The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex

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The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI32033
P932PMC publication ID2045602
P698PubMed publication ID17975670

P2093author name stringDavid H Ellison
Chao-Ling Yang
Xiaoman Zhu
P2860cites workWNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasisQ24294248
Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathwayQ24305919
Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoformsQ24537454
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4Q24541348
WNK kinases, a novel protein kinase subfamily in multi-cellular organismsQ28188729
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>Q28204197
Regulation of WNK1 by an autoinhibitory domain and autophosphorylationQ28206619
Human hypertension caused by mutations in WNK kinasesQ28212182
The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletionQ28255750
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretionQ28506376
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoformQ28567514
WNK1 affects surface expression of the ROMK potassium channel independent of WNK4Q28571983
Comparison of WNK4 and WNK1 kinase and inhibiting activitiesQ28580008
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain IIQ28581920
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinasesQ28583124
WNK kinases regulate thiazide-sensitive Na-Cl cotransportQ28584824
Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic interventionQ28591574
Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cellsQ30781595
Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome.Q31039816
Molecular mechanisms of human hypertensionQ32138445
Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransportQ33736529
Mammalian distal tubule: physiology, pathophysiology, and molecular anatomyQ33807213
Negative regulators of sodium transport in the kidney: key factors in understanding salt-sensitive hypertension?Q34187739
Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3).Q34326671
WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cellsQ34524228
WNK1 kinase isoform switch regulates renal potassium excretion.Q34694518
WNK kinases: molecular regulators of integrated epithelial ion transportQ35858400
Sodium and potassium handling by the aldosterone-sensitive distal nephron: the pivotal role of the distal and connecting tubuleQ35877684
Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertensionQ36002090
Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters.Q36079002
WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransportersQ36600738
WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1).Q40339717
Properties of WNK1 and implications for other family membersQ40424747
Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cellsQ40441541
Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral densityQ44055170
A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 geneQ46585008
Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo.Q50646202
A molecular switch controlling renal sodium and potassium excretionQ79333308
Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubuleQ80238253
Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse modelQ80292340
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectprotein serine/threonine kinase activityQ14326094
WNK lysine deficient protein kinase 3Q21112960
P304page(s)3403-11
P577publication date2007-11-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleThe thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex
P478volume117

Reverse relations

cites work (P2860)
Q36425591A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo
Q27000474A molecular update on pseudohypoaldosteronism type II
Q38003087Advances in WNK signaling of salt and potassium metabolism: clinical implications
Q41966666Aldosterone does not require angiotensin II to activate NCC through a WNK4-SPAK-dependent pathway
Q37328447Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway.
Q37864472Aldosterone paradox: differential regulation of ion transport in distal nephron.
Q34462143Altered expression of regulators of the cortical chloride transporters NKCC1 and KCC2 in schizophrenia
Q40328947Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling
Q36106011Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action
Q41372396CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
Q35882568Critical role of the SPAK protein kinase CCT domain in controlling blood pressure
Q34241490Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension
Q36414701Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension
Q28592337Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone
Q52975643Distal convoluted tubule.
Q24641916Domains of WNK1 kinase in the regulation of ROMK1
Q54532817Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.
Q37619138Enhanced phosphorylation of Na(+)-Cl- co-transporter in experimental metabolic syndrome: role of insulin
Q38335855Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension
Q37934598Exploring the intricate regulatory network controlling the thiazide-sensitive NaCl cotransporter (NCC).
Q37337316Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1.
Q43120944Familial Hyperkalemic Hypertension: A New Early-onset Pediatric Case
Q48542753Functionomics of NCC mutations in Gitelman syndrome using a novel mammalian cell-based activity assay.
Q47105803GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase
Q35086469Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing
Q90612398Hereditary causes of primary aldosteronism and other disorders of apparent excess mineralocorticoid activity
Q37603366Hereditary tubular transport disorders: implications for renal handling of Ca2+ and Mg2+.
Q34985526Insulin resistance, obesity, hypertension, and renal sodium transport
Q36368224Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity
Q47678208K+-induced natriuresis is preserved during Na+ depletion and accompanied by inhibition of the Na+-Cl- cotransporter
Q36099458Kidney kinase network regulates renal ion cotransport
Q33429488LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension
Q37310454Long-term renal denervation normalizes disrupted blood pressure circadian rhythm and ameliorates cardiovascular injury in a rat model of metabolic syndrome
Q46255939Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse
Q89254963Low serum chloride in patients with chronic heart failure: clinical associations and prognostic significance
Q40779586Modulation of NCC activity by low and high K(+) intake: insights into the signaling pathways involved.
Q24598213Molecular physiology of the thiazide-sensitive sodium-chloride cotransporter
Q36862737Multigene kinase network, kidney transport, and salt in essential hypertension
Q33590418NaCl cotransporter abundance in urinary vesicles is increased by calcineurin inhibitors and predicts thiazide sensitivity
Q33841859Non-pharmacological aspects of blood pressure management: what are the data?
Q37758369Pathophysiological roles of WNK kinases in the kidney
Q38019993Pathophysiology of salt sensitivity hypertension
Q26998714Pendrin as a novel target for diuretic therapy
Q33855431PharmGKB summary: Diuretics pathway, pharmacodynamics
Q36746113Potassium and Its Discontents: New Insight, New Treatments
Q37604706Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension
Q42477697Regulated endocytosis of NCC.
Q82605409Regulation of WNK1 kinase by extracellular potassium
Q36494423Regulation of the renal Na+-Cl- cotransporter by phosphorylation and ubiquitylation
Q34174710Regulation of with-no-lysine kinase signaling by Kelch-like proteins
Q64089122Relationship between a Weighted Multi-Gene Algorithm and Blood Pressure Control in Hypertension
Q24651730Renal and brain isoforms of WNK3 have opposite effects on NCCT expression
Q38383563Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.
Q37298485Role of BKbeta1 in Na+ reabsorption by cortical collecting ducts of Na+-deprived mice
Q35623025SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation
Q30501923Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature
Q24304374Similar effects of all WNK3 variants on SLC12 cotransporters
Q46146557Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure
Q64067566The Effect of Genetically Guided Mathematical Prediction and the Blood Pressure Response to Pharmacotherapy in Hypertension Patients
Q42407751The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride
Q37857562The WNK kinase network regulating sodium, potassium, and blood pressure
Q34560188The WNKs: atypical protein kinases with pleiotropic actions.
Q42852253The activity of the thiazide-sensitive Na(+)-Cl(-) cotransporter is regulated by protein phosphatase PP4.
Q38690025The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension
Q54769616The renal WNK kinase pathway: a new link to hypertension.
Q38169097The sodium chloride cotransporter SLC12A3: new roles in sodium, potassium, and blood pressure regulation
Q42927380The soybean root-specific protein kinase GmWNK1 regulates stress-responsive ABA signaling on the root system architecture
Q24623288The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs
Q41847172Through a glass darkly: salt transport by the distal tubule
Q26863205Ubiquitylation and control of renal Na+ balance and blood pressure
Q39698346Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis
Q37628829WNK kinases and blood pressure control
Q34548846WNK kinases and renal sodium transport in health and disease: an integrated view
Q37992360WNK kinases and the kidney
Q24649138WNK kinases, renal ion transport and hypertension
Q48235281WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.
Q45361616WNK3 abrogates the NEDD4-2-mediated inhibition of the renal Na+-Cl- cotransporter
Q24646108WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter
Q37969554WNK3 is a putative chloride-sensing kinase.
Q24310130WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway
Q37258483WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction
Q24652877WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway
Q34420520WNK4 is the major WNK positively regulating NCC in the mouse kidney
Q35543284With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume