| scholarly article | Q13442814 |
| P2093 | author name string | Jin Kumagai | |
| O David Sherwood | |||
| Aaron J W Hsueh | |||
| Masataka Kudo | |||
| Koji Nakabayashi | |||
| Shinya Nishi | |||
| Sheau Yu Hsu | |||
| P433 | issue | 5555 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | G protein-coupled receptor activity | Q14859545 |
| Relaxin family peptide receptor 1 | Q21108186 | ||
| Relaxin/insulin-like family peptide receptor 1 | Q21990075 | ||
| P304 | page(s) | 671-4 | |
| P577 | publication date | 2002-01-25 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | Activation of orphan receptors by the hormone relaxin | |
| P478 | volume | 295 |
| Q47071893 | A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3. |
| Q39445866 | A convenient method for europium-labeling of a recombinant chimeric relaxin family peptide R3/I5 for receptor-binding assays |
| Q37022179 | A genome-wide inventory of neurohormone GPCRs in the red flour beetle Tribolium castaneum. |
| Q42852067 | A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism. |
| Q38761448 | A novel BRET-based binding assay for interaction studies of relaxin family peptide receptor 3 with its ligands |
| Q46547377 | A novel, adenylate cyclase, signaling mechanism of relaxin H2 action. |
| Q35080128 | A single-nucleotide polymorphism of human neuropeptide s gene originated from Europe shows decreased bioactivity |
| Q35960484 | Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290. |
| Q42441964 | Activation of the luteinizing hormone receptor in the extracellular domain |
| Q48071023 | Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimer's disease patients |
| Q37560684 | Alternative splicing of G protein-coupled receptors: physiology and pathophysiology |
| Q38850557 | Anti-fibrotic actions of relaxin. |
| Q51561929 | Application of the novel bioluminescent ligand-receptor binding assay to relaxin-RXFP1 system for interaction studies. |
| Q36163310 | Basic progress and future therapeutic perspectives of relaxin in ischemic heart disease |
| Q24802524 | Biology of primate relaxin: a paracrine signal in early pregnancy? |
| Q24556617 | Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2 |
| Q33979590 | C-peptide: new findings and therapeutic implications in diabetes |
| Q37638152 | Cardiovascular effects of relaxin: from basic science to clinical therapy |
| Q36597958 | Cellular and molecular biology of orphan G protein-coupled receptors |
| Q37165951 | Characterization of relaxin receptor (RXFP1) desensitization and internalization in primary human decidual cells and RXFP1-transfected HEK293 cells |
| Q28570216 | Characterization of the rat INSL3 receptor |
| Q48482494 | Characterization, cDNA cloning and expression pattern of relaxin gene during embryogenesis of Danio rerio. |
| Q93160101 | Characterizing relaxin receptor expression and exploring relaxin's effect on tissue remodeling/fibrosis in the human bladder |
| Q37294469 | Chimeric RXFP1 and RXFP2 Receptors Highlight the Similar Mechanism of Activation Utilizing Their N-Terminal Low-Density Lipoprotein Class A Modules. |
| Q47333527 | Chronic intracerebroventricular administration of relaxin-3 increases body weight in rats |
| Q64980635 | Circulating Relaxin-1 Level Is a Surrogate Marker of Myocardial Fibrosis in HFrEF. |
| Q36342562 | Clinical laboratory evaluation of male subfertility |
| Q36509796 | Cloning, expression, and functional characterization of relaxin receptor (leucine-rich repeat-containing g protein-coupled receptor 7) splice variants from human fetal membranes |
| Q43719593 | Combination therapy with relaxin and methylprednisolone augments the effects of either treatment alone in inhibiting subepithelial fibrosis in an experimental model of allergic airways disease |
| Q35971938 | Comparative endocrinology of aging and longevity regulation |
| Q36913271 | Comparative genomics of leucine-rich repeats containing G protein-coupled receptors and their ligands |
| Q43773743 | Conservation of the heterodimeric glycoprotein hormone subunit family proteins and the LGR signaling system from nematodes to humans |
| Q58294694 | Conserved Synteny Between the Ciona Genome and Human Paralogons Identifies Large Duplication Events in the Molecular Evolution of the Insulin-Relaxin Gene Family |
| Q36025314 | Constitutive formation of an RXFP1-signalosome: a novel paradigm in GPCR function and regulation |
| Q33717728 | Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family. |
| Q46856414 | Cryptorchidism in LhrKO animals and the effect of testosterone-replacement therapy |
| Q30369442 | Crystal structure of LGR4-Rspo1 complex: insights into the divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors (LGRs). |
| Q35138860 | Cyclic nucleotide signalling in kidney fibrosis |
| Q28085274 | Dedifferentiation, Transdifferentiation, and Proliferation: Mechanisms Underlying Cardiac Muscle Regeneration in Zebrafish |
| Q28510622 | Defective postnatal development of the male reproductive tract in LGR4 knockout mice |
| Q90392310 | Delegating Sex: Differential Gene Expression in Stolonizing Syllids Uncovers the Hormonal Control of Reproduction |
| Q40409497 | Demonstration of upregulated H2 relaxin mRNA expression during neuroendocrine differentiation of LNCaP prostate cancer cells and production of biologically active mammalian recombinant 6 histidine-tagged H2 relaxin |
| Q28578664 | Detection, localization, and action of the INSL3 receptor, LGR8, in rat kidney |
| Q33789534 | Development of a selective agonist for relaxin family peptide receptor 3. |
| Q49104282 | Distribution of G-protein-coupled receptor (GPCR)135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing. |
| Q34416196 | Disturbed relaxin signaling pathway and testicular dysfunction in mouse offspring upon maternal exposure to simazine |
| Q39188093 | Diverse regulation of cardiac expression of relaxin receptor by α1- and β1-adrenoceptors |
| Q90679581 | Effect of relaxin-3 on Kiss-1, gonadotropin-releasing hormone, and gonadotropin subunit gene expression |
| Q28748277 | Effects of human relaxin on orthodontic tooth movement and periodontal ligaments in rats |
| Q40018536 | Effects of recombinant H2 relaxin on the expression of matrix metalloproteinases and tissue inhibitor metalloproteinase in cultured early placental extravillous trophoblasts |
| Q37184401 | Effects of serelaxin in acute heart failure patients with renal impairment: results from RELAX-AHF |
| Q90284940 | Efficacy of relaxin for cisplatin-induced testicular dysfunction and epididymal spermatotoxicity |
| Q80586556 | Elevated concentrations of serum relaxin are associated with metastatic disease in breast cancer patients |
| Q38238450 | Emerging role of serelaxin in the therapeutic armamentarium for heart failure |
| Q35033297 | Emerging roles for orphan G-protein-coupled receptors in the cardiovascular system |
| Q34749669 | Evolution of a potential hormone antagonist following gene splicing during primate evolution |
| Q24300545 | Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5 |
| Q21283971 | Evolution of the relaxin-like peptide family |
| Q47268876 | Evolution of the signaling system in relaxin-family peptides |
| Q48081817 | Evolutionary conservation of bursicon in the animal kingdom. |
| Q73073424 | Exploiting the co-evolution of interacting proteins to discover interaction specificity |
| Q37153073 | Exploring novel hormones essential for seawater adaptation in teleost fish |
| Q37590172 | Expression and function of G-protein-coupled receptors in the male reproductive tract |
| Q37373673 | Expression of LGR7 in the primate corpus luteum implicates the corpus luteum as a relaxin target organ |
| Q39678375 | Expression of RXFP1 Is Decreased in Idiopathic Pulmonary Fibrosis. Implications for Relaxin-based Therapies |
| Q50585036 | Expression of insulin-like factor 3 hormone-receptor system in the reproductive organs of male goats. |
| Q54632846 | Expression of relaxin receptor LRG7, canine relaxin, and relaxin-like factor in the pelvic diaphragm musculature of dogs with and without perineal hernia. |
| Q52565250 | Expression pattern of the orphan receptor LGR4/GPR48 gene in the mouse. |
| Q37348698 | Female hormone receptors are differentially expressed in mouse fibrocartilages |
| Q73874810 | Female mice carrying a ubiquitin promoter-Insl3 transgene have descended ovaries and inguinal hernias but normal fertility |
| Q36455977 | Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia |
| Q36964320 | Full-length LGR5-positive cells have chemoresistant characteristics in colorectal cancer |
| Q35105373 | Functional Assays for Identifying Ligands at Orphan G Protein-Coupled Receptors |
| Q93551696 | G Protein-Coupled Receptors |
| Q26744192 | G-Protein-coupled receptors as potential drug candidates in preeclampsia: targeting the relaxin/insulin-like family peptide receptor 1 for treatment and prevention |
| Q48551552 | G-protein-coupled receptor (GPCR)-142 does not contribute to relaxin-3 binding in the mouse brain: further support that relaxin-3 is the physiological ligand for GPCR135. |
| Q36248054 | G-protein-coupled receptor deorphanizations |
| Q36945165 | Gene trap mutagenesis in mice: new perspectives and tools in cancer research |
| Q35162661 | Genes and male infertility: what can go wrong? |
| Q38366456 | Genetic analysis of the human Insulin-like 3 gene: absence of mutations in a Greek paediatric cohort with testicular maldescent |
| Q40409544 | Genetic targeting of relaxin and insl3 signaling in mice |
| Q24310672 | H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis |
| Q28198638 | H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2 |
| Q37026024 | Hormonal and genetic control of testicular descent |
| Q91818920 | Human Relaxin-2 Fusion Protein Treatment Prevents and Reverses Isoproterenol-Induced Hypertrophy and Fibrosis in Mouse Heart |
| Q40409491 | Human medullary thyroid carcinoma: a source and potential target for relaxin-like hormones |
| Q40414071 | Human recombinant relaxin reduces heart injury and improves ventricular performance in a swine model of acute myocardial infarction |
| Q92659220 | Human relaxin-2 attenuates hepatic steatosis and fibrosis in mice with non-alcoholic fatty liver disease |
| Q38031427 | Human relaxin-2: historical perspectives and role in cancer biology |
| Q47774900 | Human relaxins (RLNH1, RLNH2), their receptor (RXFP1) and fetoplacental growth |
| Q37765316 | Human testicular insulin-like factor 3: in relation to development, reproductive hormones and andrological disorders |
| Q48355239 | Hypothalamic mapping of orexigenic action and Fos-like immunoreactivity following relaxin-3 administration in male Wistar rats. |
| Q28583258 | INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent |
| Q28291581 | INSL5 is a high affinity specific agonist for GPCR142 (GPR100) |
| Q28295354 | Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7 |
| Q34771756 | Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1. |
| Q28574084 | Identification and structural characterization of the neuronal luteinizing hormone receptor associated with sensory systems |
| Q28206382 | Identification of Relaxin-3/INSL7 as a Ligand for GPCR142 |
| Q28206403 | Identification of Relaxin-3/INSL7 as an Endogenous Ligand for the Orphan G-protein-coupled Receptor GPCR135 |
| Q53745055 | Identification of hydrophobic interactions between relaxin-3 and its receptor RXFP3: implication for a conformational change in the B-chain C-terminus during receptor binding. |
| Q36436057 | Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin |
| Q24313352 | Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8 |
| Q34501476 | Identification of small-molecule agonists of human relaxin family receptor 1 (RXFP1) by using a homogenous cell-based cAMP assay |
| Q35841561 | Idiopathic pulmonary fibrosis: emerging concepts on pharmacotherapy |
| Q21093262 | Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates |
| Q28594721 | Impaired nipple development and parturition in LGR7 knockout mice |
| Q47233606 | Implantation and pregnancy following in vitro fertilization and the effect of recombinant human relaxin administration in Macaca fascicularis |
| Q26781446 | In a Class of Their Own - RXFP1 and RXFP2 are Unique Members of the LGR Family |
| Q28480533 | In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency |
| Q37021533 | Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway |
| Q45268115 | Inappropriate activation of androgen receptor by relaxin via beta-catenin pathway |
| Q47654729 | Inhibition of markers of hepatic stellate cell activation by the hormone relaxin |
| Q35044697 | Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin |
| Q36363214 | Insect neuropeptide and peptide hormone receptors: current knowledge and future directions |
| Q57572349 | Insulin-Like Factor 3: A Novel Circulating Hormone of Testicular Origin in Humans |
| Q35893296 | Insulin-like 3 signalling in testicular descent |
| Q36163317 | Insulin-like factor 3: where are we now? |
| Q47119371 | Insulin-like peptide 3 expressed in the silkworm possesses intrinsic disulfide bonds and full biological activity |
| Q40409539 | Insulin-relaxin family peptide signaling and receptors in mouse brain membranes and neuronal cells. |
| Q38330262 | Insulin/IGF signaling and its regulation in Drosophila |
| Q91849164 | Interaction of starfish gonadotropin with its receptor: Effect of chimeric relaxin-like gonad-stimulating peptides |
| Q28184238 | Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes |
| Q35383835 | International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides. |
| Q34683416 | Investigation of interactions at the extracellular loops of the relaxin family peptide receptor 1 (RXFP1). |
| Q37083919 | Involvement of Cyclic Guanosine Monophosphate-Dependent Protein Kinase I in Renal Antifibrotic Effects of Serelaxin |
| Q49066811 | Is the pregnancy hormone relaxin an important player in human heart failure? |
| Q40409559 | LGR7-truncate is a splice variant of the relaxin receptor LGR7 and is a relaxin antagonist in vitro |
| Q33281293 | Lifespan regulation by evolutionarily conserved genes essential for viability |
| Q46547368 | Localization of LGR7 (relaxin receptor) mRNA and protein in rat forebrain: correlation with relaxin binding site distribution |
| Q48853808 | Localization of LGR7 gene expression in adult mouse brain using LGR7 knock-out/LacZ knock-in mice: correlation with LGR7 mRNA distribution. |
| Q48174089 | Luteal and hypophyseal expression of the canine relaxin (RLN) system during pregnancy: Implications for luteotropic function |
| Q37375380 | Matrix metalloproteinase induction by relaxin causes cartilage matrix degradation in target synovial joints |
| Q37081723 | Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4 |
| Q36203507 | Mechanisms of renal vasodilation and hyperfiltration during pregnancy: current perspectives and potential implications for preeclampsia |
| Q64108083 | Molecular Mechanisms and Signaling Pathways Involved in Sertoli Cell Proliferation |
| Q35769881 | Molecular and genetic regulation of testis descent and external genitalia development |
| Q44160453 | Molecular characterization of insulin-like peptide genes and their expression in the African malaria mosquito, Anopheles gambiae |
| Q33203804 | Molecular cloning, sequence analysis and expression of the snake follicle-stimulating hormone receptor |
| Q34756498 | Molecular effects of proinsulin C-peptide |
| Q58911048 | Molecular mechanisms of preeclampsia |
| Q60304268 | Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis |
| Q36882876 | Multi-functional norrin is a ligand for the LGR4 receptor. |
| Q36692812 | Multiple signals regulate phospholipase CBeta3 in human myometrial cells |
| Q62089532 | Mutation analysis of INSL3 and GREAT/LGR8 genes in familial cryptorchidism |
| Q30439664 | Mutations in the insulin-like factor 3 receptor are associated with osteoporosis |
| Q35581367 | N-terminal pro B type natriuretic peptide, but not the new putative cardiac hormone relaxin, predicts prognosis in patients with chronic heart failure |
| Q24561753 | Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension |
| Q35899860 | New Drugs You Are Going to Read About: Serelaxin, Ularitide, TRV027. |
| Q36324350 | New Insights into biological roles of relaxin and relaxin-related peptides |
| Q36163304 | New insight into the transcriptional regulation of vascular endothelial growth factor expression in the endometrium by estrogen and relaxin |
| Q21296667 | New insights into ligand-receptor pairing and coevolution of relaxin family peptides and their receptors in teleosts |
| Q35208680 | New insights into the evolution of the relaxin-LGR signaling system |
| Q36092159 | New members of the insulin family: regulators of metabolism, growth and now ... reproduction |
| Q38209074 | Novel drug mechanisms in development for heart failure |
| Q37749836 | Novel neurohormonal insights with therapeutic potential in chronic heart failure |
| Q38072635 | Novel vasodilators in heart failure |
| Q90087136 | Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile |
| Q28754291 | Origin of INSL3-mediated testicular descent in therian mammals |
| Q36587371 | Paracrine and endocrine roles of insulin-like factor 3. |
| Q28566896 | Paracrine regulation of mammalian oocyte maturation and male germ cell survival |
| Q83997329 | Peptide derivatives of the LGR7 relaxin receptor control the functional activity of relaxin-sensitive adenylate cyclase |
| Q24536334 | Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands |
| Q43124940 | Phylogenomic analysis reveals extensive phylogenetic mosaicism in the human GPCR superfamily |
| Q98498361 | Physiology and evolution of the INSL3/RXFP2 hormone/receptor system in higher vertebrates |
| Q35873683 | Postgenomic characterization of G-protein-coupled receptors |
| Q30251531 | Potential new drug treatments for congestive heart failure |
| Q35085649 | Primate preimplantation embryo is a target for relaxin during early pregnancy |
| Q35653980 | Profiling of relaxin and its receptor proteins in boar reproductive tissues and spermatozoa. |
| Q50600080 | Prolonged RXFP1 and RXFP2 signaling can be explained by poor internalization and a lack of beta-arrestin recruitment. |
| Q57490061 | Protective Role of Testicular Hormone INSL3 From Atrophy and Weakness in Skeletal Muscle |
| Q35044621 | Protective effect of relaxin in cardiac anaphylaxis: involvement of the nitric oxide pathway. |
| Q44414360 | R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization. |
| Q41682526 | RLN2 Is a Positive Regulator of AKT-2-Induced Gene Expression Required for Osteosarcoma Cells Invasion and Chemoresistance |
| Q58764679 | RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice a Gα-Protein/PI3Kß/γ/Nitric Oxide-Coupled Pathway |
| Q50934711 | Rapid preparation of bioluminescent tracers for relaxin family peptides using sortase-catalysed ligation. |
| Q58701291 | Real-time examination of cAMP activity at relaxin family peptide receptors using a BRET-based biosensor |
| Q36163296 | Recent progress in relaxin-3-related research |
| Q45111906 | Recombinant expression of an insulin-like peptide 3 (INSL3) precursor and its enzymatic conversion to mature human INSL3. |
| Q38220684 | Recombinant human relaxin-2: (how) can a pregnancy hormone save lives in acute heart failure? |
| Q28756592 | Regulation of receptor signaling by relaxin A chain motifs: derivation of pan-specific and LGR7-specific human relaxin analogs |
| Q37345765 | Relative roles of the epithelial and stromal tissue compartment(s) in mediating the actions of relaxin and estrogen on cell proliferation and apoptosis in the mouse lower reproductive tract |
| Q58766683 | Relaxin 2/RXFP1 Signaling Induces Cell Invasion via the β-Catenin Pathway in Endometrial Cancer |
| Q92813124 | Relaxin Positively Influences Ischemia-Reperfusion Injury in Solid Organ Transplantation: A Comprehensive Review |
| Q36859936 | Relaxin Receptor RXFP1 and RXFP2 Expression in Ligament, Tendon, and Shoulder Joint Capsule of Rats. |
| Q34958919 | Relaxin activates peroxisome proliferator-activated receptor γ (PPARγ) through a pathway involving PPARγ coactivator 1α (PGC1α) |
| Q36578873 | Relaxin acts on stromal cells to promote epithelial and stromal proliferation and inhibit apoptosis in the mouse cervix and vagina |
| Q42477870 | Relaxin affects cell organization and early and late stages of spermatogenesis in a coculture of rat testicular cells |
| Q91648877 | Relaxin and fibrosis: Emerging targets, challenges, and future directions |
| Q38802490 | Relaxin and insulin-like peptide 3 in the musculoskeletal system: from bench to bedside |
| Q37229308 | Relaxin and its role in the development and treatment of fibrosis |
| Q36835818 | Relaxin as a natural agent for vascular health |
| Q40409483 | Relaxin downregulates the calcium binding protein S100A4 in MDA-MB-231 human breast cancer cells |
| Q35221931 | Relaxin enhances the oncogenic potential of human thyroid carcinoma cells |
| Q45863191 | Relaxin expression from tumor-targeting adenoviruses and its intratumoral spread, apoptosis induction, and efficacy |
| Q93498721 | Relaxin family peptide |
| Q37275915 | Relaxin family peptide receptor 1 activation stimulates peroxisome proliferator-activated receptor gamma |
| Q24311590 | Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms |
| Q35939966 | Relaxin family peptide receptors Rxfp1 and Rxfp2: mapping of the mRNA and protein distribution in the reproductive tract of the male rat. |
| Q24564959 | Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways |
| Q37705025 | Relaxin family peptide systems and the central nervous system. |
| Q39030385 | Relaxin family peptides: structure-activity relationship studies. |
| Q39091465 | Relaxin has anti-apoptotic effects on human trophoblast-derived HTR-8/SV neo cells |
| Q36467817 | Relaxin in cardiovascular and renal disease. |
| Q34640853 | Relaxin induces matrix-metalloproteinases-9 and -13 via RXFP1: induction of MMP-9 involves the PI3K, ERK, Akt and PKC-ζ pathways |
| Q35046881 | Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide |
| Q79074302 | Relaxin inhibits lipopolysaccharide‐induced adhesion of neutrophils to coronary endothelial cells by a nitric oxide‐mediated mechanism |
| Q28586427 | Relaxin is a key mediator of prostate growth and male reproductive tract development |
| Q34982356 | Relaxin peptide hormones are protective during the early stages of ischemic stroke in male rats. |
| Q34825770 | Relaxin peptides are new global players. |
| Q39720492 | Relaxin pretreatment decreases infarct size in male rats after middle cerebral artery occlusion |
| Q42914480 | Relaxin promotes growth and maturation of mouse neonatal cardiomyocytes in vitro: clues for cardiac regeneration |
| Q24806222 | Relaxin receptors and nitric oxide synthases: search for the missing link |
| Q36955141 | Relaxin reduces xenograft tumour growth of human MDA-MB-231 breast cancer cells |
| Q36439602 | Relaxin regulates hyaluronan synthesis and aquaporins in the cervix of late pregnant mice |
| Q36163291 | Relaxin research in the postgenomic era. |
| Q51596404 | Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload. |
| Q39807254 | Relaxin signaling activates peroxisome proliferator-activated receptor gamma |
| Q40409527 | Relaxin signaling from natural receptors |
| Q40585938 | Relaxin signaling in reproductive tissues. |
| Q33562024 | Relaxin stimulates cAMP production in MCF-7 cells upon overexpression of type V adenylyl cyclase |
| Q40348456 | Relaxin stimulates leukocyte adhesion and migration through a relaxin receptor LGR7-dependent mechanism |
| Q33757389 | Relaxin stimulates multiple signaling pathways: activation of cAMP, PI3K, and PKCzeta in THP-1 cells |
| Q38940630 | Relaxin' the Heart: A Novel Therapeutic Modality |
| Q37356318 | Relaxin, a pleiotropic vasodilator for the treatment of heart failure. |
| Q41463324 | Relaxin-2 in Cardiometabolic Diseases: Mechanisms of Action and Future Perspectives |
| Q24658067 | Relaxin-3 stimulates the hypothalamic-pituitary-gonadal axis |
| Q33766119 | Relaxin-Family Peptide Receptors 1 and 2 Are Fully Functional in the Bovine |
| Q46547365 | Relaxin-induced angiogenesis in ovary contributes to follicle development |
| Q45075430 | Relaxin-induced changes in renal sodium excretion in the anesthetized male rat. |
| Q40684572 | Relaxin-like bioactivity of ovine Insulin 3 (INSL3) analogues |
| Q39909562 | Relaxin-like factor (RLF)/insulin-like peptide 3 (INSL3) is secreted from testicular Leydig cells as a monomeric protein comprising three domains B-C-A with full biological activity in boars. |
| Q39856605 | Relaxin/RXFP1 signaling in prostate cancer progression |
| Q38373223 | Relaxin: a novel agent for the treatment of acute heart failure |
| Q34146511 | Relaxin: antifibrotic properties and effects in models of disease |
| Q38080804 | Relaxin: new pathophysiological aspects and pharmacological perspectives for an old protein |
| Q33873275 | Relaxin: review of biology and potential role in treating heart failure |
| Q35547829 | Relaxin‐like peptides in cancer |
| Q38383238 | Renal impairment and worsening of renal function in acute heart failure: can new therapies help? The potential role of serelaxin |
| Q45050521 | Reperfusion therapy with recombinant human relaxin-2 (Serelaxin) attenuates myocardial infarct size and NLRP3 inflammasome following ischemia/reperfusion injury via eNOS-dependent mechanism |
| Q34794707 | Reproductive biology of the relaxin-like factor (RLF/INSL3). |
| Q48853760 | Restricted expression of LGR8 in intralaminar thalamic nuclei of rat brain suggests a role in sensorimotor systems. |
| Q57572358 | Role of INSL3 and LGR8 in cryptorchidism and testicular functions |
| Q39032858 | Secretory overexpression and isotopic labeling of the chimeric relaxin family peptide R3/I5 in Pichia pastoris |
| Q38215304 | Serelaxin : a potential new drug for the treatment of acute heart failure |
| Q90746332 | Serelaxin alleviates cardiac fibrosis through inhibiting endothelial-to-mesenchymal transition via RXFP1 |
| Q38798476 | Serelaxin for the treatment of heart failure |
| Q36318249 | Serum relaxin levels as a novel biomarker for detection of acute myocardial infarction |
| Q29619896 | Seven-transmembrane receptors |
| Q28256577 | Signal switching after stimulation of LGR7 receptors by human relaxin 2 |
| Q40409516 | Signaling pathways of the LGR7 and LGR8 receptors determined by reporter genes |
| Q34207111 | Signaling receptome: a genomic and evolutionary perspective of plasma membrane receptors involved in signal transduction |
| Q48037448 | Simultaneously Targeting Myofibroblast Contractility and Extracellular Matrix Cross-Linking as a Therapeutic Concept in Airway Fibrosis. |
| Q39673607 | Site-specific DOTA/europium-labeling of recombinant human relaxin-3 for receptor-ligand interaction studies |
| Q47736912 | Skeletal myoblasts overexpressing relaxin improve differentiation and communication of primary murine cardiomyocyte cell cultures |
| Q34478007 | Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3. |
| Q27653164 | Solution structure of a conformationally restricted fully active derivative of the human relaxin-like factor |
| Q33735961 | Spatio-temporal expression profile of stem cell-associated gene LGR5 in the intestine during thyroid hormone-dependent metamorphosis in Xenopus laevis |
| Q28264243 | Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity |
| Q64983553 | Staphylococcus epidermidis is involved in a mechanism for female reproduction in mice. |
| Q64055035 | Starfish Gonadotropic Hormone: From Gamete-Shedding Substance to Relaxin-Like Gonad-Stimulating Peptide |
| Q37472847 | Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists |
| Q36202062 | Structural biology of glycoprotein hormones and their receptors |
| Q29616716 | Structural diversity of G protein-coupled receptors and significance for drug discovery |
| Q44237456 | Structural requirements for the interaction of sheep insulin-like factor 3 with relaxin receptors in rat atria |
| Q27650936 | Structure of the R3/I5 Chimeric Relaxin Peptide, a Selective GPCR135 and GPCR142 Agonist |
| Q80975645 | Studies of the molecular mechanisms of action of relaxin on the adenylyl cyclase signaling system using synthetic peptides derived from the LGR7 relaxin receptor |
| Q40409551 | Studies on soluble ectodomain proteins of relaxin (LGR7) and insulin 3 (LGR8) receptors. |
| Q24293265 | Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex |
| Q30575864 | Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization |
| Q38807047 | Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1. |
| Q34559725 | T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane |
| Q38231840 | Targeting the relaxin hormonal pathway in prostate cancer. |
| Q30486707 | The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors |
| Q46232213 | The Intracellular Effect of Relaxin on Female Anterior Cruciate Ligament Cells |
| Q40325392 | The R273H p53 mutation can facilitate the androgen-independent growth of LNCaP by a mechanism that involves H2 relaxin and its cognate receptor LGR7. |
| Q52851745 | The actions of relaxin on the human cardiovascular system. |
| Q30992109 | The chemistry and biology of human relaxin-3. |
| Q36815189 | The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1 |
| Q36367155 | The different ligand-binding modes of relaxin family peptide receptors RXFP1 and RXFP2 |
| Q46562059 | The effects of blocking the actions of estrogen and progesterone on the rates of proliferation and apoptosis of cervical epithelial and stromal cells during the second half of pregnancy in rats |
| Q24297116 | The electrostatic interactions of relaxin-3 with receptor RXFP4 and the influence of its B-chain C-terminal conformation |
| Q37147122 | The emerging role of relaxin as a novel therapeutic pathway in the treatment of chronic kidney disease |
| Q43592780 | The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3. |
| Q28256544 | The human LGR7 low-density lipoprotein class A module requires calcium for structure |
| Q43489034 | The human insulin superfamily of polypeptide hormones |
| Q34584710 | The human relaxin receptor (LGR7): expression in the fetal membranes and placenta |
| Q40109540 | The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells. |
| Q54329962 | The metastatic potential of canine mammary tumours can be assessed by mRNA expression analysis of connective tissue modulators. |
| Q53243282 | The miR-363-GATA6-Lgr5 pathway is critical for colorectal tumourigenesis. |
| Q35423895 | The minimal active structure of human relaxin-2 |
| Q35069888 | The orl rat is more responsive to methacholine challenge than wild type |
| Q34426610 | The pregnancy hormone relaxin binds to and activates the human glucocorticoid receptor. |
| Q24792242 | The prolactin and growth hormone families: pregnancy-specific hormones/cytokines at the maternal-fetal interface |
| Q38744356 | The relationship of circulating relaxin-2 concentrations with short-term prognosis in patients with acute heart failure: the RELAHF study |
| Q89890444 | The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease |
| Q34431687 | The relaxin family peptide receptors and their ligands: new developments and paradigms in the evolution from jawless fish to mammals |
| Q30352669 | The relaxin receptor (RXFP1) utilizes hydrophobic moieties on a signaling surface of its N-terminal low density lipoprotein class A module to mediate receptor activation. |
| Q34754727 | The role of RXFP2 in mediating androgen-induced inguinoscrotal testis descent in LH receptor knockout mice |
| Q35972135 | The structural determinants of insulin-like Peptide 3 activity |
| Q28306165 | The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7 |
| Q24552114 | Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor |
| Q89556458 | Tissue-specific relaxin-2 is differentially associated with the presence/size of an arterial aneurysm and the severity of atherosclerotic disease in humans |
| Q46610827 | Transgene insertion on mouse chromosome 6 impairs function of the uterine cervix and causes failure of parturition. |
| Q37103863 | Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration |
| Q24792157 | Trophoblast-uterine interactions at implantation |
| Q34211198 | Two insulin-like peptide family members from the mosquito Aedes aegypti exhibit differential biological and receptor binding activities |
| Q34009712 | Upregulation of relaxin after experimental subarachnoid hemorrhage in rabbits |
| Q38436608 | Upregulation of relaxin receptors in the PDL by biophysical force. |
| Q74752787 | Use of defined-function mutants to access receptor-receptor interactions |
| Q40414083 | Use of relaxin in orthodontics |
| Q92435331 | Using the novel HiBiT tag to label cell surface relaxin receptors for BRET proximity analysis |
| Q39895267 | daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway |
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