The role of multiple marks in epigenetic silencing and the emergence of a stable bivalent chromatin state

scientific article (publication date: 2013)

The role of multiple marks in epigenetic silencing and the emergence of a stable bivalent chromatin state is …
instance of (P31):
scholarly articleQ13442814

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P818arXiv ID1205.2571
P8978DBLP publication IDjournals/ploscb/MukhopadhyayS13
P356DOI10.1371/JOURNAL.PCBI.1003121
P932PMC publication ID3715441
P698PubMed publication ID23874171
P5875ResearchGate publication ID250925662

P2093author name stringAnirvan M Sengupta
Swagatam Mukhopadhyay
P2860cites workSpatial epigenetic control of mono- and bistable gene expressionQ21090179
The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4Q24536072
Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modificationsQ24545952
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein associationQ24675122
Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-riboseQ24675630
Structure of the coiled-coil dimerization motif of Sir4 and its interaction with Sir3Q27641394
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylaseQ27860668
Chromatin modifications and their functionQ27861067
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylationQ27930884
The Paf1 complex is required for efficient transcription elongation by RNA polymerase IQ27931337
Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatinQ27932245
Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3.Q27933756
Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA associationQ27933908
Domain structure and protein interactions of the silent information regulator Sir3 revealed by screening a nested deletion library of protein fragmentsQ27935281
SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeastQ27936734
Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitroQ27937816
The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1pQ27940017
Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiaeQ27940105
The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1Q27940230
Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcriptionQ28131683
The complex language of chromatin regulation during transcriptionQ28131748
Shape, size, and robustness: feasible regions in the parameter space of biochemical networksQ28474347
Redundant roles for histone H3 N-terminal lysine residues in subtelomeric gene repression in Saccharomyces cerevisiaeQ28768691
Histone variants: deviants?Q29391535
Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae.Q29465402
Active genes are tri-methylated at K4 of histone H3Q29547668
The establishment, inheritance, and function of silenced chromatin in Saccharomyces cerevisiaeQ29614854
Dot1p modulates silencing in yeast by methylation of the nucleosome coreQ29614855
Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeastQ29614857
Histone ubiquitination: triggering gene activityQ29617523
Breaking through to the other side: silencers and barriersQ30827036
Histone H2B ubiquitylation controls processive methylation but not monomethylation by Dot1 and Set1.Q33220208
POF and HP1 bind expressed exons, suggesting a balancing mechanism for gene regulationQ33306115
Heterochromatin formation involves changes in histone modifications over multiple cell generationsQ33854167
Ordered nucleation and spreading of silenced chromatin in Saccharomyces cerevisiae.Q33893339
Identification of a non-basic domain in the histone H4 N-terminus required for repression of the yeast silent mating lociQ33937860
Histone acetylation and deacetylation in yeastQ34187792
A Polycomb-based switch underlying quantitative epigenetic memoryQ34203201
Cell cycle requirements in assembling silent chromatin in Saccharomyces cerevisiae.Q34302415
Histone variants meet their matchQ34390385
The molecular biology of the SIR proteinsQ34448539
Symmetry, asymmetry, and kinetics of silencing establishment in Saccharomyces cerevisiae revealed by single-cell optical assaysQ34533909
Breaking barriers to transcription elongationQ34561019
Spreading of silent chromatin: inaction at a distanceQ34567039
Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatinQ44179355
Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencingQ44200809
Insights into the impact of histone acetylation and methylation on Sir protein recruitment, spreading, and silencing in Saccharomyces cerevisiaeQ45839171
DNA replication-independent silencing in S. cerevisiae.Q46025439
Simplifying a complex codeQ46559925
Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation statesQ46567995
Theory for the stability and regulation of epigenetic landscapes.Q53320217
Dynamics of Replication-Independent Histone Turnover in Budding YeastQ57233862
Evidence for silencing compartments within the yeast nucleus: a role for telomere proximity and Sir protein concentration in silencer-mediated repressionQ61783589
Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosageQ72802227
Role of the conserved Sir3-BAH domain in nucleosome binding and silent chromatin assemblyQ80407843
Heterochromatin spreading at yeast telomeres occurs in M phaseQ34567071
Domains of gene silencing near the left end of chromosome III in Saccharomyces cerevisiaeQ34614877
A unique class of conditional sir2 mutants displays distinct silencing defects in Saccharomyces cerevisiae.Q34616104
Theoretical analysis of epigenetic cell memory by nucleosome modification.Q34629739
Epigenetic chromatin silencing: bistability and front propagationQ34712052
Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegationQ34762156
Dot1 and histone H3K79 methylation in natural telomeric and HM silencingQ34894936
Epigenetic inheritance during the cell cycleQ34950028
Spreading of Sir3 protein in cells with severe histone H3 hypoacetylationQ35146066
Chromatin assembly factor I contributes to the maintenance, but not the re-establishment, of silencing at the yeast silent mating lociQ35188576
A model for step-wise assembly of heterochromatin in yeast.Q35788642
Genome-wide, as opposed to local, antisilencing is mediated redundantly by the euchromatic factors Set1 and H2A.Z.Q36082186
Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast.Q36102455
Mechanism for epigenetic variegation of gene expression at yeast telomeric heterochromatinQ36374195
Genome-wide patterns of histone modifications in yeast.Q36567360
Simple histone acetylation plays a complex role in the regulation of gene expressionQ36596204
Cross-regulation of histone modificationsQ36994157
Genetic and genomewide analysis of simultaneous mutations in acetylated and methylated lysine residues in histone H3 in Saccharomyces cerevisiaeQ37102604
Polycomb complexes and epigenetic statesQ37148660
The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersionQ37150874
Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferaseQ37208358
The establishment of gene silencing at single-cell resolutionQ37337415
Silent information regulator 3: the Goldilocks of the silencing complexQ37676731
Chromatin as a potential carrier of heritable informationQ37714146
Synthetic lethal screens identify gene silencing processes in yeast and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome coreQ39027163
Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylationQ39674793
Cell-cycle control of the establishment of mating-type silencing in S. cerevisiaeQ39864429
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryoteQ40903819
A common telomeric gene silencing assay is affected by nucleotide metabolismQ41770563
Chronux: a platform for analyzing neural signalsQ41811731
Dynamics of Sir3 spreading in budding yeast: secondary recruitment sites and euchromatic localizationQ41872924
Inheritance of epigenetic chromatin silencingQ41981789
Locus dependence in epigenetic chromatin silencingQ42068901
A nonhistone protein-protein interaction required for assembly of the SIR complex and silent chromatinQ42105834
Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms.Q42602158
Limitations of silencing at native yeast telomeresQ42673247
Mutational analysis of the Sir3 BAH domain reveals multiple points of interaction with nucleosomes.Q43127474
Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatinQ43430561
Acetylation of the yeast histone H4 N terminus regulates its binding to heterochromatin protein SIR3.Q43803659
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)e1003121
P577publication date2013-01-01
P1433published inPLOS Computational BiologyQ2635829
P1476titleThe role of multiple marks in epigenetic silencing and the emergence of a stable bivalent chromatin state
P478volume9

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cites work (P2860)
Q35533119Breaking an epigenetic chromatin switch: curious features of hysteresis in Saccharomyces cerevisiae telomeric silencing
Q36213177Cooperative stabilization of the SIR complex provides robust epigenetic memory in a model of SIR silencing in Saccharomyces cerevisiae.
Q64076011How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory
Q41882363Mechanistic stochastic model of histone modification pattern formation
Q64057207Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent

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