The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1

scientific article (publication date: 24 December 1999)

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.274.52.37370
P3181OpenCitations bibliographic resource ID1763985
P698PubMed publication ID10601307
P5875ResearchGate publication ID12700723

P50authorPaulo A. FerreiraQ37375133
Brij B SinghQ56459702
P2093author name stringD Schick
R Roepman
H H Patel
P2860cites workCloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1Q24303588
A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathwayQ24309825
A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complexQ24310068
Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12Q24313009
The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complexQ24316128
Export of importin alpha from the nucleus is mediated by a specific nuclear transport factorQ24316152
A giant nucleopore protein that binds Ran/TC4Q24317506
A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2Q24317523
The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88Q24322912
Sequence analysis of a cDNA encoding a human nuclear pore complex protein, hnup153Q24324042
A novel receptor-mediated nuclear protein import pathwayQ24324050
Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteinsQ24336504
Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domainQ24534076
Nuclear transport: run by Ran?Q24539168
The Ran/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motifQ24564692
A nuclear localization domain in the hnRNP A1 proteinQ24672627
Two distinct classes of Ran-binding sites on the nucleoporin Nup-358Q24682217
Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2Q24683146
Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope associationQ24683718
Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved regionQ24685870
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear poresQ27930079
Cytosolic Sec13p complex is required for vesicle formation from the endoplasmic reticulum in vitro.Q27932134
Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteinsQ27932702
The yeast nucleoporin rip1p contributes to multiple export pathways with no essential role for its FG-repeat region.Q27934181
Exportin 1 (Crm1p) is an essential nuclear export factorQ27939696
Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferaseQ28131695
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAsQ28131708
Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporinsQ28131733
Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesiclesQ28138876
Nuclear export receptors: from importin to exportinQ28250554
Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4Q28257159
Leptomycins A and B, new antifungal antibiotics. II. Structure elucidationQ28275288
SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activationQ28282094
Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich regionQ28566768
A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasmQ28582932
Identification of a signal for rapid export of proteins from the nucleusQ29547742
CRM1 is responsible for intracellular transport mediated by the nuclear export signalQ29547861
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleusQ29616325
An RNA-export mediator with an essential nuclear export signalQ29617266
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNAQ29620175
The GTP-binding protein Ran/TC4 is required for protein import into the nucleusQ29620192
Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factorQ29620193
Evidence for a role of CRM1 in signal-mediated nuclear protein exportQ29620231
Retina-specifically expressed novel subtypes of bovine cyclophilinQ34295471
Effects of leptomycin B on the cell cycle of fibroblasts and fission yeast cellsQ34299989
Protein export from the nucleus requires the GTPase Ran and GTP hydrolysisQ34321978
Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsinQ34401695
Nuclear protein importQ34426767
Localization of the gene encoding the Ran-binding protein RanBP2 to human chromosome 2q11-q13 by fluorescence in situ hybridizationQ34434403
RanBP2 associates with Ubc9p and a modified form of RanGAP1Q36105014
Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+ which encodes a 115-kD protein preferentially localized in the nucleus and its peripheryQ36220366
GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein importQ36685432
Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein exportQ41104206
A look at messenger RNP moving through the nuclear poreQ41367422
Nucleocytoplasmic transport: the last 200 nanometersQ41708889
The NES-Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiaeQ42676980
The cell as a collection of protein machines: preparing the next generation of molecular biologistsQ46148013
A pre-mRNA-binding protein accompanies the RNA from the gene through the nuclear pores and into polysomesQ48066850
Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization.Q50714829
Expression of rod and cone visual pigments in goldfish and zebrafish: a rhodopsin-like gene is expressed in cones.Q50782519
Zinc stabilizes the SecB binding site of SecA.Q52534778
The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.Q55067902
The nuclear pore complexQ71778522
Ran and nuclear transportQ77171854
Leptomycins A and B, new antifungal antibiotics. III. Mode of action of leptomycin B on Schizosaccharomyces pombeQ93660763
P433issue52
P407language of work or nameEnglishQ1860
P1104number of pages9
P304page(s)37370-37378
P577publication date1999-12-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1
P478volume274

Reverse relations

cites work (P2860)
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Q30816567Analysis of the antibody repertoire of astrocytoma patients against antigens expressed by gliomas
Q89978329Arabidopsis RanBP2-Type Zinc Finger Proteins Related to Chloroplast RNA Editing Factor OZ1
Q34691832Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function
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Q24649299Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons
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Q33855277Inhibition of CRM1-mediated nuclear export of transcription factors by leukemogenic NUP98 fusion proteins
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Q33746245Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes
Q30362076Molecular Characterization and Functional Analysis of Annulate Lamellae Pore Complexes in Nuclear Transport in Mammalian Cells.
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Q38411212Nup214 is required for CRM1-dependent nuclear protein export in vivo
Q36572321Nup358/RanBP2 attaches to the nuclear pore complex via association with Nup88 and Nup214/CAN and plays a supporting role in CRM1-mediated nuclear protein export
Q33423272Phylogenetic analysis, subcellular localization, and expression patterns of RPD3/HDA1 family histone deacetylases in plants
Q34384095Protein export from the nucleus
Q44521176RPGRIP1s with distinct neuronal localization and biochemical properties associate selectively with RanBP2 in amacrine neurons
Q35178128Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability
Q21145250RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism
Q36243860Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Q39941426SUMOylation regulates nuclear localization of Krüppel-like factor 5.
Q34396844Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.
Q35206381Signaling to p53: ribosomal proteins find their way.
Q27640720Structure and Ubiquitin Interactions of the Conserved Zinc Finger Domain of Npl4
Q64062442Structure and interactions of the archaeal motility repression module ArnA-ArnB that modulates archaellum gene expression in
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Q48794579The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.
Q35047496The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity
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Q38162850Type-II histone deacetylases: elusive plant nuclear signal transducers
Q27933355Ubiquitin interactions of NZF zinc fingers
Q36392210Viral interactions with the cytoskeleton: a hitchhiker's guide to the cell

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