RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells

scientific article

RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/EMBOJ.2010.304
P3181OpenCitations bibliographic resource ID4754503
P932PMC publication ID3018799
P698PubMed publication ID21113133
P5875ResearchGate publication ID49640965

P50authorPhilippe PaseroQ42396002
Wojciech PiwkoQ63967127
P2093author name stringKay Hofmann
Daniel W Gerlich
Matthias Peter
Michael H Olma
Michael Held
Patrick G A Pedrioli
Julien N Bianco
P2860cites workLive-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cellsQ24295682
Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunitQ24299871
Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivoQ24300037
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1Q24301361
CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylationQ24306802
A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cellsQ24307672
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complexQ24312855
Cloning of a differentially expressed I kappa B-related proteinQ24316435
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Regulation of DNA repair throughout the cell cycleQ37088926
Regulated proteolysis of DNA polymerase eta during the DNA-damage response in C. elegansQ37105901
An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligasesQ37289496
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Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores.Q39131699
Histone H3-K56 acetylation is important for genomic stability in mammalsQ39857418
FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16.Q39992783
Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.Q40464510
DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cellsQ40814143
p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cellsQ40918524
Ubiquitylation of FACT by the cullin-E3 ligase Rtt101 connects FACT to DNA replicationQ42204697
Analysis of cell-based RNAi screens.Q42692808
Astrin regulates meiotic spindle organization, spindle pole tethering and cell cycle progression in mouse oocytesQ43266697
Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinasesQ44504054
The Cullin Rtt101p Promotes Replication Fork Progression through Damaged DNA and Natural Pause SitesQ63965584
Human CtIP promotes DNA end resectionQ24646062
Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockageQ27930463
Restoration of silencing in Saccharomyces cerevisiae by tethering of a novel Sir2-interacting protein, Esc8.Q27932665
Proteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repairQ27932933
Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencingQ27935062
Functional characterization of Pwp2, a WD family protein essential for the assembly of the 90 S pre-ribosomal particleQ27936916
Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae.Q27937523
Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNAQ27939872
Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancerQ27939939
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damageQ28238604
Replication protein A phosphorylation and the cellular response to DNA damageQ28274289
ATM and related protein kinases: safeguarding genome integrityQ29547735
ATR: an essential regulator of genome integrityQ29547883
Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell deathQ29614845
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction mapQ29618911
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaksQ30014828
DDB1 maintains genome integrity through regulation of Cdt1Q33255742
Sequential and synergistic modification of human RPA stimulates chromosomal DNA repairQ33302234
Topoisomerase I suppresses genomic instability by preventing interference between replication and transcriptionQ34031653
CellCognition: time-resolved phenotype annotation in high-throughput live cell imaging.Q34130316
53BP1, a mediator of the DNA damage checkpointQ34153067
Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cellsQ34284545
A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene regionQ34349610
Tandem affinity purification combined with inducible shRNA expression as a tool to study the maturation of macromolecular assembliesQ34415431
UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.Q34417183
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sitesQ34479820
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligaseQ34641190
Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroyQ35651812
Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family.Q35740993
A means to a DNA end: the many roles of Ku.Q35762470
RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.Q35856709
Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathwaysQ35878420
Regulation of rtt107 recruitment to stalled DNA replication forks by the cullin rtt101 and the rtt109 acetyltransferaseQ36325888
High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancerQ36465618
Maintenance of fork integrity at damaged DNA and natural pause sitesQ36767344
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)4210-4222
P577publication date2010-11-26
P1433published inThe EMBO JournalQ1278554
P1476titleRNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells
P478volume29

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