The RanBP2/RanGAP1*SUMO1/Ubc9 complex: a multisubunit E3 ligase at the intersection of sumoylation and the RanGTPase cycle

scientific article

The RanBP2/RanGAP1*SUMO1/Ubc9 complex: a multisubunit E3 ligase at the intersection of sumoylation and the RanGTPase cycle is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4161/NUCL.21980
P932PMC publication ID3474663
P698PubMed publication ID22925898
P5875ResearchGate publication ID230749897

P2093author name stringAndreas Werner
Annette Flotho
P2860cites workRanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolismQ21145250
HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiencyQ24300016
The mechanisms of PML-nuclear body formationQ24311595
The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and functionQ24314715
A giant nucleopore protein that binds Ran/TC4Q24317506
Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25Q24319821
A domain unique to plant RanGAP is responsible for its targeting to the plant nuclear rimQ24555045
Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNAQ24645940
SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosisQ24647369
Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalphaQ24648999
SUMO-1 targets RanGAP1 to kinetochores and mitotic spindlesQ24671070
Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entryQ27324750
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognitionQ27865256
Sumoylation regulates Kap114-mediated nuclear transportQ27935803
The nucleoporin RanBP2 has SUMO1 E3 ligase activityQ28115025
The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1Q28140575
Concepts in sumoylation: a decade onQ28257220
Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich regionQ28566768
Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complexQ29617624
Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viabilityQ35178128
The nucleoporin Nup358 associates with and regulates interphase microtubulesQ36499514
The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear importQ36631203
RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on BorealinQ37035146
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?Q37099825
SUMOylation and deSUMOylation at a glanceQ37425378
Crm1 is a mitotic effector of Ran-GTP in somatic cellsQ40418909
RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export.Q40468913
The RanGTP gradient - a GPS for the mitotic spindleQ46603162
The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.Q48794579
The RanBP2/RanGAP1*SUMO1/Ubc9 complex is a multisubunit SUMO E3 ligase.Q50336151
The Nucleoporin Nup358/RanBP2 Promotes Nuclear Import in a Cargo- and Transport Receptor-Specific MannerQ57447920
P433issue5
P921main subjectprotein sumoylationQ3503705
P304page(s)429-432
P577publication date2012-08-27
P1433published inNucleusQ26842588
P1476titleThe RanBP2/RanGAP1*SUMO1/Ubc9 complex: a multisubunit E3 ligase at the intersection of sumoylation and the RanGTPase cycle
P478volume3

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cites work (P2860)
Q95644850Alterations in SUMOylation of the hyperpolarization-activated cyclic nucleotide gated ion channel 2 during persistent inflammation
Q35100466Coding and noncoding expression patterns associated with rare obesity-related disorders: Prader-Willi and Alström syndromes.
Q37308644Emerging roles of sumoylation in the regulation of actin, microtubules, intermediate filaments, and septins
Q35662095IBS: an illustrator for the presentation and visualization of biological sequences
Q48297889Importin-β and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function.
Q30362076Molecular Characterization and Functional Analysis of Annulate Lamellae Pore Complexes in Nuclear Transport in Mammalian Cells.
Q37225511Small ubiquitin-related modifier 1 is involved in hepatocellular carcinoma progression via mediating p65 nuclear translocation
Q55059510The GTPase RAN regulates multiple steps of the centrosome life cycle.
Q28118320Variants of Transient Receptor Potential Melastatin Member 4 in Childhood Atrioventricular Block

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