Potential new drug treatments for congestive heart failure

scientific article

Potential new drug treatments for congestive heart failure is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1080/13543784.2016.1181749
P698PubMed publication ID27104862

P2093author name stringBarry H Greenberg
Felice Lin
Hao A Tran
P2860cites workActivation of orphan receptors by the hormone relaxinQ24292229
Epidemiology and risk profile of heart failureQ24630778
Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of CardiologyQ27024879
Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclaseQ27661554
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.Q27824766
Effect of nesiritide in patients with acute decompensated heart failureQ28242547
Angiotensin-neprilysin inhibition versus enalapril in heart failureQ28247091
Haemodynamic and renal effects of urodilatin in healthy volunteersQ54271784
Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromesQ57628743
Rationale and design of ARTS: a randomized, double-blind study of BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney diseaseQ57911462
Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injuryQ28252995
Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled studyQ28291971
Levosimendan vs dobutamine for patients with acute decompensated heart failure: the SURVIVE Randomized TrialQ28300233
The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study InvestigatorsQ28372091
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathyQ28593656
Heart disease and stroke statistics--2014 update: a report from the American Heart AssociationQ29547691
Cardiac myosin activation: a potential therapeutic approach for systolic heart failureQ30583292
Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: a systematic overview of data from individual patients. ACE-Inhibitor Myocardial Infarction Collaborative GroupQ30596519
Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial--the Losartan Heart Failure Survival Study ELITE II.Q31383623
Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research GroupQ33157410
Hemodynamic and renal effects of low-dose brain natriuretic peptide infusion in humans: a randomized, placebo-controlled crossover studyQ33186937
Cardiac myosin activation part 1: from concept to clinicQ33913192
Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome TrialQ34003169
Pharmacologic therapy for pulmonary arterial hypertension in adults: CHEST guideline and expert panel reportQ34064492
A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failureQ34106793
Improvement of cardiac function by a cardiac Myosin activator in conscious dogs with systolic heart failureQ34117227
Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance.Q34134694
Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarctionQ34187441
Cardiorenal actions of TRV120027, a novel ß-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failureQ34207537
Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man studyQ34209528
The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial.Q34209536
Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trialQ34310960
Rationale and design of MinerAlocorticoid Receptor antagonist Tolerability Study-Heart Failure (ARTS-HF): a randomized study of finerenone vs. eplerenone in patients who have worsening chronic heart failure with diabetes and/or chronic kidney diseasQ34462504
Role of neprilysin inhibitor combinations in hypertension: insights from hypertension and heart failure trialsQ34472913
Nonsteroidal antagonists of the mineralocorticoid receptorQ34481103
Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failureQ34620874
ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with theQ34640762
Effect of serelaxin on cardiac, renal, and hepatic biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) development program: correlation with outcomesQ34646866
Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS).Q34682919
Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxideQ35046881
The natriuretic peptides in cardiovascular medicineQ35954254
A review of the renal and neurohormonal effects of B-type natriuretic peptideQ36050051
Emerging therapies for the management of decompensated heart failure: from bench to bedsideQ36686323
C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic targetQ36708991
Urodilatin: a better natriuretic peptide?Q36947430
Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trialQ37094366
Neuregulin in cardiovascular development and diseaseQ37118330
The role of Neuregulin-1beta/ErbB signaling in the heartQ37155921
Cyclic GMP signaling in cardiovascular pathophysiology and therapeuticsQ37420916
Learning from recent trials and shaping the future of acute heart failure trialsQ37531278
Role of guanylate cyclase modulators in decompensated heart failureQ37537154
Forecasting the impact of heart failure in the United States: a policy statement from the American Heart AssociationQ37538031
Acute intravenous injection of serelaxin (recombinant human relaxin-2) causes rapid and sustained bradykinin-mediated vasorelaxation.Q37648577
The vulnerability of the heart as a pluricellular paracrine organ: lessons from unexpected triggers of heart failure in targeted ErbB2 anticancer therapyQ37670521
Cell death in the pathogenesis of heart disease: mechanisms and significanceQ37690704
Renin-angiotensin blockade combined with natriuretic peptide system augmentation: novel therapeutic concepts to combat heart failureQ37694008
Molecular pharmacology of the mineralocorticoid receptor: prospects for novel therapeuticsQ37902778
CONSENSUS to EMPHASIS: the overwhelming evidence which makes blockade of the renin-angiotensin-aldosterone system the cornerstone of therapy for systolic heart failure.Q37911729
Soluble guanylate cyclase: a potential therapeutic target for heart failureQ38012596
Serelaxin : a potential new drug for the treatment of acute heart failureQ38215304
Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction: The SOCRATES-REDUCED Randomized TrialQ38400549
Riociguat for patients with pulmonary hypertension caused by systolic left ventricular dysfunction: a phase IIb double-blind, randomized, placebo-controlled, dose-ranging hemodynamic study.Q38449826
Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure: the ASTRONAUT randomized trialQ38454911
Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responsesQ38500442
Riociguat: a novel new drug for treatment of pulmonary hypertensionQ38502798
Effect of levosimendan on the short-term clinical course of patients with acutely decompensated heart failure.Q39210310
Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study.Q39305717
G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics.Q40226288
Atrial natriuretic factor: Its (patho)physiological significance in humansQ42599434
Intravenous recombinant human relaxin in compensated heart failure: a safety, tolerability, and pharmacodynamic trial.Q42616224
The Role of Neprilysin Inhibitors in Cardiovascular DiseaseQ42700358
Use of aldosterone antagonists in heart failureQ43258043
Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial.Q44074134
Eplerenone in patients with systolic heart failure and mild symptomsQ44272913
First clinical experience with TRV027: pharmacokinetics and pharmacodynamics in healthy volunteersQ44339339
EURObservational Research Programme: the Heart Failure Pilot Survey (ESC-HF Pilot).Q46414626
Dilated cardiomyopathy in Erb-b4-deficient ventricular muscleQ46465736
Meta-analysis: angiotensin-receptor blockers in chronic heart failure and high-risk acute myocardial infarctionQ46708478
Effects of the renal natriuretic peptide urodilatin (ularitide) in patients with decompensated chronic heart failure: a double-blind, placebo-controlled, ascending-dose trialQ46843197
Rationale and design of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES).Q48640874
Intravenous nesiritide, a natriuretic peptide, in the treatment of decompensated congestive heart failure. Nesiritide Study Group.Q53907769
Comparison of candoxatril and atrial natriuretic factor in healthy men. Effects on hemodynamics, sympathetic activity, heart rate variability, and endothelin.Q54157090
Haemodynamic and renal effects of urodilatin bolus injections in patients with congestive heart failureQ54261496
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectcongestive heart failureQ19000661
P304page(s)811-826
P577publication date2016-04-22
P1433published inExpert Opinion on Investigational DrugsQ5421208
P1476titlePotential new drug treatments for congestive heart failure
P478volume25

Reverse relations

cites work (P2860)
Q88599261Drugs' development in acute heart failure: what went wrong?
Q38987955Evolving therapies for the management of chronic and acute decompensated heart failure
Q53545050Identification of porcine relaxin in plasma by liquid chromatography-high resolution mass spectrometry.
Q90751712Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure
Q38827338Therapeutic Potential of Nitroxyl (HNO) Donors in the Management of Acute Decompensated Heart Failure

Search more.