The sox family of transcription factors: versatile regulators of stem and progenitor cell fate

scientific article published on January 2013

The sox family of transcription factors: versatile regulators of stem and progenitor cell fate is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.STEM.2012.12.007
P932PMC publication ID3608206
P698PubMed publication ID23290134
P5875ResearchGate publication ID234068775

P50authorKonrad HochedlingerQ40635003
P2093author name stringAbby Sarkar
P2860cites workEvidence that SOX2 overexpression is oncogenic in the lungQ21091126
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoansQ22122222
Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cellsQ24300409
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motifQ24301723
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cellsQ24320635
Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cellsQ24321427
Core transcriptional regulatory circuitry in human embryonic stem cellsQ24322016
A DNA repair complex functions as an Oct4/Sox2 coactivator in embryonic stem cellsQ24338952
Pioneer transcription factors: establishing competence for gene expressionQ24625373
Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens developmentQ24632689
Mediator and cohesin connect gene expression and chromatin architectureQ24632695
In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampusQ24683755
Molecular dissection of mesenchymal-epithelial interactions in the hair follicleQ24815112
Vertebrate neurogenesis is counteracted by Sox1-3 activityQ28205692
Impaired generation of mature neurons by neural stem cells from hypomorphic Sox2 mutants.Q46825911
Neural crest development is regulated by the transcription factor Sox9.Q47590677
Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages.Q48137548
Expression of SOX9 and SOX10 in central neuroepithelial tumor.Q48490738
Consequence of the loss of Sox2 in the developing brain of the mouse.Q49062642
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine.Q51894736
Gene expression dynamics during germline specification in mice identified by quantitative single-cell gene expression profiling.Q52011445
Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells.Q52165452
Region-specific expression of chicken Sox2 in the developing gut and lung epithelium: regulation by epithelial-mesenchymal interactions.Q52181466
A dermal niche for multipotent adult skin-derived precursor cells.Q54695107
A vascular niche and a VEGF–Nrp1 loop regulate the initiation and stemness of skin tumoursQ59059617
Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocystsQ64147198
Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectodermQ73386441
Epigenetic modifications of SOX2 enhancers, SRR1 and SRR2, correlate with in vitro neural differentiationQ80755054
Conversion of Sox17 into a pluripotency reprogramming factor by reengineering its association with Oct4 on DNAQ83801901
Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouseQ37388268
Vertebrate endoderm development and organ formationQ37540224
All purpose Sox: The many roles of Sox proteins in gene expressionQ37561823
Sox2 roles in neural stem cellsQ37592557
SOX-partner code for cell specification: Regulatory target selection and underlying molecular mechanismsQ37595687
The building blocks of mammalian lung developmentQ37845284
Strategies for homeostatic stem cell self-renewal in adult tissuesQ37887870
Sox2 acts through Sox21 to regulate transcription in pluripotent and differentiated cellsQ39295340
Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cellsQ39368485
Phosphorylation of Sox2 cooperates in reprogramming to pluripotent stem cellsQ39644415
Identification of Sox-2 regulatory region which is under the control of Oct-3/4-Sox-2 complexQ39681929
The transcription factor Sox2 is required for osteoblast self-renewalQ39701765
Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cellsQ40018314
Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitorsQ41397974
Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6.Q41602939
Convergent genesis of an adult neural crest-like dermal stem cell from distinct developmental origins.Q42726870
Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesisQ42748705
Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors.Q43246655
The EGF receptor-sox2-EGF receptor feedback loop positively regulates the self-renewal of neural precursor cellsQ43250678
Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh.Q43280135
Acetylation of sox2 induces its nuclear export in embryonic stem cells.Q45932983
Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene familiesQ28218989
An extended transcriptional network for pluripotency of embryonic stem cellsQ28273615
Having it both ways: Sox protein function between conservation and innovationQ28282314
Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cellsQ28505222
Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryoQ28506803
Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brainQ28507690
Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cellsQ28509072
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endodermQ28510560
Sox3 expression in undifferentiated spermatogonia is required for the progression of spermatogenesisQ28512219
Inhibition of DNA binding of Sox2 by the SUMO conjugationQ28512713
Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cellsQ28513079
Multipotent cell lineages in early mouse development depend on SOX2 functionQ28513175
Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional networkQ28513471
EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sortingQ28566955
Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cellsQ28571047
SOX10 Maintains Multipotency and Inhibits Neuronal Differentiation of Neural Crest Stem CellsQ28579735
Sox2 is required for development of taste bud sensory cellsQ28584894
Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiationQ28585078
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewalQ28585188
Sox2 is required for sensory organ development in the mammalian inner earQ28585583
Master transcription factors determine cell-type-specific responses to TGF-β signalingQ28586183
Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humansQ28586560
Depletion of definitive gut endoderm in Sox17-null mutant miceQ28586636
Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2Q28587495
Sox8 is a specific marker for muscle satellite cells and inhibits myogenesisQ28587628
SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland.Q28589695
SOX9 induces and maintains neural stem cellsQ28591508
SOX2 is a dose-dependent regulator of retinal neural progenitor competenceQ28592758
Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiationQ28593870
Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromesQ28594392
Integration of external signaling pathways with the core transcriptional network in embryonic stem cellsQ29547179
Polycomb complexes repress developmental regulators in murine embryonic stem cellsQ29547274
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblastsQ29614794
A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genesQ29618455
Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest.Q30434442
Sequentially acting Sox transcription factors in neural lineage developmentQ35624720
Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors.Q35739616
Role of the murine reprogramming factors in the induction of pluripotencyQ35739848
SRY-box-containing gene 2 regulation of nuclear receptor tailless (Tlx) transcription in adult neural stem cellsQ35774130
Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cellsQ35892477
From stem cells to neurons and glia: a Soxist's view of neural developmentQ36247699
p27(Kip1) directly represses Sox2 during embryonic stem cell differentiation.Q36546981
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancerQ36568988
Chromatin connections to pluripotency and cellular reprogrammingQ36874359
Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitorsQ36948830
Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochleaQ36984946
Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expressionQ37023123
Multiple roles for Sox2 in the developing and adult mouse tracheaQ37186879
MEF promotes stemness in the pathogenesis of gliomasQ37267797
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomasQ30491937
Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelinationQ30856297
Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cellsQ33518513
Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biologyQ33597213
Sox2 is essential for formation of trophectoderm in the preimplantation embryoQ33754449
Hair follicle stem cells are specified and function in early skin morphogenesisQ33881467
SOX2 functions to maintain neural progenitor identityQ33968061
Slug and Sox9 cooperatively determine the mammary stem cell stateQ34030957
Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genomeQ34034406
CARM1 mediates modulation of Sox2.Q34064911
Enhancer decommissioning by LSD1 during embryonic stem cell differentiationQ34088491
Epigenetic priming of a pre-B cell-specific enhancer through binding of Sox2 and Foxd3 at the ESC stage.Q34125382
Pluripotency factors in embryonic stem cells regulate differentiation into germ layersQ34191627
Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of miceQ34222321
Thyroid hormone signaling acts as a neurogenic switch by repressing Sox2 in the adult neural stem cell niche.Q34258653
Direct reprogramming of fibroblasts into neural stem cells by defined factorsQ34263432
Direct conversion of fibroblasts into stably expandable neural stem cellsQ34263438
Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factorQ34280164
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phaseQ34299819
SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adultQ34394410
Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissuesQ34417194
Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissuesQ34498687
Mutations in SOX2 cause anophthalmia-esophageal-genital (AEG) syndromeQ34565729
Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cellsQ34588851
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells.Q34630308
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermisQ34992445
SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cellsQ35015452
Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signalingQ35081512
Cell lineage mapping of taste bud cells and keratinocytes in the mouse tongue and soft palateQ35112373
Sox2 activates cell proliferation and differentiation in the respiratory epitheliumQ35132159
The Sox2 high mobility group transcription factor inhibits mature osteoblast function in transgenic miceQ35196457
Sox17 expression confers self-renewal potential and fetal stem cell characteristics upon adult hematopoietic progenitorsQ35237399
BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 aloneQ35347934
Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in Müller glial cell developmentQ35546792
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)15-30
P577publication date2013-01-01
P1433published inCell Stem CellQ2943975
P1476titleThe sox family of transcription factors: versatile regulators of stem and progenitor cell fate
P478volume12

Reverse relations

cites work (P2860)
Q36105585A Model for Dimerization of the SOX Group E Transcription Factor Family
Q89861887A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin
Q89865594A Sox2/miR-486-5p axis regulates survival of GBM cells by inhibiting tumor suppressor networks
Q41785451A comparison of midline and tracheal gene regulation during Drosophila development
Q103806230A comprehensive library of human transcription factors for cell fate engineering
Q36998992A feedback amplification loop between stem cells and their progeny promotes tissue regeneration and tumorigenesis
Q27304874A new role of hindbrain boundaries as pools of neural stem/progenitor cells regulated by Sox2.
Q33991455A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12.
Q91137743A transition from SoxB1 to SoxE transcription factors is essential for progression from pluripotent blastula cells to neural crest cells
Q92512525AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation
Q33830062Aberrant activation of the human sex-determining gene in early embryonic development results in postnatal growth retardation and lethality in mice
Q36438178Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis
Q47644098Activating the regenerative potential of Müller glia cells in a regeneration-deficient retina.
Q34372142Adult neural stem cells stake their ground
Q33786699An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos
Q38682159An epigenetic gateway to brain tumor cell identity
Q35023613Antagonistic cross-regulation between Sox9 and Sox10 controls an anti-tumorigenic program in melanoma.
Q38920277Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity
Q35802967Associations between SOX2 and miR-200b expression with the clinicopathological characteristics and prognosis of patients with glioma
Q89849568Biomarkers in retinoblastoma
Q89180807Bmi1-Progenitor Cell Ablation Impairs the Angiogenic Response to Myocardial Infarction
Q35878154C. elegans SoxB genes are dispensable for embryonic neurogenesis but required for terminal differentiation of specific neuron types
Q96126115CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation
Q57293755CDK1 interacts with Sox2 and promotes tumor initiation in human melanoma
Q35500089CRISPR reveals a distal super-enhancer required for Sox2 expression in mouse embryonic stem cells
Q96229704CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment
Q50078680Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells.
Q60938527Cancer Stem Cells and Immunosuppressive Microenvironment in Glioma
Q39814561Cell division patterns and chromosomal segregation defects in oral cancer stem cells
Q90316495Cell lineage-specific transcriptome analysis for interpreting cell fate specification of proembryos
Q33767473Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity
Q49818426Cellular plasticity and the neuroendocrine phenotype in prostate cancer.
Q90590631Cellular rewiring in lethal prostate cancer: the architect of drug resistance
Q51418858Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver.
Q44808170Characterization of Bbx, a member of a novel subfamily of the HMG-box superfamily together with Cic.
Q35049401Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal
Q33603730Cleft Palate in a Mouse Model of SOX2 Haploinsufficiency
Q46831652Clinical and molecular insights into adenoid cystic carcinoma: Neural crest‐like stemness as a target
Q35144981Cobblestone-area forming cells derived from patients with mantle cell lymphoma are enriched for CD133+ tumor-initiating cells
Q50597477Colitis induces enteric neurogenesis through a 5-HT4-dependent mechanism.
Q90171356Common genetic variation in the Angelman syndrome imprinting centre affects the imprinting of chromosome 15
Q47180115Comparative expression patterns of Sox2 and Sox19 genes in the forebrain of developing and adult turbot (Scophthalmus maximus).
Q36285585Comparison of gene expression of SOX2 and OCT4 in normal tissue, polyps, and colon adenocarcinoma using immunohistochemical staining
Q36559976Comprehensive profiling reveals mechanisms of SOX2-mediated cell fate specification in human ESCs and NPCs
Q93008384Comprehensive proteogenomic analysis of human embryonic and induced pluripotent stem cells
Q33975619Concise review: breast cancer stem cells: regulatory networks, stem cell niches, and disease relevance
Q89522110Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2
Q33812168Conservation of Repeats at the Mammalian KCNQ1OT1-CDKN1C Region Suggests a Role in Genomic Imprinting
Q38659223Control of Adult Neurogenesis by Short-Range Morphogenic-Signaling Molecules
Q35804263Conversion of Adipose Tissue-Derived Mesenchymal Stem Cells to Neural Stem Cell-Like Cells by a Single Transcription Factor, Sox2.
Q90132161Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition
Q36977690Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide.
Q92589643Crosstalk between BMP and Notch Induces Sox2 in Cerebral Endothelial Cells
Q42370578DNA hypermethylated status and gene expression of PAX1/SOX1 in patients with colorectal carcinoma
Q35750899DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis.
Q28241115De novo SOX11 mutations cause Coffin-Siris syndrome
Q26826876Dedifferentiation and reprogramming: origins of cancer stem cells
Q53688854Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis.
Q48125870Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse.
Q60919557Direct Single-Molecule Observation of Sequential DNA Bending Transitions by the Sox2 HMG Box
Q42359796Discrete adipose-derived stem cell subpopulations may display differential functionality after in vitro expansion despite convergence to a common phenotype distribution
Q42428268Distinct transcription factor complexes act on a permissive chromatin landscape to establish regionalized gene expression in CNS stem cells
Q39303968Down-regulation of Sox11 is required for efficient osteogenic differentiation of adipose-derived stem cells
Q91972644Downregulation of SOX2 may be targeted by miR-590-5p and inhibits epithelial-to-mesenchymal transition in non-small-cell lung cancer
Q36846730Downregulation of YAP-dependent Nupr1 promotes tumor-repopulating cell growth in soft matrices.
Q60930372Duplication and expression of Sox genes in spiders
Q26750598EMT Involved in Migration of Stem/Progenitor Cells for Pituitary Development and Regeneration
Q101476535Ectopic activation of GABAB receptors inhibits neurogenesis and metamorphosis in the cnidarian Nematostella vectensis
Q92978893Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations
Q41759849Embryonic development of the nervous system in the planarian Schmidtea polychroa
Q30368596En1 directs superior olivary complex neuron positioning, survival, and expression of FoxP1.
Q35955399Endogenous molecular network reveals two mechanisms of heterogeneity within gastric cancer
Q38811601Engineering of Adult Neurogenesis and Gliogenesis
Q35042144Enhanced SOX2 expression in retinoblastoma tissues and peripheral blood is associated with the clinicopathological characteristics of the disease
Q36290871Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming
Q33584325Epigenetic regulation of sox30 is associated with testis development in mice
Q37291110Epigenetic reprogramming in cancer
Q41451606Epigenomic Landscapes of hESC-Derived Neural Rosettes: Modeling Neural Tube Formation and Diseases.
Q39411041Epithelial-to-Mesenchymal Transition in the Pathogenesis and Therapy of Head and Neck Cancer
Q26783904Esophageal Cancer: Insights From Mouse Models
Q92283827Evaluation of PAX8 expression promotes the proliferation of stomach Cancer cells
Q53684369Exogenous IL6 induces mRNA splice variant MBD2_v2 to promote stemness in TP53 wild-type, African American PCa cells.
Q38664830Expansion by whole genome duplication and evolution of the sox gene family in teleost fish
Q33614186Expression of multiple Sox genes through embryonic development in the ctenophore Mnemiopsis leidyi is spatially restricted to zones of cell proliferation
Q37562037Extensive ex vivo expansion of functional human erythroid precursors established from umbilical cord blood cells by defined factors
Q88955678FGFR1-ERK1/2-SOX2 axis promotes cell proliferation, epithelial-mesenchymal transition, and metastasis in FGFR1-amplified lung cancer
Q38787528Functional characterization of the Japanese flounder (Paralichthys olivaceus) Sox2 gene promoter
Q64060134GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell
Q38253305Genetic regulation of mammalian gonad development.
Q59137018Genome-wide transcriptome profiling and spatial expression analyses identify signals and switches of development in tapeworms
Q47894744Glioma CpG Island Methylator Phenotype (G-CIMP): Biological and Clinical Implications
Q35142985Global changes in gene expression of Barrett's esophagus compared to normal squamous esophagus and gastric cardia tissues
Q59795540Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis
Q47295042HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway
Q38956257High nuclear SOX2 expression is associated with radiotherapy response in small (T1/T2) oral squamous cell carcinoma
Q42353637High-content analysis of tumour cell invasion in three-dimensional spheroid assays
Q90345683Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck
Q47711110Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate.
Q58600583Homodimerization regulates an endothelial specific signature of the SOX18 transcription factor
Q30998939Human Genes Encoding Transcription Factors and Chromatin-Modifying Proteins Have Low Levels of Promoter Polymorphism: A Study of 1000 Genomes Project Data
Q47133638Human cancer stem cells are a target for cancer prevention using (-)-epigallocatechin gallate.
Q33789793IGF-1 mediated Neurogenesis Involves a Novel RIT1/Akt/Sox2 Cascade
Q37662428Identification of FDA-approved drugs targeting breast cancer stem cells along with biomarkers of sensitivity.
Q40958923Identification of HECT E3 ubiquitin ligase family genes involved in stem cell regulation and regeneration in planarians
Q54183542Identification, molecular characterization and analysis of the expression pattern of SoxF subgroup genes the Yellow River carp, Cyprinus carpio.
Q52657793Immunoexpression of P63 and SOX2 in triple-negative breast cancers, Indonesia.
Q34410160Immunohistochemical molecular phenotypes of gastric cancer based on SOX2 and CDX2 predict patient outcome
Q47903319Increased SOX2 expression in salivary gland carcinoma ex pleomorphic adenoma progression: an association with adverse outcome
Q38727627Induced Expression of Cancer Stem Cell Markers ALDH1A3 and Sox-2 in Hierarchical Reconstitution of Apoptosis-resistant Human Breast Cancer Cells
Q36407341Induction of Pluripotency in Astrocytes through a Neural Stem Cell-like State
Q88573696Inhibition of UGT8 suppresses basal-like breast cancer progression by attenuating sulfatide-αVβ5 axis
Q35320368Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis
Q47283050Injury Induces Endogenous Reprogramming and Dedifferentiation of Neuronal Progenitors to Multipotency
Q26745881Insulin-secreting β cells require a post-genomic concept
Q54943523JMJD1B Demethylates H4R3me2s and H3K9me2 to Facilitate Gene Expression for Development of Hematopoietic Stem and Progenitor Cells.
Q49874413LSD1 demethylase and the methyl-binding protein PHF20L1 prevent SET7 methyltransferase-dependent proteolysis of the stem-cell protein Sox2.
Q47095936Linc-ROR promotes esophageal squamous cell carcinoma progression through the derepression of SOX9.
Q88656991Lineage Plasticity in Cancer Progression and Treatment
Q64283472Live-cell imaging reveals enhancer-dependent transcription in the absence of enhancer proximity
Q59329604Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy
Q92266755Loss of the tumor suppressor, Tp53, enhances the androgen receptor-mediated oncogenic transformation and tumor development in the mouse prostate
Q64244685Low Levels of Sox2 are required for Melanoma Tumor-Repopulating Cell Dormancy
Q89530406Low SOX12 Expression Is Correlated With Poor Prognosis in Patients With Gastric Cancer
Q47118198Major depletion of SOX2+ stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling.
Q34049100Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression
Q36731080Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT.
Q38696293MiR-429 suppresses glioblastoma multiforme by targeting SOX2.
Q92063622Midkine signaling maintains the self-renewal and tumorigenic capacity of glioma initiating cells
Q37223292Mobilized adult pituitary stem cells contribute to endocrine regeneration in response to physiological demand.
Q36685442Molecular and functional interactions between AKT and SOX2 in breast carcinoma
Q34577342Molecular and genetic aspects of odontogenic lesions.
Q26741572Molecular basis for the genome engagement by Sox proteins
Q38736146Molecular features of cellular reprogramming and development
Q58694941Molecular iodine inhibits the expression of stemness markers on cancer stem-like cells of established cell lines derived from cervical cancer
Q92541919Multiple Functions and Mechanisms Underlying the Role of METTL3 in Human Cancers
Q26771156Multipotent pancreas progenitors: Inconclusive but pivotal topic
Q89919423Mutation in Bmpr1b Leads to Optic Disc Coloboma and Ventral Retinal Gliosis in Mice
Q33648954NOS2 expression in glioma cell lines and glioma primary cell cultures: correlation with neurosphere generation and SOX-2 expression
Q35206740Neural stem and progenitor cell fate transition requires regulation of Musashi1 function
Q58792698Neuroprotective Properties of Asiatic Acid against 5-Fluorouracil Chemotherapy in the Hippocampus in an Adult Rat Model
Q42366642Novel SOX17 frameshift mutations in endometrial cancer are functionally distinct from recurrent missense mutations
Q41470840Nucleocytoplasmic shuttling of SOX14A and SOX14B transcription factors
Q33721392Nucleosome eviction along with H3K9ac deposition enhances Sox2 binding during human neuroectodermal commitment
Q42153591Oncogenic activity of SOX1 in glioblastoma
Q99548635Organotypic Culture of Acinar Cells for the Study of Pancreatic Cancer Initiation
Q36772053Oxidative stress induces the acquisition of cancer stem-like phenotype in breast cancer detectable by using a Sox2 regulatory region-2 (SRR2) reporter
Q98155024PAK5 promotes the cell stemness ability by phosphorylating SOX2 in lung squamous cell carcinomas
Q90841057PHF20L1 antagonizes SOX2 proteolysis triggered by the MLL1/WDR5 complexes
Q58708128PR-LncRNA signature regulates glioma cell activity through expression of SOX factors
Q42362093Patient-derived osteosarcoma cells are resistant to methotrexate.
Q41854138Pattern of Neurogenesis and Identification of Neuronal Progenitor Subtypes during Pallial Development in Xenopus laevis
Q38959990Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming
Q38892190Personalized and targeted therapy of esophageal squamous cell carcinoma: an update
Q37616736Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice.
Q27301172Placental mesenchymal stromal cells rescue ambulation in ovine myelomeningocele.
Q36142170Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells
Q38637870Pluripotency transcription factors in lung cancer-a review.
Q38390837Pluripotency transcription factors in the pathogenesis of colorectal cancer and implications for prognosis
Q57698394Positional specificity of different transcription factor classes within enhancers
Q37599778Positive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system
Q90191288Post-translational modification of SOX family proteins: Key biochemical targets in cancer?
Q57153312Potential Strategies Overcoming the Temozolomide Resistance for Glioblastoma
Q39107981Potential therapeutic targets of epithelial-mesenchymal transition in melanoma
Q35000680Profiling gene promoter occupancy of Sox2 in two phenotypically distinct breast cancer cell subsets using chromatin immunoprecipitation and genome-wide promoter microarrays
Q35854187Prognostic significance of SOX-1 expression in human hepatocelluar cancer.
Q40668131Prognostic value of Sox2 expression in digestive tract cancers: A meta-analysis
Q27009513Progress and renewal in gustation: new insights into taste bud development
Q93159741Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase
Q34028448QKI impairs self-renewal and tumorigenicity of oral cancer cells via repression of SOX2
Q48385582RIT1 GTPase Regulates Sox2 Transcriptional Activity and Hippocampal Neurogenesis.
Q90381449Reciprocal Regulation of TRPS1 and miR-221 in Intervertebral Disc Cells
Q64062687Recursive Motif Analyses Identify Brain Epigenetic Transcription Regulatory Modules
Q55338777Reduction of Movement in Neurological Diseases: Effects on Neural Stem Cells Characteristics.
Q30740000Regeneration of Xenopus laevis spinal cord requires Sox2/3 expressing cells
Q41967111Regulatory factor X transcription factors control Musashi1 transcription in mouse neural stem/progenitor cells
Q26853155Reprogramming cells with synthetic proteins
Q52806036Reprogramming to resist.
Q26860974Role of SOX family of transcription factors in central nervous system tumors
Q92560045Roles and regulation of SOX transcription factors in skeletogenesis
Q28077896Roles of N-Myc and STAT interactor in cancer: From initiation to dissemination
Q48501628Roles of Two Sox9 Genes during Gonadal Development in Japanese Flounder: Sex Differentiation, Spermatogenesis and Gonadal Function Maintenance.
Q61799611SIX1 represses senescence and promotes SOX2-mediated cellular plasticity during tumorigenesis
Q36014328SOX-2, but not Oct4, is highly expressed in early-stage endometrial adenocarcinoma and is related to tumour grading
Q35079337SOX1 down-regulates β-catenin and reverses malignant phenotype in nasopharyngeal carcinoma
Q94550391SOX1 promotes differentiation of nasopharyngeal carcinoma cells by activating retinoid metabolic pathway
Q34786506SOX10, a novel HMG-box-containing tumor suppressor, inhibits growth and metastasis of digestive cancers by suppressing the Wnt/β-catenin pathway
Q47411086SOX10-positive cells emerge in the rat pituitary gland during late embryogenesis and start to express S100β.
Q48132953SOX10/keratin dual-color immunohistochemistry: An effective first-line test for the workup of epithelioid malignant neoplasms in FNA and small biopsy specimens.
Q64987827SOX11: friend or foe in tumor prevention and carcinogenesis?
Q64106662SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis
Q92433227SOX12 promotes the growth of multiple myeloma cells by enhancing Wnt/β-catenin signaling
Q89948388SOX13 promotes colorectal cancer metastasis by transactivating SNAI2 and c-MET
Q43083428SOX15 and other SOX family members are important mediators of tumorigenesis in multiple cancer types
Q57793556SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh
Q38632090SOX2 Is a Marker for Stem-like Tumor Cells in Bladder Cancer
Q90475646SOX2 Regulates P63 and Stem/Progenitor Cell State in the Corneal Epithelium
Q38239137SOX2 and cancer: current research and its implications in the clinic
Q37680006SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas
Q40134764SOX2 as a New Regulator of HPV16 Transcription.
Q35833703SOX2 boosts major tumor progression genes in prostate cancer and is a functional biomarker of lymph node metastasis.
Q50454918SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma.
Q36076413SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer
Q33882664SOX2 expression is regulated by BRAF and contributes to poor patient prognosis in colorectal cancer
Q60924945SOX2 haploinsufficiency promotes impaired vision at advanced age
Q38373829SOX2 immunity and tissue resident memory in children and young adults with glioma
Q34396696SOX2 is a cancer-specific regulator of tumour initiating potential in cutaneous squamous cell carcinoma.
Q33607622SOX2 is required to maintain cancer stem cells in ovarian cancer.
Q58779082SOX2 recruits KLF4 to regulate nasopharyngeal carcinoma proliferation via PI3K/AKT signaling
Q50062529SOX2 regulates common and specific stem cell features in the CNS and endoderm derived organs.
Q58562769SOX2 regulates radioresistance in cervical cancer via the hedgehog signaling pathway
Q38947301SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinoma
Q35623883SOX2 reprograms resident astrocytes into neural progenitors in the adult brain
Q58709738SOX4 can redirect TGF-β-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesis
Q34517496SOX4 inhibits GBM cell growth and induces G0/G1 cell cycle arrest through Akt-p53 axis
Q52655063SOX5 predicts poor prognosis in lung adenocarcinoma and promotes tumor metastasis through epithelial-mesenchymal transition.
Q42376306SOX7 Is Required for Muscle Satellite Cell Development and Maintenance.
Q55287245SOX7 Target Genes and Their Contribution to Its Tumor Suppressive Function.
Q39605234SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development
Q64095213SOX9 Stem-Cell Factor: Clinical and Functional Relevance in Cancer
Q92668907SOX9 promotes tumor progression through the axis BMI1-p21CIP
Q37608199SOX9: a stem cell transcriptional regulator of secreted niche signaling factors
Q36669685SOXC Genes and the Control of Skeletogenesis
Q35651336SOXE transcription factors form selective dimers on non-compact DNA motifs through multifaceted interactions between dimerization and high-mobility group domains
Q55412924SOXF factors regulate murine satellite cell self-renewal and function through inhibition of β-catenin activity.
Q34920765SRY interference of normal regulation of the RET gene suggests a potential role of the Y-chromosome gene in sexual dimorphism in Hirschsprung disease.
Q47727544Screening the expression characteristics of several miRNAs in G93A-SOD1 transgenic mouse: altered expression of miRNA-124 is associated with astrocyte differentiation by targeting Sox2 and Sox9.
Q36144932Serine Protease Activation Essential for Endothelial-Mesenchymal Transition in Vascular Calcification.
Q90357657Sex-determining region Y box-containing genes: regulators and biomarkers in gynecological cancers
Q92574568Skip is essential for Notch signaling to induce Sox2 in cerebral arteriovenous malformations
Q27320285Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells
Q89595502Sox100B Regulates Progenitor-Specific Gene Expression and Cell Differentiation in the Adult Drosophila Intestine
Q48228658Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others
Q86958106Sox2 as a servant of two masters
Q41260832Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells
Q40934365Sox2 function as a negative regulator to control HAMP expression
Q41456346Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection
Q54678218Sox2 in the adult rat sensory nervous system.
Q59792939Sox2 is associated with cancer stem-like properties in colorectal cancer
Q51075741Sox2 is dispensable for primary melanoma and metastasis formation.
Q51075761Sox2 is not required for melanomagenesis, melanoma growth and melanoma metastasis in vivo.
Q47138957Sox2 modulates motility and enhances progression of colorectal cancer via the Rho-ROCK signaling pathway
Q33891224Sox2 promotes malignancy in glioblastoma by regulating plasticity and astrocytic differentiation
Q27021641Sox2 transcription network acts as a molecular switch to regulate properties of neural stem cells
Q48519185Sox21 deletion in mice causes postnatal growth deficiency without physiological disruption of hypothalamic-pituitary endocrine axes.
Q38845654Sox2: regulation of expression and contribution to brain tumors
Q64124379Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes
Q90585665Sox4 Promotes Atoh1-Independent Intestinal Secretory Differentiation Toward Tuft and Enteroendocrine Fates
Q34997327Sox6 up-regulation by macrophage migration inhibitory factor promotes survival and maintenance of mouse neural stem/progenitor cells
Q52883380Sox9 regulates self-renewal and tumorigenicity by promoting symmetrical cell division of cancer stem cells in hepatocellular carcinoma.
Q34972366Sox9: a master regulator of the pancreatic program
Q42680572SoxB, cell cycle and neurogenesis
Q26739989SoxD Transcription Factors: Multifaceted Players of Neural Development
Q38940310Specification and epigenetic programming of the human germ line
Q47657636Spinal Cord Cells from Pre-metamorphic Stages Differentiate into Neurons and Promote Axon Growth and Regeneration after Transplantation into the Injured Spinal Cord of Non-regenerative Xenopus laevis Froglets
Q38113992Spinal cord regeneration: lessons for mammals from non-mammalian vertebrates
Q35776368Sry-type HMG box 18 contributes to the differentiation of bone marrow-derived mesenchymal stem cells to endothelial cells
Q60953089Stem-like Human Breast Cancer Cells Initiate Vasculogenic Mimicry on Matrigel
Q37336266Stem/progenitor cells in the developing human cerebellum: an immunohistochemical study
Q34552512Structure-function relationships in human testis-determining factor SRY: an aromatic buttress underlies the specific DNA-bending surface of a high mobility group (HMG) box.
Q42464662Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages
Q42550899Systematic variation in the pattern of gene paralog retention between the teleost superorders Ostariophysi and Acanthopterygii
Q28079501Targeting SOX2 as a Therapeutic Strategy in Glioblastoma
Q38798880The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis
Q90240183The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells
Q24337113The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma
Q97074390The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication
Q92410942The Role of RB in Prostate Cancer Progression
Q38359533The Roles of the Stem Cell-Controlling Sox2 Transcription Factor: from Neuroectoderm Development to Alzheimer's Disease?
Q36115146The Sox transcriptional factors: Functions during intestinal development in vertebrates
Q90366123The acquisition of positional information across the radial axis of the cochlea
Q38733504The dark side of SOX2: cancer - a comprehensive overview
Q34460364The evolving cancer stem cell paradigm: implications in veterinary oncology
Q38909845The future of iPS cells in advancing regenerative medicine.
Q90641451The great escape: tumour cell plasticity in resistance to targeted therapy
Q40211236The influence of rAAV2-mediated SOX2 delivery into neonatal and adult human RPE cells; a comparative study
Q46275180The maternal-zygotic transition and zygotic activation of the Mnemiopsis leidyi genome occurs within the first three cleavage cycles
Q26785448The network of pluripotency, epithelial-mesenchymal transition, and prognosis of breast cancer
Q50981882The pleiotrophin-ALK axis is required for tumorigenicity of glioblastoma stem cells.
Q35828678The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers
Q26768676The role of pluripotency factors to drive stemness in gastrointestinal cancer
Q27003938The structure, function and evolution of proteins that bind DNA and RNA
Q27015644Thyroid tumor-initiating cells: increasing evidence and opportunities for anticancer therapy (review)
Q58695226Towards precision medicine: linking genetic and cellular heterogeneity in gastric cancer
Q55642025Transcription factor profiling identifies Sox9 as regulator of proliferation and differentiation in corneal epithelial stem/progenitor cells.
Q88035347Transcriptional and Epigenetic Control of Mammalian Olfactory Epithelium Development
Q36264232Transcriptional regulation of human sperm-associated antigen 16 gene by S-SOX5
Q31056690Transcriptome analysis reveals differentially expressed genes associated with germ cell and gonad development in the Southern bluefin tuna (Thunnus maccoyii).
Q64273377Transcriptome analysis reveals differentially expressed genes between human primary bone marrow mesenchymal stem cells and human primary dermal fibroblasts
Q33858412Transforming growth factor-beta signaling network regulates plasticity and lineage commitment of lung cancer cells
Q37237114Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses
Q35833007Triple negative breast cancers comprise a highly tumorigenic cell subpopulation detectable by its high responsiveness to a Sox2 regulatory region 2 (SRR2) reporter
Q37353994Ube2s regulates Sox2 stability and mouse ES cell maintenance
Q90087095Up-regulation of microRNA-200c-3p inhibits invasion and migration of renal cell carcinoma cells via the SOX2-dependent Wnt/β-catenin signaling pathway
Q37311518Upregulation of SOX9 in osteosarcoma and its association with tumor progression and patients' prognosis
Q99233800VDR-SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment
Q36095539Validation and comparison of instruments to identify frail patientes in primary care settings: Study protocol.
Q98576948Y chromosome in health and diseases
Q38901912YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells
Q33628528YB-1 regulates Sox2 to coordinately sustain stemness and tumorigenic properties in a phenotypically distinct subset of breast cancer cells
Q93346841[Development and homeostasis of taste buds in mammals]
Q38794065mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance.
Q37535463miR-126 functions as a tumor suppressor in osteosarcoma by targeting Sox2.
Q34096085miR-21 promotes the differentiation of hair follicle-derived neural crest stem cells into Schwann cells
Q28828459miR-30 Family Controls Proliferation and Differentiation of Intestinal Epithelial Cell Models by Directing a Broad Gene Expression Program That Includes SOX9 and the Ubiquitin Ligase Pathway
Q99241288miR-425-5p, a SOX2 target, regulates the expression of FOXJ3 and RAB31 and promotes the survival of GSCs
Q34501859miRNA-124 down-regulates SOX8 expression and suppresses cell proliferation in non-small cell lung cancer
Q53648897miRNA-124 down-regulates SOX8 expression and suppresses cell proliferation in non-small cell lung cancer.
Q48451281nNOS Translocates into the Nucleus and Interacts with Sox2 to Protect Neurons Against Early Excitotoxicity via Promotion of Shh Transcription.
Q36835178β-catenin and Kras/Foxm1 signaling pathway are critical to restrict Sox9 in basal cells during pulmonary branching morphogenesis

Search more.