scholarly article | Q13442814 |
P356 | DOI | 10.1152/AJPRENAL.00440.2013 |
P698 | PubMed publication ID | 24107425 |
P2093 | author name string | G. Pathare | |
J. G. J. Hoenderop | |||
P. San-Cristobal | |||
R. J. M. Bindels | |||
P2860 | cites work | Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain | Q22010235 |
MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases | Q24297671 | ||
The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex | Q24299205 | ||
KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron | Q24307394 | ||
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension | Q24321928 | ||
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4 | Q24338315 | ||
A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension | Q24538746 | ||
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4 | Q24541348 | ||
Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1 | Q24548301 | ||
WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia | Q24621479 | ||
The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs | Q24623288 | ||
Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform | Q24633475 | ||
Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members | Q24633684 | ||
Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway | Q24648927 | ||
WNK kinases, renal ion transport and hypertension | Q24649138 | ||
WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway | Q24652877 | ||
Human hypertension caused by mutations in WNK kinases | Q28212182 | ||
Aldosterone resistance: structural and functional considerations and new perspectives | Q28240204 | ||
Expression of the potassium channel ROMK in adult and fetal human kidney | Q28250878 | ||
Mechanisms of disease: WNK-ing at the mechanism of salt-sensitive hypertension | Q28254512 | ||
Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1 | Q28268511 | ||
Vasopressin induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter in the distal convoluted tubule | Q28281414 | ||
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion | Q28506376 | ||
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform | Q28567514 | ||
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II | Q28581920 | ||
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases | Q28583124 | ||
Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention | Q28591574 | ||
Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome. | Q31039816 | ||
A regulatory locus of phosphorylation in the N terminus of the Na-K-Cl cotransporter, NKCC1. | Q31098918 | ||
Molecular mechanisms of human hypertension | Q32138445 | ||
Functional expression of a pseudohypoaldosteronism type I mutated epithelial Na+ channel lacking the pore-forming region of its alpha subunit. | Q33858466 | ||
Dysfunction of epithelial sodium transport: from human to mouse. | Q33888866 | ||
Divalent cation transport by the distal nephron: insights from Bartter's and Gitelman's syndromes | Q34039926 | ||
Blood pressure control--special role of the kidneys and body fluids | Q34126033 | ||
Glucocorticoid and mineralocorticoid resistance/hypersensitivity syndromes | Q34262743 | ||
Hypercalciuria in familial hyperkalemia and hypertension accompanies hyperkalemia and precedes hypertension: description of a large family with the Q565E WNK4 mutation | Q34338478 | ||
KLHL2 interacts with and ubiquitinates WNK kinases | Q34356315 | ||
SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction | Q34457030 | ||
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. | Q34464530 | ||
WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia | Q34470465 | ||
WNK kinases influence TRPV4 channel function and localization | Q34483111 | ||
WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells | Q34524228 | ||
WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4. | Q34571331 | ||
WNK1 kinase isoform switch regulates renal potassium excretion. | Q34694518 | ||
Regulation of the epithelial sodium channel by accessory proteins | Q35013324 | ||
Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway | Q35210213 | ||
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities | Q35754537 | ||
Inactivating mutations of the mineralocorticoid receptor in Type I pseudohypoaldosteronism. | Q35768966 | ||
WNK kinases: molecular regulators of integrated epithelial ion transport | Q35858400 | ||
WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway | Q35964473 | ||
Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process | Q35974133 | ||
Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension | Q36002090 | ||
Role of the WNK-activated SPAK kinase in regulating blood pressure | Q36039159 | ||
Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters. | Q36079002 | ||
Potassium-related inherited tubulopathies | Q36523990 | ||
The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein | Q36738674 | ||
WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron | Q37143452 | ||
The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications. | Q37163747 | ||
Clinical and molecular features of type 1 pseudohypoaldosteronism | Q37538319 | ||
Hereditary renal tubular disorders | Q37555071 | ||
Pathophysiological roles of WNK kinases in the kidney | Q37758369 | ||
Claudins and renal salt transport | Q37950889 | ||
Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension | Q38335855 | ||
The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension | Q38690025 | ||
Syndrome of hypertension and hyperkalemia with normal glomerular filtration rate | Q39499102 | ||
The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction | Q39986392 | ||
Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells | Q40237008 | ||
Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density | Q44055170 | ||
A novel mutation of the epithelial Na+ channel causes type 1 pseudohypoaldosteronism. | Q44177359 | ||
Different inactivating mutations of the mineralocorticoid receptor in fourteen families affected by type I pseudohypoaldosteronism | Q44467022 | ||
WNK1, a Gene within a Novel Blood Pressure Control Pathway, Tissue-Specifically Generates Radically Different Isoforms with and without a Kinase Domain | Q44599907 | ||
A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene | Q46585008 | ||
Flexible and floating choroid plexus cyst of the third ventricle: an ultrasonographic video documentation | Q48369550 | ||
Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo. | Q50646202 | ||
Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved. | Q50647853 | ||
Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade. | Q54597041 | ||
Salt handling and hypertension | Q56904729 | ||
P433 | issue | 11 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | F1513-20 | |
P577 | publication date | 2013-12-01 | |
P1433 | published in | American Journal of Physiology - Renal Physiology | Q2610177 |
P1476 | title | A molecular update on pseudohypoaldosteronism type II | |
P478 | volume | 305 |
Q30277654 | American Society of Nephrology Quiz and Questionnaire 2015: Electrolytes and Acid-Base Disorders |
Q36817088 | An unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron |
Q36363337 | Cell-specific regulation of L-WNK1 by dietary K. |
Q38307745 | Dietary potassium and the renal control of salt balance and blood pressure |
Q52975643 | Distal convoluted tubule. |
Q89087654 | Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension |
Q48148360 | Hydrochlorothiazide treatment increases the abundance of the NaCl cotransporter in urinary extracellular vesicles of essential hypertensive patients |
Q35140143 | Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3 |
Q37139457 | Hypertension: the missing WNKs |
Q33838442 | Is There a Role for Genomics in the Management of Hypertension? |
Q52390102 | Mechanisms and controversies in mutant Cul3-mediated Familial Hyperkalemic Hypertension. |
Q90435040 | Monogenic hypertension |
Q47269007 | Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects |
Q91942489 | Overview of Monogenic or Mendelian Forms of Hypertension |
Q51406832 | Phosphorylation of KLHL3 at serine 433 impairs its interaction with the acidic motif of WNK4: a molecular dynamics study. |
Q38984717 | Physiology and pathophysiology of potassium homeostasis |
Q48000331 | Potassium Sensing by Renal Distal Tubules Requires Kir4.1. |
Q57289570 | Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway |
Q38594795 | Repairing the basic defect in cystic fibrosis - one approach is not enough. |
Q33770703 | Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension. |
Q92736068 | Unveiling the Distinct Mechanisms by which Disease-Causing Mutations in the Kelch Domain of KLHL3 Disrupt the Interaction with the Acidic Motif of WNK4 through Molecular Dynamics Simulation |
Q50141002 | With no lysine kinase 4 modulates sodium potassium 2 chloride cotransporter activity in vivo. |
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