Phosphopeptide interactions with BRCA1 BRCT domains: More than just a motif

scientific article published in March 2015

Phosphopeptide interactions with BRCA1 BRCT domains: More than just a motif is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.PBIOMOLBIO.2015.02.003
P932PMC publication ID4728184
P698PubMed publication ID25701377
P5875ResearchGate publication ID272569035

P50authorTom BlundellQ7814993
Qian WuQ57451839
Harry JubbQ42822785
P2860cites workBACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair functionQ24291119
The BRCT Domain Is a Phospho-Protein Binding DomainQ24298428
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damageQ24306743
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage responseQ24306765
CCDC98 targets BRCA1 to DNA damage sitesQ24321418
Structure of an XRCC1 BRCT domain: a new protein-protein interaction moduleQ24533379
BRCT domains: easy as one, two, threeQ24635835
Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1Q24651980
Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1Q27635011
Structural consequences of a cancer-causing BRCA1-BRCT missense mutationQ27639943
Insights from the crystal structure of the sixth BRCT domain of topoisomerase IIβ binding protein 1Q27658324
Comparison of the structures and peptide binding specificities of the BRCT domains of MDC1 and BRCA1Q27659872
Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide RecognitionQ27667456
Structural basis for the BRCA1 BRCT interaction with the proteins ATRIP and BAAT1Q27686827
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1Q28115843
Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNAQ28145077
Detection of multiscale pockets on protein surfaces using mathematical morphology.Q51773359
Left-handed polyproline II helices commonly occur in globular proteins.Q52402236
A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screeningQ63363987
The BRCT regions of tumor suppressor BRCA1 and of XRCC1 show DNA end binding activity with a multimerizing featureQ64388283
Mutations and polymorphisms in the familial early-onset breast cancer (BRCA1) gene. Breast Cancer Information CoreQ71532382
Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteinsQ73034981
Thermodynamics of phosphopeptide tethering to BRCT: the structural minima for inhibitor designQ80764882
Stereochemistry of polypeptide chain configurationsQ28190300
BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein TargetingQ28212263
Phosphopeptide Binding Specificities of BRCA1 COOH-terminal (BRCT) DomainsQ28212425
Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signalingQ28260142
Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancerQ28260830
Linkage of early-onset familial breast cancer to chromosome 17q21Q28268902
Interactions between BRCT repeats and phosphoproteins: tangled up in twoQ28289371
DNA-PK: the means to justify the ends?Q28305446
Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 PhosphopeptideQ29031393
Analysis of membrane and surface protein sequences with the hydrophobic moment plotQ29618183
A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteinsQ29619879
From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repairQ29619880
Charting the landscape of tandem BRCT domain-mediated protein interactionsQ33782757
BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycleQ34313012
Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten familiesQ34321216
Tandem BRCT Domains: DNA's Praetorian Guard.Q34865929
Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor designQ35445886
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.Q37235809
Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cellsQ37254703
BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activityQ37524847
Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.Q40557832
CREDO: a structural interactomics database for drug discoveryQ42119055
Structure-activity relationship studies to probe the phosphoprotein binding site on the carboxy terminal domains of the breast cancer susceptibility gene 1.Q42761664
Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex.Q46651078
BRCA1 protein products ... Functional motifs...Q48062839
BRCA1 mutations in primary breast and ovarian carcinomasQ48078473
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2-3
P407language of work or nameEnglishQ1860
P921main subjectpeptideQ172847
DNA damageQ5205747
transcription factorQ407384
phosphoproteinQ423934
nuclear proteinQ16860021
chemical modelQ25109595
biomedical investigative techniqueQ66648976
neoplasm proteinQ66894191
Fanconi anemia complementation group proteinsQ77044783
P304page(s)143-8
P577publication date2015-03-01
P1433published inProgress in Biophysics and Molecular BiologyQ15753863
P1476titlePhosphopeptide interactions with BRCA1 BRCT domains: More than just a motif
P478volume117

Reverse relations

cites work (P2860)
Q55639040A new bioinformatics tool to help assess the significance of BRCA1 variants.
Q50329367ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair
Q90581419DNA breakpoint assay reveals a majority of gross duplications occur in tandem reducing VUS classifications in breast cancer predisposition genes
Q37367852Dynamic structures in DNA damage responses & cancer.
Q49936294Gene-Specific Genetic Complementation between Brca1 and Cobra1 During Mouse Mammary Gland Development.
Q57826033Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer
Q37693410Identification of recurrent BRCA1 mutation and its clinical relevance in Chinese Triple-negative breast cancer cohort
Q38326236Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites
Q57029697The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection
Q58084799The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans

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