Breaking an epigenetic chromatin switch: curious features of hysteresis in Saccharomyces cerevisiae telomeric silencing

scientific article published on 23 December 2014

Breaking an epigenetic chromatin switch: curious features of hysteresis in Saccharomyces cerevisiae telomeric silencing is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...9k3516N
P356DOI10.1371/JOURNAL.PONE.0113516
P932PMC publication ID4275178
P698PubMed publication ID25536038
P5875ResearchGate publication ID270001400

P2093author name stringAnirvan M Sengupta
Adel Dayarian
Swagatam Mukhopadhyay
Vijayalakshmi H Nagaraj
P2860cites workSpatial epigenetic control of mono- and bistable gene expressionQ21090179
Stochastic mRNA synthesis in mammalian cellsQ21146037
Stochastic kinetic analysis of developmental pathway bifurcation in phage lambda-infected Escherichia coli cellsQ24548020
Kinetic Proofreading: A New Mechanism for Reducing Errors in Biosynthetic Processes Requiring High SpecificityQ24563898
Single-RNA counting reveals alternative modes of gene expression in yeastQ24619115
Transcriptional pulsing of a developmental geneQ27317160
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylationQ27930884
Epigenetic inheritance of transcriptional states in S. cerevisiaeQ27934639
The red/white colony color assay in the yeast Saccharomyces cerevisiae: epistatic growth advantage of white ade8-18, ade2 cells over red ade2 cellsQ27937076
The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stabilityQ27937288
The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1pQ27940017
Getting started with yeastQ28131602
Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcriptionQ28131683
Green fluorescent protein as a marker for gene expressionQ28131684
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Titration and hysteresis in epigenetic chromatin silencingQ46110152
Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation statesQ46567995
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Optimal path to epigenetic switching.Q51978639
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Single-Cell Observations Reveal Intermediate Transcriptional Silencing StatesQ58028867
Evidence for silencing compartments within the yeast nucleus: a role for telomere proximity and Sir protein concentration in silencer-mediated repressionQ61783589
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Epigenetics as a first exit problemQ77521168
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1Q28203762
Kinetic amplification of enzyme discriminationQ28217105
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A simple histone code opens many paths to epigeneticsQ28482317
The role of multiple marks in epigenetic silencing and the emergence of a stable bivalent chromatin stateQ28534712
DNA replication fidelityQ29616841
Heterochromatin and epigenetic control of gene expressionQ29618486
Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversityQ33220546
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Real-time kinetics of gene activity in individual bacteriaQ34477297
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Epigenetic chromatin silencing: bistability and front propagationQ34712052
Chromosomal position effects are linked to sir2-mediated variation in transcriptional burst sizeQ34978151
Clustering heterochromatin: Sir3 promotes telomere clustering independently of silencing in yeastQ35003595
Methylation and epigenetic fidelityQ35120823
The boundaries of the silenced HMR domain in Saccharomyces cerevisiaeQ35191933
DNA replication fidelityQ35677447
Histones and histone modificationsQ35842800
Identification and characterization of Sir2 inhibitors through phenotypic assays in yeastQ35971905
Small molecule regulation of Sir2 protein deacetylasesQ36255278
Mechanism for epigenetic variegation of gene expression at yeast telomeric heterochromatinQ36374195
ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENONQ37617203
Chromatin as a potential carrier of heritable informationQ37714146
Modeling the dynamic epigenome: from histone modifications towards self-organizing chromatinQ37997087
Epigenetics meets mathematics: towards a quantitative understanding of chromatin biologyQ38036575
Vernalization - a cold-induced epigenetic switchQ38039298
Noise can induce bimodality in positive transcriptional feedback loops without bistabilityQ39921387
A common telomeric gene silencing assay is affected by nucleotide metabolismQ41770563
Dynamics of Sir3 spreading in budding yeast: secondary recruitment sites and euchromatic localizationQ41872924
Inheritance of epigenetic chromatin silencingQ41981789
Locus dependence in epigenetic chromatin silencingQ42068901
Effects of Perinuclear Chromosome Tethers in the Telomeric URA3/5FOA System Reflect Changes to Gene Silencing and not Nucleotide Metabolism.Q42259289
Limitations of silencing at native yeast telomeresQ42673247
Multistability in the lactose utilization network of Escherichia coliQ44770275
Mechanism of transcriptional silencing in yeastQ45225621
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesscikit-learnQ1026367
scikit-imageQ22442795
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
P304page(s)e113516
P577publication date2014-12-23
P1433published inPLOS OneQ564954
P1476titleBreaking an epigenetic chromatin switch: curious features of hysteresis in Saccharomyces cerevisiae telomeric silencing
P478volume9

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cites work (P2860)
Q92554953Epigenetics recording varied environment and complex cell events represents the origin of cellular aging
Q49819276Epigenomics in 3D: importance of long-range spreading and specific interactions in epigenomic maintenance.
Q64063155Yeast epigenetics: the inheritance of histone modification states

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