Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)

scientific article

Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3) is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.FEBSLET.2011.06.037
P3181OpenCitations bibliographic resource ID4373744
P698PubMed publication ID21762696
P5875ResearchGate publication ID51495990

P50authorHarry W M SteinbuschQ55178235
Nico P. DantumaQ44287534
P2093author name stringDenise J H P Hermes
Natalia Kholod
Nadja Kemmerling
Fred W van Leeuwen
Frank J A Dennissen
P2860cites workProteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's diseaseQ44365109
Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD.Q46792024
The ubiquitin pathway in Parkinson's diseaseQ48015939
Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative diseaseQ48219211
Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathiesQ48676892
Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cellsQ61788079
Microtiter plate transformation using the LiAc/SS carrier DNA/PEG methodQ80078238
Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8Q24301536
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonismQ24309753
UBE3A/E6-AP mutations cause Angelman syndromeQ24311799
Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolasesQ24320112
Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolutionQ24532257
Structural basis for the specificity of ubiquitin C-terminal hydrolasesQ27619057
Structural Insights into the Assembly and Function of the SAGA Deubiquitinating ModuleQ27660560
Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide GelsQ27860531
The ubiquitin systemQ27860803
Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patientsQ28258349
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseasesQ28269333
A genomic and functional inventory of deubiquitinating enzymesQ28284911
Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity phosphatase related to VH1 related (VHR).Q34104087
Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brainQ34274379
Tricine-SDS-PAGE.Q34615345
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brainsQ34620363
DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitinationQ35048728
Ubiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulationQ37274327
Targeting proteins for destruction by the ubiquitin system: implications for human pathobiologyQ37286190
Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.Q37387675
Minimal length requirement for proteasomal degradation of ubiquitin-dependent substratesQ39939165
Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradationQ42917499
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectneurodegenerationQ1755122
protein catabolic processQ14876077
Ubiquitin C-terminal hydrolase L3Q21126400
Ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)Q21991377
P304page(s)2568-74
P577publication date2011-08-19
P1433published inFEBS LettersQ1388051
P1476titleMutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)
P478volume585

Reverse relations

cites work (P2860)
Q35529325Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin
Q44552006Characterizing polyubiquitinated forms of the neurodegenerative ubiquitin mutant UBB+1.
Q47262421Deposition of mutant ubiquitin in parkinsonism-dementia complex of Guam.
Q55315713Different Expression Levels of Human Mutant Ubiquitin B+1 (UBB+1) Can Modify Chronological Lifespan or Stress Resistance of Saccharomyces cerevisiae.
Q52332790Dysfunction of Protein Quality Control in Parkinsonism-Dementia Complex of Guam.
Q35739138Extended ubiquitin species are protein-based DUB inhibitors
Q35668908Impacts of Chromatin States and Long-Range Genomic Segments on Aging and DNA Methylation
Q26782999Misframed ubiquitin and impaired protein quality control: an early event in Alzheimer's disease
Q28539822Mutant ubiquitin UBB+1 induces mitochondrial fusion by destabilizing mitochondrial fission-specific proteins and confers resistance to oxidative stress-induced cell death in astrocytic cells
Q37955915Review: unchained maladie - a reassessment of the role of Ubb(+1) -capped polyubiquitin chains in Alzheimer's disease.
Q38848112Role of frameshift ubiquitin B protein in Alzheimer's disease
Q26741828Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction
Q43180105Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers
Q38393072Ubiquitin-dependent proteolysis in yeast cells expressing neurotoxic proteins.

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