| scholarly article | Q13442814 |
| P2093 | author name string | B Margolis | |
| N Li | |||
| A Ullrich | |||
| J Schlessinger | |||
| T Pawson | |||
| A Koch | |||
| M Mohammadi | |||
| A Zilberstein | |||
| D R Hurwitz | |||
| P2860 | cites work | A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis | Q36926005 |
| Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction | Q39585633 | ||
| Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules. | Q40817131 | ||
| Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1. | Q40820033 | ||
| Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts. | Q41092881 | ||
| PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex | Q41737568 | ||
| Generation of recombinant cytoplasmic domain of epidermal growth factor receptor with intrinsic protein tyrosine kinase activity | Q41739529 | ||
| Ligand-induced transformation by a noninternalizing epidermal growth factor receptor | Q41743656 | ||
| PDGF induction of tyrosine phosphorylation of GTPase activating protein | Q41758485 | ||
| Identification of a novel autophosphorylation site (P4) on the epidermal growth factor receptor | Q41928036 | ||
| Analysis of mammalian fibroblast transformation by normal and mutated human EGF receptors | Q42054821 | ||
| Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing | Q42806503 | ||
| Sequence similarity of phospholipase C with the non-catalytic region of src. | Q48099424 | ||
| Cloning of bovine GAP and its interaction with oncogenic ras p21. | Q48316676 | ||
| Molecular cloning of two types of GAP complementary DNA from human placenta | Q67985384 | ||
| Epidermal growth factor | Q68508116 | ||
| Effect of phospholipase C-gamma overexpression on PDGF-induced second messengers and mitogenesis | Q68770632 | ||
| EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling | Q69078300 | ||
| Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases | Q24299026 | ||
| Binding of GAP to activated PDGF receptors | Q24302443 | ||
| Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity | Q24558728 | ||
| A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps | Q24616538 | ||
| Signal transduction by receptors with tyrosine kinase activity | Q27860624 | ||
| Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro | Q28256314 | ||
| A novel viral oncogene with structural similarity to phospholipase C | Q28307371 | ||
| Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells | Q28609939 | ||
| Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor | Q28609951 | ||
| Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates | Q28624927 | ||
| Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro | Q28625928 | ||
| All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor | Q28626012 | ||
| Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins | Q30195844 | ||
| Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex | Q30450356 | ||
| Src homology region 2 domains direct protein-protein interactions in signal transduction | Q30454167 | ||
| Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products | Q33634611 | ||
| Evidence that autophosphorylation of solubilized receptors for epidermal growth factor is mediated by intermolecular cross-phosphorylation | Q33834940 | ||
| Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium | Q33840438 | ||
| Autophosphorylation sites on the epidermal growth factor receptor. | Q34245370 | ||
| Tyrosine phosphorylation of phospholipase C-II in vitro by the epidermal growth factor receptor. | Q36056666 | ||
| Functional heterogeneity of proto-oncogene tyrosine kinases: the C terminus of the human epidermal growth factor receptor facilitates cell proliferation | Q36764628 | ||
| P433 | issue | 13 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | phosphorylation | Q242736 |
| signaling receptor binding | Q14819233 | ||
| RAS p21 protein activator 1 | Q21104745 | ||
| P304 | page(s) | 4375-80 | |
| P577 | publication date | 1990-12-01 | |
| P1433 | published in | The EMBO Journal | Q1278554 |
| P1476 | title | The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma | |
| P478 | volume | 9 |
| Q30194697 | A 31-amino-acid N-terminal extension regulates c-Crk binding to tyrosine-phosphorylated proteins |
| Q24600945 | A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction |
| Q28609913 | A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling |
| Q30450210 | A protein that is highly related to GTPase-activating protein-associated p62 complexes with phospholipase C gamma |
| Q33938449 | A single amino acid substitution is sufficient to modify the mitogenic properties of the epidermal growth factor receptor to resemble that of gp185erbB-2 |
| Q36807981 | A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activate phospholipase C. |
| Q24310428 | A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1 |
| Q36530938 | Activation of insulin-epidermal growth factor (EGF) receptor chimerae regulates EGF receptor binding affinity |
| Q41063499 | Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. |
| Q24310421 | Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes |
| Q41649277 | Alteration of the kinetic properties of the epidermal growth factor receptor tyrosine kinase by basic proteins |
| Q36652647 | Analysis of the role of the Shc and Grb2 proteins in signal transduction by the v-ErbB protein |
| Q36701137 | Association and phosphorylation-dependent dissociation of proteins in the insulin receptor complex |
| Q28186547 | Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences |
| Q22254063 | Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors |
| Q34438565 | Cross talk among tyrosine kinase receptors in PC12 cells: desensitization of mitogenic epidermal growth factor receptors by the neurotrophic factors, nerve growth factor and basic fibroblast growth factor |
| Q41814651 | Detection of a 60 kDa tyrosine-phosphorylated protein in insulin-stimulated hepatoma cells that associates with the SH2 domain of phosphatidylinositol 3-kinase |
| Q30450251 | Differential Modulation of Plasminogen Activator Gene Expression by Oncogene-Encoded Protein Tyrosine Kinases |
| Q42815996 | Differential effects of carboxy-terminal sequence deletions on platelet-derived growth factor receptor signaling activities and interactions with cellular substrates |
| Q30192897 | Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins |
| Q42844403 | Differentiation of peptide molecular recognition by phospholipase C gamma-1 Src homology-2 domain and a mutant Tyr phosphatase PTP1bC215S. |
| Q37244088 | Direct analysis of the binding of Src-homology 2 domains of phospholipase C to the activated epidermal growth factor receptor |
| Q36821816 | Dissecting the activating mutations in v-erbB of avian erythroblastosis virus strain R |
| Q38062331 | Epidermal growth factor receptor (EGFR) as a therapeutic target in rheumatoid arthritis |
| Q35687404 | Epidermal growth factor receptor: elements of intracellular communication |
| Q34914079 | Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity |
| Q30175330 | Functional independence and interdependence of the Src homology domains of phospholipase C-gamma1 in B-cell receptor signal transduction. |
| Q30195307 | GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion |
| Q24305821 | Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor |
| Q24563877 | High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains |
| Q24293518 | Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma |
| Q36812823 | In vitro phosphorylation of the erythropoietin receptor and an associated protein, pp130 |
| Q31169174 | Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors |
| Q24337412 | Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes |
| Q33958301 | Interallelic complementation among DER/flb alleles: implications for the mechanism of signal transduction by receptor-tyrosine kinases |
| Q41082448 | Ligand-induced transphosphorylation between different FGF receptors |
| Q41443192 | Limited proteolysis of phospholipase C-gamma 1 indicates stable association of X and Y domains with enhanced catalytic activity |
| Q28609932 | Molecular Mechanism for a Role of SHP2 in Epidermal Growth Factor Receptor Signaling |
| Q24596400 | Molecular features of the viral and cellular Src kinases involved in interactions with the GTPase-activating protein |
| Q24612979 | Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinase |
| Q40366179 | Mutation of proline-1003 to glycine in the epidermal growth factor (EGF) receptor enhances responsiveness to EGF. |
| Q42506168 | Non-catalytic activation of phospholipase C-gamma 1 in vitro by epidermal growth factor receptor |
| Q38084894 | Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis |
| Q27303898 | PKCδ localization at the membrane increases matrix traction force dependent on PLCγ1/EGFR signaling |
| Q24293143 | Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation |
| Q27012953 | Phosphoinositides: tiny lipids with giant impact on cell regulation |
| Q24561989 | Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C |
| Q36152346 | Phospholipase Cgamma activation and phosphoinositide hydrolysis are essential for embryonal development |
| Q34268347 | Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer |
| Q24336223 | Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo |
| Q24672516 | Phosphotyrosine interactome of the ErbB-receptor kinase family |
| Q28645713 | Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types |
| Q36812664 | Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo |
| Q37385906 | Positive and negative tissue-specific signaling by a nematode epidermal growth factor receptor |
| Q33996974 | Protein-protein interactions in signaling cascades |
| Q28578484 | Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein |
| Q41787609 | Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns |
| Q30479311 | R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes. |
| Q33872553 | RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity |
| Q41582081 | Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras |
| Q39585343 | Ras-GAP binding and phosphorylation by herpes simplex virus type 2 RR1 PK (ICP10) and activation of the Ras/MEK/MAPK mitogenic pathway are required for timely onset of virus growth |
| Q38193038 | Receptor tyrosine kinases: legacy of the first two decades |
| Q30176334 | Requirement for phospholipase C-gamma1 enzymatic activity in growth factor-induced mitogenesis |
| Q37165007 | Role of rap1B and p21ras GTPase-activating protein in the regulation of phospholipase C-gamma 1 in human platelets |
| Q38287574 | Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor |
| Q36676458 | SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence |
| Q29038594 | SH2 Domains Recognize Contextual Peptide Sequence Information to Determine Selectivity |
| Q24337707 | SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange |
| Q36962473 | SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors |
| Q30195496 | SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma |
| Q21245515 | SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome |
| Q37334950 | Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution |
| Q35929162 | Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase |
| Q30362141 | Spatially defined EGF receptor activation reveals an F-actin-dependent phospho-Erk signaling complex. |
| Q58697915 | The Effect of Canertinib on Sensitivity of Cytotoxic Drugs in Tamoxifen-Resistant Breast Cancer Cells In Vitro |
| Q37630052 | The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer |
| Q30195199 | The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels |
| Q41541366 | The Xmrk receptor tyrosine kinase is activated in Xiphophorus malignant melanoma. |
| Q37523399 | The biochemistry of ras p21. |
| Q52861971 | The discovery of modular binding domains: building blocks of cell signalling. |
| Q36692048 | The epidermal growth factor receptor phosphorylates GTPase-activating protein (GAP) at Tyr-460, adjacent to the GAP SH2 domains |
| Q41080866 | The inhibition of the GTPase activating protein-Ha-ras interaction by acidic lipids is due to physical association of the C-terminal domain of the GTPase activating protein with micellar structures |
| Q43131495 | The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF binding |
| Q30193166 | The nonreceptor protein-tyrosine kinase CSK complexes directly with the GTPase-activating protein-associated p62 protein in cells expressing v-Src or activated c-Src |
| Q24315811 | The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein |
| Q30454058 | The protooncogene c-sea encodes a transmembrane protein-tyrosine kinase related to the Met/hepatocyte growth factor/scatter factor receptor |
| Q40959643 | Transgenic mouse models of breast cancer |
| Q41674582 | Transmembrane signalling at the epidermal growth factor receptor. Positive regulation by the C-terminal phosphotyrosine residues |
| Q40594366 | Transmembrane signalling in eukaryotes: a comparison between higher and lower eukaryotes |
| Q33937612 | Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3′-kinase SH2 domains: a model for SH2-mediated receptor-target interactions |
| Q36797419 | Tyrosine phosphorylation of inducible nitric oxide synthase: implications for potential post-translational regulation |
| Q41904109 | Where EGF receptors transmit their signals |
| Q41511473 | p120 GAP requirement in normal and malignant human hematopoiesis |
| Q42070469 | p120 Ras GTPase-activating protein associates with fibroblast growth factor receptors in Drosophila |
| Q30009048 | p120RasGAP Protein Mediates Netrin-1 Protein-induced Cortical Axon Outgrowth and Guidance |
| Q33557412 | p120RasGAP mediates ephrin/Eph-dependent attenuation of FGF/ERK signals during cell fate specification in ascidian embryos |
| Q36236129 | pp60c-src is a positive regulator of growth factor-induced cell scattering in a rat bladder carcinoma cell line |
| Q33680497 | β-Adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt. |
Search more.