| scholarly article | Q13442814 |
| P50 | author | Nicholas W. Wood | Q42592839 |
| Alexander J. Whitworth | Q42943935 | ||
| Alan Renton | Q44478769 | ||
| Andrey Y. Abramov | Q48291443 | ||
| Robert J. Harvey | Q49489445 | ||
| L. Miguel Martins | Q58740567 | ||
| Sonia Gandhi | Q67390619 | ||
| Helene Plun-Favreau | Q30089857 | ||
| Susanne Krüger Kjaer | Q38297251 | ||
| P2093 | author name string | Howard Desmond | |
| Emma Deas | |||
| Samantha H Y Loh | |||
| P2860 | cites work | PINK1 is selectively stabilized on impaired mitochondria to activate Parkin | Q21145802 |
| Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells | Q22009395 | ||
| PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1 | Q24312106 | ||
| The kinase domain of mitochondrial PINK1 faces the cytoplasm | Q24321709 | ||
| PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons | Q24322788 | ||
| Hereditary early-onset Parkinson's disease caused by mutations in PINK1 | Q24337084 | ||
| The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. | Q40074115 | ||
| Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. | Q40201823 | ||
| Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress | Q40262236 | ||
| C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1. | Q40285081 | ||
| Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations | Q40389365 | ||
| L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner. | Q46688403 | ||
| Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes | Q48545239 | ||
| Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism | Q48742196 | ||
| Mitochondrial import of Omi: the definitive role of the putative transmembrane region and multiple processing sites in the amino-terminal segment. | Q50671800 | ||
| Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa | Q82213842 | ||
| PINK1 protein in normal human brain and Parkinson's disease | Q24337151 | ||
| Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology | Q24675079 | ||
| Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling | Q28506506 | ||
| Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice | Q28507648 | ||
| The PINK1/Parkin pathway regulates mitochondrial morphology | Q29615641 | ||
| PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy | Q29616005 | ||
| PINK1-dependent recruitment of Parkin to mitochondria in mitophagy | Q29620567 | ||
| Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin | Q29622838 | ||
| Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide | Q30273591 | ||
| The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. | Q33292556 | ||
| A method for measuring mitochondrial mass and activity | Q33383918 | ||
| The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach | Q33394532 | ||
| 17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy | Q33525555 | ||
| Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity | Q33714875 | ||
| A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease | Q33871331 | ||
| Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain | Q34207965 | ||
| PINK1 mutations are associated with sporadic early-onset parkinsonism | Q34345883 | ||
| PINK1 (PARK6) associated Parkinson disease in Ireland | Q34362007 | ||
| Mitochondrial fusion and fission in mammals | Q34526830 | ||
| A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis | Q34623508 | ||
| Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin | Q34892238 | ||
| Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. | Q36446511 | ||
| Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery | Q36657599 | ||
| Characterization of PINK1 processing, stability, and subcellular localization | Q36802214 | ||
| The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases | Q37336182 | ||
| Mitophagy and Parkinson's disease: the PINK1-parkin link. | Q37587126 | ||
| PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death | Q39873016 | ||
| Mitochondrial PINK1--a novel cardioprotective kinase? | Q39934273 | ||
| Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1. | Q40046504 | ||
| Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1. | Q40051916 | ||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | mitochondrion | Q39572 |
| regulation of reactive oxygen species metabolic process | Q14864254 | ||
| PTEN induced kinase 1 | Q21112306 | ||
| Presenilin associated rhomboid like | Q21133412 | ||
| Presenilin associated, rhomboid-like | Q21985962 | ||
| P304 | page(s) | 867-879 | |
| P577 | publication date | 2010-12-06 | |
| P1433 | published in | Human Molecular Genetics | Q2720965 |
| P1476 | title | PINK1 cleavage at position A103 by the mitochondrial protease PARL | |
| P478 | volume | 20 |
| Q36172257 | A Ubl/ubiquitin switch in the activation of Parkin |
| Q41846746 | A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment. |
| Q38014338 | Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1). |
| Q38084832 | Atypical protein phosphatases: emerging players in cellular signaling |
| Q28084804 | Autophagosome dynamics in neurodegeneration at a glance |
| Q36657697 | Autophagy in Ischemic Livers: A Critical Role of Sirtuin 1/Mitofusin 2 Axis in Autophagy Induction |
| Q90271568 | Autophagy, apoptosis, and mitochondria: molecular integration and physiological relevance in skeletal muscle |
| Q41166658 | BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria |
| Q42380694 | BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy |
| Q28391455 | Beyond mitophagy: cytosolic PINK1 as a messenger of mitochondrial health |
| Q34379744 | Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A |
| Q38120932 | Bioinformatics perspective on rhomboid intramembrane protease evolution and function |
| Q40394013 | Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease |
| Q36636038 | Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila |
| Q28383414 | Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy |
| Q44039446 | Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese. |
| Q58586113 | Crosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome System |
| Q89497672 | Culprit or Bystander: Defective Mitophagy in Alzheimer's Disease |
| Q36810811 | Cytosolic PINK1 promotes the targeting of ubiquitinated proteins to the aggresome-autophagy pathway during proteasomal stress |
| Q35860557 | Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-κB Pathway and Promotes Non-selective Mitophagy |
| Q24314939 | Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy |
| Q58712192 | Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy |
| Q36526622 | Drosophila as a model to study mitochondrial dysfunction in Parkinson's disease |
| Q37336130 | Drosophila clueless is involved in Parkin-dependent mitophagy by promoting VCP-mediated Marf degradation |
| Q91867181 | Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer's Disease Pathogenesis |
| Q92811394 | Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson's Disease |
| Q38093581 | Function and characteristics of PINK1 in mitochondria |
| Q38557027 | Genes associated with Parkinson's disease: regulation of autophagy and beyond |
| Q52718062 | Gintonin Mitigates MPTP-Induced Loss of Nigrostriatal Dopaminergic Neurons and Accumulation of α-Synuclein via the Nrf2/HO-1 Pathway. |
| Q24318901 | Hexokinase activity is required for recruitment of parkin to depolarized mitochondria |
| Q28392567 | How Parkinsonian toxins dysregulate the autophagy machinery |
| Q96230246 | Human telomerase reverse transcriptase positively regulates mitophagy by inhibiting the processing and cytoplasmic release of mitochondrial PINK1 |
| Q41459590 | Identification of the N-terminal transmembrane domain of StarD7 and its importance for mitochondrial outer membrane localization and phosphatidylcholine transfer |
| Q92924523 | Imaging Mitochondrial Functions: from Fluorescent Dyes to Genetically-Encoded Sensors |
| Q26766040 | Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration |
| Q36111814 | Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy |
| Q38790377 | Intramembrane proteases as drug targets |
| Q37876486 | Intramembrane proteolysis in regulated protein trafficking |
| Q34042190 | Keeping the immune system in check: a role for mitophagy |
| Q36560469 | Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging |
| Q33652051 | Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase |
| Q49612593 | Mechanisms, pathophysiological roles and methods for analyzing mitophagy - recent insights |
| Q37520524 | MicroRNA-181a suppresses parkin-mediated mitophagy and sensitizes neuroblastoma cells to mitochondrial uncoupler-induced apoptosis |
| Q36124905 | Mitochondria: the next (neurode)generation |
| Q89697766 | Mitochondrial E3 Ubiquitin Ligase Parkin: Relationships with Other Causal Proteins in Familial Parkinson's Disease and Its Substrate-Involved Mouse Experimental Models |
| Q58905388 | Mitochondrial Regulation by PINK1-Parkin Signaling |
| Q91982212 | Mitochondrial Transport and Turnover in the Pathogenesis of Amyotrophic Lateral Sclerosis |
| Q27001551 | Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder |
| Q38021865 | Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences |
| Q28115890 | Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression |
| Q35874914 | Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment |
| Q28083423 | Mitochondrial protein quality control: the mechanisms guarding mitochondrial health |
| Q37673241 | Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health |
| Q35799128 | Mitochondrial quality control and dynamics in Parkinson's disease |
| Q38944334 | Mitochondrial quality control by the Pink1/Parkin system |
| Q41429779 | Mitochondrial quality control in amyotrophic lateral sclerosis: towards a common pathway? |
| Q34309906 | Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism. |
| Q37987023 | Mitochondrial quality control: a matter of life and death for neurons |
| Q47147902 | Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy. |
| Q35223923 | Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease. |
| Q27001001 | Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart |
| Q94564493 | MitophAging: Mitophagy in Aging and Disease |
| Q39381679 | Mitophagy Transcriptome: Mechanistic Insights into Polyphenol-Mediated Mitophagy. |
| Q52375973 | Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance. |
| Q89552152 | Mitophagy in Acute Kidney Injury and Kidney Repair |
| Q90663952 | Mitophagy in Cardiovascular Diseases |
| Q91795612 | Mitophagy: An Emerging Role in Aging and Age-Associated Diseases |
| Q28383419 | Mitophagy: Basic Mechanism and Potential Role in Kidney Diseases |
| Q29248361 | Neuronal Mitophagy in Neurodegenerative Diseases |
| Q36563117 | Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain |
| Q35451190 | Nitric oxide induction of Parkin translocation in PTEN-induced putative kinase 1 (PINK1) deficiency: functional role of neuronal nitric oxide synthase during mitophagy |
| Q54977052 | Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy. |
| Q38215011 | Organellophagy: eliminating cellular building blocks via selective autophagy |
| Q24337079 | Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease |
| Q90711435 | PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome |
| Q64779288 | PINK1 Interacts with VCP/p97 and Activates PKA to Promote NSFL1C/p47 Phosphorylation and Dendritic Arborization in Neurons |
| Q24296955 | PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility |
| Q26866451 | PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease |
| Q37461824 | PINK1 as a molecular checkpoint in the maintenance of mitochondrial function and integrity |
| Q34641661 | PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria |
| Q34322599 | PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding |
| Q49371050 | PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol |
| Q38971958 | PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease |
| Q29622844 | PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65 |
| Q33638689 | PINK1 is degraded through the N-end rule pathway |
| Q24310717 | PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402 |
| Q29617292 | PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity |
| Q36920801 | PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage |
| Q37635610 | PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology? |
| Q36851332 | PINK1- and Parkin-mediated mitophagy at a glance |
| Q27316288 | PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix |
| Q44168907 | PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress |
| Q36476931 | PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy |
| Q38946190 | Parkin and mitophagy in cancer. |
| Q63359720 | Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy |
| Q26995496 | Parkin structure and function |
| Q37953288 | Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson's disease |
| Q36186542 | Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways |
| Q41828029 | Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1. |
| Q36080554 | Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode |
| Q61809108 | Potential Role of Mic60/Mitofilin in Parkinson's Disease |
| Q38641954 | Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease |
| Q89975356 | Protein Kinase C Isozymes and Autophagy during Neurodegenerative Disease Progression |
| Q37686264 | Quality control gone wrong: mitochondria, lysosomal storage disorders and neurodegeneration |
| Q27011609 | Quality control in mitochondria: use it, break it, fix it, trash it |
| Q37882863 | Quality control of mitochondrial proteostasis |
| Q48357636 | Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's disease |
| Q38116806 | Recent advances in Parkinson’s disease genetics. |
| Q42051309 | Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5 |
| Q37946954 | Rhomboid proteases in plants - still in square one? |
| Q88437809 | Role and mechanisms of autophagy in acetaminophen-induced liver injury |
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| Q37167886 | SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria |
| Q52677022 | Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease. |
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| Q41772411 | Structural and mechanistic basis of Parl activity and regulation. |
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