Improvement of cardiac function by a cardiac Myosin activator in conscious dogs with systolic heart failure

scientific article

Improvement of cardiac function by a cardiac Myosin activator in conscious dogs with systolic heart failure is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1161/CIRCHEARTFAILURE.109.930321
P698PubMed publication ID20498236

P50authorStephen F VatnerQ96766914
P2093author name stringXin Zhao
Christophe Depre
Patricio Abarzúa
Fady I Malik
You-Tang Shen
Sunil K Dhar
David J Morgans
P433issue4
P921main subjectheart failureQ181754
systolic heart failureQ17326470
systoleQ496359
P304page(s)522-527
P577publication date2010-05-24
P1433published inCirculation: Heart FailureQ2865806
P1476titleImprovement of cardiac function by a cardiac Myosin activator in conscious dogs with systolic heart failure
P478volume3

Reverse relations

cites work (P2860)
Q37139621A myosin activator improves actin assembly and sarcomere function of human-induced pluripotent stem cell-derived cardiomyocytes with a troponin T point mutation
Q35315333A new model of congestive heart failure in rats
Q87990980Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues
Q85798807Alterations in cardiac structure and function in a modified rat model of myocardial hypertrophy
Q34070160Analytical comparison of natural and pharmaceutical ventricular myosin activators
Q38139089Antagonist molecules in the treatment of angina
Q38939243Cardiac Myosin Activators in Systolic Heart Failure: More Friend than Foe?
Q37851240Cardiac inotropes: current agents and future directions
Q33913192Cardiac myosin activation part 1: from concept to clinic
Q30583292Cardiac myosin activation: a potential therapeutic approach for systolic heart failure
Q84799461Cardiac myosin activation: will theory and practice coincide?
Q55025652Cardiac myosin activators for heart failure therapy: focus on omecamtiv mecarbil.
Q45989354Cardiac myosin activators: up and coming.
Q64080564Cardioprotective Properties of Omecamtiv Mecarbil against Ischemia and Reperfusion Injury
Q37402519Changes in cardiac structure and function in a modified rat model of myocardial hypertrophy
Q39776361Characterization of an investigative safety pharmacology model to assess comprehensive cardiac function and structure in chronically instrumented conscious beagle dogs
Q44655145Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF): a phase 2, pharmacokinetic, randomised, placebo-controlled trial
Q46143451Direct Myosin Activation by Omecamtiv Mecarbil for Heart Failure with Reduced Ejection Fraction
Q39155695Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin.
Q34209528Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study
Q88599261Drugs' development in acute heart failure: what went wrong?
Q55286667Effects of the cardiac myosin activator Omecamtiv-mecarbil on severe chronic aortic regurgitation in Wistar rats.
Q92443501Engineered Cardiac Tissues Generated in the Biowire™ II: A Platform for Human-Based Drug Discovery
Q37363558Focal energy deprivation underlies arrhythmia susceptibility in mice with calcium-sensitized myofilaments
Q49907634Frequency-dependent effects of omecamtiv mecarbil on cell shortening of isolated canine ventricular cardiomyocytes.
Q38780801From Bench to Bedside: New Approaches to Therapeutic Discovery for Heart Failure
Q38376055Heart failure: novel therapeutic approaches
Q37258267Incorporating development of a patient-reported outcome instrument in a clinical drug development program: examples from a heart failure program
Q33894414Influence of metabolic dysfunction on cardiac mechanics in decompensated hypertrophy and heart failure
Q35265639Inhibition of smooth muscle myosin as a novel therapeutic target for hypertension
Q38208442Inotropes and inodilators for acute heart failure: sarcomere active drugs in focus
Q43161763Letter by Teerlink et al Regarding Article, "Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity".
Q41242943Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil
Q37920401Medical therapy for chronic heart failure
Q99546570Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts
Q36341946Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C
Q47572193New heart failure pharmacotherapy in clinical trials: a hope in progress
Q38594785New medical therapies for heart failure
Q92069739New perspective in heart failure management: could myosin activators be the answer?
Q38759494New pharmacological approaches in heart failure therapy: developments and possibilities.
Q38209074Novel drug mechanisms in development for heart failure
Q41856322Novel strategies for the treatment of heart failure
Q46650156Omecamtiv Mecarbil Abolishes Length-Mediated Increase in Guinea Pig Cardiac Myofiber Ca2+ Sensitivity
Q33768442Omecamtiv Mecarbil, a Cardiac Myosin Activator, Increases Ca2+ Sensitivity in Myofilaments With a Dilated Cardiomyopathy Mutant Tropomyosin E54K.
Q38639973Omecamtiv mecarbil: a new cardiac myosin activator for the treatment of heart failure
Q57316359Omecamtiv mecarbil: a promising new drug in systolic heart failure
Q36972415Pharmacological Strategies to Retard Cardiovascular Aging
Q40964821Population pharmacokinetic-pharmacodynamic modeling of omecamtiv mecarbil, a cardiac myosin activator, in healthy volunteers and patients with stable heart failure
Q30251531Potential new drug treatments for congestive heart failure
Q58784267Prolonged cross-bridge binding triggers muscle dysfunction in a model of myosin-based hypertrophic cardiomyopathy
Q38478051RNA-sequencing analysis reveals new alterations in cardiomyocyte cytoskeletal genes in patients with heart failure
Q36645693Relative bioavailability, food effect, and safety of the single-dose pharmacokinetics of omecamtiv mecarbil following administration of different modified-release formulations in healthy subjects
Q90446344Shock - Classification and Pathophysiological Principles of Therapeutics
Q37031923Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity
Q27024879Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology
Q34209536The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial.
Q38870685The myosin activator omecamtiv mecarbil: a promising new inotropic agent
Q36036237The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat
Q42278153The role of super-relaxed myosin in skeletal and cardiac muscle
Q30582828Thin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts
Q37858515Use of inotropic agents in patients with advanced heart failure: lessons from recent trials and hopes for new agents
Q41021204Why So Few New Cardiovascular Drugs Translate to the Clinics

Search more.