| scholarly article | Q13442814 |
| review article | Q7318358 |
| P2093 | author name string | John M Denu | |
| Olivera Grubisha | |||
| Brian C Smith | |||
| P2860 | cites work | Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity | Q22010164 |
| The human histone deacetylase family | Q34119283 | ||
| How does calorie restriction work? | Q34175282 | ||
| Yeast life-span extension by calorie restriction is independent of NAD fluctuation | Q34275342 | ||
| Calorie restriction extends yeast life span by lowering the level of NADH. | Q34289946 | ||
| Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases | Q35040959 | ||
| Plasmid accumulation reduces life span in Saccharomyces cerevisiae. | Q41275726 | ||
| Nicotinamide: a jack of all trades (but master of none?) | Q44415052 | ||
| Negative control of p53 by Sir2alpha promotes cell survival under stress | Q24291828 | ||
| hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase | Q24291829 | ||
| Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase | Q24293656 | ||
| Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma | Q24294948 | ||
| The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase | Q24296836 | ||
| Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence | Q24297146 | ||
| Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity | Q24298021 | ||
| Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase | Q24310456 | ||
| Sir2 mediates longevity in the fly through a pathway related to calorie restriction | Q24560016 | ||
| The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms | Q24597989 | ||
| Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase | Q27860668 | ||
| A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. | Q27931475 | ||
| Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin | Q27931533 | ||
| Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae | Q27933365 | ||
| The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases | Q27934108 | ||
| Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans | Q28131824 | ||
| Genetic pathways that regulate ageing in model organisms | Q28138437 | ||
| Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins | Q28139564 | ||
| Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan | Q28203572 | ||
| Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1 | Q28203762 | ||
| Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening | Q28210511 | ||
| Mammalian SIRT1 represses forkhead transcription factors | Q28246430 | ||
| The Sir2 family of protein deacetylases | Q28266179 | ||
| Identification of a small molecule inhibitor of Sir2p | Q28344005 | ||
| Sirtuin activators mimic caloric restriction and delay ageing in metazoans | Q29547766 | ||
| Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration | Q29616075 | ||
| Extrachromosomal rDNA circles--a cause of aging in yeast | Q29618308 | ||
| Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration | Q29618751 | ||
| Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity | Q30432790 | ||
| Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product | Q30454472 | ||
| Caloric restriction and aging: an update | Q33930339 | ||
| The new life of a centenarian: signalling functions of NAD(P). | Q33976408 | ||
| P433 | issue | 18 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 4607-4616 | |
| P577 | publication date | 2005-09-01 | |
| P1433 | published in | FEBS Journal | Q1388041 |
| P1476 | title | Small molecule regulation of Sir2 protein deacetylases | |
| P478 | volume | 272 |
| Q46372781 | 17β-Estradiol via SIRT1/Acetyl-p53/NF-kB Signaling Pathway Rescued Postnatal Rat Brain Against Acute Ethanol Intoxication |
| Q42075509 | A glycolytic burst drives glucose induction of global histone acetylation by picNuA4 and SAGA. |
| Q30578694 | A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease |
| Q37289500 | Adrenergic signaling and oxidative stress: a role for sirtuins? |
| Q33567417 | Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells |
| Q35533119 | Breaking an epigenetic chromatin switch: curious features of hysteresis in Saccharomyces cerevisiae telomeric silencing |
| Q91639090 | Calmodulin Is the Fundamental Regulator of NADK-Mediated NAD Signaling in Plants |
| Q37829704 | Catalysis and mechanistic insights into sirtuin activation |
| Q37681309 | Dietary restriction and brain health. |
| Q85225058 | Discovery and validation of SIRT2 inhibitors based on tenovin-6: use of a ¹H-NMR method to assess deacetylase activity |
| Q37343700 | Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. |
| Q36927936 | Effects of Low Concentrations of Rotenone upon Mitohormesis in SH-SY5Y Cells |
| Q24314812 | Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters |
| Q37852611 | Erratum to: resveratrol and red wine, healthy heart and longevity |
| Q90465813 | FK866 inhibits the epithelial-mesenchymal transition of hepatocarcinoma MHCC97-H cells |
| Q37384514 | Functional complementation of sir2Δ yeast mutation by the human orthologous gene SIRT1. |
| Q36283905 | Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease |
| Q36728127 | Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt |
| Q24657553 | Histone H4 lysine 16 acetylation regulates cellular lifespan |
| Q36599926 | Histone deacetylase inhibitors as therapeutics for polyglutamine disorders |
| Q38081381 | Histone deacetylases and their functions in plants |
| Q28489057 | In Bacillus subtilis, the sirtuin protein deacetylase, encoded by the srtN gene (formerly yhdZ), and functions encoded by the acuABC genes control the activity of acetyl coenzyme A synthetase |
| Q92891433 | Inhibition of the SIRT1 signaling pathway exacerbates endoplasmic reticulum stress induced by renal ischemia/reperfusion injury in type 1 diabetic rats |
| Q24338619 | Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis |
| Q27025850 | Is physical activity able to modify oxidative damage in cardiovascular aging? |
| Q58762005 | Lysine acetylation modulates mouse sperm capacitation |
| Q35252505 | Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studies |
| Q37061505 | Mechanisms and molecular probes of sirtuins. |
| Q42008823 | Mechanistic studies on the effects of nicotinamide on megakaryocytic polyploidization and the roles of NAD+ levels and SIRT inhibition |
| Q35019476 | Neuroprotective effects of resveratrol on damages of mouse cortical neurons induced by β-amyloid through activation of SIRT1/Akt1 pathway |
| Q40217521 | Nicotinamide (vitamin B3) increases the polyploidisation and proplatelet formation of cultured primary human megakaryocytes |
| Q39247299 | Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells |
| Q37180789 | Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons |
| Q24669960 | Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going? |
| Q36267307 | Nutrition, sirtuins and aging |
| Q51788735 | Reduced silent information regulator 1 signaling exacerbates myocardial ischemia-reperfusion injury in type 2 diabetic rats and the protective effect of melatonin. |
| Q35874520 | Regulation of poly(ADP-ribose) polymerase-1-dependent gene expression through promoter-directed recruitment of a nuclear NAD+ synthase |
| Q33932159 | Respected Sir(2): magic target for diabetes |
| Q37711262 | Resveratrol and red wine, healthy heart and longevity. |
| Q37429176 | SIRT1 genetic variation is related to BMI and risk of obesity |
| Q28509650 | SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages |
| Q36539471 | SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. |
| Q37625383 | SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions |
| Q51068064 | Serum sirtuin 1 levels in patients with polycystic ovary syndrome. |
| Q36545639 | Sirt1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells |
| Q24303857 | Sirtuin functions in health and disease |
| Q37788970 | Sirtuin mechanism and inhibition: explored with N(ε)-acetyl-lysine analogs |
| Q34024712 | Sirtuin-mediated nuclear differentiation and programmed degradation in Tetrahymena |
| Q37548942 | Sirtuins and p53. |
| Q34350843 | Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease |
| Q37661233 | The effect of Ramadan fasting on sirtuin and visfatin levels. |
| Q21563464 | The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases |
| Q33237401 | Use of transcriptional synergy to augment sensitivity of a splicing reporter assay |
| Q35018928 | Visfatin as a novel mediator released by inflamed human endothelial cells |
| Q36994681 | Yeast mother cell-specific ageing, genetic (in)stability, and the somatic mutation theory of ageing. |
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