Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase

scientific article

Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.01270-12
P3181OpenCitations bibliographic resource ID487362
P932PMC publication ID3554216
P698PubMed publication ID23184662
P5875ResearchGate publication ID233774845

P50authorMarkus WelckerQ42710721
P2093author name stringBruce E Clurman
Alexey G Ryazanov
Yi Liao
Jherek Swanger
Yong Chi
John H Carter
Asli A Hizli
P2860cites workThe role of protein synthesis in cell cycling and cancerQ37442358
Tipping the balance: Cdk2 enables Myc to suppress senescenceQ37780375
Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasmQ39527068
Ribosomal slowdown mediates translational arrest during cellular division.Q40100414
Regulation of elongation factor-2 kinase by pH.Q40692268
Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathwayQ41064925
Involvement of the 24-kDa cap-binding protein in regulation of protein synthesis in mitosisQ41372346
Cyclic AMP-dependent protein kinase phosphorylates rabbit reticulocyte elongation factor-2 kinase and induces calcium-independent activityQ41826546
Three phosphorylation sites in elongation factor 2.Q41923582
Mitotic modulation of translation elongation factor 1 leads to hindered tRNA delivery to ribosomes.Q42148482
Mass spectrometry-based identification of protein kinase substrates utilizing engineered kinases and thiophosphate labelingQ42789498
Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylationQ42809976
Ca2+/calmodulin-dependent phosphorylation of elongation factor 2Q68989080
Mechanism of elongation factor 2 (EF-2) inactivation upon phosphorylation. Phosphorylated EF-2 is unable to catalyze translocationQ69665326
Identification of the phosphorylation sites in elongation factor-2 from rabbit reticulocytesQ70162872
Regulation of protein synthesis in mammalian cells. II. Inhibition of protein synthesis at the level of initiation during mitosisQ71723650
Structure and activity of diphtheria toxin. II. Attack by trypsin at a specific site within the intact toxin moleculeQ71761007
Mass spectrometry-based identification of protein kinase substrates utilizing engineered kinases and thiophosphate labelingQ95763687
cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent mannerQ24310776
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.Q24535599
A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38deltaQ24535672
Increased phosphorylation of elongation factor 2 during mitosis in transformed human amnion cells correlates with a decreased rate of protein synthesisQ24558118
Structures of modified eEF2 80S ribosome complexes reveal the role of GTP hydrolysis in translocationQ27644523
Mapping the functional domains of elongation factor-2 kinaseQ28140181
Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradationQ28208407
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesisQ28218978
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398Q28237559
The life and death of translation elongation factor 2Q28278773
Identification of the major Mr 100,000 substrate for calmodulin-dependent protein kinase III in mammalian cells as elongation factor-2Q28303188
Changes in the phosphorylation of initiation factor eIF-2alpha, elongation factor eEF-2 and p70 S6 kinase after transient focal cerebral ischaemia in mice.Q31004671
Cell-cycle-dependent translational controlQ34132807
Regulation of peptide-chain elongation in mammalian cellsQ34992462
Signalling to translation: how signal transduction pathways control the protein synthetic machineryQ36765810
Regulation of mRNA Translation during cellular division.Q37073508
Identification of CDK2 substrates in human cell lysatesQ37384948
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectprotein autophosphorylationQ3630494
glycogen synthase kinase 3 betaQ5514576
mitogen-activated protein kinase 1Q6590503
phosphorylationQ242736
Cyclin dependent kinase 2Q511968
cell biologyQ7141
Eukaryotic translation elongation factor 2Q21173658
Eukaryotic elongation factor 2 kinaseQ21201161
P304page(s)596-604
P577publication date2013-02-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titlePhosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase
P478volume33

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cites work (P2860)
Q41563428A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation
Q96135799A novel landscape of nuclear human CDK2 substrates revealed by in situ phosphorylation
Q52667723Convergent Mechanisms Underlying Rapid Antidepressant Action.
Q39117876Depression of leukocyte protein synthesis, immune function and growth performance induced by high environmental temperature in broiler chickens.
Q43150982Dynamics of elongation factor 2 kinase regulation in cortical neurons in response to synaptic activity
Q37623642Environmental stress affects the activity of metabolic and growth factor signaling networks and induces autophagy markers in MCF7 breast cancer cells
Q37707024Eukaryotic elongation factor 2 is a prognostic marker and its kinase a potential therapeutic target in HCC.
Q38253509Eukaryotic elongation factor 2 kinase confers tolerance to stress conditions in cancer cells
Q55072541Eukaryotic elongation factor 2 kinase controls proliferation and migration of vascular smooth muscle cells.
Q97521963Evidence That Phosphorylation of the α-Subunit of eIF2 Does Not Essentially Inhibit mRNA Translation in Wheat Germ Cell-Free System
Q64260502Glucose-dependent phosphorylation signaling pathways and crosstalk to mitochondrial respiration in insulin secreting cells
Q37080748High Expression of PTGR1 Promotes NSCLC Cell Growth via Positive Regulation of Cyclin-Dependent Protein Kinase Complex
Q39628738Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma
Q37501785Involvement of nucleoside diphosphate kinase b and elongation factor 2 in Leishmania braziliensis antimony resistance phenotype
Q38812867Lapatinib resistance in HER2+ cancers: latest findings and new concepts on molecular mechanisms
Q28266122Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor
Q35636275Mechanism of cytoplasmic mRNA translation
Q34504365PP2A inhibition overcomes acquired resistance to HER2 targeted therapy
Q41049605Paradoxical Roles of Elongation Factor-2 Kinase in Stem Cell Survival
Q42362534Protein Translation and Signaling in Human Eosinophils
Q36810786Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs
Q47236714RAD54 N-terminal domain is a DNA sensor that couples ATP hydrolysis with branch migration of Holliday junctions
Q41011074Regulation and function of phosphorylation on VP8, the major tegument protein of bovine herpesvirus 1.
Q35090040Stimulators of translation identified during a small molecule screening campaign
Q55262536The observed alteration in BCL2 expression following lithium treatment is influenced by the choice of normalization method.
Q33636990The translation elongation factor eEF2 is a novel tumor‑associated antigen overexpressed in various types of cancers.
Q28534586Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death
Q35319555To be or not to be: the regulation of mRNA fate as a survival strategy during mammalian hibernation
Q64212178Translational Control in Echinoderms: The Calm Before the Storm
Q40149612Zanos et al. reply.

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