In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets

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In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets is …
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scholarly articleQ13442814

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P356DOI10.1677/JOE-10-0120
P8608Fatcat IDrelease_t7n5hbmgvvglpg2p5eb6g7c52q
P932PMC publication ID2951179
P698PubMed publication ID20807725
P5875ResearchGate publication ID46107473

P50authorTom HearnQ42506876
David I. WilsonQ57320695
Sian EllardQ58327173
Sarah SugdenQ40009650
Karen Piper HanleyQ40009685
Neil A. HanleyQ40009724
P2093author name stringAndrew Berry
Ann-Marie Patch
Louise J Williams
Melanie J Carvell
P2860cites workFunctional enhancement and protection of dopaminergic terminals by RAB3B overexpressionQ22001521
Neurogenin3 activates the islet differentiation program while repressing its own expressionQ24298415
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreasQ24306349
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetesQ24338339
The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granulesQ24539832
neurogenin3 is required for the development of the four endocrine cell lineages of the pancreasQ24647944
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3Q24674625
Low levels of glucose transporters and K+ATP channels in human pancreatic beta cells early in development.Q27865188
Notch signalling controls pancreatic cell differentiationQ28504686
Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cellsQ28506010
Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretionQ28510313
SOX9 is required for maintenance of the pancreatic progenitor cell poolQ28510325
Expression of neurogenin3 reveals an islet cell precursor population in the pancreasQ40867538
Is GLUT2 required for glucose sensing?Q41348402
Insulin secretory deficiency and glucose intolerance in Rab3A null miceQ44268165
The development of new density gradient media for purifying human islets and islet-quality assessmentsQ44728999
Ex vivo analysis of acinar and endocrine cell development in the human embryonic pancreas.Q46679922
The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1.Q46910146
Beta cell differentiation during early human pancreas developmentQ47795996
A complete genetic analysis of neuronal Rab3 function.Q47952687
Novel SOX9 expression during human pancreas development correlates to abnormalities in Campomelic dysplasia.Q52117028
Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene.Q52522147
p57Kip2 (cdkn1c): sequence, splice variants and unique temporal and spatial expression pattern in the rat pancreasQ57499701
The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreasQ59069706
Canine, human, and rat plasma insulin responses to galanin administration: species response differencesQ71622914
Early pattern of differentiation in the human pancreasQ73929081
Glucose-induced desensitization of the pancreatic beta-cell is species dependentQ77649463
Mutant neurogenin-3 in congenital malabsorptive diarrheaQ80219406
cAMP-GEFII is a direct target of cAMP in regulated exocytosisQ28512994
Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosisQ28586557
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitorsQ29619012
Pdx1 and BETA2/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin geneQ30439989
Proendocrine genes coordinate the pancreatic islet differentiation program in vitroQ30448603
Distinct role of Rab3A and Rab3B in secretory activity of rat melanotrophsQ33249017
Regulation of membrane trafficking: structural insights from a Rab/effector complexQ33548065
Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulationQ33777882
beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factorsQ33939828
Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3.Q33963287
Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24.Q33963885
Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferationQ34020996
Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosisQ34281843
Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cellsQ34404247
Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function.Q34427073
ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosisQ34468268
Mutant neurogenin-3 in congenital malabsorptive diarrheaQ34549325
Beta cells can be generated from endogenous progenitors in injured adult mouse pancreasQ34744604
Gene expression cascades in pancreatic developmentQ35029666
Sox9 coordinates a transcriptional network in pancreatic progenitor cellsQ35973342
Rab27a: a new face in beta cell metabolism-secretion couplingQ36029242
Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosisQ36125027
Human embryo and early fetus researchQ36551960
Comparative analysis of insulin gene promoters: implications for diabetes researchQ36666021
Pancreas and beta-cell development: from the actual to the possibleQ36690767
Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cellsQ36979725
Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development.Q38338055
Ectopic SOX9 mediates extracellular matrix deposition characteristic of organ fibrosisQ40009427
Function and expression of melatonin receptors on human pancreatic isletsQ40025366
A key role for beta-cell cytosolic phospholipase A(2) in the maintenance of insulin stores but not in the initiation of insulin secretionQ40760882
Expression profiles of SF-1, DAX1, and CYP17 in the human fetal adrenal gland: potential interactions in gene regulationQ40833873
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectNeurogenin 3Q21119142
RAB3B, member RAS oncogene familyQ21135210
P304page(s)151-61
P577publication date2010-11-01
P1433published inJournal of EndocrinologyQ6295150
P1476titleIn vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets
P478volume207

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cites work (P2860)
Q48235399Cellular and molecular mechanisms coordinating pancreas development
Q47294747Consequences of Rab GTPase dysfunction in genetic or acquired human diseases
Q37193414Development of the human pancreas from foregut to endocrine commitment.
Q52609387Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors.
Q35196346Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells.
Q34319297Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion
Q41128616Insulin regulates Rab3-Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes
Q38021286Lineage determinants in early endocrine development
Q37845287Pancreas organogenesis: from bud to plexus to gland
Q46501784Pathways governing development of stem cell-derived pancreatic β cells: lessons from embryogenesis.
Q38822498Revisiting the immunocytochemical detection of Neurogenin 3 expression in mouse and man.
Q34472666The stress of starvation: glucocorticoid restraint of beta cell development
Q35222865The window period of NEUROGENIN3 during human gestation

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