scholarly article | Q13442814 |
P2093 | author name string | David H Ellison | |
Chao-Ling Yang | |||
Xiaoman Zhu | |||
P2860 | cites work | WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis | Q24294248 |
Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway | Q24305919 | ||
Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms | Q24537454 | ||
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4 | Q24541348 | ||
WNK kinases, a novel protein kinase subfamily in multi-cellular organisms | Q28188729 | ||
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE> | Q28204197 | ||
Regulation of WNK1 by an autoinhibitory domain and autophosphorylation | Q28206619 | ||
Human hypertension caused by mutations in WNK kinases | Q28212182 | ||
The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion | Q28255750 | ||
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion | Q28506376 | ||
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform | Q28567514 | ||
WNK1 affects surface expression of the ROMK potassium channel independent of WNK4 | Q28571983 | ||
Comparison of WNK4 and WNK1 kinase and inhibiting activities | Q28580008 | ||
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II | Q28581920 | ||
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases | Q28583124 | ||
WNK kinases regulate thiazide-sensitive Na-Cl cotransport | Q28584824 | ||
Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention | Q28591574 | ||
Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells | Q30781595 | ||
Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome. | Q31039816 | ||
Molecular mechanisms of human hypertension | Q32138445 | ||
Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport | Q33736529 | ||
Mammalian distal tubule: physiology, pathophysiology, and molecular anatomy | Q33807213 | ||
Negative regulators of sodium transport in the kidney: key factors in understanding salt-sensitive hypertension? | Q34187739 | ||
Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3). | Q34326671 | ||
WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells | Q34524228 | ||
WNK1 kinase isoform switch regulates renal potassium excretion. | Q34694518 | ||
WNK kinases: molecular regulators of integrated epithelial ion transport | Q35858400 | ||
Sodium and potassium handling by the aldosterone-sensitive distal nephron: the pivotal role of the distal and connecting tubule | Q35877684 | ||
Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension | Q36002090 | ||
Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters. | Q36079002 | ||
WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters | Q36600738 | ||
WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1). | Q40339717 | ||
Properties of WNK1 and implications for other family members | Q40424747 | ||
Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells | Q40441541 | ||
Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density | Q44055170 | ||
A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene | Q46585008 | ||
Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo. | Q50646202 | ||
A molecular switch controlling renal sodium and potassium excretion | Q79333308 | ||
Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule | Q80238253 | ||
Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model | Q80292340 | ||
P433 | issue | 11 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | protein serine/threonine kinase activity | Q14326094 |
WNK lysine deficient protein kinase 3 | Q21112960 | ||
P304 | page(s) | 3403-11 | |
P577 | publication date | 2007-11-01 | |
P1433 | published in | Journal of Clinical Investigation | Q3186904 |
P1476 | title | The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex | |
P478 | volume | 117 |
Q36425591 | A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo |
Q27000474 | A molecular update on pseudohypoaldosteronism type II |
Q38003087 | Advances in WNK signaling of salt and potassium metabolism: clinical implications |
Q41966666 | Aldosterone does not require angiotensin II to activate NCC through a WNK4-SPAK-dependent pathway |
Q37328447 | Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. |
Q37864472 | Aldosterone paradox: differential regulation of ion transport in distal nephron. |
Q34462143 | Altered expression of regulators of the cortical chloride transporters NKCC1 and KCC2 in schizophrenia |
Q40328947 | Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling |
Q36106011 | Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action |
Q41372396 | CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension |
Q35882568 | Critical role of the SPAK protein kinase CCT domain in controlling blood pressure |
Q34241490 | Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension |
Q36414701 | Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension |
Q28592337 | Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone |
Q52975643 | Distal convoluted tubule. |
Q24641916 | Domains of WNK1 kinase in the regulation of ROMK1 |
Q54532817 | Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels. |
Q37619138 | Enhanced phosphorylation of Na(+)-Cl- co-transporter in experimental metabolic syndrome: role of insulin |
Q38335855 | Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension |
Q37934598 | Exploring the intricate regulatory network controlling the thiazide-sensitive NaCl cotransporter (NCC). |
Q37337316 | Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1. |
Q43120944 | Familial Hyperkalemic Hypertension: A New Early-onset Pediatric Case |
Q48542753 | Functionomics of NCC mutations in Gitelman syndrome using a novel mammalian cell-based activity assay. |
Q47105803 | GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase |
Q35086469 | Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing |
Q90612398 | Hereditary causes of primary aldosteronism and other disorders of apparent excess mineralocorticoid activity |
Q37603366 | Hereditary tubular transport disorders: implications for renal handling of Ca2+ and Mg2+. |
Q34985526 | Insulin resistance, obesity, hypertension, and renal sodium transport |
Q36368224 | Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity |
Q47678208 | K+-induced natriuresis is preserved during Na+ depletion and accompanied by inhibition of the Na+-Cl- cotransporter |
Q36099458 | Kidney kinase network regulates renal ion cotransport |
Q33429488 | LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension |
Q37310454 | Long-term renal denervation normalizes disrupted blood pressure circadian rhythm and ameliorates cardiovascular injury in a rat model of metabolic syndrome |
Q46255939 | Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse |
Q89254963 | Low serum chloride in patients with chronic heart failure: clinical associations and prognostic significance |
Q40779586 | Modulation of NCC activity by low and high K(+) intake: insights into the signaling pathways involved. |
Q24598213 | Molecular physiology of the thiazide-sensitive sodium-chloride cotransporter |
Q36862737 | Multigene kinase network, kidney transport, and salt in essential hypertension |
Q33590418 | NaCl cotransporter abundance in urinary vesicles is increased by calcineurin inhibitors and predicts thiazide sensitivity |
Q33841859 | Non-pharmacological aspects of blood pressure management: what are the data? |
Q37758369 | Pathophysiological roles of WNK kinases in the kidney |
Q38019993 | Pathophysiology of salt sensitivity hypertension |
Q26998714 | Pendrin as a novel target for diuretic therapy |
Q33855431 | PharmGKB summary: Diuretics pathway, pharmacodynamics |
Q36746113 | Potassium and Its Discontents: New Insight, New Treatments |
Q37604706 | Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension |
Q42477697 | Regulated endocytosis of NCC. |
Q82605409 | Regulation of WNK1 kinase by extracellular potassium |
Q36494423 | Regulation of the renal Na+-Cl- cotransporter by phosphorylation and ubiquitylation |
Q34174710 | Regulation of with-no-lysine kinase signaling by Kelch-like proteins |
Q64089122 | Relationship between a Weighted Multi-Gene Algorithm and Blood Pressure Control in Hypertension |
Q24651730 | Renal and brain isoforms of WNK3 have opposite effects on NCCT expression |
Q38383563 | Revisiting the NaCl cotransporter regulation by with-no-lysine kinases. |
Q37298485 | Role of BKbeta1 in Na+ reabsorption by cortical collecting ducts of Na+-deprived mice |
Q35623025 | SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation |
Q30501923 | Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature |
Q24304374 | Similar effects of all WNK3 variants on SLC12 cotransporters |
Q46146557 | Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure |
Q64067566 | The Effect of Genetically Guided Mathematical Prediction and the Blood Pressure Response to Pharmacotherapy in Hypertension Patients |
Q42407751 | The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride |
Q37857562 | The WNK kinase network regulating sodium, potassium, and blood pressure |
Q34560188 | The WNKs: atypical protein kinases with pleiotropic actions. |
Q42852253 | The activity of the thiazide-sensitive Na(+)-Cl(-) cotransporter is regulated by protein phosphatase PP4. |
Q38690025 | The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension |
Q54769616 | The renal WNK kinase pathway: a new link to hypertension. |
Q38169097 | The sodium chloride cotransporter SLC12A3: new roles in sodium, potassium, and blood pressure regulation |
Q42927380 | The soybean root-specific protein kinase GmWNK1 regulates stress-responsive ABA signaling on the root system architecture |
Q24623288 | The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs |
Q41847172 | Through a glass darkly: salt transport by the distal tubule |
Q26863205 | Ubiquitylation and control of renal Na+ balance and blood pressure |
Q39698346 | Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis |
Q37628829 | WNK kinases and blood pressure control |
Q34548846 | WNK kinases and renal sodium transport in health and disease: an integrated view |
Q37992360 | WNK kinases and the kidney |
Q24649138 | WNK kinases, renal ion transport and hypertension |
Q48235281 | WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4. |
Q45361616 | WNK3 abrogates the NEDD4-2-mediated inhibition of the renal Na+-Cl- cotransporter |
Q24646108 | WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter |
Q37969554 | WNK3 is a putative chloride-sensing kinase. |
Q24310130 | WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway |
Q37258483 | WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction |
Q24652877 | WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway |
Q34420520 | WNK4 is the major WNK positively regulating NCC in the mouse kidney |
Q35543284 | With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume |