Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes

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Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/IJMS13032893
P3181OpenCitations bibliographic resource ID1130193
P932PMC publication ID3317694
P698PubMed publication ID22489132
P5875ResearchGate publication ID223970688

P50authorLudmilla Morozova-RocheQ56997607
P2093author name stringThomas Vogl
Anna L Gharibyan
P2860cites workNeutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicansQ21090509
Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamidesQ21145828
Analysis of the MRP8-MRP14 protein-protein interaction by the two-hybrid system suggests a prominent role of the C-terminal domain of S100 proteins in dimer formationQ22008586
Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free statesQ22008796
Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritisQ24297982
Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and functionQ24318378
Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromesQ80043875
Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritisQ80137309
Calcium-binding proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancerQ80404832
Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cellsQ81144246
VITAL FACTORS IN THE MANAGEMENT OF PROSTATIC OBSTRUCTIONQ81286737
Structural and functional insights into RAGE activation by multimeric S100BQ24322846
Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitroQ24540945
Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiationQ24631640
Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 proteinQ24641894
Inflammation and cancerQ24649640
Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI ...Q24650933
Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cellsQ24658240
RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesisQ24658378
The structure of human MRP8, a member of the S100 calcium-binding protein family, by MAD phasing at 1.9 A resolutionQ27622273
The crystal structure of human MRP14 (S100A9), a Ca(2+)-dependent regulator protein in inflammatory processQ27637868
The structure of S100A12 in a hexameric form and its proposed role in receptor signallingQ27637958
The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteinsQ27645299
The crystal structures of human S100B in the zinc- and calcium-loaded state at three pH values reveal zinc ligand swappingQ27665078
Myeloid-derived suppressor cells as regulators of the immune systemQ28131637
S100 protein subcellular localization during epidermal differentiation and psoriasisQ28155924
S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunityQ28184564
Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular eventsQ28238975
Ionomycin-regulated phosphorylation of the myeloid calcium-binding protein p14Q28239285
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shockQ28244377
MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent mannerQ28264008
Crystal structures of the helix-loop-helix calcium-binding proteinsQ28271755
Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasisQ28275735
S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end productsQ28276090
Corpora amylacea in adenocarcinoma of the prostate: incidence and histology within needle core biopsiesQ28276978
S100A8 and S100A9 activate MAP kinase and NF-kappaB signaling pathways and trigger translocation of RAGE in human prostate cancer cellsQ28282599
The S100 family of EF-hand calcium-binding proteins: functions and pathologyQ28284255
Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissuesQ28294324
Solution structure of zinc- and calcium-bound rat S100B as determined by nuclear magnetic resonance spectroscopyQ28566033
DAMPs, PAMPs and alarmins: all we need to know about dangerQ29547535
Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 detected by ultraviolet matrix-assisted laser desorption/ionization mass spectrometryQ30801637
Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 are confirmed by electrospray ionization-mass analysisQ31806915
Myeloid-related protein-14 is a p38 MAPK substrate in human neutrophilsQ33215420
Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activityQ33243153
NMR studies of the E140Q mutant of the carboxy-terminal domain of calmodulin reveal global conformational exchange in the Ca2+-saturated state.Q42654826
Increase of calcium levels in epithelial cells induces translocation of calcium-binding proteins migration inhibitory factor-related protein 8 (MRP8) and MRP14 to keratin intermediate filamentsQ42821504
Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureusQ42869319
Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritisQ43905357
Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectinQ44321883
Purification and structural analysis of a murine chemotactic cytokine (CP-10) with sequence homology to S100 proteinsQ46012232
Metal ions modulate the folding and stability of the tumor suppressor protein S100A2.Q46097265
S100A8 and S100A9 in human arterial wall. Implications for atherogenesis.Q46745779
Probing the S100 protein family through genomic and functional analysisQ47328349
Calgranulins in cystic fluid and serum from patients with ovarian carcinomasQ47390431
A soluble protein characteristic of the nervous systemQ47721048
An update of the S100 nomenclatureQ48699135
The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cellsQ50335842
Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4.Q54336370
S100A8 enhances osteoclastic bone resorption in vitro through activation of Toll-like receptor 4: implications for bone destruction in murine antigen-induced arthritis.Q54386801
The structure of S100A12 in a hexameric form and its proposed role in receptor signallingQ56804236
Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathwayQ57189369
Defective chemoattractant-induced calcium signalling in S100A9 null neutrophilsQ57359914
Proinflammatory cytokines upregulate expression of calprotectin (L1 protein, MRP-8/MRP-14) in cultured human keratinocytesQ61999553
Expression and Role of Myeloid-related Protein-14 in Clinical and Experimental SepsisQ63359105
Troponin and Parvalbumin Calcium Binding Regions Predicted in Myosin Light Chain and T4 LysozymeQ66907974
Classification of benign diseases associated with prostatic pain: prostatitis or prostatodynia?Q67357038
A protein complex expressed during terminal differentiation of monomyelocytic cells is an inhibitor of cell growthQ68662893
Phosphorylation of MRP14, an S100 protein expressed during monocytic differentiation, modulates Ca(2+)-dependent translocation from cytoplasm to membranes and cytoskeletonQ70890815
Phosphorylation of myeloid-related proteins MRP-14 and MRP-8 during human neutrophil activationQ71740085
Oligomeric forms of the metastasis-related Mts1 (S100A4) protein stimulate neuronal differentiation in cultures of rat hippocampal neuronsQ73038419
Zinc binding reverses the calcium-induced arachidonic acid-binding capacity of the S100A8/A9 protein complexQ73203632
Amyloidosis of the seminal vesicles simulating tumor invasion of prostatic carcinoma on endorectal MR imagesQ73469030
Increased perivascular synovial membrane expression of myeloid-related proteins in psoriatic arthritisQ73497787
Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritisQ73574466
NMR studies of Ca2+ binding to the regulatory domains of cardiac and E41A skeletal muscle troponin C reveal the importance of site I to energetics of the induced structural changesQ73894132
Zinc-reversible antimicrobial activity of recombinant calprotectin (migration inhibitory factor-related proteins 8 and 14)Q74296097
Biophysical characterization of S100A8 and S100A9 in the absence and presence of bivalent cationsQ33260804
Cancer and complementQ33567710
New perspectives on S100 proteins: a multi-functional Ca(2+)-, Zn(2+)- and Cu(2+)-binding protein familyQ33587204
S100A8 and S100A9 in experimental osteoarthritis.Q33873682
S100 proteins in Corpora amylacea from normal human brain.Q33904267
S100beta interaction with tau is promoted by zinc and inhibited by hyperphosphorylation in Alzheimer's diseaseQ33939347
MRP8 and MRP14, phagocyte-specific danger signals, are sensitive biomarkers of disease activity in cryopyrin-associated periodic syndromesQ34240472
S100 proteins and their influence on pro-survival pathways in cancerQ34337425
MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytesQ34343550
Proinflammatory S100 proteins in arthritis and autoimmune diseaseQ34375738
MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death programQ34580601
Myeloid cell function in MRP-14 (S100A9) null miceQ34783815
S100A8/A9 activate key genes and pathways in colon tumor progressionQ34802977
Benign prostatic hyperplasia: age-related tissue-remodelingQ36069075
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomersQ36178075
1H NMR assignments of apo calcyclin and comparative structural analysis with calbindin D9k and S100 betaQ36279523
S100A8 and S100A9 in inflammation and cancerQ36538576
Inflammation in prostate carcinogenesisQ36554784
S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern moleculesQ36582027
A review of the S100 proteins in cancerQ36848759
We find them here, we find them there: functional bacterial amyloid.Q37011811
Pathologies involving the S100 proteins and RAGE.Q37056421
Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostateQ37182479
S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathwayQ37331858
The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancerQ37487325
Natural and amyloid self-assembly of S100 proteins: structural basis of functional diversity.Q37803273
Biochemical and biophysical features of both oligomer/fibril and cell membrane in amyloid cytotoxicity.Q37803276
S100A8/A9 amyloidosis in the ageing prostate: relating ex vivo and in vitro studiesQ38004968
Global gene expression profiling unveils S100A8/A9 as candidate markers in H-ras-mediated human breast epithelial cell invasion.Q38498421
Prostatic calculi: a reviewQ39837849
Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritisQ39911998
Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependentQ39973796
Mast cell and monocyte recruitment by S100A12 and its hinge domainQ40010360
MRP-8 and MRP-14, two abundant Ca(2+)-binding proteins of neutrophils and monocytesQ40882126
High level expression and dimer characterization of the S100 EF-hand proteins, migration inhibitory factor-related proteins 8 and 14.Q41032857
Architectural patterns of high-grade prostatic intraepithelial neoplasiaQ42510562
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectorganic chemistryQ11351
catalysisQ82264
inflammationQ101991
self-assemblyQ910150
transport proteinQ2111029
nerve tissue proteinQ6996861
regulation of cytoskeleton organizationQ15317712
S100 calcium binding protein A9Q21102026
S100 calcium binding protein A8Q21114543
macromolecular substanceQ75174158
inflammation mediatorsQ66765004
P304page(s)2893-2917
P577publication date2012-03-05
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titlePro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes
P478volume13