G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells

scientific article

G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI13275
P932PMC publication ID151025
P698PubMed publication ID12093892
P5875ResearchGate publication ID11281701

P2093author name stringScott H Kaufmann
Timothy J Kottke
April L Blajeski
Vy A Phan
P2860cites workCharacterization of MAD2B and other mitotic spindle checkpoint genesQ22009979
Chfr defines a mitotic stress checkpoint that delays entry into metaphaseQ22254761
CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosisQ24307548
Identification of a human mitotic checkpoint gene: hsMAD2Q24308986
Prevention of mammalian DNA reduplication, following the release from the mitotic spindle checkpoint, requires p53 protein, but not p53-mediated transcriptional activityQ77640430
Defective G1-S cell cycle checkpoint function sensitizes cells to microtubule inhibitor-induced apoptosisQ78125116
CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localizationQ24318574
Mutations of mitotic checkpoint genes in human cancersQ24320018
The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochoresQ24651512
Taxol suppresses dynamics of individual microtubules in living human tumor cellsQ24657911
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signalQ28138891
Mutations in the p53 gene occur in diverse human tumour typesQ28249770
Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2Q28588417
MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cellsQ28593914
Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transportQ28612313
Requirement for p53 and p21 to sustain G2 arrest after DNA damageQ29547667
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNAQ29615251
Complexity in the spindle checkpointQ30304873
Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines.Q30326722
Cell-cycle inhibitors: three families united by a common causeQ33895611
Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamicsQ34059677
Waiting for anaphase: Mad2 and the spindle assembly checkpointQ34132901
Retention of the BUB3 checkpoint protein on lagging chromosomesQ35552257
Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrationsQ36598611
Characterization of the p53-dependent postmitotic checkpoint following spindle disruptionQ39574377
S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase functionQ40769630
Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell linesQ40944054
Comparison of paclitaxel-, 5-fluoro-2'-deoxyuridine-, and epidermal growth factor (EGF)-induced apoptosis. Evidence for EGF-induced anoikisQ40952877
Involvement of p21 in mitotic exit after paclitaxel treatment in MCF-7 breast adenocarcinoma cell lineQ41073290
The spindle assembly checkpointQ41239083
Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway.Q41328186
Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA.Q41358760
Microtubules and actin filaments: dynamic targets for cancer chemotherapyQ41713562
Cell adhesiveness and the cell cycle: correlation in synchronized Balb/c 3T3 cellsQ42824089
A multistep model for paclitaxel-induced apoptosis in human breast cancer cell linesQ43770900
Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosisQ43857351
p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest.Q45285580
Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.Q45984566
Mechanism of inhibition of cell proliferation by Vinca alkaloids.Q46826837
Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitroQ48483340
DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function.Q52195713
Mechanisms of Taxol-induced cell death are concentration dependent.Q52531670
p53-independent apoptosis and p53-dependent block of DNA rereplication following mitotic spindle inhibition in human cells.Q54086137
The spindle checkpointQ56951146
Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1Q59063779
Production of large numbers of mitotic mammalian cells by use of the reversible microtubule inhibitor NocodazoleQ59795201
Microtubule assembly in living cells after release from nocodazole block: the effects of metabolic inhibitors, taxol and PHQ72503177
p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cellsQ74190453
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectbreast cancerQ128581
P304page(s)91-99
P577publication date2002-07-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleG(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells
P478volume110

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