Identification of a human mitotic checkpoint gene: hsMAD2

scientific article

Identification of a human mitotic checkpoint gene: hsMAD2 is …
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scholarly articleQ13442814

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P356DOI10.1126/SCIENCE.274.5285.246
P3181OpenCitations bibliographic resource ID4767796
P698PubMed publication ID8824189

P2093author name stringY Li
R Benezra
P433issue5285
P407language of work or nameEnglishQ1860
P921main subjectMitotic arrest deficient 2 like 1Q21132390
P304page(s)246-8
P577publication date1996-10-11
P1433published inScienceQ192864
P1476titleIdentification of a human mitotic checkpoint gene: hsMAD2
P478volume274

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cites work (P2860)
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Q52536820Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers
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Q37745480Neuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival.
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Q24315748Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint
Q37709125Prognostic and predictive values of CDK1 and MAD2L1 in lung adenocarcinoma.
Q33574972Prognostic utility of chromosomal instability detected by fluorescence in situ hybridization in fine-needle aspirates from oral squamous cell carcinomas
Q36694133Promoter hypermethylation of the Chfr gene in neoplastic and non-neoplastic gastric epithelia
Q24299702Re-evaluating the role of Tao1 in the spindle checkpoint
Q34646656Recent advances in cancer research: mouse models of tumorigenesis
Q30452748Recognizing chromosomes in trouble: association of the spindle checkpoint protein Bub3p with altered kinetochores and a unique defective centromere
Q38612159Regulation of the Cyclin B Degradation System by an Inhibitor of Mitotic Proteolysis
Q37015055Requirements for protein phosphorylation and the kinase activity of polo-like kinase 1 (Plk1) for the kinetochore function of mitotic arrest deficiency protein 1 (Mad1).
Q35552257Retention of the BUB3 checkpoint protein on lagging chromosomes
Q34019827Role of Cyclin B1/Cdc2 Up-Regulation in the Development of Mitotic Prometaphase Arrest in Human Breast Cancer Cells Treated with Nocodazole
Q40249347Role of MEK/ERK pathway in the MAD2-mediated cisplatin sensitivity in testicular germ cell tumour cells
Q39285369Role of cyclin B1/Cdc2 in mediating Bcl-XL phosphorylation and apoptotic cell death following nocodazole-induced mitotic arrest
Q74114602Role of mitotic control in spermatogenesis
Q34182193Roles of MAPK and Spindle Assembly Checkpoint in Spontaneous Activation and MIII Arrest of Rat Oocytes
Q36123872SAC-ing mitotic errors: how the spindle assembly checkpoint (SAC) plays defense against chromosome mis-segregation
Q58126198Screening of cell cycle-related genes regulated by KIAA0101 in gastric cancer
Q73270846Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers
Q28190327Securin is required for chromosomal stability in human cells
Q93163984Separase-triggered apoptosis enforces minimal length of mitosis
Q24305356Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1
Q42673791Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage
Q24676152Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2
Q33497326Spindle assembly checkpoint protein dynamics reveal conserved and unsuspected roles in plant cell division
Q47281299Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents
Q24679269Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity
Q24682946Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
Q33787823Spindle checkpoint requires Mad1-bound and Mad1-free Mad2.
Q42930766Spindle checkpoint signaling requires the mis6 kinetochore subcomplex, which interacts with mad2 and mitotic spindles
Q39687466Spindle-kinetochore attachment requires the combined action of Kin I-like Klp5/6 and Alp14/Dis1-MAPs in fission yeast
Q22008675Structural requirements and dynamics of mitosin-kinetochore interaction in M phase
Q24534133Structure and interactions of the translation initiation factor eIF1
Q33581534Suppression of chemically induced and spontaneous mouse oocyte activation by AMP-activated protein kinase
Q37544007Synthetic genetic array screen identifies PP2A as a therapeutic target in Mad2-overexpressing tumors
Q46288094Taming the Beast: Control of APC/C(Cdc20)-Dependent Destruction.
Q41392338Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion.
Q30498045Temporal changes in Hec1 phosphorylation control kinetochore–microtubule attachment stability during mitosis
Q48460354Ten-Eleven Translocation 1 and 2 Confer Overlapping Transcriptional Programs for the Proliferation of Cultured Adult Neural Stem Cells
Q37595514The Caenorhabditis elegans kinetochore reorganizes at prometaphase and in response to checkpoint stimuli
Q39732713The DNA damage response to non-replicating adeno-associated virus: Centriole overduplication and mitotic catastrophe independent of the spindle checkpoint.
Q24298478The GTPase Gem and its partner Kif9 are required for chromosome alignment, spindle length control, and mitotic progression
Q32010161The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair
Q64056668The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells
Q24314385The Human Homologue of Bub3 Is Required for Kinetochore Localization of Bub1 and a Mad3/Bub1-related Protein Kinase
Q61735093The Kinetochore of Higher Eucaryotes: A Molecular View
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Q28586108The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells
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Q38103187The detection and implication of genome instability in cancer
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Q81126953The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments
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Q36273867The microtubule-dependent motor centromere-associated protein E (CENP-E) is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules.
Q33503223The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle
Q41146841The mitotic checkpoint complex (MCC): looking back and forth after 15 years
Q28188970The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins
Q42688555The promoter region of the human BUBR1 gene and its expression analysis in lung cancer
Q35013042The property of DNA polymerase zeta: REV7 is a putative protein involved in translesion DNA synthesis and cell cycle control
Q36614217The role of Six1 signaling in paclitaxel-dependent apoptosis in MCF-7 cell line.
Q35622956The role of mitotic checkpoint in maintaining genomic stability
Q41239083The spindle assembly checkpoint
Q36322881The spindle assembly checkpoint is not essential for CSF arrest of mouse oocytes
Q36456381The spindle assembly checkpoint: preventing chromosome mis-segregation during mitosis and meiosis
Q56951146The spindle checkpoint
Q27932971The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins
Q33976673The spindle checkpoint, aneuploidy, and cancer
Q27931883The spindle checkpoint.
Q35853950The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation
Q35563514The spindle checkpoint: from normal cell division to tumorigenesis.
Q34931754The spindle checkpoint: structural insights into dynamic signalling
Q27860766The spindle-assembly checkpoint in space and time
Q38717231The vertebrate cell kinetochore and its roles during mitosis
Q27939354The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint
Q24311706Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint
Q24648756Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation
Q40426933Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype
Q24322683Ubiquitylation-dependent localization of PLK1 in mitosis
Q24541554Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres
Q36366483Unraveling cell division mechanisms with small-molecule inhibitors
Q28510724Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E
Q35747590Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer
Q36293815Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells
Q28653059Widespread pollution of the South American atmosphere predates the industrial revolution by 240 y
Q28138144Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation
Q24322833ZW10 Helps Recruit Dynactin and Dynein to the Kinetochore
Q24299625Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions
Q77116066[When chromosomal dynamics control cell division]
Q33958873c-Myc overexpression uncouples DNA replication from mitosis
Q34186421fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence
Q74406181hBUB1 defects in leukemia and lymphoma cells
Q48037929mph1, a member of the Mps1-like family of dual specificity protein kinases, is required for the spindle checkpoint in S. pombe
Q40879237p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells
Q35153630p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest
Q24290396p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase
Q35746700polo Is Identified as a Suppressor of bubR1 Nondisjunction in a Deficiency Screen of the Third Chromosome in Drosophila melanogaster

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