The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

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The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1040353471
P356DOI10.1038/NATURE06617
P3181OpenCitations bibliographic resource ID1055756
P932PMC publication ID2562698
P698PubMed publication ID18273011
P5875ResearchGate publication ID232801484

P50authorRobert TjianQ906579
Nicole KingQ4795064
Daniel S. RokhsarQ5218667
Peer BorkQ7160367
William McGinnisQ8015418
Asaf SalamovQ28050892
Uffe HellstenQ28050897
Ivica LetunicQ28833310
Antonis RokasQ42352198
Jessica B LyonsQ53997385
Daniel J RichterQ59981982
David PincusQ88731645
Alan KuoQ96187093
Harris ShapiroQ96233911
Jarrod ChapmanQ110244026
Gerard ManningQ28958324
David M. GoodsteinQ30518918
Igor V. GrigorievQ30519357
Nicholas PutnamQ30530377
P2093author name stringW Todd Miller
Monika Abedin
Derek Lemons
William Dirks
Wendell A Lim
Kevin J Wright
Wanqing Li
Yoh Isogai
Susan L Young
Scott Nichols
Stephen Fairclough
Matthew Good
Andrea Morris
M Jody Westbrook
Richard Zuzow
Michael Marr
J G I Sequencing
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P275copyright licenseCreative Commons Attribution-NonCommercial-ShareAlike 3.0 UnportedQ15643954
P6216copyright statuscopyrightedQ50423863
P433issue7180
P407language of work or nameEnglishQ1860
P921main subjectMonosigaQ35131894
P304page(s)783-8
P577publication date2008-02-14
P1433published inNatureQ180445
P1476titleThe genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
P478volume451

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Q38060917From tumor prevention to therapy: empowering p53 to fight back
Q35837317Functional Characterization of Cnidarian HCN Channels Points to an Early Evolution of Ih.
Q38198555Functional conservation and divergence of J-domain-containing ZUO1/ZRF orthologs throughout evolution
Q38065993Functional diversity and pharmacological profiles of the FKBPs and their complexes with small natural ligands
Q45826237Functional insights into the core-TFIIH from a comparative survey
Q26853567Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis
Q45924993Functional replacement of a primary metabolic pathway via multiple independent eukaryote-to-eukaryote gene transfers and selective retention.
Q42607613Functional roles of Notch signaling in the cnidarian Nematostella vectensis
Q43068640Functional transition of Pak proto-oncogene during early evolution of metazoans
Q60948018G Proteins and GPCRs in C. elegans Development: A Story of Mutual Infidelity
Q48122857Gene Regulatory Networks for the Haploid-to-Diploid Transition of Chlamydomonas reinhardtii
Q28751404Gene duplication and the origins of morphological complexity in pancrustacean eyes, a genomic approach
Q28654542Gene expansion shapes genome architecture in the human pathogen Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient terrestrial mucorales (Mucoromycotina)
Q56890351Gene family innovation, conservation and loss on the animal stem lineage
Q35137456Gene splicing of an invertebrate beta subunit (LCavβ) in the N-terminal and HOOK domains and its regulation of LCav1 and LCav2 calcium channels
Q47071563Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene
Q57231609Genome Portal, Joint Genome Institute
Q36665790Genome analysis of the unicellular green alga Chlamydomonas reinhardtii Indicates an ancient evolutionary origin for key pattern recognition and cell-signaling protein families
Q96116465Genome editing enables reverse genetics of multicellular development in the choanoflagellate Salpingoeca rosetta
Q112611290Genome sequencing and de novo assembly of the giant unicellular alga Acetabularia acetabulum using droplet MDA
Q41258354Genome-wide analysis of the sox family in the calcareous sponge Sycon ciliatum: multiple genes with unique expression patterns
Q33333945Genomes of model organisms: know thy tools
Q22065894Genomic analysis of organismal complexity in the multicellular green alga Volvox carteri
Q34024217Genomic insights into Wnt signaling in an early diverging metazoan, the ctenophore Mnemiopsis leidyi
Q21245387Genomic organization, evolution, and expression of photoprotein and opsin genes in Mnemiopsis leidyi: a new view of ctenophore photocytes
Q47822018Genomic survey of premetazoans shows deep conservation of cytoplasmic tyrosine kinases and multiple radiations of receptor tyrosine kinases.
Q34555096Genomics and evolution of protein phosphatases
Q35411477Genomics of Volvocine Algae.
Q42718044Glycoprotein hormones and their receptors emerged at the origin of metazoans
Q56750618Glycosyltransferases promote development and prevent promiscuous cell aggregation in the choanoflagellateS. rosetta
Q28648296Green algae and the origins of multicellularity in the plant kingdom
Q90640387Growth and single cell kinetics of the loricate choanoflagellate Diaphanoeca grandis
Q37388142Harnessing genomics for evolutionary insights
Q99619633Hedgehog signaling is required for endomesodermal patterning and germ cell development in the sea anemone Nematostella vectensis
Q58377349Heparan Sulfate Surfaces to Probe the Functions of the Master Regulator of the Extracellular Space
Q34632074Higher level taxonomy and molecular phylogenetics of the Choanoflagellatea
Q38045275Horizontal gene transfer in choanoflagellates
Q37882048How do they do Wnt they do?: regulation of transcription by the Wnt/β-catenin pathway.
Q38047030How was the notochord born?
Q112293300Human tRNAs with inosine 34 are essential to efficiently translate eukarya-specific low-complexity proteins
Q28550424Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization
Q61229487IMCC: Quantitative Analysis of the Inter-module Connectivity for Bio-network
Q34778817Identification and analysis of putative homologues of mechanosensitive channels in pathogenic protozoa.
Q27320213Identification of 526 conserved metazoan genetic innovations exposes a new role for cofactor E-like in neuronal microtubule homeostasis
Q46312852Identification of Aldh1a, Cyp26 and RAR orthologs in protostomes pushes back the retinoic acid genetic machinery in evolutionary time to the bilaterian ancestor
Q42661149Identification of a human ABCC10 orthologue in Catharanthus roseus reveals a U12-type intron determinant for the N-terminal domain feature.
Q112700263Identification of collagen 1α3 in teleost fish species and typical collision induced internal fragmentations
Q24321548Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats
Q36094320Identification of the kinase that activates a nonmetazoan STAT gives insights into the evolution of phosphotyrosine-SH2 domain signaling.
Q39769086Identification, localization, and functional implications of the microdomain-forming stomatin family in the ciliated protozoan Paramecium tetraurelia
Q41574266Imaging collagen in scar tissue: developments in second harmonic generation microscopy for biomedical applications
Q37599019Immortality and the base of multicellular life: Lessons from cnidarian stem cells
Q33849582Improving animal phylogenies with genomic data
Q53013895In silico identification and characterization of the MAPK family members of unicellular model eukaryote Tetrahymena thermophila.
Q34157354Incorporation of a horizontally transferred gene into an operon during cnidarian evolution
Q28079314Independent evolution of genomic characters during major metazoan transitions
Q34286083Independent evolution of striated muscles in cnidarians and bilaterians.
Q91637658Inherency of Form and Function in Animal Development and Evolution
Q37642681Innovation and constraint leading to complex multicellularity in the Ascomycota.
Q35163675Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view
Q91596473Insights into the evolution of digestive systems from studies of Trichoplax adhaerens
Q37107569Insights into the origin of metazoan filopodia and microvilli
Q91782414Insights into the origin of metazoan multicellularity from predatory unicellular relatives of animals
Q42135019Integrin-mediated adhesion complex: Cooption of signaling systems at the dawn of Metazoa
Q38113551Interactions of photosynthesis with genome size and function
Q37698269Intercellular junction assembly, dynamics, and homeostasis
Q26852861Intracellular calcium channels in protozoa
Q37528149Intrinsically disordered regions of p53 family are highly diversified in evolution
Q38770008Introduction: History of SH2 Domains and Their Applications
Q27351922Intron evolution: testing hypotheses of intron evolution using the phylogenomics of tetraspanins
Q37224844KF-1 Ubiquitin Ligase: An Anxiety Suppressor
Q44496171KF-1 ubiquitin ligase: anxiety suppressor model
Q36023280KLF/SP Transcription Factor Family Evolution: Expansion, Diversification, and Innovation in Eukaryotes.
Q28681520LBP/BPI proteins and their relatives: conservation over evolution and roles in mutualism
Q30010003Lack of Csk-mediated negative regulation in a unicellular SRC kinase
Q33675663Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity.
Q58482881Large-Scale Parsimony Analysis of Metazoan Indels in Protein-Coding Genes
Q90781043Light-regulated collective contractility in a multicellular choanoflagellate
Q34118422Lineage-specific expansion of DNA-binding transcription factor families
Q34314862Linear motif-mediated interactions have contributed to the evolution of modularity in complex protein interaction networks
Q38841444Losing Complexity: The Role of Simplification in Macroevolution
Q98198778MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII
Q103776588MOB: Pivotal Conserved Proteins in Cytokinesis, Cell Architecture and Tissue Homeostasis
Q35157106Major diversification of voltage-gated K+ channels occurred in ancestral parahoxozoans.
Q37785132Mannose 6-phosphate receptor homology domain-containing lectins in mammalian endoplasmic reticulum-associated degradation.
Q24647521Mapping the tree of life: progress and prospects
Q37998043Marine protistan diversity
Q45977392Mating in the Closest Living Relatives of Animals Is Induced by a Bacterial Chondroitinase.
Q33899466Mechanism and evolution of cytosolic Hedgehog signal transduction
Q28235875Mechanisms and functions of Hedgehog signalling across the metazoa
Q38592891Mechanotransduction's impact on animal development, evolution, and tumorigenesis
Q37432747Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex
Q36967449Meta-Analysis of EMT Datasets Reveals Different Types of EMT.
Q27316581Metabolic and chaperone gene loss marks the origin of animals: evidence for Hsp104 and Hsp78 chaperones sharing mitochondrial enzymes as clients
Q58066414Metazoan Complexity
Q34582288Metazoan-like signaling in a unicellular receptor tyrosine kinase.
Q36972635Metazoans evolved by taking domains from soluble proteins to expand intercellular communication network
Q52794337Methods for analyzing the evolutionary relationship of NF-κB proteins using free, web-driven bioinformatics and phylogenetic tools.
Q28740823Microbial Pathogens in the Fungal Kingdom
Q90421599Miles to go (mtgo) encodes FNDC3 proteins that interact with the chaperonin subunit CCT3 and are required for NMJ branching and growth in Drosophila
Q116287593Mirroring the effect of geological evolution: Protist divergence in the Atacama Desert
Q33359181Missing pieces of an ancient puzzle: evolution of the eukaryotic membrane-trafficking system
Q37983305Mitochondrial carrier homolog 2 (MTCH2): the recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis
Q51520370Mitogenomics at the base of Metazoa.
Q59798385Modular Proteoglycan Perlecan/: Mutations, Phenotypes, and Functions
Q36153880Modular evolution of phosphorylation-based signalling systems
Q57470143Molecular Evolution of the Major Arthropod Chemoreceptor Gene Families
Q24617046Molecular and functional properties of P2X receptors--recent progress and persisting challenges
Q41760477Molecular cloning and characterization of a tyrosine phosphatase from Monosiga brevicollis
Q33654331Molecular evolution of the Yap/Yorkie proto-oncogene and elucidation of its core transcriptional program
Q28296614Molecular evolution of the cadherin superfamily
Q33983673Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING
Q36879246Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II
Q90179710Molecular mechanistic insights: The emerging role of SOXF transcription factors in tumorigenesis and development
Q90623692MotifAnalyzer-PDZ: A computational program to investigate the evolution of PDZ-binding target specificity
Q42780575Multicellularity: From brief encounters to lifelong unions
Q21090093Multigene Phylogeny of Choanozoa and the Origin of Animals
Q44643253Multiple Wnts are involved in Hydra organizer formation and regeneration.
Q33988346Multiple independent fusions of glucose-6-phosphate dehydrogenase with enzymes in the pentose phosphate pathway
Q35924226Multiscale modeling of form and function
Q29031715My Oldest Sister Is a Sea Walnut?
Q41905980Myosin regulatory light chain diphosphorylation slows relaxation of arterial smooth muscle
Q43884710NK homeobox genes with choanocyte-specific expression in homoscleromorph sponges.
Q112291997Negative elongation factor regulates muscle progenitor expansion for efficient myofiber repair and stem cell pool repopulation
Q112618400Neural stemness contributes to cell tumorigenicity
Q55932456Never Ending Analysis of a Century Old Evolutionary Debate: “Unringing” the Urmetazoon Bell
Q99721733New Lineage of Microbial Predators Adds Complexity to Reconstructing the Evolutionary Origin of Animals
Q34535226New genes as drivers of phenotypic evolution
Q39939700New insights into the autoinhibition mechanism of glycogen synthase kinase-3beta
Q28652533New tricks for "old" domains: how novel architectures and promiscuous hubs contributed to the organization and evolution of the ECM
Q64068120Nomenclature and Comparative Morphology of the Teneurin/TCAP/ADGRL Protein Families
Q47798489Not only tendons: The other architecture of collagen fibrils
Q46795621Notch Signaling in Development, Tissue Homeostasis, and Disease
Q26771105Notch-Mediated Cell Adhesion
Q38937915Notch: A multi-functional integrating system of microenvironmental signals
Q84686003Novel GPS-containing G protein-coupled receptor from Monosiga brevicollis
Q47771870Novel Scenarios of Early Animal Evolution—Is It Time to Rewrite Textbooks?
Q41116989Novel family GH3 β-glucosidases or β-xylosidases of unknown function found in various animal groups, including birds and reptiles
Q37233430Novel types of Ca2+ release channels participate in the secretory cycle of Paramecium cells
Q42054319Nuclear receptor complement of the cnidarian Nematostella vectensis: phylogenetic relationships and developmental expression patterns
Q90879092Nutrient Transport Driven by Microbial Active Carpets
Q38239452Of early animals, anaerobic mitochondria, and a modern sponge.
Q37697331On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes
Q49646997On the origin of biological construction, with a focus on multicellularity.
Q91346197Opposing Action of Hedgehog and Insulin Signaling Balances Proliferation and Autophagy to Determine Follicle Stem Cell Lifespan
Q21089699Origin and evolution of glutamyl-prolyl tRNA synthetase WHEP domains reveal evolutionary relationships within Holozoa
Q83410676Origin and evolution of laminin gene family diversity
Q40890233Origin and evolution of lysyl oxidases
Q61796370Origin and evolution of plexins, semaphorins, and Met receptor tyrosine kinases
Q33510261Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes.
Q84372267Origin and evolution of ubiquitin-conjugating enzymes from Guillardia theta nucleomorph to hominoid
Q42469449Origin of Pax and Six gene families in sponges: Single PaxB and Six1/2 orthologs in Chalinula loosanoffi
Q42479211Origin of animal epithelia: insights from the sponge genome.
Q42435003Origin of chordate peptides by horizontal protozoan gene transfer in early metazoans and protists: evolution of the teneurin C-terminal associated peptides (TCAP).
Q58733217Origin of exon skipping-rich transcriptomes in animals driven by evolution of gene architecture
Q34353566Origin of metazoan cadherin diversity and the antiquity of the classical cadherin/β-catenin complex
Q35005363Origins of Myc proteins--using intrinsic protein disorder to trace distant relatives
Q44593074Origins of multicellular complexity: Volvox and the volvocine algae
Q22337303Origins of neurogenesis, a cnidarian view
Q24635071Orthology prediction methods: a quality assessment using curated protein families
Q89771836Overview of Basic Mechanisms of Notch Signaling in Development and Disease
Q28660752Oxygen requirements of the earliest animals
Q28477906PTB domain-directed substrate targeting in a tyrosine kinase from the unicellular choanoflagellate Monosiga brevicollis
Q33815949Parallel expansions of Sox transcription factor group B predating the diversifications of the arthropods and jawed vertebrates
Q37812093Parasite annexins--new molecules with potential for drug and vaccine development
Q33909288Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases
Q57166993Patterns of Ancestral Animal Codon Usage Bias Revealed Through Holozoan Protists
Q38361542Peptide-gated ion channels and the simple nervous system of Hydra
Q37392591Pharmacology of ciliated protozoa--drug (in)sensitivity and experimental drug (ab)use
Q52729364Phosphorylation control of the ubiquitin ligase Cbl is conserved in choanoflagellates.
Q42413402Phosphotyrosine signaling: evolving a new cellular communication system
Q53129316Phosphotyrosine signalling and the origin of animal multicellularity.
Q27333622Phylogenetic Patterns of Codon Evolution in the ACTIN-DEPOLYMERIZING FACTOR/COFILIN (ADF/CFL) Gene Family
Q35085360Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages.
Q41075690Phylogenetic analysis of the teneurins: conserved features and premetazoan ancestry
Q39043809Phylogenetic evidence for the modular evolution of metazoan signalling pathways
Q26741622Phylogenetic-Derived Insights into the Evolution of Sialylation in Eukaryotes: Comprehensive Analysis of Vertebrate β-Galactoside α2,3/6-Sialyltransferases (ST3Gal and ST6Gal)
Q45944195Phylogenetic-signal dissection of nuclear housekeeping genes supports the paraphyly of sponges and the monophyly of Eumetazoa.
Q38599960Phylogenomic Insights into Animal Evolution
Q55030863Phylogenomics demonstrates that breviate flagellates are related to opisthokonts and apusomonads
Q38024900Phylogenomics meets neuroscience: how many times might complex brains have evolved?
Q28240393Phylogenomics revives traditional views on deep animal relationships
Q30863609Phylogeny and evolution of Rab7 and Rab9 proteins
Q28751278Phylogeny and function of the invertebrate p53 superfamily
Q37375071Phylogeny of Tec family kinases identification of a premetazoan origin of Btk, Bmx, Itk, Tec, Txk, and the Btk regulator SH3BP5.
Q18776012Phylogeny of the “Forgotten” Cellular Slime Mold, Fonticula alba, Reveals a Key Evolutionary Branch within Opisthokonta
Q28708481Phylostratigraphic profiles reveal a deep evolutionary history of the vertebrate head sensory systems
Q21245316Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoa
Q28277090Physico-genetic determinants in the evolution of development
Q37393080Physiology and Evolution of Voltage-Gated Calcium Channels in Early Diverging Animal Phyla: Cnidaria, Placozoa, Porifera and Ctenophora
Q51905964Piwi expression in archeocytes and choanocytes in demosponges: insights into the stem cell system in demosponges.
Q34014242Placozoa and the evolution of Metazoa and intrasomatic cell differentiation
Q38976301Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1.
Q38003524Plant Proteus: brown algal morphological plasticity and underlying developmental mechanisms
Q45911166Plant vegetative and animal cytoplasmic actins share functional competence for spatial development with protists.
Q92691115Pluripotency and the origin of animal multicellularity
Q42265701Polyploidy and the evolution of complex traits
Q42705317Positive selection of tyrosine loss in metazoan evolution.
Q37402345Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains.
Q34447869Pre-metazoan origins and evolution of the cadherin adhesome
Q26739742Precambrian origins of the TNFR superfamily
Q60950822Predicted glycosyltransferases promote development and prevent spurious cell clumping in the choanoflagellate
Q35468637Premetazoan ancestry of the Myc-Max network
Q21183992Premetazoan genome evolution and the regulation of cell differentiation in the choanoflagellate Salpingoeca rosetta
Q36120898Premetazoan origin of the hippo signaling pathway
Q46002820Preparation of high-molecular-weight genomic DNA from Monosiga brevicollis and other choanoflagellates.
Q27672465Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis
Q35119485Processes of fungal proteome evolution and gain of function: gene duplication and domain rearrangement
Q88938266Programming self-organizing multicellular structures with synthetic cell-cell signaling
Q21145789Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor
Q42845318Protein evolution in cell and tissue development: going beyond sequence and transcriptional analysis
Q33950954Protein functional links in Trypanosoma brucei, identified by gene fusion analysis.
Q33384109Protists are microbes too: a perspective
Q28661921Punctuated emergences of genetic and phenotypic innovations in eumetazoan, bilaterian, euteleostome, and hominidae ancestors
Q30502984RNA interference in marine and freshwater sponges: actin knockdown in Tethya wilhelma and Ephydatia muelleri by ingested dsRNA expressing bacteria
Q90521897Reconstruction of protein domain evolution using single-cell amplified genomes of uncultured choanoflagellates sheds light on the origin of animals
Q55121687Reconstruction of the ancestral metazoan genome reveals an increase in genomic novelty.
Q30157090Reengineering the signaling properties of a Src family kinase
Q100945033Regeneration in sponge Sycon ciliatum partly mimics postlarval development
Q37408606Regulated aggregative multicellularity in a close unicellular relative of metazoa
Q39946025Regulation of Src and Csk nonreceptor tyrosine kinases in the filasterean Ministeria vibrans
Q37876443Regulation of spatiotemporal expression of cell-cell adhesion molecules during development of Dictyostelium discoideum
Q33738188Regulation of the cholesterol biosynthetic pathway and its integration with fatty acid biosynthesis in the oleaginous microalga Nannochloropsis oceanica
Q34059249Regulatory Factor X (RFX)-mediated transcriptional rewiring of ciliary genes in animals
Q87712503Research perspectives of biomedical gerontology and brain aging research: longevity genes in the brain
Q38331475Retromer and sorting nexins in endosomal sorting
Q37043759Reverse transcriptase and intron number evolution
Q36794564Review of Ets1 structure, function, and roles in immunity
Q62570592Revision of the Capsaspora genome using read mating information adjusts the view on premetazoan genome
Q112722973Role of epigenetics in unicellular to multicellular transition in Dictyostelium
Q92225836Rosette Colonies of Choanoflagellates (Salpingoeca rosetta) Show Increased Food Vacuole Formation Compared with Single Swimming Cells
Q34326156SECOM: a novel hash seed and community detection based-approach for genome-scale protein domain identification
Q29038594SH2 Domains Recognize Contextual Peptide Sequence Information to Determine Selectivity
Q46487364SNAREing the basis of multicellularity: consequences of protein family expansion during evolution
Q26996018SRC-family tyrosine kinases in oogenesis, oocyte maturation and fertilization: an evolutionary perspective
Q90554408Selective factors in the evolution of multicellularity in choanoflagellates
Q37003103Sequence comparative analysis using networks: software for evaluating de novo transcript assembly from next-generation sequencing
Q38271438Serendipity or prepared mind? Recollections of the KOP translocation (1967) and of one form of Perrault syndrome
Q28757825Seventeen new complete mtDNA sequences reveal extensive mitochondrial genome evolution within the Demospongiae
Q28646166Sex is a ubiquitous, ancient, and inherent attribute of eukaryotic life
Q36432826Short toxin-like proteins abound in Cnidaria genomes
Q37954785Signaling pathways and axis formation in the lower metazoa
Q30157711Signaling properties of a non-metazoan Src kinase and the evolutionary history of Src negative regulation
Q38716994Similar Ratios of Introns to Intergenic Sequence across Animal Genomes
Q90521917Single cell ecology
Q34397362Single nucleus genome sequencing reveals high similarity among nuclei of an endomycorrhizal fungus
Q48042704Single-cell measurement of ammonium and bicarbonate uptake within a photosymbiotic bioeroding sponge
Q43823205Single-domain β-thymosins: the family history
Q37638325Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation
Q38148534Sox proteins: regulators of cell fate specification and differentiation
Q35178248Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer
Q38729293Spheres of Hope, Packets of Doom: the Good and Bad of Outer Membrane Vesicles in Interspecies and Ecological Dynamics
Q47665914Sponge genes provide new insight into the evolutionary origin of the neurogenic circuit.
Q34047051Sponges as models to study emergence of complex animals
Q47213998Sponges: A Reservoir of Genes Implicated in Human Cancer
Q38062396Stem cell dynamics in Cnidaria: are there unifying principles?
Q33732822Stem cell-specific activation of an ancestral myc protooncogene with conserved basic functions in the early metazoan Hydra
Q22337198Sterols in a unicellular relative of the metazoans
Q93101041Still Enigmatic: Innate Immunity in the Ctenophore Mnemiopsis leidyi
Q99352806Structural Characterization and Computational Analysis of PDZ domains in Monosiga brevicollis
Q27675829Structural Insights into Cellulolytic and Chitinolytic Enzymes Revealing Crucial Residues of Insect β-N-acetyl-D-hexosaminidase
Q90949258Structural Insights into the Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII)
Q34233642Structural basis for conservation in the CYP51 family
Q50459741Structural molecular components of septate junctions in cnidarians point to the origin of epithelial junctions in eukaryotes.
Q50540049Structure and expression of conserved Wnt pathway components in the demosponge Amphimedon queenslandica.
Q28475452Synthesizing and salvaging NAD: lessons learned from Chlamydomonas reinhardtii
Q38048246TCF/LEFs and Wnt signaling in the nucleus.
Q38206430TRPV6 channels
Q97870153Tannins from senescent Rhizophora mangle mangrove leaves have a distinctive effect on prokaryotic and eukaryotic communities in a Distichlis spicata salt marsh soil
Q117427787Technical note: The silicon isotopic composition of choanoflagellates: implications for a mechanistic understanding of isotopic fractionation during biosilicification
Q96609005Temperature sensitivities of metazoan and pre-metazoan Src kinases
Q22122176The Amphimedon queenslandica genome and the evolution of animal complexity
Q38771269The Birth of Animal Development: Multicellularity and the Germline
Q24337583The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins
Q34363810The Capsaspora genome reveals a complex unicellular prehistory of animals
Q28598278The Cosmic Zoo: The (Near) Inevitability of the Evolution of Complex, Macroscopic Life
Q34523527The Dynamic Regulatory Genome of Capsaspora and the Origin of Animal Multicellularity
Q28603054The Evolution of COP9 Signalosome in Unicellular and Multicellular Organisms
Q28642185The Evolution of the Secreted Regulatory Protein Progranulin
Q33879071The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals
Q57220385The Evolutionary Origin of Animals and Fungi
Q28656451The Fox/Forkhead transcription factor family of the hemichordate Saccoglossus kowalevskii
Q38773345The Function and Evolution of Nuclear Receptors in Insect Embryonic Development
Q34997600The GPCR repertoire in the demosponge Amphimedon queenslandica: insights into the GPCR system at the early divergence of animals
Q21972829The Genome of Naegleria gruberi Illuminates Early Eukaryotic Versatility
Q35996462The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity.
Q47380403The Insect Chemoreceptor Superfamily Is Ancient in Animals
Q59405758The Multiple Origins of Complex Multicellularity
Q57179384The Nuclear Receptor Field: A Historical Overview and Future Challenges
Q46036492The Origin of Animal Multicellularity and Cell Differentiation.
Q37642606The Rh protein family: gene evolution, membrane biology, and disease association
Q35239082The Rosetteless gene controls development in the choanoflagellate S. rosetta
Q28255020The SH2 domain-containing proteins in 21 species establish the provenance and scope of phosphotyrosine signaling in eukaryotes
Q38029732The SOX family of genes in cancer development: biological relevance and opportunities for therapy
Q35964142The TALE face of Hox proteins in animal evolution
Q27681387The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton
Q30662577The actinin family of actin cross-linking proteins - a genetic perspective.
Q42686796The adaptive evolution divergence of triosephosphate isomerases between parasitic and free-living flatworms and the discovery of a potential universal target against flatworm parasites
Q30318335The age of protein kinases
Q45734650The alternative NADH dehydrogenase is present in mitochondria of some animal taxa
Q38403959The analysis of eight transcriptomes from all poriferan classes reveals surprising genetic complexity in sponges
Q35575349The ancient function of RB-E2F pathway: insights from its evolutionary history
Q38345421The ancient roots of calcium signalling evolutionary tree
Q34473067The antiquity of chordate odorant receptors is revealed by the discovery of orthologs in the cnidarian Nematostella vectensis
Q21093626The backbone of the post-synaptic density originated in a unicellular ancestor of choanoflagellates and metazoans
Q84077561The cell adhesion molecule DdCAD-1 regulates morphogenesis through differential spatiotemporal expression in Dictyostelium discoideum
Q39018629The cellular and molecular basis of cnidarian neurogenesis.
Q43269380The choanoflagellate Monosiga brevicollis karyotype revealed by the genome sequence: telomere-linked helicase genes resemble those of some fungi
Q45979614The choanoflagellates: heterotrophic nanoflagellates and sister group of the metazoa.
Q37801332The cnidarian nematocyst: a miniature extracellular matrix within a secretory vesicle.
Q34999420The conserved metalloprotease invadolysin localizes to the surface of lipid droplets.
Q34029056The default state of the cell: quiescence or proliferation?
Q98196738The diversification and lineage-specific expansion of nitric oxide signaling in Placozoa: insights in the evolution of gaseous transmission
Q21560967The diversification of the LIM superclass at the base of the metazoa increased subcellular complexity and promoted multicellular specialization
Q59569369The earliest fossil record of the animals and its significance
Q35081193The eukaryotic ancestor had a complex ubiquitin signaling system of archaeal origin
Q47764464The evolution and function of the Pax/Six regulatory network in sponges
Q38262432The evolution of MDM2 family genes
Q33431470The evolution of Runx genes II. The C-terminal Groucho recruitment motif is present in both eumetazoans and homoscleromorphs but absent in a haplosclerid demosponge.
Q35771544The evolution of animal genomes
Q37301036The evolution of cell types in animals: emerging principles from molecular studies
Q59793167The evolution of ependymin-related proteins
Q33772478The evolution of extracellular matrix
Q37995158The evolution of metazoan extracellular matrix
Q37677301The evolution of the GPCR signaling system in eukaryotes: modularity, conservation, and the transition to metazoan multicellularity
Q28727852The evolution of the Wnt pathway
Q42950778The evolution of the four subunits of voltage-gated calcium channels: ancient roots, increasing complexity, and multiple losses
Q28744006The evolution of thrombospondins and their ligand-binding activities
Q30157512The evolutionarily conserved arrangement of domains in SRC family kinases is important for substrate recognition
Q46135590The evolutionary analysis reveals domain fusion of proteins with Frizzled-like CRD domain
Q42485451The evolutionary history of YAP and the hippo/YAP pathway
Q43294454The evolutionary history of lysine biosynthesis pathways within eukaryotes
Q39873154The evolutionary history of the E2F and DEL genes in Viridiplantae
Q33955921The evolutionary history of the catenin gene family during metazoan evolution
Q28752612The fibrillar collagen family
Q64087426The first identification of complete Eph-ephrin signalling in ctenophores and sponges reveals a role for neofunctionalization in the emergence of signalling domains
Q34270689The functions of grainy head-like proteins in animals and fungi and the evolution of apical extracellular barriers
Q30918699The gene complement of the ancestral bilaterian - was Urbilateria a monster?
Q22065604The genome of the ctenophore Mnemiopsis leidyi and its implications for cell type evolution
Q43809640The genome of the sponge Amphimedon queenslandica provides new perspectives into the origin of Toll-like and interleukin 1 receptor pathways.
Q35630989The genome portal of the Department of Energy Joint Genome Institute
Q38139494The genomic and cellular foundations of animal origins
Q37606400The granulin gene family: from cancer to dementia
Q21195912The homeodomain complement of the ctenophore Mnemiopsis leidyi suggests that Ctenophora and Porifera diverged prior to the ParaHoxozoa
Q36093876The human phosphotyrosine signaling network: evolution and hotspots of hijacking in cancer
Q28749058The initiation of metamorphosis as an ancient polyphenic trait and its role in metazoan life-cycle evolution
Q48041758The last common ancestor of animals lacked the HIF pathway and respired in low-oxygen environments
Q34056277The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system
Q37300635The molecular origins of multicellular transitions
Q61460308The mouth, the anus, and the blastopore—open questions about questionable openings
Q35839976The origin and evolution of G protein-coupled receptor kinases
Q38361538The origin and evolution of synaptic proteins - choanoflagellates lead the way.
Q37497066The origin of Metazoa: a transition from temporal to spatial cell differentiation.
Q39289407The origin of Metazoa: a unicellular perspective.
Q89808107The origin of animal body plans: a view from fossil evidence and the regulatory genome
Q113186028The origin of animals: an ancestral reconstruction of the unicellular-to-multicellular transition
Q34045549The origin of the Hox/ParaHox genes, the Ghost Locus hypothesis and the complexity of the first animal
Q34502445The origin of the animals and a 'Savannah' hypothesis for early bilaterian evolution.
Q50459532The origins of developmental gene regulation.
Q37317007The origins of multicellularity and the early history of the genetic toolkit for animal development
Q56531721The other eukaryotes in light of evolutionary protistology
Q38825614The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches
Q91695083The p53 gene family in vertebrates: Evolutionary considerations
Q48479586The predictability of evolution: glimpses into a post-Darwinian world.
Q39246180The predicted secretomes of Monosiga brevicollis and Capsaspora owczarzaki, close unicellular relatives of metazoans, reveal new insights into the evolution of the metazoan extracellular matrix
Q37123067The primary cilium at the crossroads of mammalian hedgehog signaling
Q37808329The primary role of fibrinogen-related proteins in invertebrates is defense, not coagulation
Q36755352The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan
Q34041711The proto-MHC of placozoans, a region specialized in cellular stress and ubiquitination/proteasome pathways
Q28252420The regulation of protein phosphorylation
Q89029029The remembrance of the things past: Conserved signalling pathways link protozoa to mammalian nervous system
Q41436775The repertoires of ubiquitinating and deubiquitinating enzymes in eukaryotic genomes
Q85114455The rise of genomics sheds light on the dawn of animals
Q33787253The role of exon shuffling in shaping protein-protein interaction networks
Q38375711The role of fibrinogen-related proteins in the gastropod immune response
Q38960452The role of ficolin-like protein (PcFLP1) in the antibacterial immunity of red swamp crayfish (Procambarus clarkii).
Q33716090The scale and evolutionary significance of horizontal gene transfer in the choanoflagellate Monosiga brevicollis
Q92227516The significance of sponges for comparative studies of developmental evolution
Q28301865The solute carrier families have a remarkably long evolutionary history with the majority of the human families present before divergence of Bilaterian species
Q38071714The sox family of transcription factors: versatile regulators of stem and progenitor cell fate
Q37776425The spectrin-ankyrin-4.1-adducin membrane skeleton: adapting eukaryotic cells to the demands of animal life
Q37676279The stem cell system in demosponges: insights into the origin of somatic stem cells.
Q38051058The stem cell system in demosponges: suggested involvement of two types of cells: archeocytes (active stem cells) and choanocytes (food-entrapping flagellated cells).
Q112557535The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis
Q33527545The synapsin gene family in basal chordates: evolutionary perspectives in metazoans
Q52720562The triple helix of collagens - an ancient protein structure that enabled animal multicellularity and tissue evolution.
Q92318680The ventral epithelium of Trichoplax adhaerens deploys in distinct patterns cells that secrete digestive enzymes, mucus or diverse neuropeptides
Q33690172The voyage of the microbial eukaryote
Q34055251Thousands of rab GTPases for the cell biologist
Q42912620Three Dimensional Organization of Genome Might Have Guided the Dynamics of Gene Order Evolution in Eukaryotes
Q44310843Three families of LTR retrotransposons are present in the genome of the choanoflagellate Monosiga brevicollis
Q56889970Toward a systems level view of the ECM and related proteins: a framework for the systematic definition and analysis of biological systems
Q97088314Towards reconstructing the dipteran demise of an ancient essential gene: E3 ubiquitin ligase Murinedouble minute
Q104063284Towards understanding the origin of animal development
Q35968813Tracing the Evolutionary History of Inositol, 1, 4, 5-Trisphosphate Receptor: Insights from Analyses of Capsaspora owczarzaki Ca2+ Release Channel Orthologs
Q28656003Tracing the evolution of the p53 tetramerization domain
Q46710454Tracking the ancestry of a deeply conserved eumetazoan SINE domain
Q50625150Tracking the origin and divergence of cholinesterases and neuroligins: the evolution of synaptic proteins.
Q36358937Transcription factor networks directing the development, function, and evolution of innate lymphoid effectors
Q91744538Transcription factors in SOX family: Potent regulators for cancer initiation and development in the human body
Q97524917Transcriptomic and Ultrastructural Signatures of K+-Induced Aggregation in Phytophthora parasitica Zoospores
Q35051161Trask phosphorylation defines the reverse mode of a phosphotyrosine signaling switch that underlies cell anchorage state
Q42287488Trichoplax adhaerens reveals a network of nuclear receptors sensitive to 9-cis-retinoic acid at the base of metazoan evolution
Q47140201Tumorigenesis as a process of gradual loss of original cell identity and gain of properties of neural precursor/progenitor cells.
Q27692524Tyrosine kinase signaling and the emergence of multicellularity
Q34461401Understanding "green" multicellularity: do seaweeds hold the key?
Q34150586Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki
Q28274960Unicellular Ca2+ signaling 'toolkit' at the origin of metazoa
Q57479870Unicellular Origin of the Animal MicroRNA Machinery
Q38188212Unicellular eukaryotes as models in cell and molecular biology: critical appraisal of their past and future value.
Q43917078Unique genome of dicyemid mesozoan: highly shortened spliceosomal introns in conservative exon/intron structure
Q111195907Using the F/R-ratio for an evaluation of the ability of the demosponge Halichondria panicea to nourish solely on phytoplankton versus free-living bacteria in the sea
Q37944602Vascular smooth muscle myosin light chain diphosphorylation: mechanism, function, and pathological implications
Q37809303Volvox: simple steps to developmental complexity?
Q33463343WNT/beta-catenin signalling and epithelial patterning in the homoscleromorph sponge Oscarella
Q55452270We are not so special.
Q38712484What Defines the "Kingdom" Fungi?
Q88916801What Makes an Animal? The Molecular Quest for the Origin of the Animal Kingdom
Q28743958What are nuclear receptor ligands?
Q90549808What lies beneath: Hydra provides cnidarian perspectives into the evolution of FGFR docking proteins
Q37828883What sponges can tell us about the evolution of developmental processes.
Q30364669Where cell fate conversions meet Chinese philosophy.
Q42365202Whole-genome metabolic model of Trichoderma reesei built by comparative reconstruction
Q86155850Why flying dogs are rare: A general theory of luck in evolutionary transitions
Q88268314Wingless Signaling: A Genetic Journey from Morphogenesis to Metastasis
Q34011176Wnt gene loss in flatworms.
Q48503756Wnt signaling and polarity in freshwater sponges.
Q58794971Xenacoelomorpha Survey Reveals That All 11 Animal Homeobox Gene Classes Were Present in the First Bilaterians
Q54120973Yeast can accommodate phosphotyrosine: v-Src toxicity in yeast arises from a single disrupted pathway.
Q35698749dbHiMo: a web-based epigenomics platform for histone-modifying enzymes.
Q84583329p53 ancestry: gazing through an evolutionary lens
Q42833802p53 in the game of transposons
Q92459922α-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes

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