Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

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Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1039989354
P356DOI10.1038/15500
P3181OpenCitations bibliographic resource ID1865160
P698PubMed publication ID10545951

P50authorAndrzej S. KrolewskiQ87809680
Maciej T MaleckiQ89424369
Alessandro DoriaQ54241891
P2093author name stringM Montminy
J H Warram
M Saad
L Fields
T Orban
U S Jhala
A Antonellis
P2860cites workNo evidence of linkage or diabetes-associated mutations in the transcription factors BETA2/NEUROD1 and PAX4 in Type II diabetes in FranceQ58328382
A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDMQ61861656
Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. National Diabetes Data GroupQ66972631
New susceptibility locus for NIDDM is localized to human chromosome 20qQ73303103
Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient miceQ24314353
The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2Q24319898
Crystal structure of MyoD bHLH domain-DNA complex: perspectives on DNA recognition and implications for transcriptional activationQ27731319
The transcriptional coactivators p300 and CBP are histone acetyltransferasesQ27860843
Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimerQ28238671
Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300Q28270979
Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)Q28298538
A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12qQ28304128
The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cellsQ28512414
Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domainsQ33641257
p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin geneQ33786590
The NeuroD1/BETA2 sequences essential for insulin gene transcription colocalize with those necessary for neurogenesis and p300/CREB binding protein bindingQ33957229
Molecular cloning of a human neuroD from a neuroblastoma cell line specifically expressed in the fetal brain and adult cerebellumQ34407198
Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factorQ36706855
Characterization of the MODY3 phenotype. Early-onset diabetes caused by an insulin secretion defectQ37363218
Molecular cloning and characterization of the gene encoding human NeuroD.Q42460236
Distinct antibody specificities to a 64-kD islet cell antigen in type 1 diabetes as revealed by trypsin treatmentQ42938684
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)Q48056898
Phenotypic characteristics of early-onset autosomal-dominant type 2 diabetes unlinked to known maturity-onset diabetes of the young (MODY) genes.Q51563362
International criteria for the diagnosis of diabetes and impaired glucose tolerance.Q53426836
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecttype 2 diabetesQ3025883
sequence-specific DNA bindingQ14818107
transcription factor 3Q21111604
Neuronal differentiation 1Q21118835
P304page(s)323-8
P577publication date1999-11-01
P1433published inNature GeneticsQ976454
P1476titleMutations in NEUROD1 are associated with the development of type 2 diabetes mellitus
P478volume23