Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative

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Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.272.5.2668
P8608Fatcat IDrelease_b4jfpyfacjeofnuqayy4ppskx4
P3181OpenCitations bibliographic resource ID2614625
P698PubMed publication ID9006902

P2093author name stringK Brown
H Ellinger-Ziegelbauer
K Kelly
U Siebenlist
P2860cites workJNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domainQ24308838
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2Q24313872
Selective interaction of JNK protein kinase isoforms with transcription factorsQ24317346
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3Q24320233
Cloning, characterization, and modeling of mouse and human guanylate kinasesQ24321518
Complexity of the primary genetic response to mitogenic activation of human T cellsQ36767575
Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteinsQ37531019
Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.Q38292576
Rho family members: Activators of MAP kinase cascadesQ40476489
Parallel signal processing among mammalian MAPKsQ40501929
Diversity in function and regulation of MAP kinase pathwaysQ40695933
Receptor tyrosine kinases and their targetsQ40757554
Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.Q41228912
Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell deathQ41228964
Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1).Q41344713
Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.Q41461969
MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha.Q42812855
Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinaseQ42820729
Transforming G protein-coupled receptors potently activate JNK (SAPK). Evidence for a divergence from the tyrosine kinase signaling pathway.Q42829329
Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cellsQ59054505
c-Jun N-terminal kinase but not mitogen-activated protein kinase is sensitive to cAMP inhibition in T lymphocytesQ71942057
Ras-dependent growth factor regulation of MEK kinase in PC12 cellsQ72156822
Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinaseQ24336591
Characterization of the structure and function of a novel MAP kinase kinase (MKK6)Q24336966
A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B siteQ24630534
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathwayQ24650627
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferaseQ27860571
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomesQ27860600
MAP kinase pathways in yeast: for mating and moreQ27938176
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1Q28114883
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activationQ28131755
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cellsQ28237789
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylationQ28243308
A brain serine/threonine protein kinase activated by Cdc42 and Rac1Q28249559
A divergence in the MAP kinase regulatory network defined by MEK kinase and RafQ28263195
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transductionQ28271470
Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activityQ28276063
Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activationQ28277712
The MAPK signaling cascadeQ28292599
The primary structure of MEK, a protein kinase that phosphorylates the ERK gene productQ28316871
MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinaseQ28581201
MAPKs: new JNK expands the groupQ28611010
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosisQ29547567
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathwayQ29614258
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cellsQ29618480
Activation of Raf as a result of recruitment to the plasma membraneQ29618481
The stress-activated protein kinase subfamily of c-Jun kinasesQ29620001
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-JunQ29620103
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKKQ29620274
Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinaseQ30450248
Development of a highly efficient expression cDNA cloning system: application to oncogene isolationQ33595726
Raf-1 is required for T cell IL2 production.Q34063531
Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.Q34323179
Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascadeQ34379018
ERKs, extracellular signal-regulated MAP-2 kinasesQ36468781
GTPase-deficient G alpha 16 and G alpha q induce PC12 cell differentiation and persistent activation of cJun NH2-terminal kinasesQ36557162
c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinasesQ36667357
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectMAPK cascadeQ14758900
mitogen-activated protein kinase kinase kinase 3Q21154917
P304page(s)2668-74
P577publication date1997-01-31
P1433published inJournal of Biological ChemistryQ867727
P1476titleDirect activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative
P478volume272