Transmembrane signalling at the epidermal growth factor receptor. Positive regulation by the C-terminal phosphotyrosine residues

scientific article published on July 1991

Transmembrane signalling at the epidermal growth factor receptor. Positive regulation by the C-terminal phosphotyrosine residues is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BJ2770305
P932PMC publication ID1151233
P698PubMed publication ID1713444
P5875ResearchGate publication ID21443226

P50authorKristian HelinQ24704761
P2093author name stringMeldolesi J
Beguinot L
Pandiella A
Magni M
P2860cites workTransmembrane signalling at epidermal growth factor receptors overexpressed in NIH 3T3 cells. Phosphoinositide hydrolysis, cytosolic Ca2+ increase and alkalinization correlate with epidermal-growth-factor-induced cell proliferationQ42802902
EGF raises cytosolic Ca2+ in A431 and Swiss 3T3 cells by a dual mechanism. Redistribution from intracellular stores and stimulated influxQ42808086
Evidence for the platelet-derived growth factor-stimulated tyrosine phosphorylation of the platelet-derived growth factor receptor in vivo. Immunopurification using a monoclonal antibody to phosphotyrosineQ42818537
Regulation of Phospholipase C-γ1 by Profilin and Tyrosine PhosphorylationQ43486850
Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine PhosphorylationQ44763188
Epidermal growth factor (EGF) stimulates inositol trisphosphate formation in cells which overexpress the EGF receptorQ58192858
Epidermal growth factorQ68508116
Effect of phospholipase C-gamma overexpression on PDGF-induced second messengers and mitogenesisQ68770632
Epidermal growth factor stimulates the phosphorylation of the calcium-dependent 35,000-dalton substrate in intact A-431 cellsQ68934470
Monoclonal antibodies to three phospholipase C isozymes from bovine brainQ69041898
EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signalingQ69078300
Activation of an EGFR/neu chimeric receptor: early intracellular signals and cell proliferation responsesQ69375861
Neutron and gamma ray scattering measurements for subsurface geochemistryQ81107664
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinasesQ24299026
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gammaQ24314441
Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulationQ24339590
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applicationsQ24561689
Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinaseQ24607466
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Signal transduction by receptors with tyrosine kinase activityQ27860624
A new generation of Ca2+ indicators with greatly improved fluorescence propertiesQ27860793
Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptorQ28609951
Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substratesQ28624927
Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitroQ28625928
All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptorQ28626012
Inositol trisphosphate, a novel second messenger in cellular signal transductionQ29618048
Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calciumQ33840438
Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cellsQ35103454
Tyrosine phosphorylation of phospholipase C-II in vitro by the epidermal growth factor receptor.Q36056666
The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activityQ36710439
Functional heterogeneity of proto-oncogene tyrosine kinases: the C terminus of the human epidermal growth factor receptor facilitates cell proliferationQ36764628
Platelet-derived growth factor: mechanism of action and possible in vivo functionQ37565963
Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptorsQ37685971
Transmembrane signalling at the epidermal growth factor receptorQ38761772
Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cellsQ41248381
PDGF induction of tyrosine phosphorylation of GTPase activating proteinQ41758485
Plasma membrane hyperpolarization and [Ca2+]i increase induced by fibroblast growth factor in NIH-3T3 fibroblasts: resemblance to early signals generated by platelet-derived growth factorQ42795747
The effect of epidermal growth factor on membrane potential. Rapid hyperpolarization followed by persistent fluctuationsQ42796172
P407language of work or nameEnglishQ1860
P921main subjecttransmembrane proteinQ424204
P304page(s)305-311
P577publication date1991-07-01
P1433published inBiochemical JournalQ864221
P1476titleTransmembrane signalling at the epidermal growth factor receptor. Positive regulation by the C-terminal phosphotyrosine residues
P478volume277 ( Pt 2)

Reverse relations

cites work (P2860)
Q67905746Comparison of effects of HGF and EGF on cellular calcium in rat hepatocytes
Q40529855Effects of gravity on the cellular response to epidermal growth factor
Q40345685Extracellular matrix modulates epidermal growth factor receptor activation in rat glomerular epithelial cells
Q67555822The perfused liver is capable of producing all transferrin glycan variants found in the sera of intact rats
Q28678514The role of individual SH2 domains in mediating association of phospholipase C-gamma1 with the activated EGF receptor
Q40852795Volume-regulated chloride conductance in the LNCaP human prostate cancer cell line

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