Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1

scientific article

Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1 is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1995PNAS...9210427B
P356DOI10.1073/PNAS.92.22.10427
P3181OpenCitations bibliographic resource ID5083769
P932PMC publication ID40810
P698PubMed publication ID7479798
P5875ResearchGate publication ID15718899

P2093author name stringM Gallo
I Pastan
U Brinkmann
E Brinkmann
P2860cites workInternucleosomal DNA cleavage precedes diphtheria toxin-induced cytolysis. Evidence that cell lysis is not a simple consequence of translation inhibitionQ46943728
Active site of Pseudomonas aeruginosa exotoxin A. Glutamic acid 553 is photolabeled by NAD and shows functional homology with glutamic acid 148 of diphtheria toxinQ69901284
The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding proteinQ24601947
Basic local alignment search toolQ25938991
Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeastQ28300714
Cell cycle control and cancerQ29617536
Heterogeneous expression of four MAP kinase isoforms in human tissuesQ34236130
Expression cloning of cDNAs that render cancer cells resistant to Pseudomonas and diphtheria toxin and immunotoxinsQ36437495
CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiaeQ36694359
B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in miceQ37599304
Mediation of c-Myc-induced apoptosis by p53.Q41441186
DNA fragmentation and cytolysis in U937 cells treated with diphtheria toxin or other inhibitors of protein synthesisQ41529992
Diphtheria toxin- and Pseudomonas A toxin-mediated apoptosis. ADP ribosylation of elongation factor-2 is required for DNA fragmentation and cell lysis and synergy with tumor necrosis factor-alphaQ41602974
Characterization of the endogenous ADP‐ribosylation of wild‐type and mutant elongation factor 2 in eukaryotic cellsQ41633623
An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cellsQ43181718
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytesQ44192187
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)10427-31
P577publication date1995-10-24
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleCloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1
P478volume92

Reverse relations

cites work (P2860)
Q37163577A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.
Q24316050A novel class of RanGTP binding proteins
Q39109984AKT activation drives the nuclear localization of CSE1L and a pro-oncogenic transcriptional activation in ovarian cancer cells.
Q36733758Activation of human monocytes induces differential resistance to apoptosis with rapid down regulation of caspase-8/FLICE.
Q45886755Age-associated reduction of nuclear protein import in human fibroblasts
Q35446035Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox
Q37902996Apoptosis: why and how does it occur in biology?
Q38207085Biological significance of the importin-β family-dependent nucleocytoplasmic transport pathways
Q40742771Both ran and importins have the ability to function as nuclear mRNA export factors
Q38946743CAS (CSE1L) signaling pathway in tumor progression and its potential as a biomarker and target for targeted therapy
Q24538843CAS, the human homologue of the yeast chromosome-segregation gene CSE1, in proliferation, apoptosis, and cancer
Q38838677CSE1L Links cAMP/PKA and Ras/ERK pathways and regulates the expressions and phosphorylations of ERK1/2, CREB, and MITF in melanoma cells
Q93370153CSE1L participates in regulating cell mitosis in human seminoma
Q54304418CSE1L, DIDO1 and RBM39 in colorectal adenoma to carcinoma progression.
Q36465278CSE1L, a novel microvesicle membrane protein, mediates Ras-triggered microvesicle generation and metastasis of tumor cells
Q36776409CSE1L/CAS, the cellular apoptosis susceptibility protein, enhances invasion and metastasis but not proliferation of cancer cells
Q28143929Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product
Q37225702Cellular apoptosis susceptibility (CAS) is linked to integrin β1 and required for tumor cell migration and invasion in hepatocellular carcinoma (HCC).
Q34079161Cellular apoptosis susceptibility (CSE1L/CAS) protein in cancer metastasis and chemotherapeutic drug-induced apoptosis
Q58855510Cellular apoptosis susceptibility (chromosome segregation 1-like,CSE1L) gene is a key regulator of apoptosis, migration and invasion in colorectal cancer
Q74450818Cellular apoptosis susceptibility gene capts maps to mouse chromosome 2
Q44614489Changes in apoptosis-related pathways in acute myelocytic leukemia
Q40758360Characterization of the nuclear export signal of polypyrimidine tract-binding protein
Q41149227Clinical targeting recombinant immunotoxins for cancer therapy
Q51827727Comparative genomics of phylogenetically diverse unicellular eukaryotes provide new insights into the genetic basis for the evolution of the programmed cell death machinery.
Q36588598Correlations between cytoplasmic CSE1L in neoplastic colorectal glands and depth of tumor penetration and cancer stage
Q34012520Cse1l is essential for early embryonic growth and development
Q77323192Cse1p functions as the nuclear export receptor for importin alpha in yeast
Q39576650Cse1p is involved in export of yeast importin alpha from the nucleus
Q24682912Determination of the functional domain organization of the importin alpha nuclear import factor
Q31528548Different cell death mechanisms and gene expression in human cells induced by pentachlorophenol and its major metabolite, tetrachlorohydroquinone
Q39664096Differential distributions of CSE1L/CAS and E-cadherin in the polarized and non-polarized epithelial glands of neoplastic colorectal epithelium.
Q33958788Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids
Q42566713Dopaminergic modulation of the hippocampal neuropil proteome identified by bioorthogonal noncanonical amino acid tagging (BONCAT)
Q36470491Drosophila importin alpha1 performs paralog-specific functions essential for gametogenesis
Q35743289Early decline in serum phospho-CSE1L levels in vemurafenib/sunitinib-treated melanoma and sorafenib/lapatinib-treated colorectal tumor xenografts
Q24316152Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor
Q39882647Function of CSE1L/CAS in the secretion of HT-29 human colorectal cells and its expression in human colon
Q54147751Furin-mediated cleavage of Pseudomonas exotoxin-derived chimeric toxins.
Q34669312Heme-binding-mediated negative regulation of the tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) by IDO2
Q35406015High expression of cytoplasmic phosphorylated CSE1L in malignant melanoma but not in benign nevi: phosphorylated CSE1L for the discrimination between melanoma and benign nevi
Q35096785Immunobiological treatments of hairy-cell leukaemia
Q36328016Immunoconjugates in the management of hairy cell leukemia
Q34646650Immunotoxins for targeted cancer therapy
Q79199423Immunotoxins for targeted cancer therapy
Q33745138Immunotoxins in cancer therapy
Q27934542Importin/karyopherin protein family members required for mRNA export from the nucleus
Q39670788Increased cellular apoptosis susceptibility (CSE1L/CAS) protein expression promotes protrusion extension and enhances migration of MCF-7 breast cancer cells
Q47721363Karyopherins and kissing cousins
Q39492684Knockdown of CSE1L Gene in Colorectal Cancer Reduces Tumorigenesis in Vitro
Q35765243Localization of the cell proliferation and apoptosis-associated CAS protein in lymphoid neoplasms
Q28266122Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor
Q39223766MIR-137 suppresses growth and invasion, is downregulated in oligodendroglial tumors and targets CSE1L.
Q37680800Molecules that modulate Apaf-1 activity
Q46620423Novel functional interaction between Na+/H+ exchanger 1 and tyrosine phosphatase SHP-2.
Q35633427Nuclear transport and cancer: from mechanism to intervention
Q44272650Nucleocytoplasmic transport and cell proliferation
Q26766876Oncostatic-Cytoprotective Effect of Melatonin and Other Bioactive Molecules: A Common Target in Mitochondrial Respiration
Q35613110Predictive medicine in non-malignant urological disorders
Q53165543Presence of CSE1L protein in urine of patients with urinary bladder urothelial carcinomas.
Q33208475Prognostic relevance of 20q13 gains in sporadic colorectal cancers: a FISH analysis
Q52649983Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer.
Q37154413Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome
Q40197604Radiotherapy response in oral squamous carcinoma cell lines: evaluation of apoptotic proteins as prognostic factors
Q37165245Recombinant immunotoxins containing truncated bacterial toxins for the treatment of hematologic malignancies
Q37581788Recombinant immunotoxins for the treatment of chemoresistant hematologic malignancies.
Q53668245Recombinant toxins in haematologic malignancies and solid tumours.
Q73538310Recombinant toxins that bind to the urokinase receptor are cytotoxic without requiring binding to the alpha(2)-macroglobulin receptor
Q36055888Ribosome inactivating proteins and apoptosis
Q48209402Role of MAML1 and MEIS1 in Esophageal Squamous Cell Carcinoma Depth of Invasion.
Q33745103Serum cellular apoptosis susceptibility protein is a potential prognostic marker for metastatic colorectal cancer
Q28279309Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer
Q35955008Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential.
Q36518331The Cellular Apoptosis Susceptibility Protein (CAS) Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis and Cell Proliferation
Q24568254The human CAS protein which is homologous to the CSE1 yeast chromosome segregation gene product is associated with microtubules and mitotic spindle
Q24322912The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88
Q41077459The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase
Q33599759The regulation of apoptosis by microbial pathogens.
Q28140575The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1
Q24338336hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes
Q38858838hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair

Search more.