14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2

scientific article

14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2 is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CCELL.2014.11.025
P3181OpenCitations bibliographic resource ID930966
P932PMC publication ID4325275
P698PubMed publication ID25670079

P50authorMien-Chie HungQ1532952
Joe E. EnsorQ40421901
Frank J LoweryQ56871266
Sunil AcharyaQ86705772
P2093author name stringLin Zhang
Aysegul A Sahin
Jia Xu
Jun Yao
Ping Li
Xiang H-F Zhang
Dihua Yu
Yi Xiao
Qingling Zhang
Hai Wang
Ozgur Sahin
Yohei Saito
Jitao David Zhang
Wen-Ling Kuo
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Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumorsQ28588676
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A multigenic program mediating breast cancer metastasis to boneQ29614308
Metastasis to bone: causes, consequences and therapeutic opportunitiesQ29614310
Specificity and versatility in tgf-beta signaling through SmadsQ29616324
Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylationQ33202126
Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosisQ33292546
Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers.Q33755493
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A novel role for 14-3-3sigma in regulating epithelial cell polarityQ33816790
S6K1 promotes invasiveness of breast cancer cells in a model of metastasis of triple-negative breast cancerQ33961949
Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb studyQ34480536
Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cellsQ34580134
Loss of Yes-associated protein (YAP) expression is associated with estrogen and progesterone receptors negativity in invasive breast carcinomasQ35581149
Targeting the TGFβ signalling pathway in diseaseQ36462348
Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins.Q36477042
Restriction of intestinal stem cell expansion and the regenerative response by YAP.Q36508081
14-3-3σ Positively Regulates p53 and Suppresses Tumor GrowthQ36549508
ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence.Q37219985
Targeting the p53 pathwayQ37260683
Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53.Q37269206
Roles of TGFbeta in metastasisQ37339711
YAP: at the crossroad between transformation and tumor suppressionQ37357685
Upregulation of neutrophil gelatinase-associated lipocalin by ErbB2 through nuclear factor-kappaB activationQ37479941
Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt.Q37593591
Gain or loss of TGFbeta signaling in mammary carcinoma cells can promote metastasisQ37608885
A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesisQ37631216
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewalQ37909890
The Hippo pathway and human cancer.Q38087215
PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.Q38357857
Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunitQ38712325
Yes-associated protein (YAP) functions as a tumor suppressor in breast.Q39962753
Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.Q40285122
A structural basis for 14-3-3sigma functional specificity.Q40454476
Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads.Q40649890
Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathwaysQ42520359
An alternative DNA damage pathway to apoptosis in hematological cancersQ46698546
Programmed cell senescence during mammalian embryonic development.Q50709155
Roles for negative cell regulator 14-3-3σ in control of MDM2 activitiesQ58884817
14-3-3 zeta down-regulates p53 in mammary epithelial cells and confers luminal fillingQ80869587
MicroRNA-200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancerQ85936182
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
breast cancerQ128581
P304page(s)177-192
P577publication date2015-02-01
P1433published inCancer CellQ280018
P1476title14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2
P478volume27

Reverse relations

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