in transcription negative feedback loops: simulation and experimental analysis
Q37338858Noise reduction facilitated by dosage compensation in gene networks
Q51607759Noise-aided computation within a synthetic gene network through morphable and robust logic gates.
Q35016879Noise-aided logic in an electronic analog of synthetic genetic networks
Q35047931Noise-based switches and amplifiers for gene expression
Q46904631Noise-induced regime shifts: A quantitative characterization.
Q33305706Noise-induced switches in network systems of the genetic toggle switch
Q37128860Non-transcriptional regulatory processes shape transcriptional network dynamics
Q46443633Nonlinear Kinetic Behavior in Constitutional Dynamic Reaction Networks
Q33892231Nonlinear protein degradation and the function of genetic circuits
Q33291673Nonlinear regulation enhances the phenotypic expression of trans-acting genetic polymorphisms
Q34520921Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses
Q100438580Novel Tunable Spatio-Temporal Patterns From a Simple Genetic Oscillator Circuit
Q42291805Nucleoid and cytoplasmic localization of small RNAs in Escherichia coli.
Q28822213Numerical algebraic geometry for model selection and its application to the life sciences
Q73575704On episode sensitization in recurrent affective disorders: the role of noise
Q57661646On genetic logic circuits: forcing digital electronics standards?
Q33711386On schemes of combinatorial transcription logic
Q33233059On the attenuation and amplification of molecular noise in genetic regulatory networks
Q51900330On the number of steady states in a multiple futile cycle.
Q47694765On the role of topology in regulating transcriptional cascades
Q30463780On-chip cellomics assay enabling algebraic and geometric understanding of epigenetic information in cellular networks of living systems. 1. Temporal aspects of epigenetic information in bacteria
Q36739284Operator sequence alters gene expression independently of transcription factor occupancy in bacteria
Q33322237OptCircuit: an optimization based method for computational design of genetic circuits
Q56568085Optically Controlled Oscillators in an Engineered Bioelectric Tissue
Q34270962Optimal homeostasis necessitates bistable control
Q51978639Optimal path to epigenetic switching.
Q28469330Optimal signal processing in small stochastic biochemical networks
Q51942433Optimal transition paths of stochastic chemical kinetic systems.
Q35095781Optimization of a stochastically simulated gene network model via simulated annealing.
Q39004632Optimization of industrial microorganisms: recent advances in synthetic dynamic regulators.
Q48268108Optimization-based synthesis of stochastic biocircuits with statistical specifications.
Q47161059Optimizing DNA assembly based on statistical language modelling
Q40298597Optimizing genetic circuits by global sensitivity analysis
Q53975052Optimizing information flow in small genetic networks. III. A self-interacting gene.
Q38983934Optogenetic characterization methods overcome key challenges in synthetic and systems biology
Q38239866Orchestration of plasma cell differentiation by Bach2 and its gene regulatory network
Q33883302Origin of bistability underlying mammalian cell cycle entry
Q34567666Paper-based synthetic gene networks
Q46333120Parallel logic gates in synthetic gene networks induced by non-Gaussian noise
Q47572001Parallel replica dynamics method for bistable stochastic reaction networks: Simulation and sensitivity analysis
Q30918589Parameter estimation methods for gene circuit modeling from time-series mRNA data: a comparative study
Q39897505Parameter identification using stochastic simulations reveals a robustness in CD95 apoptotic response
Q42999572Parameter mismatches and oscillation death in coupled oscillators
Q91361801Pathways to cellular supremacy in biocomputing
Q54320003Pattern formation in individual-based systems with time-varying parameters.
Q41879890Perfect sampling of the master equation for gene regulatory networks
Q42292651Period doubling induced by thermal noise amplification in genetic circuits
Q34576936Permanent genetic memory with >1-byte capacity
Q91869804Perspective: The promise of multi-cellular engineered living systems
Q26752520Phenotypic Variability in Synthetic Biology Applications: Dealing with Noise in Microbial Gene Expression
Q28709545Phenotypic models of evolution and development: geometry as destiny
Q35989384Phenotypic states become increasingly sensitive to perturbations near a bifurcation in a synthetic gene network
Q33627376Phenotypic switching in gene regulatory networks
Q34502643Phenotypic variation in bacteria: the role of feedback regulation
Q51454060Phosphatases modulate the bistable sporulation gene expression pattern in Bacillus subtilis.
Q35378297Phosphate sink containing two-component signaling systems as tunable threshold devices
Q43165431Photoregulation of DNA transcription by using photoresponsive T7 promoters and clarification of its mechanism
Q58045973Physical approaches to the dynamics of genetic circuits: a tutorial
Q34576205Physicochemical modelling of cell signalling pathways.
Q43057419Piecewise linear and Boolean models of chemical reaction networks
Q53419017Plant Science. Plant synthetic biology takes root.
Q47833507Plasmid-borne prokaryotic gene expression: sources of variability and quantitative system characterization
Q33239285Plasticity of the cis-regulatory input function of a gene
Q92578991Polar-opposite fates
Q33570920Polarization and migration in the zebrafish posterior lateral line system
Q36793610Positive feedback in cellular control systems.
Q24535235Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion
Q36544660Positive feedback produces broad distributions in maximum activation attained within a narrow time window in stochastic biochemical reactions
Q40896161Positive receptor feedback during lineage commitment can generate ultrasensitivity to ligand and confer robustness to a bistable switch
Q42128441Positive-feedback loops as a flexible biological module
Q51601491Post-transcriptional Boolean computation by combining aptazymes controlling mRNA translation initiation and tRNA activation.
Q33280627Potential energy landscape and robustness of a gene regulatory network: toggle switch
Q45743869Potential landscape of high dimensional nonlinear stochastic dynamics with large noise
Q28533397Potential role of a bistable histidine kinase switch in the asymmetric division cycle of Caulobacter crescentus
Q98565963Precision design of stable genetic circuits carried in highly-insulated E. coli genomic landing pads
Q36627240Precision metabolic engineering: The design of responsive, selective, and controllable metabolic systems
Q35146614Prediction and measurement of an autoregulatory genetic module
Q96022845Predictive biology: modelling, understanding and harnessing microbial complexity
Q21131128Preparing synthetic biology for the world
Q36689586Principles of cell-free genetic circuit assembly
Q34502550Principles of genetic circuit design
Q93222054Probabilistic control of HIV latency and transactivation by the Tat gene circuit
Q33536831Probability distributed time delays: integrating spatial effects into temporal models
Q41239727Process-based design of dynamical biological systems
Q28236112Programmable bacteria detect and record an environmental signal in the mammalian gut
Q91595611Programmable bacteria induce durable tumor regression and systemic antitumor immunity
Q34322635Programmable cells: interfacing natural and engineered gene networks
Q36701147Programmable control of bacterial gene expression with the combined CRISPR and antisense RNA system.
Q28476817Programmable ligand detection system in plants through a synthetic signal transduction pathway
Q35879638Programmable probiotics for detection of cancer in urine.
Q59909679Programmable protein circuits in living cells
Q51693435Programmed population control by cell-cell communication and regulated killing.
Q36536989Programming and engineering biological networks
Q50034999Programming gene and engineered-cell therapies with synthetic biology.
Q34087556Programming languages for synthetic biology
Q36969039Programming microbial population dynamics by engineered cell-cell communication
Q34358693Promoter strength driving TetR determines the regulatory properties of Tet-controlled expression systems
Q90683378Protein assembly systems in natural and synthetic biology
Q90929333Protein circuits reprogram cells
Q37651395Protocols for implementing an Escherichia coli based TX-TL cell-free expression system for synthetic biology
Q36209832Pulse Detecting Genetic Circuit - A New Design Approach
Q48205353Quantifying cellular capacity identifies gene expression designs with reduced burden
Q34347484Quantifying evolvability in small biological networks
Q33732108Quantifying uncertainty, variability and likelihood for ordinary differential equation models
Q34205663Quantitative analysis of cellular metabolic dissipative, self-organized structures
Q28083248Quantitative and logic modelling of molecular and gene networks
Q91835374Quantitative and synthetic biology approaches to combat bacterial pathogens
Q50773215Quantitative characterization of genetic parts and circuits for plant synthetic biology.
Q35354735Quantitative dynamic modelling of the gene regulatory network controlling adipogenesis
Q37080844Queueing up for enzymatic processing: correlated signaling through coupled degradation
Q90707198Quorum sensing for population-level control of bacteria and potential therapeutic applications
Q40822695Quorum-Sensing Synchronization of Synthetic Toggle Switches: A Design Based on Monotone Dynamical Systems Theory
Q34747424Quorum-sensing crosstalk-driven synthetic circuits: from unimodality to trimodality.
Q38301085RNA aptamers as genetic control devices: the potential of riboswitches as synthetic elements for regulating gene expression
Q36470934RNA synthetic biology
Q34081665Rapid and tunable post-translational coupling of genetic circuits
Q91787916Rapid loss of a green fluorescent plasmid in Escherichia coli O157:H7
Q35804156Rapidly characterizing the fast dynamics of RNA genetic circuitry with cell-free transcription-translation (TX-TL) systems
Q41630217Rate-limiting steps in transcription dictate sensitivity to variability in cellular components
Q38668511Rational design of a bacterial transcriptional cascade for amplifying gene expression capacity
Q41833855Rational design of a fusion partner for membrane protein expression in E. coli
Q28249187Rational design of memory in eukaryotic cells
Q41444663Rational design of modular circuits for gene transcription: A test of the bottom-up approach
Q52638161Rational engineering of synthetic microbial systems: from single cells to consortia.
Q99594700Rational programming of history-dependent logic in cellular populations
Q34108156Rationally designed logic integration of regulatory signals in mammalian cells
Q43111559Reaction coordinates for the flipping of genetic switches
Q46091653Realizing the potential of synthetic biology
Q36895178Recent Progress on Systems and Synthetic Biology Approaches to Engineer Fungi As Microbial Cell Factories.
Q26781904Recent advances and opportunities in synthetic logic gates engineering in living cells
Q97066772Recent advances in natural products exploitation in Streptomyces via synthetic biology
Q38700387Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition
Q90699072Reconciling periodic rhythms of large-scale biological networks by optimal control
Q30971329Reconstructing gene regulatory dynamics from high-dimensional single-cell snapshot data
Q53035308Reconstructing the single-cell-level behavior of a toggle switch from population-level measurements.
Q34470075Reconstruction of genetic circuits
Q38757688Redesigning metabolism based on orthogonality principles
Q28485150Redirector: designing cell factories by reconstructing the metabolic objective
Q36279891Regulating synthetic gene networks in 3D materials
Q37348683Regulation by transcription factors in bacteria: beyond description
Q33901103Regulation of endogenous human gene expression by ligand-inducible TALE transcription factors.
Q34739540Regulation of glioblastoma cell invasion by PKC iota and RhoB.
Q29616626Regulation of noise in the expression of a single gene
Q38172811Regulatory RNAs: charming gene management styles for synthetic biology applications
Q37495403Regulatory circuit design and evolution using phage lambda.
Q41852792Regulatory consequences of gene translocation in bacteria
Q55209742Remote Control of Mammalian Cells with Heat-Triggered Gene Switches and Photothermal Pulse Trains.
Q37419607Remote optical switch for localized and selective control of gene interference.
Q34778767Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt
Q33817686Response acceleration in post-translationally regulated genetic circuits
Q52014853Response delays and the structure of transcription networks.
Q48094104Responses to auxin signals: an operating principle for dynamical sensitivity yet high resilience
Q36481173Rethinking the Hierarchy of Sugar Utilization in Bacteria.
Q34028331Reverse engineering gene networks using singular value decomposition and robust regression
Q35022482Reverse engineering gene networks: Integrating genetic perturbations with dynamical modeling
Q37700679Rewiring cells: synthetic biology as a tool to interrogate the organizational principles of living systems
Q34032017Rewritable digital data storage in live cells via engineered control of recombination directionality
Q44817179Ribozyme déjà vu.
Q34433193Ribozyme-based insulator parts buffer synthetic circuits from genetic context
Q45956205Roadmap on semiconductor-cell biointerfaces.
Q42103346Robust and sensitive control of a quorum-sensing circuit by two interlocked feedback loops
Q35610464Robust design of biological circuits: evolutionary systems biology approach
Q42126712Robust dynamics in minimal hybrid models of genetic networks
Q21563483Robust network topologies for generating switch-like cellular responses
Q36979323Robust stability of genetic regulatory networks with distributed delay
Q34458342Robust synchronization control scheme of a population of nonlinear stochastic synthetic genetic oscillators under intrinsic and extrinsic molecular noise via quorum sensing
Q37249135Robust synthetic biology design: stochastic game theory approach
Q33995378Robust synthetic gene network design via library-based search method
Q36160722Robust, tunable genetic memory from protein sequestration combined with positive feedback
Q51961254Robustness analysis of cellular memory in an autoactivating positive feedback system.
Q28469133Robustness can evolve gradually in complex regulatory gene networks with varying topology
Q28476105Robustness of circadian clocks to daylight fluctuations: hints from the picoeucaryote Ostreococcus tauri
Q42183156Robustness of self-organizing chemoattractant field arising from precise pulse induction of its breakdown enzyme: a single-cell level analysis of PDE expression in Dictyostelium.
Q52765532Robustness of synthetic oscillators in growing and dividing cells.
Q93132800Rock-paper-scissors: Engineered population dynamics increase genetic stability
Q57382799Role of Core Biological Motifs in Dose-Response Modeling: An Example with Switchlike Circuits
Q51804668Role of cooperative binding on noise expression.
Q35955737Roles for microRNAs in conferring robustness to biological processes
Q51040110Roles of noise in single and coupled multiple genetic oscillators.
Q28482220Roles of protein ubiquitination and degradation kinetics in biological oscillations
Q33901124Rule-based design of synthetic transcription factors in eukaryotes.
Q34424966Rules for biological regulation based on error minimization
Q36136105SYNTHETIC BIOLOGY. Emergent genetic oscillations in a synthetic microbial consortium
Q94064383Scaling Computation and Memory in Living Cells
Q59386082Scaling up genetic circuit design for cellular computing: advances and prospects.
Q34224888Self-organisation and orderly processes by individual protein complexes in the bacterial cell
Q29619706Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability
Q35888342Self-regulation in a minimal model of chemical self-replication
Q38200876Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development.
Q39728911Semi-synthetic mammalian gene regulatory networks
Q40324429Sensitivity analysis of discrete stochastic systems
Q37622910Sequence tolerance of the phage lambda PRM promoter: implications for evolution of gene regulatory circuitry
Q36408706Sequestration-based bistability enables tuning of the switching boundaries and design of a latch
Q39281466Shaping development by stochasticity and dynamics in gene regulation
Q41863552Shared control of gene expression in bacteria by transcription factors and global physiology of the cell.
Q40213625Sharp developmental thresholds defined through bistability by antagonistic gradients of retinoic acid and FGF signaling
Q31121879Sharpening of expression domains induced by transcription and microRNA regulation within a spatio-temporal model of mid-hindbrain boundary formation
Q58573197Sigma factor-mediated tuning of bacterial cell-free synthetic genetic oscillators
Q42065933Signal transduction network motifs and biological memory
Q35692350Signal-to-Noise Ratio Measures Efficacy of Biological Computing Devices and Circuits
Q24676805Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades
Q33414399Simple molecular networks that respond optimally to time-periodic stimulation
Q40847240Simplified mechanistic models of gene regulation for analysis and design.
Q87689786Simulating Genetic Circuits in Bacterial Populations with Growth Heterogeneity
Q51955626Simulating rare events in equilibrium or nonequilibrium stochastic systems.
Q58921899Single Impulsive Controller for Exponential Synchronization of Stochastic Lur'e Networks with Impulsive Disturbance
Q43148003Single cell resolution in regulation of gene expression
Q41773810Single-cell behavior and population heterogeneity: solving an inverse problem to compute the intrinsic physiological state functions.
Q35931760Single-cell zeroth-order protein degradation enhances the robustness of synthetic oscillator
Q51268251Small-number effects: a third stable state in a genetic bistable toggle switch.
Q36954927Small-scale copy number variation and large-scale changes in gene expression.
Q29619703Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell
Q30667434Solution of the chemical master equation by radial basis functions approximation with interface tracking
Q33551049Solving the chemical master equation using sliding windows
Q35875319Sources of Variability in a Synthetic Gene Oscillator.
Q35410976Space-induced bifurcation in repression-based transcriptional circuits
Q27335171Spatial analysis of expression patterns predicts genetic interactions at the mid-hindbrain boundary
Q30579452Spatiotemporal control of gene expression with pulse-generating networks.
Q36651612Spatiotemporal dynamics of distributed synthetic genetic circuits
Q51052164Specialization and bet hedging in heterogeneous populations.
Q33325607Stability analysis of genetic regulatory network with additive noises.
Q35649571Stability and multiattractor dynamics of a toggle switch based on a two-stage model of stochastic gene expression
Q59040782Stability of Uncertain Impulsive Stochastic Genetic Regulatory Networks with Time-Varying Delay in the Leakage Term
Q51039245Stability of bacterial toggle switches is enhanced by cell-cycle lengthening by several orders of magnitude.
Q28828703State Space Truncation with Quantified Errors for Accurate Solutions to Discrete Chemical Master Equation
Q33707494Statistical mechanical model of coupled transcription from multiple promoters due to transcription factor titration
Q34490588Statistical method for revealing form-function relations in biological networks
Q38936609Steady state statistical correlations predict bistability in reaction motifs.
Q37620369Steady-State-Preserving Simulation of Genetic Regulatory Systems.
Q51401049Steady-state parameter sensitivity in stochastic modeling via trajectory reweighting.
Q51217273Steady-state simulation of metastable stochastic chemical systems.
Q36164508Stem cell biology: a view toward the future
Q28554812Stochastic Simulation Service: Bridging the Gap between the Computational Expert and the Biologist
Q90244564Stochastic activation and bistability in a Rab GTPase regulatory network
Q51552704Stochastic analysis of a miRNA-protein toggle switch.
Q47570097Stochastic analysis of bistability in coherent mixed feedback loops combining transcriptional and posttranscriptional regulations.
Q51430807Stochastic binary modeling of cells in continuous time as an alternative to biochemical reaction equations.
Q43743698Stochastic fluctuations in gene expression far from equilibrium: Omega expansion and linear noise approximation.
Q34805489Stochastic gene expression as a many-body problem
Q73756864Stochastic gene expression: density of defects frozen into permanent Turing patterns
Q36510612Stochastic model reduction using a modified Hill-type kinetic rate law.
Q34694165Stochastic models for regulatory networks of the genetic toggle switch
Q50949348Stochastic phenotype transition of a single cell in an intermediate region of gene state switching.
Q34294676Stochastic simulations of a synthetic bacteria-yeast ecosystem
Q51920181Stochastic simulations of genetic switch systems.
Q51895644Stochastic simulations of the repressilator circuit.
Q33797254Stochastic simulations of the tetracycline operon
Q28533292Stochastic stabilization of phenotypic States: the genetic bistable switch as a case study
Q54615468Stochastic suppression of gene expression oscillators under intercell coupling.
Q46685546Stochastic switching as a survival strategy in fluctuating environments
Q34023196Stochastic switching induced adaptation in a starved Escherichia coli population
Q33281141Stochastic synchronization of genetic oscillator networks
Q29617360Stochasticity in gene expression: from theories to phenotypes
Q28365103Stochasticity in transcriptional regulation: origins, consequences, and mathematical representations
Q36095581Stochasticity or the fatal 'imperfection' of cloning
Q31129063Stochasticity, bistability and the wisdom of crowds: a model for associative learning in genetic regulatory networks
Q37729531Strategies for protein synthetic biology.
Q64099481Strategies in regulating glioblastoma signaling pathways and anti-invasion therapy
Q41023000Stress-response balance drives the evolution of a network module and its host genome
Q51827715Structural principles for periodic orbits in glass networks.
Q34598769Structure and function of negative feedback loops at the interface of genetic and metabolic networks
Q24683513Structure and function of the feed-forward loop network motif
Q35817179Sufficient and necessary conditions for Lyapunov stability of genetic networks with SUM regulatory logic
Q40415705Super-transient scaling in time-delay autonomous Boolean network motifs
Q36785269Sustained oscillations in extended genetic oscillatory systems
Q35075492Switch of sensitivity dynamics revealed with DyGloSA toolbox for dynamical global sensitivity analysis as an early warning for system's critical transition
Q40862173Switchable genetic oscillator operating in quasi-stable mode
Q51639127Symbolic dynamics and computation in model gene networks.
Q28601294SynBioSS-aided design of synthetic biological constructs
Q51822085Synchronization and clustering of synthetic genetic networks: a role for cis-regulatory modules.
Q48916964Synchronization and local convergence analysis of networks with dynamic diffusive coupling.
Q51944444Synchronization of electronic genetic networks.
Q51861524Synchronization of genetic oscillators.
Q45062978Synchronized DNA cycling across a bacterial population
Q51491869Synchronizing genetic oscillators by signaling molecules.
Q33894343Synchronizing genetic relaxation oscillators by intercell signaling
Q42728840Synergistic Synthetic Biology: Units in Concert
Q57169472Synthesis of control unit for future biocomputer
Q28547818Synthesizing Configurable Biochemical Implementation of Linear Systems from Their Transfer Function Specifications
Q40150543Synthesizing a novel genetic sequential logic circuit: a push-on push-off switch
Q48271402Synthesizing artificial devices that redirect cellular information at will
Q33726226Synthesizing genetic sequential logic circuit with clock pulse generator
Q41001797Synthetic Biology Platform for Sensing and Integrating Endogenous Transcriptional Inputs in Mammalian Cells
Q47567791Synthetic Biology between Self-Regulation and Public Discourse: Ethical Issues and the Many Roles of the Ethicist
Q89682079Synthetic Biology for Terraformation Lessons from Mars, Earth, and the Microbiome
Q38784006Synthetic Biology-The Synthesis of Biology
Q34829709Synthetic Biology: A Bridge between Artificial and Natural Cells
Q34257757Synthetic Biology: Bits and pieces come to life
Q39206961Synthetic Biology: Engineering Living Systems from Biophysical Principles
Q46554724Synthetic Gene Expression Circuits for Designing Precision Tools in Oncology
Q38857177Synthetic Morphogenesis
Q36685861Synthetic RNA circuits
Q33954134Synthetic RNA modules for fine-tuning gene expression levels in yeast by modulating RNase III activity
Q64231486Synthetic Switches and Regulatory Circuits in Plants
Q64947796Synthetic Toolkit for Complex Genetic Circuit Engineering in Saccharomyces cerevisiae.
Q26998440Synthetic analog and digital circuits for cellular computation and memory
Q46384419Synthetic associative learning in engineered multicellular consortia.
Q38805497Synthetic biology approaches in cancer immunotherapy, genetic network engineering, and genome editing
Q35225038Synthetic biology approaches to improve biocatalyst identification in metagenomic library screening
Q38310499Synthetic biology devices and circuits for RNA-based 'smart vaccines': a propositional review
Q26776378Synthetic biology devices for in vitro and in vivo diagnostics
Q35057524Synthetic biology for therapeutic applications
Q38427592Synthetic biology guides biofuel production.
Q26995293Synthetic biology in mammalian cells: next generation research tools and therapeutics
Q37754036Synthetic biology in the analysis and engineering of signaling processes
Q37925394Synthetic biology moving into the clinic
Q38788838Synthetic biology routes to bio-artificial intelligence
Q28078320Synthetic biology to access and expand nature's chemical diversity
Q36586096Synthetic biology--putting engineering into biology
Q53392485Synthetic biology. Dynamic genome engineering in living cells.
Q34702375Synthetic biology. Genomically encoded analog memory with precise in vivo DNA writing in living cell populations
Q51555152Synthetic biology: Building genetic containment.
Q46339074Synthetic biology: Engineering explored
Q58929371Synthetic biology: Enter the living machine
Q59267606Synthetic biology: From the first synthetic cell to see its current situation and future development
Q46138224Synthetic biology: Precision timing in a cell
Q39782355Synthetic biology: a foundation for multi-scale molecular biology
Q35907569Synthetic biology: advancing biological frontiers by building synthetic systems
Q33958771Synthetic biology: applications come of age
Q35988630Synthetic biology: insights into biological computation.
Q33981040Synthetic biology: integrated gene circuits
Q26991913Synthetic biology: lessons from engineering yeast MAPK signalling pathways
Q31059198Synthetic biology: mapping the scientific landscape
Q24672399Synthetic biology: new engineering rules for an emerging discipline
Q42919282Synthetic biology: promises and challenges
Q51602891Synthetic biology: starting from scratch.
Q34534926Synthetic cell biology
Q36711501Synthetic circuit of inositol phosphorylceramide synthase in Leishmania : a chemical biology approach
Q40091404Synthetic circuits integrating logic and memory in living cells
Q28818778Synthetic circuits that process multiple light and chemical signal inputs
Q36922643Synthetic circuits, devices and modules
Q24634044Synthetic conversion of a graded receptor signal into a tunable, reversible switch
Q35495012Synthetic feedback control using an RNAi-based gene-regulatory device
Q42404665Synthetic feedback loop model for increasing microbial biofuel production using a biosensor
Q42152728Synthetic gene circuits for metabolic control: design trade-offs and constraints
Q36715725Synthetic gene circuits: design with directed evolution
Q28246672Synthetic gene networks that count
Q42174382Synthetic human cell fate regulation by protein-driven RNA switches
Q27004099Synthetic in vitro circuits
Q37993331Synthetic in vitro transcription circuits
Q42172472Synthetic lateral inhibition governs cell-type bifurcation with robust ratios.
Q37926924Synthetic mammalian gene networks as a blueprint for the design of interactive biohybrid materials
Q90212671Synthetic metabolic computation in a bioluminescence-sensing system
Q92545011Synthetic microbial consortium with specific roles designated by genetic circuits for cooperative chemical production
Q58742109Synthetic negative feedback circuits using engineered small RNAs
Q26747209Synthetic promoter design for new microbial chassis
Q34995237Synthetic protein scaffolds provide modular control over metabolic flux.
Q38844812Synthetic strategies for plant signalling studies: molecular toolbox and orthogonal platforms.
Q26826954Synthetic therapeutic gene circuits in mammalian cells
Q39551932Synthetic two-way communication between mammalian cells
Q33590158Systematic design methodology for robust genetic transistors based on I/O specifications via promoter-RBS libraries
Q34551665Systems Biology-Derived Discoveries of Intrinsic Clocks
Q37405937Systems and Synthetic biology: tackling genetic networks and complex diseases.
Q38153035Systems approaches for synthetic biology: a pathway toward mammalian design
Q37679194Systems biology as an integrated platform for bioinformatics, systems synthetic biology, and systems metabolic engineering
Q24650979Systems biology: On the cell cycle and its switches
Q37691412Systems metabolic engineering: genome-scale models and beyond
Q54483777Taming Living Logic Using Formal Methods
Q36601206Teaching bacteria a new language.
Q42224055Temperature dependence of ssrA-tag mediated protein degradation
Q37901364Temporal and spatial oscillations in bacteria
Q56535270Ten years of synergy
Q24544957The Bacillus subtilis sin operon: an evolvable network motif
Q33131302The Constructor: a web application optimizing cloning strategies based on modules from the registry of standard biological parts
Q41864814The EAL domain protein YciR acts as a trigger enzyme in a c-di-GMP signalling cascade in E. coli biofilm control
Q36961678The Hsp90 capacitor, developmental remodeling, and evolution: the robustness of gene networks and the curious evolvability of metamorphosis
Q40669814The JNK cascade as a biochemical switch in mammalian cells: ultrasensitive and all-or-none responses
Q28728419The PLOS ONE synthetic biology collection: six years and counting
Q37189067The Switch in a Genetic Toggle System with Lévy Noise
Q34423743The Synthetic Biology Open Language (SBOL) provides a community standard for communicating designs in synthetic biology.
Q37831976The application of Tet repressor in prokaryotic gene regulation and expression
Q28478128The bacterial nanorecorder: engineering E. coli to function as a chemical recording device
Q28660797The biological microprocessor, or how to build a computer with biological parts
Q33505795The capacity for multistability in small gene regulatory networks
Q42158249The cellular Ising model: a framework for phase transitions in multicellular environments.
Q34808329The dynamic microbe: green fluorescent protein brings bacteria to light
Q45339220The dynamics of hybrid metabolic-genetic oscillators
Q51168235The effect of negative feedback on noise propagation in transcriptional gene networks.
Q42583601The effects of cascade length, kinetics and feedback loops on biological signal transduction dynamics in a simplified cascade model
Q46680813The effects of intrinsic noise on the behaviour of bistable cell regulatory systems under quasi-steady state conditions.
Q34360772The engineer's approach to biology
Q61817292The finite state projection based Fisher information matrix approach to estimate information and optimize single-cell experiments
Q37542425The impact of synthetic biology on drug discovery
Q34087717The incoherent feedforward loop can provide fold-change detection in gene regulation
Q36902026The influence of assortativity on the robustness and evolvability of gene regulatory networks upon gene birth
Q44485583The inheritance of process: a dynamical systems approach
Q24610233The interplay between transcription factors and microRNAs in genome-scale regulatory networks
Q28486543The interplay of intrinsic and extrinsic bounded noises in biomolecular networks
Q29547498The large-scale organization of metabolic networks
Q50750676The limiting dynamics of a bistable molecular switch with and without noise.
Q35079971The mathematical model of the Bcl-2 family mediated MOMP regulation can perform a non-trivial pattern recognition
Q87415582The new drug circuit
Q33549707The origins of time-delay in template biopolymerization processes
Q34066433The pedestrian watchmaker: genetic clocks from engineered oscillators
Q28751801The role of predictive modelling in rationally re-engineering biological systems
Q27004594The role of single-cell analyses in understanding cell lineage commitment
Q34982488The second wave of synthetic biology: from modules to systems
Q45073741The spatiotemporal system dynamics of acquired resistance in an engineered microecology
Q28658602The synthetic biology future
Q33599575The synthetic integron: an in vivo genetic shuffling device
Q33283067The tailless ortholog nhr-67 regulates patterning of gene expression and morphogenesis in the C. elegans vulva
Q34214749The tandem repeats enabling reversible switching between the two phases of β-lactamase substrate spectrum
Q90611954The threshold of an excitable system serves as a control mechanism for noise filtering during chemotaxis
Q38608345The timing of transcriptional regulation in synthetic gene circuits
Q42285224The transcription analysis of duck enteritis virus UL49.5 gene using real-time quantitative reverse transcription PCR.
Q34510780The transcriptional heat shock response of Salmonella typhimurium shows hysteresis and heated cells show increased resistance to heat and acid stress
Q38261294The yeast galactose network as a quantitative model for cellular memory
Q64057207Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent
Q94606243Theoretical investigation of a genetic switch for metabolic adaptation
Q42534065Theory of time-resolved somatic complementation and its use to explore the sporulation control network in Physarum polycephalum
Q33308922Threshold-dominated regulation hides genetic variation in gene expression networks
Q37653016Thrombin-mediated transcriptional regulation using DNA aptamers in DNA-based cell-free protein synthesis
Q38635679Time-Delayed Models of Gene Regulatory Networks
Q28474998Timing cellular decision making under noise via cell-cell communication
Q30491644TinkerCell: modular CAD tool for synthetic biology
Q21145327To lyse or not to lyse: transient-mediated stochastic fate determination in cells infected by bacteriophages
Q34449117Toehold switches: de-novo-designed regulators of gene expression
Q42912719Toggle switch: noise determines the winning gene
Q33936663Toggles and oscillators: new genetic circuit designs
Q26783565Tools and Principles for Microbial Gene Circuit Engineering
Q51025210Topological structures enhance the presence of dynamical regimes in synthetic networks.
Q91596015Topology-dependent interference of synthetic gene circuit function by growth feedback
Q37663602Toward engineering synthetic microbial metabolism
Q42810644Toward integration of in vivo molecular computing devices: successes and challenges
Q33912780Towards a circuit engineering discipline
Q36964778Towards a whole-cell modeling approach for synthetic biology
Q62639674Towards an Aspect-Oriented Design and Modelling Framework for Synthetic Biology
Q34290853Towards an artificial cell.
Q64123052Towards control of cellular decision-making networks in the epithelial-to-mesenchymal transition
Q37696969Towards genome-scale signalling network reconstructions
Q39686518Towards programmable plant genetic circuits
Q34280185Towards the rational design of synthetic cells with prescribed population dynamics
Q34185672Tracking operator state fluctuations in gene expression in single cells
Q30496523Tracking, tuning, and terminating microbial physiology using synthetic riboregulators.
Q37210945Transcript degradation and noise of small RNA-controlled genes in a switch activated network in Escherichia coli
Q52374505Transcription Factor Target Gene Network governs the Logical Abstraction Analysis of the Synthetic Circuit in Leishmaniasis.
Q47215199Transcription control engineering and applications in synthetic biology.
Q46853848Transcription factor logic using chemical complementation
Q51273544Transcriptional bursting diversifies the behaviour of a toggle switch: hybrid simulation of stochastic gene expression.
Q51172346Transcriptional delay stabilizes bistable gene networks.
Q33257709Transcriptional dynamics of the embryonic stem cell switch
Q90857569Transcriptional programming using engineered systems of transcription factors and genetic architectures
Q36614050Transferring a synthetic gene circuit from yeast to mammalian cells
Q40168881Transient Thresholding: A Mechanism Enabling Noncooperative Transcriptional Circuitry to Form a Switch
Q53258376Transient amplification limits noise suppression in biochemical networks.
Q47928642Transient dynamics and their control in time-delay autonomous Boolean ring networks
Q35753726Transient dynamics of genetic regulatory networks
Q41132625Transitions in genetic toggle switches driven by dynamic disorder in rate coefficients
Q34480721Transplantation of prokaryotic two-component signaling pathways into mammalian cells
Q58599910Tumour-targeting bacteria engineered to fight cancer
Q42559140Tunability of the ratio of cell states after the synthetic diversification by the diversity generator.
Q51357163Tunable oscillations and chaotic dynamics in systems with localized synthesis.
Q35428115Tunable protein degradation in bacteria
Q94468469Tunable self-cleaving ribozymes for modulating gene expression in eukaryotic systems
Q35518808Tunable synthetic phenotypic diversification on Waddington's landscape through autonomous signaling
Q33812384Tuning and controlling gene expression noise in synthetic gene networks.
Q33222305Tuning genetic control through promoter engineering
Q40873667Tuning the activation threshold of a kinase network by nested feedback loops
Q24630346Tuning the dials of Synthetic Biology
Q47424197Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors.
Q43742995Tuning the range and stability of multiple phenotypic states with coupled positive-negative feedback loops
Q24649674Tweaking biological switches through a better understanding of bistability behavior
Q51891278Two-component genetic switch as a synthetic module with tunable stability.
Q37104172Tying new knots in synthetic biology
Q33926820Ultrasensitivity and noise propagation in a synthetic transcriptional cascade.
Q35619490Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback
Q90658690Ultrasound imaging of gene expression in mammalian cells
Q38687542Unbiased Bayesian inference for population Markov jump processes via random truncations.
Q42554196Unconditional global exponential stability in Lagrange sense of genetic regulatory networks with SUM regulatory logic
Q42256635Unlimited multistability and Boolean logic in microbial signalling
Q97646471Unstructured kinetic models to simulate an arabinose switch that decouples cell growth from metabolite production
Q37690978Use of two-component signal transduction systems in the construction of synthetic genetic networks
Q36458860Use of virtual cell in studies of cellular dynamics
Q45056046Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
Q35835041Using noise to control heterogeneity of isogenic populations in homogenous environments.
Q36813978Using synthetic biology to make cells tomorrow's test tubes
Q28484856Using topology to tame the complex biochemistry of genetic networks
Q51916299Variable-free exploration of stochastic models: a gene regulatory network example.
Q47192978Versatile and on-demand biologics co-production in yeast.
Q34307600Whole-cell biocomputing
Q24655513Writing DNA with GenoCAD
Q36201149Yeast Replicator: A High-Throughput Multiplexed Microfluidics Platform for Automated Measurements of Single-Cell Aging
Q33983770proTeOn and proTeOff, new protein devices that inducibly activate bacterial gene expression

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