A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome

scientific article

A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/EMBOJ.2010.14
P3181OpenCitations bibliographic resource ID3296311
P932PMC publication ID2845271
P698PubMed publication ID20186120
P5875ResearchGate publication ID41578805

P50authorJoanna RorbachQ37384096
Zofia M Chrzanowska-LightowlersQ39034391
Martijn A HuynenQ54900907
Aleksandra PajakQ58682412
P2093author name stringHans J Wessels
Robert N Lightowlers
Jan A Smeitink
Paul M Smith
Ricarda Richter
P2860cites workProteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunitQ24291321
mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAGQ24684201
Release Factors 2 from Escherichia coli and Thermus thermophilus: structural, spectroscopic and microcalorimetric studiesQ27643716
Structural basis for translation termination on the 70S ribosomeQ27651016
The m-AAA protease defective in hereditary spastic paraplegia controls ribosome assembly in mitochondriaQ27931873
Alteration of a novel dispensable mitochondrial ribosomal small-subunit protein, Rsm28p, allows translation of defective COX2 mRNAsQ27937086
Evolution of a protein-rich mitochondrial ribosome: implications for human genetic diseaseQ28214131
The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins presentQ28215976
A Heuristic method for assigning a false-discovery rate for protein identifications from Mascot database search resultsQ28306772
Wobble modification defect in tRNA disturbs codon-anticodon interaction in a mitochondrial diseaseQ28348375
Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomicsQ29615818
Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per proteinQ29617305
Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNAQ29617951
Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometryQ29619562
A note on difficult structure alignment problems.Q30366938
High-throughput RNAi screening in vitro: from cell lines to primary cells.Q30853817
Hungry codons promote frameshifting in human mitochondrial ribosomesQ34092844
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA.Q34470091
Initiation and elongation factors in mammalian mitochondrial protein biosynthesisQ35805073
Peptidyl-tRNA hydrolase and its critical role in protein biosynthesisQ36540178
Unconventional decoding of the AUA codon as methionine by mitochondrial tRNAMet with the anticodon f5CAU as revealed with a mitochondrial in vitro translation systemQ37128170
Hydrolysis of fMet-tRNA by peptidyl transferaseQ37494976
The human mitochondrial ribosome recycling factor is essential for cell viabilityQ39941411
In vivo labeling and analysis of human mitochondrial translation productsQ41244321
Structure of the Mammalian Mitochondrial Ribosome Reveals an Expanded Functional Role for Its Component ProteinsQ41628956
Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis.Q43206485
Recycling of ribosomal complexes stalled at the step of elongation in Escherichia coliQ46530968
A tripeptide 'anticodon' deciphers stop codons in messenger RNA.Q55033645
Inhibition of mitochondrial protein synthesis promotes increased stability of nuclear-encoded respiratory gene transcriptsQ62599936
Structural analyses of peptide release factor 1 from Thermotoga maritima reveal domain flexibility required for its interaction with the ribosomeQ80456132
P4510describes a project that usesImageQuantQ112270642
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectmitochondrionQ39572
Chromosome 12 open reading frame 65Q21108400
Mitochondrial ribosomal protein L58Q21114680
Mitochondrial ribosomal protein L3Q21117740
Mitochondrial ribosomal protein L12Q21123372
P304page(s)1116-25
P577publication date2010-03-17
P1433published inThe EMBO JournalQ1278554
P1476titleA functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome
P478volume29

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cites work (P2860)
Q5029607855S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP
Q37589775Adult Onset Leigh Syndrome in the Intensive Care Setting: A Novel Presentation of a C12orf65 Related Mitochondrial Disease
Q28534793Analysis of 953 human proteins from a mitochondrial HEK293 fraction by complexome profiling
Q27688018Architecture of the large subunit of the mammalian mitochondrial ribosome
Q101216841ArfB can displace mRNA to rescue stalled ribosomes
Q38208304Biochemical aspects of bacterial strategies for handling the incomplete translation processes.
Q24306779Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18
Q92513768C6orf203 is an RNA-binding protein involved in mitochondrial protein synthesis
Q24301700C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome
Q35955997C7orf30 specifically associates with the large subunit of the mitochondrial ribosome and is involved in translation
Q50336116Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons
Q52690101Cultured bloodstream Trypanosoma brucei adapt to life without mitochondrial translation release factor 1.
Q103000578Elongational stalling activates mitoribosome-associated quality control
Q34038470Ends of the line for tmRNA-SmpB.
Q54365117Escherichia coli YaeJ protein mediates a novel ribosome-rescue pathway distinct from SsrA- and ArfA-mediated pathways.
Q36320971Evolution and diversification of the organellar release factor family.
Q36671051GRSF1 regulates RNA processing in mitochondrial RNA granules.
Q28551066Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria
Q24337773Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit
Q38103369Human pentatricopeptide proteins: only a few and what do they do?
Q39790413ICT1 comes to the rescue of mitochondrial ribosomes
Q37054242Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome
Q27680847Identification of residues required for stalled-ribosome rescue in the codon-independent release factor YaeJ
Q38851848Immature Colon Carcinoma Transcript 1 Is Essential for Prostate Cancer Cell Viability and Proliferation
Q39605528Immature Colon Carcinoma Transcript-1 (ICT1) Expression Correlates with Unfavorable Prognosis and Survival in Patients with Colorectal Cancer
Q50074468Immature colon carcinoma transcript-1 promotes proliferation of gastric cancer cells
Q36433451Infantile Progressive Hepatoencephalomyopathy with Combined OXPHOS Deficiency due to Mutations in the Mitochondrial Translation Elongation Factor Gene GFM1.
Q38624841Integrating mitochondrial translation into the cellular context
Q37572851Interactions between peptidyl tRNA hydrolase homologs and the ribosomal release factor Mrf1 in S. pombe mitochondria.
Q39603767Knockdown of Immature Colon Carcinoma Transcript 1 Inhibits Proliferation and Promotes Apoptosis of Non-Small Cell Lung Cancer Cells
Q35654956Knockdown of immature colon carcinoma transcript-1 inhibits proliferation of glioblastoma multiforme cells through Gap 2/mitotic phase arrest
Q35785438L-GRAAL: Lagrangian graphlet-based network aligner
Q24299607MPV17L2 is required for ribosome assembly in mitochondria
Q34104663MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome.
Q39307037MRPS27 is a pentatricopeptide repeat domain protein required for the translation of mitochondrially encoded proteins.
Q35234097MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention
Q35857108Mechanism of protein biosynthesis in mammalian mitochondria
Q98471226Mechanism of ribosome rescue by alternative ribosome-rescue factor B
Q38193805Mechanism of trans-translation revealed by in vitro studies
Q38177561Mitochondria: impaired mitochondrial translation in human disease
Q38742965Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein
Q38218724Mitochondrial protein synthesis: figuring the fundamentals, complexities and complications, of mammalian mitochondrial translation.
Q64964896Mitochondrial transcription and translation: overview.
Q33960447Mutations in C12orf65 in patients with encephalomyopathy and a mitochondrial translation defect
Q42961760Mutations in mitochondrial ribosomal protein MRPL12 leads to growth retardation, neurological deterioration and mitochondrial translation deficiency
Q26822920Non-Standard Genetic Codes Define New Concepts for Protein Engineering
Q37728203Ornithine Aminotransferase, an Important Glutamate-Metabolizing Enzyme at the Crossroads of Multiple Metabolic Pathways
Q42739615Overcoming stalled translation in human mitochondria
Q30039559Polypeptide release factors and stop codon recognition in the apicoplast and mitochondrion of Plasmodium falciparum
Q38162474Protein biosynthesis in mitochondria
Q37505599Proteomic analysis of cellular soluble proteins from human bronchial smooth muscle cells by combining nondenaturing micro 2DE and quantitative LC-MS/MS. 2. Similarity search between protein maps for the analysis of protein complexes
Q41457400Proteomic profiling of the mitochondrial ribosome identifies Atp25 as a composite mitochondrial precursor protein.
Q46268758RNA cytosine methyltransferase Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity.
Q42148714Release of nonstop ribosomes is essential
Q33743269Resolving nonstop translation complexes is a matter of life or death
Q35667578Response to "Ribosome Rescue and Translation Termination at Non-standard Stop Codons by ICT1 in Mammalian Mitochondria"
Q35262060Ribosome rescue and translation termination at non-standard stop codons by ICT1 in mammalian mitochondria.
Q52604997Ribosome rescue by Escherichia coli ArfA (YhdL) in the absence of trans-translation system
Q39186842Screening of critical genes in lung adenocarcinoma via network analysis of gene expression profile
Q27681815Solution structure and siRNA-mediated knockdown analysis of the mitochondrial disease-related protein C12orf65
Q38088898Specialization from synthesis: how ribosome diversity can customize protein function
Q27678063Structural Basis for the Rescue of Stalled Ribosomes: Structure of YaeJ Bound to the Ribosome
Q21203749Structure based hypothesis of a mitochondrial ribosome rescue mechanism
Q26863528Termination of protein synthesis in mammalian mitochondria
Q21131103The fail-safe system to rescue the stalled ribosomes in Escherichia coli
Q58802699The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis
Q27016551The human mitochondrial transcriptome and the RNA-binding proteins that regulate its expression
Q38895517The process of mammalian mitochondrial protein synthesis.
Q26860816The tmRNA ribosome-rescue system
Q28543547Whole cell formaldehyde cross-linking simplifies purification of mitochondrial nucleoids and associated proteins involved in mitochondrial gene expression
Q34699801YaeJ is a novel ribosome-associated protein in Escherichia coli that can hydrolyze peptidyl-tRNA on stalled ribosomes
Q51607451freeQuant: A Mass Spectrometry Label-Free Quantification Software Tool for Complex Proteome Analysis.
Q38207993tmRNA-mediated trans-translation as the major ribosome rescue system in a bacterial cell

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