| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1040459040 |
| P356 | DOI | 10.1038/35071111 |
| P8608 | Fatcat ID | release_ocb4bfajmvesrbvkbrpn3uj73q |
| P3181 | OpenCitations bibliographic resource ID | 2798911 |
| P698 | PubMed publication ID | 11298454 |
| P50 | author | Hidenori Ichijō | Q37376351 |
| Kohsuke Takeda | Q55292968 | ||
| P2093 | author name string | R Geleziunas | |
| W C Greene | |||
| W Xu | |||
| P2860 | cites work | Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein | Q22010192 |
| Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways | Q24309037 | ||
| Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx | Q24315012 | ||
| Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain | Q24336554 | ||
| Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. | Q24533236 | ||
| Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins | Q24673877 | ||
| Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain | Q24676619 | ||
| Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity | Q24682806 | ||
| Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector | Q28144477 | ||
| ASK1 is essential for JNK/SAPK activation by TRAF2 | Q28285612 | ||
| A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor | Q28288514 | ||
| A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4 | Q28288524 | ||
| Importance of the nef gene for maintenance of high virus loads and for development of AIDS | Q29618369 | ||
| Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking | Q30175880 | ||
| The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes | Q30176171 | ||
| Does HIV cause depletion of CD4+ T cells in vivo by the induction of apoptosis? | Q33547798 | ||
| Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin. | Q33786987 | ||
| Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation | Q33890494 | ||
| Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes | Q34297394 | ||
| Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. | Q36365019 | ||
| Macrophage-dependent apoptosis of CD4+ T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor | Q36376717 | ||
| Evasion of cytotoxic T lymphocyte (CTL) responses by nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells. | Q36380292 | ||
| A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity | Q41333852 | ||
| HIV-1 upregulates Fas ligand expression in CD4+ T cells in vitro and in vivo: association with Fas-mediated apoptosis and modulation by aurintricarboxylic acid | Q42632861 | ||
| Induction of fas ligand expression by an acutely lethal simian immunodeficiency virus, SIVsmmPBj14. | Q45751971 | ||
| Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4. | Q55067967 | ||
| P433 | issue | 6830 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | HIV | Q15787 |
| P304 | page(s) | 834-8 | |
| P577 | publication date | 2001-04-12 | |
| P1433 | published in | Nature | Q180445 |
| P1476 | title | HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell | |
| P478 | volume | 410 |
| Q36908259 | A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: potential impact on CTL epitopes |
| Q39170271 | A novel mechanism for HIV1-mediated bystander CD4+ T-cell death: neighboring dying cells drive the capacity of HIV1 to kill noncycling primary CD4+ T cells. |
| Q45722478 | ASK1 regulates influenza virus infection-induced apoptotic cell death |
| Q35579416 | ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction |
| Q44036971 | Activation of the p38 signaling pathway by heat shock involves the dissociation of glutathione S-transferase Mu from Ask1. |
| Q36784055 | Activation/proliferation and apoptosis of bystander goat lymphocytes induced by a macrophage-tropic chimeric caprine arthritis encephalitis virus expressing SIV Nef. |
| Q41813849 | Alkylating HIV-1 Nef - a potential way of HIV intervention |
| Q30160016 | Anti-CD45RO suppresses human immunodeficiency virus type 1 replication in microglia: role of Hck tyrosine kinase and implications for AIDS dementia |
| Q38070411 | Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV |
| Q35111274 | Apoptosis in HIV-1 infection. |
| Q36092837 | Apoptosis of HIV-specific CD8+ T cells: an HIV evasion strategy. |
| Q40567871 | Apoptosis of bystander T cells induced by human immunodeficiency virus type 1 with increased envelope/receptor affinity and coreceptor binding site exposure |
| Q38198723 | Apoptosis signal-regulating kinase 1 as a therapeutic target |
| Q77106544 | Apoptosis subversion: HIV-Nef provides both armor and sword |
| Q34742803 | Apoptosis-based therapies |
| Q28472613 | Apoptotic killing of HIV-1-infected macrophages is subverted by the viral envelope glycoprotein |
| Q36471285 | Attenuated disease in SIV-infected macaques treated with a monoclonal antibody against FasL. |
| Q37280434 | Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages |
| Q37620634 | Blockade of BFA-mediated apoptosis in macrophages by the HIV-1 Nef protein |
| Q35400103 | CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates |
| Q34393925 | Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways |
| Q24557445 | Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages |
| Q35153497 | Cellular heat shock factor 1 positively regulates human immunodeficiency virus-1 gene expression and replication by two distinct pathways |
| Q40161550 | Characterization of Nef-CXCR4 interactions important for apoptosis induction |
| Q34714816 | Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy |
| Q33508889 | Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds |
| Q42644285 | Combined effects of hyperglycemic conditions and HIV-1 Nef: a potential model for induced HIV neuropathogenesis |
| Q36099229 | Commitment to apoptosis in CD4(+) T lymphocytes productively infected with human immunodeficiency virus type 1 is initiated by lysosomal membrane permeabilization, itself induced by the isolated expression of the viral protein Nef |
| Q38130717 | Contributions of HIV-1 Nef to immune dysregulation in HIV-infected patients: a therapeutic target? |
| Q35261679 | Converging strategies in expression of human complex retroviruses |
| Q35105271 | Cooperative interactions of simian immunodeficiency virus Nef, AP-2, and CD3-zeta mediate the selective induction of T-cell receptor-CD3 endocytosis |
| Q34342429 | Coreceptor phenotype of natural human immunodeficiency virus with nef deleted evolves in vivo, leading to increased virulence |
| Q35792228 | Coxsackievirus B3 and the neonatal CNS: the roles of stem cells, developing neurons, and apoptosis in infection, viral dissemination, and disease |
| Q35031970 | Death and survival: viral regulation of TNF signaling pathways |
| Q35914471 | Dendritic cells infected with vpr-positive human immunodeficiency virus type 1 induce CD8+ T-cell apoptosis via upregulation of tumor necrosis factor alpha. |
| Q40409587 | Detection of human immunodeficiency virus type 1 Nef and CD4 physical interaction in living human cells by using bioluminescence resonance energy transfer |
| Q37072999 | Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo |
| Q28259926 | Differential effects of the SR proteins 9G8, SC35, ASF/SF2, and SRp40 on the utilization of the A1 to A5 splicing sites of HIV-1 RNA |
| Q37366869 | Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay |
| Q24315792 | Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class I (MHC-I) cytoplasmic tail disrupts MHC-I trafficking |
| Q33780497 | Distinct mechanisms of CD4+ and CD8+ T-cell activation and bystander apoptosis induced by human immunodeficiency virus type 1 virions |
| Q34302168 | Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef. |
| Q34782784 | Dynamics of physical interaction between HIV-1 Nef and ASK1: identifying the interacting motif(s). |
| Q35800393 | Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef. |
| Q39604845 | Efficient class I major histocompatibility complex down-regulation by simian immunodeficiency virus Nef is associated with a strong selective advantage in infected rhesus macaques |
| Q45068181 | Enhancement of immunogenicity of an HIV Env DNA vaccine by mutation of the Tyr-based endocytosis motif in the cytoplasmic domain |
| Q35757197 | Epstein-Barr virus (EBV) latent membrane protein-1 down-regulates tumor necrosis factor-alpha (TNF-alpha) receptor-1 and confers resistance to TNF-alpha-induced apoptosis in T cells: implication for the progression to T-cell lymphoma in EBV-associat |
| Q35544355 | Eradication of HIV-1 from the macrophage reservoir: an uncertain goal? |
| Q34035915 | Evidence for a cytopathogenicity determinant in HIV-1 Vpr. |
| Q33799901 | Exogenous Nef is an inhibitor of Mycobacterium tuberculosis-induced tumor necrosis factor-alpha production and macrophage apoptosis |
| Q40584535 | Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors |
| Q89878461 | Extracellular Vesicles from Human Papilloma Virus-Infected Cervical Cancer Cells Enhance HIV-1 Replication in Differentiated U1 Cell Line |
| Q33714550 | Genetic characterization of HIV type 1 Nef-induced vesicle secretion |
| Q37485148 | HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells |
| Q46658421 | HIV impairs TNF-alpha release in response to Toll-like receptor 4 stimulation in human macrophages in vitro |
| Q37427449 | HIV integration and T cell death: additional commentary. |
| Q39321661 | HIV-1 Nef and T-cell activation: a history of contradictions |
| Q40770875 | HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals |
| Q28202882 | HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication |
| Q34573902 | HIV-1 Nef increases astrocyte sensitivity towards exogenous hydrogen peroxide |
| Q45345418 | HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection |
| Q90619761 | HIV-1 Nef promotes cell proliferation and microRNA dysregulation in lung cells |
| Q40508884 | HIV-1 Nef promotes survival of TF-1 macrophages by inducing Bcl-XL expression in an extracellular signal-regulated kinase-dependent manner |
| Q61319055 | HIV-1 Nef protects human-monocyte-derived macrophages from HIV-1-induced apoptosis |
| Q57709533 | HIV-1 Nef protein expression in human CD34+ progenitors impairs the differentiation of an early T/NK cell precursor |
| Q24669980 | HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation |
| Q53501416 | HIV-1 Nef-mediated inhibition of T cell migration and its molecular determinants. |
| Q39658813 | HIV-1 Nef: hacker of the host cell |
| Q56876473 | HIV-1 Nef: negative effector of Fas? |
| Q33388690 | HIV-1 activates macrophages independent of Toll-like receptors |
| Q35988809 | HIV-1 and the hijacking of dendritic cells: a tug of war. |
| Q53882620 | HIV-1 expression protects macrophages and microglia from apoptotic death. |
| Q34648685 | HIV-1 gp120 protein downregulates Nef induced IL-6 release in immature dentritic cells through interplay of DC-SIGN |
| Q30009553 | HIV-1 infection of T cells and macrophages are differentially modulated by virion-associated Hck: a Nef-dependent phenomenon |
| Q35166833 | HIV-1 pathogenesis |
| Q34875979 | HIV-1 replication cycle |
| Q44405088 | HIV-1 viral protein R compromises cellular immune function in vivo |
| Q35108679 | HIV/host interactions: new lessons from the Red Queenʼs country |
| Q35058535 | Hide, shield and strike back: how HIV-infected cells avoid immune eradication |
| Q39683959 | Highly pathogenic simian immunodeficiency virus mne variants that emerge during the course of infection evolve enhanced infectivity and the ability to downregulate CD4 but not class I major histocompatibility complex antigens |
| Q33707527 | Human Immunodeficiency virus type 1 Nef potently induces apoptosis in primary human brain microvascular endothelial cells via the activation of caspases |
| Q52668683 | Human T Lymphocytes Are Permissive for Dengue Virus Replication. |
| Q36570464 | Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPARgamma/STAT5 signaling pathway in macaques |
| Q39699492 | Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis |
| Q36499676 | Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways |
| Q37574658 | Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation. |
| Q33755059 | Human immunodeficiency virus type 1 inhibits DNA damage-triggered apoptosis by a Nef-independent mechanism |
| Q34664366 | Human immunodeficiency virus-1 (HIV-1)-mediated apoptosis: new therapeutic targets |
| Q45722440 | Human immunodeficiency virus-1 Nef protein interacts with Tat and enhances HIV-1 gene expression |
| Q34792498 | Human retroviruses after 20 years: a perspective from the past and prospects for their future control |
| Q37386643 | Identification of human immunodeficiency virus-1 specific CD8+ and CD4+ T cell responses in perinatally-infected infants and their mothers |
| Q37034627 | Identification of potential drug targets using genomics and proteomics: a systems approach |
| Q37596524 | Impact of Nef-mediated downregulation of major histocompatibility complex class I on immune response to simian immunodeficiency virus |
| Q40417308 | Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex. |
| Q60925679 | Implications of HIV-1 Nef for "Shock and Kill" Strategies to Eliminate Latent Viral Reservoirs |
| Q56923692 | In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the r |
| Q35848314 | In vivo analysis of Nef's role in HIV-1 replication, systemic T cell activation and CD4(+) T cell loss |
| Q30009533 | In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis |
| Q34977020 | In vivo evolution of human immunodeficiency virus type 1 toward increased pathogenicity through CXCR4-mediated killing of uninfected CD4 T cells |
| Q55035589 | Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells. |
| Q35979283 | Inhibition of ER stress-mediated apoptosis in macrophages by nuclear-cytoplasmic relocalization of eEF1A by the HIV-1 Nef protein |
| Q42140292 | Inhibition of envelope-mediated CD4+-T-cell depletion by human immunodeficiency virus attachment inhibitors |
| Q33768829 | Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef |
| Q35823730 | Interplay between HIV-1 infection and host microRNAs |
| Q58750572 | Killing of Latently HIV-Infected CD4 T Cells by Autologous CD8 T Cells Is Modulated by Nef |
| Q35827257 | Klotho Regulates 14-3-3ζ Monomerization and Binding to the ASK1 Signaling Complex in Response to Oxidative Stress |
| Q34611256 | Live and let die: Nef functions beyond HIV replication |
| Q33927183 | MLV glycosylated-Gag is an infectivity factor that rescues Nef-deficient HIV-1. |
| Q37728093 | Macrophage signaling in HIV-1 infection |
| Q34545417 | Mechanisms of HIV-associated lymphocyte apoptosis: 2010 |
| Q34490256 | Mechanistic aspects of HIV-1 reverse transcription initiation |
| Q39577894 | Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef |
| Q36767508 | Modulation of the immunological synapse: a key to HIV-1 pathogenesis? |
| Q33864438 | Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage |
| Q58723116 | Monocytes and Macrophages as Viral Targets and Reservoirs |
| Q47555946 | Multiple Inhibitory Factors Act in the Late Phase of HIV-1 Replication: a Systematic Review of the Literature |
| Q28546086 | Mycobacterium tuberculosis and Human Immunodeficiency Virus Type 1 Cooperatively Modulate Macrophage Apoptosis via Toll Like Receptor 2 and Calcium Homeostasis |
| Q53622019 | Nef enhances c-Cbl phosphorylation in HIV-infected CD4+ T lymphocytes. |
| Q34552824 | Nef: agent of cell subversion |
| Q41894662 | Pro- and anti-apoptotic CD95 signaling in T cells |
| Q40631918 | Pro-apoptotic Activity of HIV-1 Auxiliary Regulatory Protein Vpr Is Subtype-dependent and Potently Enhanced by Nonconservative Changes of the Leucine Residue at Position 64 |
| Q35042496 | Prospects for an HIV vaccine: conventional approaches and DNA immunization |
| Q38931499 | Protein kinase CK2 phosphorylates the Nef protein from a neurovirulent simian immunodeficiency virus |
| Q48285845 | Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila |
| Q39065453 | Regulatory role of ASK1 in porcine circovirus type 2-induced apoptosis |
| Q37183096 | Retroviral proteomics and interactomes: intricate balances of cell survival and viral replication |
| Q36501681 | Role of MAP kinase-dependent apoptotic pathway in innate immune responses and viral infection |
| Q35666063 | Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release |
| Q34335576 | Simian immunodeficiency virus Nef protein delays the progression of CD4+ T cells through G1/S phase of the cell cycle |
| Q41749934 | Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1. |
| Q43166651 | Substitution of HIV Type 1 Nef with HTLV-1 p12. |
| Q27489673 | Suppression of a pro-apoptotic K+ channel as a mechanism for hepatitis C virus persistence |
| Q37683010 | Surface stability and immunogenicity of the human immunodeficiency virus envelope glycoprotein: role of the cytoplasmic domain |
| Q35176339 | T cell signaling and apoptosis in HIV disease |
| Q42273481 | T-Cell Signaling in HIV-1 Infection |
| Q35613792 | T-cell and neuronal apoptosis in HIV infection: implications for therapeutic intervention |
| Q41071887 | The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response |
| Q42231848 | The HIV-1 Nef protein interacts with two components of the 40S small ribosomal subunit, the RPS10 protein and the 18S rRNA. |
| Q24629787 | The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1 |
| Q61928289 | The Role of Mitochondria in HIV Infection and Its Treatment |
| Q47308542 | The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis |
| Q40558019 | The effects of HIV-1 Nef on CD4 surface expression and viral infectivity in lymphoid cells are independent of rafts |
| Q38701415 | The interaction between HIV-1 Nef and adaptor protein-2 reduces Nef-mediated CD4+ T cell apoptosis |
| Q26823236 | The macrophage: a therapeutic target in HIV-1 infection |
| Q95486222 | The origins and functions of hepatic polyploidy |
| Q26999030 | Therapeutic targets in the ASK1-dependent stress signaling pathways |
| Q34403732 | Trans-cellular introduction of HIV-1 protein Nef induces pathogenic response in Caenorhabditis elegans |
| Q34185821 | Tumor necrosis factor signaling. |
| Q36276589 | Viral strategies for evading antiviral cellular immune responses of the host |
| Q34469316 | Virus infections: escape, resistance, and counterattack. |
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