Disease-associated GPR56 Mutations Cause Bilateral Frontoparietal Polymicrogyria via Multiple Mechanisms

scientific article published on February 24, 2011

Disease-associated GPR56 Mutations Cause Bilateral Frontoparietal Polymicrogyria via Multiple Mechanisms is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M110.183830
P953full work available online athttp://intl.jbc.org/cgi/content/abstract/286/16/14215
http://www.jbc.org/article/S0021925820515160/pdf
https://api.elsevier.com/content/article/PII:S0021925820515160?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0021925820515160?httpAccept=text/xml
https://doi.org/10.1074/jbc.m110.183830
https://europepmc.org/articles/PMC3077623
https://europepmc.org/articles/PMC3077623?pdf=render
https://syndication.highwire.org/content/doi/10.1074/jbc.M110.183830
P932PMC publication ID3077623
P698PubMed publication ID21349848
P5875ResearchGate publication ID50195903

P50authorYi-Shu HuangQ89165649
P2093author name stringHsin-Yi Chen
Hsi-Hsien Lin
Cheng-Chih Hsiao
Gin-Wen Chang
I-Ju Hsieh
Nien-Yi Chiang
P2860cites workGPR56, a novel secretin-like human G-protein-coupled receptor geneQ22008816
GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasisQ24292757
The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycansQ24306406
G protein-coupled receptor-dependent development of human frontal cortexQ24321319
GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesionQ28118812
Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motifQ28262398
GPR56 regulates pial basement membrane integrity and cortical laminationQ28590062
GPR56-regulated granule cell adhesion is essential for rostral cerebellar developmentQ30490239
Post-translational proteolytic processing of the calcium-independent receptor of alpha-latrotoxin (CIRL), a natural chimera of the cell adhesion protein and the G protein-coupled receptor. Role of the G protein-coupled receptor proteolysis site [...]Q31110558
LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptorsQ33934150
GPR56 as a novel marker identifying the CD56dull CD16+ NK cell subset both in blood stream and in inflamed peripheral tissues.Q34087961
Genotype-phenotype analysis of human frontoparietal polymicrogyria syndromesQ34461647
Disease-associated mutations affect GPR56 protein trafficking and cell surface expression.Q34638842
Biochemical characterization of genetic mutations of GPR56 in patients with bilateral frontoparietal polymicrogyria (BFPP).Q34718685
Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a G alpha 12/13 and Rho pathway.Q34766205
G proteins in cancer: the prostate cancer paradigmQ35634255
Inherited diseases involving g proteins and g protein-coupled receptors.Q35640200
GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironmentQ36741906
G-protein-coupled receptor expression, function, and signaling in macrophagesQ36800734
Regulation of G-protein-coupled signaling pathways in allergic inflammationQ37204048
Adhesion-GPCRs: emerging roles for novel receptorsQ37267849
Latrophilin fragments behave as independent proteins that associate and signal on binding of LTX(N4C).Q37605159
GPCR interacting proteins (GIPs) in the nervous system: Roles in physiology and pathologiesQ37670210
Site-specific N-glycosylation regulates the GPS auto-proteolysis of CD97.Q39802247
Functional cross-interaction of the fragments produced by the cleavage of distinct adhesion G-protein-coupled receptors.Q39898517
Method for selecting and enriching cells expressing low affinity ligands for cell surface receptorsQ40411778
TM7XN1, a novel human EGF-TM7-like cDNA, detected with mRNA differential display using human melanoma cell lines with different metastatic potentialQ47976006
Bilateral frontoparietal polymicrogyria (BFPP) syndrome secondary to a 16q12.1-q21 chromosome deletion involving GPR56 geneQ56232673
The role of receptor oligomerization in modulating the expression and function of leukocyte adhesion-G protein-coupled receptorsQ80589077
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
polymicrogyriaQ2991265
Bilateral frontoparietal polymicrogyriaQ4907578
positive regulation of cell adhesionQ14860526
adhesion G protein-coupled receptor G1Q21425642
P304page(s)14215-25
P577publication date2011-02-24
2011-04-22
P1433published inJournal of Biological ChemistryQ867727
P1476titleDisease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms
Disease-associated GPR56 Mutations Cause Bilateral Frontoparietal Polymicrogyria via Multiple Mechanisms
P478volume286

Reverse relations

cites work (P2860)
Q34298001A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity
Q28259067Activation of Myeloid Cell-Specific Adhesion Class G Protein-Coupled Receptor EMR2 via Ligation-Induced Translocation and Interaction of Receptor Subunits in Lipid Raft Microdomains
Q47190670Adhesion G Protein-Coupled Receptors as Drug Targets
Q92966015Adhesion G protein-coupled receptors: opportunities for drug discovery
Q36335604Adhesion G protein-coupled receptors: signaling, pharmacology, and mechanisms of activation
Q24294618Cell adhesion receptor GPR133 couples to Gs protein
Q34320039Conventional magnetic resonance imaging and diffusion tensor imaging studies in children with novel GPR56 mutations: further delineation of a cobblestone-like phenotype
Q35104663Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish
Q52150565Degree of Cajal-Retzius Cell Mislocalization Correlates with the Severity of Structural Brain Defects in Mouse Models of Dystroglycanopathy
Q37992627Developmental disorders of the midbrain and hindbrain
Q36060390Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist
Q38706852Disease-associated extracellular loop mutations in the adhesion G protein-coupled receptor G1 (ADGRG1; GPR56) differentially regulate downstream signaling
Q21090961Disease-associated mutations prevent GPR56-collagen III interaction
Q34301363GPR56 and the developing cerebral cortex: cells, matrix, and neuronal migration
Q42004258GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2.
Q48203864GPR56-Related Polymicrogyria: Clinicoradiologic Profile of 4 Patients
Q92296632Genetic basis of functional variability in adhesion G protein-coupled receptors
Q35192004Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation.
Q52655365Membrane-association of EMR2/ADGRE2-NTF is regulated by site-specific N-glycosylation
Q38091854Midbrain and hindbrain malformations: advances in clinical diagnosis, imaging, and genetics.
Q34197122Specific expression of GPR56 by human cytotoxic lymphocytes.
Q36573973Stalk-dependent and Stalk-independent Signaling by the Adhesion G Protein-coupled Receptors GPR56 (ADGRG1) and BAI1 (ADGRB1)
Q28291130Sticky signaling--adhesion class G protein-coupled receptors take the stage
Q41182997Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains
Q58795528The Activation and Signaling Mechanisms of GPR56/ADGRG1 in Melanoma Cell
Q26864858The BAI subfamily of adhesion GPCRs: synaptic regulation and beyond
Q34458989The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development.
Q26768149The integrin-collagen connection--a glue for tissue repair?
Q56232629Three Mutations in the Bilateral Frontoparietal Polymicrogyria Gene in Pakistani Intellectual Disability Families
Q39004692Versatile Signaling Activity of Adhesion GPCRs
Q56232645Vigabatrin efficacy in GPR56-associated polymicrogyria: The role of GABAA receptor pathway

Search more.