ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence.

scientific article published on 09 August 2013

ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/CDD.2013.101
P932PMC publication ID3792425
P698PubMed publication ID23933816
P5875ResearchGate publication ID255735084

P50authorMoshe OrenQ6988150
Pier Paolo PandolfiQ7191735
Silvia Di AgostinoQ42724855
Claudio SetteQ47421898
Pamela BielliQ57028358
P2093author name stringM Sudol
G Blandino
M Cioce
S Strano
F Fausti
P2860cites workPML regulates p53 acetylation and premature senescence induced by oncogenic RasQ22254666
Physical interaction with Yes-associated protein enhances p73 transcriptional activityQ24291023
PML regulates p53 stability by sequestering Mdm2 to the nucleolusQ24296743
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cellsQ24296824
Chromatin immunoprecipitation to analyze DNA binding sites of HMGA2Q24300947
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53Q24311891
TEAD mediates YAP-dependent gene induction and growth controlQ24336045
A biomarker that identifies senescent human cells in culture and in aging skin in vivoQ24562644
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approachQ24633776
Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesisQ24641891
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary glandQ24669531
Atmospheric carbon dioxide concentrations over the past 60 million yearsQ28144787
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated versionQ28281214
Excess of rare cancers in Werner syndrome (adult progeria)Q28285360
Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP)Q28287783
Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domainQ28303362
Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated proteinQ28306685
Role of the beta catenin destruction complex in mediating chemotherapy-induced senescence-associated secretory phenotypeQ28484422
Enhanced phosphorylation of p53 by ATM in response to DNA damageQ28609838
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screenQ29615061
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressorQ29615559
RecQ helicases: caretakers of the genomeQ29618390
Positional cloning of the Werner's syndrome geneQ29618393
The senescence-associated secretory phenotype: the dark side of tumor suppressionQ29620106
Unwinding the 'Gordian knot' of helicase action.Q31879197
RecQ helicases: guardian angels of the DNA replication forkQ33314341
The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage.Q34418866
Werner protein protects nonproliferating cells from oxidative DNA damageQ34467601
Molecular genetics of RecQ helicase disordersQ34637883
The roles of tumor-derived exosomes in cancer pathogenesisQ35606520
The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant gliomaQ35642059
Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikisQ35674584
Restriction of intestinal stem cell expansion and the regenerative response by YAP.Q36508081
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stabilityQ36573932
PML Surfs into HIPPO Tumor Suppressor Pathway.Q36647912
Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases.Q37022414
YAP: at the crossroad between transformation and tumor suppressionQ37357685
PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.Q38357857
An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescenceQ39446297
SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cellsQ39454272
The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses.Q39841661
Yes-associated protein (YAP) functions as a tumor suppressor in breast.Q39962753
ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiationQ40883900
Recombinant ATM protein complements the cellular A-T phenotypeQ41099853
Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of YapQ42023045
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiencyQ43097729
DNA damage is able to induce senescence in tumor cells in vitro and in vivo.Q43931306
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.Q52536369
Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73Q58073315
Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cellsQ81419187
PGC1α confers specificity-metabolic stress and p53-dependent transcriptionQ82588762
P433issue11
P304page(s)1498-1509
P577publication date2013-08-09
P1433published inCell Death & DifferentiationQ2943974
P1476titleATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence
P478volume20

Reverse relations

cites work (P2860)
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