BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

scientific article

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function is …
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scholarly articleQ13442814

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P356DOI10.1016/S0092-8674(01)00304-X
P3181OpenCitations bibliographic resource ID1012840
P698PubMed publication ID11301010

P50authorRonny DrapkinQ37843472
P2093author name stringW S Lane
D A Haber
D M Livingston
D W Bell
S Ganesan
S B Cantor
D C Sgroi
S Grossman
D C Wahrer
E M Kass
P2860cites workStable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cellsQ22003975
Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-FosQ24302240
Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1Q24316865
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage responseQ24316950
The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.Q41164271
Induction and rejoining of DNA double-strand breaks and interphase chromosome breaks after exposure to X rays in one normal and two hypersensitive human fibroblast cell linesQ41290495
Mammalian nucleotide excision repair and syndromesQ41370274
Regulation of TFIIH ATPase and kinase activities by TFIIE during active initiation complex formationQ41481294
Rabbit beta-globin is extended beyond its UGA stop codon by multiple suppressions and translational reading gapsQ47732509
BRCA1 protein products ... Functional motifs...Q48062839
A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.Q52533204
BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene.Q52537650
Transcriptional activation by BRCA1Q59072814
Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancerQ70812480
Location of BRCA1 in human breast and ovarian cancer cellsQ70998780
ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3Q24321908
p53 modulation of TFIIH-associated nucleotide excision repair activityQ24336880
Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53Q24609153
BRCA1 is a component of the RNA polymerase II holoenzymeQ24675704
High-efficiency transformation of mammalian cells by plasmid DNAQ27860469
An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein databaseQ27861106
The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorderQ28115238
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1Q28115843
Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage responseQ28140763
Genetic analysis of BRCA1 function in a defined tumor cell lineQ28142643
Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase IIQ28251866
Role of a BRCT domain in the interaction of DNA ligase III-alpha with the DNA repair protein XRCC1Q28279796
The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repressionQ28282486
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptorQ28286827
Association of BRCA1 with Rad51 in mitotic and meiotic cellsQ28302118
The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertilityQ28505195
Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIHQ28573627
Organization of SCP1 protein molecules within synaptonemal complexes of the ratQ28574832
Brca1 controls homology-directed DNA repairQ29614844
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damageQ29619360
From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repairQ29619880
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like propertiesQ29620009
DNA damage recognition during nucleotide excision repair in mammalian cellsQ31271134
Ten years of TFIIH.Q33671312
Insights into the functions of BRCA1 and BRCA2.Q33826737
Common pathways for ultraviolet skin carcinogenesis in the repair and replication defective groups of xeroderma pigmentosumQ33853150
Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cellsQ34503003
Evidence for a transcriptional activation function of BRCA1 C-terminal regionQ34736712
Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiationQ36564865
Mutational analysis of ERCC3, which is involved in DNA repair and transcription initiation: identification of domains essential for the DNA repair functionQ38307435
SYBR Green I staining of pulsed field agarose gels is a sensitive and inexpensive way of quantitating DNA double-strand breaks in mammalian cellsQ39720624
Nucleotide excision repair in the yeast Saccharomyces cerevisiae: its relationship to specialized mitotic recombination and RNA polymerase II basal transcriptionQ40522919
Independence of R/M/N focus formation and the presence of intact BRCA1.Q40864224
TFIIH: a key component in multiple DNA transactionsQ41099885
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectdouble-strand break repairQ14818014
BRCA1 interacting protein C-terminal helicase 1Q21100487
BTB domain and CNC homolog 1Q21115419
P304page(s)149-160
P577publication date2001-04-01
P1433published inCellQ655814
P1476titleBACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function
P478volume105

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Q92608468RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci
Q36080420RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo
Q24306789RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites
Q34762756RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci
Q41808393RAS, cellular senescence and transformation: the BRCA1 DNA repair pathway at the crossroads
Q33378036Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80
Q47259551RecQ and Fe-S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions
Q64055629Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms
Q38985539Recent discoveries in the molecular pathogenesis of the inherited bone marrow failure syndrome Fanconi anemia
Q37120275Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network
Q28214575Recombinational DNA repair and human disease
Q28212699Redistribution of BRCA1 among four different protein complexes following replication blockage
Q41781885Redox control of the DNA damage-inducible protein DinG helicase activity via its iron-sulfur cluster
Q33886979Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications
Q35678377Rescue of replication failure by Fanconi anaemia proteins
Q44324983Rewiring the dynamic interactome
Q37775588Role of homologous recombination in DNA interstrand crosslink repair
Q28191496SUVi and BACH1: a new subfamily of mammalian helicases?
Q22000758Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals
Q54423137Screening for large genomic rearrangements of the BRIP1 and CHK1 genes in Finnish breast cancer families.
Q28606408Search for new loci and low-frequency variants influencing glioma risk by exome-array analysis
Q39931246Sequence conservation and differential expression of Marek's disease virus microRNAs
Q30491608Single-molecule analysis reveals differential effect of ssDNA-binding proteins on DNA translocation by XPD helicase
Q38292340Single-molecule sorting of DNA helicases
Q38987499Sp1 is necessary for gene activation of Adamts17 by estrogen
Q35604035Spectrum of variations in dog-1/FANCJ and mdf-1/MAD1 defective Caenorhabditis elegans strains after long-term propagation
Q36333360Structural basis for phosphorylation-dependent signaling in the DNA-damage response
Q24628641Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains
Q40557832Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.
Q39494743Structural characterization of BRCT-tetrapeptide binding interactions.
Q27639943Structural consequences of a cancer-causing BRCA1-BRCT missense mutation
Q24651980Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1
Q28260830Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer
Q38326236Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites
Q24292396Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure
Q29031393Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide
Q92116582Structure-Guided Synthesis and Evaluation of Small-Molecule Inhibitors Targeting Protein-Protein Interactions of BRCA1 tBRCT Domain
Q62937915Studies of TBX4 and chromosome 17q23.1q23.2: an uncommon cause of nonsyndromic clubfoot
Q37178493Superfamily 2 helicases
Q64119152Systematic analyses of regulatory variants in DNase I hypersensitive sites identified two novel lung cancer susceptibility loci
Q24514481TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage
Q33277172Tagging single nucleotide polymorphisms in the BRIP1 gene and susceptibility to breast and ovarian cancer
Q34865929Tandem BRCT Domains: DNA's Praetorian Guard.
Q39736886Targeting the FANCJ-BRCA1 interaction promotes a switch from recombination to poleta-dependent bypass
Q37161449Telomeres do the (un)twist: helicase actions at chromosome termini
Q34194407Telomeres: structures in need of unwinding
Q35130683The 17q23 amplicon and breast cancer
Q37124472The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50.
Q40486944The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci
Q24622650The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations
Q34560326The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia
Q34543616The BRCA2-EMSY connection: implications for breast and ovarian tumorigenesis
Q24298428The BRCT Domain Is a Phospho-Protein Binding Domain
Q40382210The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair
Q55671102The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J
Q54443591The DinG protein from Escherichia coli is a structure-specific helicase.
Q24312784The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells
Q35024542The Fanconi anemia pathway and ICL repair: implications for cancer therapy
Q28756516The Fanconi anemia pathway and ubiquitin
Q37356265The Fanconi anemia protein interaction network: casting a wide net.
Q34170774The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate each other's chromatin localization
Q37417960The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment
Q36052367The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function
Q36982306The Simple Chordate Ciona intestinalis Has a Reduced Complement of Genes Associated with Fanconi Anemia
Q89866885The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication
Q39082111The budding yeast protein Chl1p is required to preserve genome integrity upon DNA damage in S-phase
Q64089437The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors
Q40307700The dynamic alterations of H2AX complex during DNA repair detected by a proteomic approach reveal the critical roles of Ca(2+)/calmodulin in the ionizing radiation-induced cell cycle arrest
Q38805624The excluded DNA strand is SEW important for hexameric helicase unwinding
Q74420964The genome's best friend
Q47160579The helicase DinG responds to stress due to DNA double strand breaks
Q46888893The iron-containing domain is essential in Rad3 helicases for coupling of ATP hydrolysis to DNA translocation and for targeting the helicase to the single-stranded DNA-double-stranded DNA junction
Q34163219The relationship between the roles of BRCA genes in DNA repair and cancer predisposition
Q58084799The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans
Q42065210The ubiquitin E3 ligase activity of BRCA1 and its biological functions.
Q38065578The yin and yang of repair mechanisms in DNA structure-induced genetic instability
Q35730286Tracing the network connecting BRCA and Fanconi anaemia proteins
Q33373567Transcription factor and microRNA regulation in androgen-dependent and -independent prostate cancer cells
Q38375832Transcriptome analyses of rhesus monkey preimplantation embryos reveal a reduced capacity for DNA double-strand break repair in primate oocytes and early embryos
Q92644000Transcriptome profiling revealed multiple genes and ECM-receptor interaction pathways that may be associated with breast cancer
Q47567895Translational opportunities for broad-spectrum natural phytochemicals and targeted agent combinations in breast cancer
Q33720531Triple helix-interacting proteins and cancer
Q56625730Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles
Q28249114Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155
Q43764686Two forms of mitochondrial DNA ligase III are produced in Xenopus laevis oocytes
Q38190273Two steps forward, one step back: determining XPD helicase mechanism by single-molecule fluorescence and high-resolution optical tweezers.
Q90072078USP9X stabilizes BRCA1 and confers resistance to DNA-damaging agents in human cancer cells
Q81138696Unraveling the Fanconi anemia-DNA repair connection
Q28756062Unzipped and loaded: the role of DNA helicases and RFC clamp-loading complexes in sister chromatid cohesion
Q37577923Update on genetic predisposition to breast cancer
Q42004182WRN helicase unwinds Okazaki fragment-like hybrids in a reaction stimulated by the human DHX9 helicase
Q37144651Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins
Q42020935Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer
Q35883840hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ.

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