| scholarly article | Q13442814 |
| P50 | author | Andrei Okorokov | Q44225321 |
| P2093 | author name string | Jeffrey Cummings | |
| Simon P Joel | |||
| Lesley Jardine | |||
| Robert H te Poele | |||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1876-1883 | |
| P577 | publication date | 2002-03-01 | |
| P1433 | published in | Cancer Research | Q326097 |
| P1476 | title | DNA damage is able to induce senescence in tumor cells in vitro and in vivo | |
| P478 | volume | 62 |
| Q55322104 | "Social Life" of Senescent Cells: What Is SASP and Why Study It? |
| Q48859144 | 14-3-3β Depletion Drives a Senescence Program in Glioblastoma Cells Through the ERK/SKP2/p27 Pathway. |
| Q35962779 | 20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway |
| Q33488475 | A high-throughput method to identify novel senescence-inducing compounds. |
| Q47193915 | A mechanically interlocked molecular system programmed for the delivery of an anticancer drug |
| Q47141838 | A mechanically interlocked molecular system programmed for the delivery of an anticancer drug† †Electronic supplementary information (ESI): Experimental conditions and procedures, syntheses and compounds characterizations (1H, 13C and 2D NMR spectro |
| Q39626176 | A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts. |
| Q37535193 | A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno- and syngeneic systems. |
| Q28385780 | A novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle |
| Q37737075 | A nucleolytic lupus autoantibody is toxic to BRCA2-deficient cancer cells. |
| Q35108867 | A p53/ARF-dependent anticancer barrier activates senescence and blocks tumorigenesis without impacting apoptosis |
| Q89473494 | A previously identified apoptosis inhibitor iASPP confers resistance to chemotherapeutic drugs by suppressing senescence in cancer cells |
| Q34229984 | A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts. |
| Q34102024 | AKR1C3 overexpression mediates methotrexate resistance in choriocarcinoma cells |
| Q34162084 | ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer |
| Q37219985 | ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence. |
| Q36411149 | ATR signaling can drive cells into senescence in the absence of DNA breaks |
| Q36708466 | Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence |
| Q39150645 | Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence |
| Q34667252 | Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells |
| Q38727281 | Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner |
| Q39875703 | BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells |
| Q38776637 | BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance |
| Q37705958 | Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice. |
| Q36799307 | Bclaf1 is an important NF-κB signaling transducer and C/EBPβ regulator in DNA damage-induced senescence |
| Q55000770 | Biology of premature ageing in survivors of cancer. |
| Q50561688 | Blocking the utilization of glucose induces the switch from senescence to apoptosis in pseudolaric acid B-treated human lung cancer cells in vitro. |
| Q35040426 | Branched-chain amino acids enhance premature senescence through mammalian target of rapamycin complex I-mediated upregulation of p21 protein |
| Q57053007 | Breast cancer survival predicted by TP53 mutation status differs markedly depending on treatment |
| Q24299057 | Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1 |
| Q37425158 | Cancer therapy-induced residual bone marrow injury-Mechanisms of induction and implication for therapy |
| Q42571312 | Carnitine-induced senescence in glioblastoma cells |
| Q28301290 | Cell fusion induced by ERVWE1 or measles virus causes cellular senescence |
| Q27306356 | Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition |
| Q93082045 | Cellular Senescence and Iron Dyshomeostasis in Alzheimer's Disease |
| Q53692066 | Cellular Senescence in the Treatment of Ovarian Cancer. |
| Q35947022 | Cellular senescence and cancer chemotherapy resistance |
| Q36609955 | Cellular senescence and chromatin organisation |
| Q35815320 | Cellular senescence and organismal aging |
| Q37828383 | Cellular senescence as a target in cancer control |
| Q35628579 | Cellular senescence in cancer treatment: friend or foe? |
| Q49565626 | Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics |
| Q42426506 | Cellular senescence predicts treatment outcome in metastasised colorectal cancer. |
| Q35094229 | Chemotherapeutic approaches for targeting cell death pathways |
| Q90147993 | Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival |
| Q57629428 | Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects |
| Q36342896 | Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models |
| Q30829491 | Comparative analysis of gene expression data reveals novel targets of senescence-associated microRNAs |
| Q35493953 | Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity |
| Q37317313 | Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor |
| Q40183779 | Cyclin E expression and chemotherapeutic sensitivity in breast cancer cells |
| Q35080476 | Cyclopentenyl cytosine induces senescence in breast cancer cells through the nucleolar stress response and activation of p53. |
| Q35248527 | Cyproheptadine, an antihistaminic drug, inhibits proliferation of hepatocellular carcinoma cells by blocking cell cycle progression through the activation of P38 MAP kinase |
| Q33987511 | DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence |
| Q30537160 | DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells |
| Q89509419 | Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells |
| Q36199857 | Decreased skp2 expression is necessary but not sufficient for therapy-induced senescence in prostate cancer |
| Q25257786 | Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism |
| Q36141650 | Depletion of γ-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation |
| Q37688860 | Detection of cellular senescence within human invasive breast carcinomas distinguishes different breast tumor subtypes |
| Q35618954 | Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence? |
| Q38970720 | Down-regulation of FoxM1 inhibits viability and invasion of gallbladder carcinoma cells, partially dependent on inducement of cellular senescence |
| Q39161605 | Down-regulation of wild-type p53-induced phosphatase 1 (Wip1) plays a critical role in regulating several p53-dependent functions in premature senescent tumor cells. |
| Q36608493 | Drug-induced senescence bystander proliferation in prostate cancer cells in vitro and in vivo |
| Q35424191 | Drug-induced senescence generates chemoresistant stemlike cells with low reactive oxygen species |
| Q60312682 | Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence |
| Q38388674 | EZH2 inhibition re-sensitizes multidrug resistant B-cell lymphomas to etoposide mediated apoptosis |
| Q28543397 | Effects of 5-fluorouracil on morphology, cell cycle, proliferation, apoptosis, autophagy and ROS production in endothelial cells and cardiomyocytes |
| Q39434311 | Epithelial cell senescence: an adaptive response to pre-carcinogenic stresses? |
| Q50938398 | Excess centrosomes induce p53-dependent senescence without DNA damage in endothelial cells. |
| Q39777394 | Features of senescence and cell death induced by doxorubicin in A549 cells: organization and level of selected cytoskeletal proteins. |
| Q34025754 | Four faces of cellular senescence. |
| Q35679515 | Glyoxalase I retards renal senescence |
| Q37216997 | Guizhi Fuling Wan as a novel agent for intravesical treatment for bladder cancer in mouse model |
| Q37606476 | Hematopoietic stem cell injury induced by ionizing radiation |
| Q37616321 | Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury |
| Q39385037 | IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells |
| Q37017649 | INK4a/ARF limits the expansion of cells suffering from replication stress |
| Q37193100 | Identification of cellular senescence-specific genes by comparative transcriptomics |
| Q35773743 | Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology |
| Q64073233 | In vitro study of the Polo-like kinase 1 inhibitor volasertib in non-small-cell lung cancer reveals a role for the tumor suppressor p53 |
| Q34525129 | Inactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cells |
| Q40743589 | Increasing the complexity of respiratory syncytial virus infection: Reactive oxygen species, DNA damage, and premature senescence |
| Q52609042 | Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence. |
| Q50643738 | Inhibition of Twist1-mediated invasion by Chk2 promotes premature senescence in p53-defective cancer cells. |
| Q38230319 | Inside and out: the activities of senescence in cancer. |
| Q37295309 | Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development |
| Q34882042 | Interleukin-6 decreases senescence and increases telomerase activity in malignant human cholangiocytes |
| Q37203685 | Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases |
| Q33812688 | Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells |
| Q42324483 | Liver Yin deficiency tonifying herbal extract induces apoptosis and cell senescence in Bel-7402 human hepatocarcinoma cells |
| Q55434466 | Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence. |
| Q36689527 | Low-dose etoposide-treatment induces endoreplication and cell death accompanied by cytoskeletal alterations in A549 cells: Does the response involve senescence? The possible role of vimentin |
| Q36405926 | MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation |
| Q35994479 | MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype |
| Q33925097 | Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells. |
| Q92629967 | Mechanisms and significance of therapy-induced and spontaneous senescence of cancer cells |
| Q37500307 | Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells. |
| Q36772203 | Metronomic topotecan impedes tumor growth of MYCN-amplified neuroblastoma cells in vitro and in vivo by therapy induced senescence |
| Q37706483 | Mitotic catastrophe and cell cycle arrest are alternative cell death pathways executed by bortezomib in rituximab resistant B-cell lymphoma cells |
| Q27007045 | NF-κB in cellular senescence and cancer treatment |
| Q39181854 | Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells |
| Q35810716 | Novel ARF/p53-independent senescence pathways in cancer repression. |
| Q36657633 | Novel functions of FoxM1: from molecular mechanisms to cancer therapy |
| Q36781105 | Nucleolar repression facilitates initiation and maintenance of senescence |
| Q37401600 | Oncogene-induced cellular senescence elicits an anti-Warburg effect |
| Q37890974 | Oncogene-induced senescence and its role in tumor suppression. |
| Q60935673 | Oncogenic Metabolism Acts as a Prerequisite Step for Induction of Cancer Metastasis and Cancer Stem Cell Phenotype |
| Q37297051 | P21-PARP-1 pathway is involved in cigarette smoke-induced lung DNA damage and cellular senescence |
| Q61449898 | PDCD4 Knockdown Induces Senescence in Hepatoma Cells by Up-Regulating the p21 Expression |
| Q38981503 | PKCι depletion initiates mitotic slippage-induced senescence in glioblastoma |
| Q47437818 | PRMT5 as a druggable target for glioblastoma therapy. |
| Q47927484 | Pathways from senescence to melanoma: focus on MITF sumoylation. |
| Q39300990 | Persistent DNA damage caused by low levels of mitomycin C induces irreversible cell senescence |
| Q27334288 | Plk1 inhibition causes post-mitotic DNA damage and senescence in a range of human tumor cell lines |
| Q48505210 | Preclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer |
| Q42123911 | Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells |
| Q37893959 | Pro-senescence therapy for cancer treatment |
| Q37053539 | Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis |
| Q40279139 | Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes |
| Q47095396 | Protein and chemotherapy profiling of extracellular vesicles harvested from therapeutic induced senescent triple negative breast cancer cells |
| Q35118638 | Proteomics analysis of normal and senescent NG108-15 cells: GRP78 plays a negative role in cisplatin-induced senescence in the NG108-15 cell line |
| Q34116777 | Radiation-induced cell death mechanisms |
| Q36767034 | Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells |
| Q91643126 | Radiosensitization of Non-Small Cell Lung Cancer Cells by the Plk1 Inhibitor Volasertib Is Dependent on the p53 Status |
| Q36077635 | Reactive oxygen species and hematopoietic stem cell senescence |
| Q39002281 | Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular carcinoma |
| Q34392752 | Reactive oxygen species in normal and tumor stem cells. |
| Q61796114 | Real-time imaging of senescence in tumors with DNA damage |
| Q35083731 | Recombinant alpha2(IV)NC1 domain inhibits tumor cell-extracellular matrix interactions, induces cellular senescence, and inhibits tumor growth in vivo |
| Q34056137 | Regulation of DNA repair mechanism in human glioma xenograft cells both in vitro and in vivo in nude mice |
| Q64094156 | Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment |
| Q34665706 | Regulation of senescence in cancer and aging |
| Q34656775 | Resveratrol enhances ionizing radiation-induced premature senescence in lung cancer cells |
| Q34638026 | Resveratrol induces premature senescence in lung cancer cells via ROS-mediated DNA damage |
| Q28081010 | Retinoids induce cellular senescence in breast cancer cells by RAR-β dependent and independent pathways: Potential clinical implications (Review) |
| Q35561999 | Reversal of human cellular senescence: roles of the p53 and p16 pathways |
| Q35942243 | Rhus coriaria induces senescence and autophagic cell death in breast cancer cells through a mechanism involving p38 and ERK1/2 activation |
| Q36479612 | Role of senescence marker p16 INK4a measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults |
| Q24801155 | Role of the p53/p21 system in the response of human colon carcinoma cells to Doxorubicin |
| Q41676837 | Role of wild-type p53-induced phosphatase 1 in cancer |
| Q39739211 | Selenium compounds activate early barriers of tumorigenesis |
| Q91605067 | Senescence and Cancer |
| Q27687881 | Senescence and the pro-tumorigenic stroma |
| Q37168870 | Senescence at a glance |
| Q36903843 | Senescence in tumours: evidence from mice and humans |
| Q38072351 | Senescence regulation by the p53 protein family |
| Q35080496 | Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis |
| Q35080064 | Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS) |
| Q33702243 | Senescent tumor cells lead the collective invasion in thyroid cancer |
| Q93060574 | Short and Long-Term Effects of the Exposure of Breast Cancer Cell Lines to Different Ratios of Free or Co-Encapsulated Liposomal Paclitaxel and Doxorubicin |
| Q55215006 | Significance of cellular senescence in aging and cancer. |
| Q60959037 | Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells |
| Q51766043 | Simultaneous induction and blockade of autophagy by a single agent. |
| Q28068732 | Small molecule compounds that induce cellular senescence |
| Q39049084 | Sodium valproate induces cell senescence in human hepatocarcinoma cells |
| Q40284257 | Spontaneous senescence in the MDA-MB-231 cell line |
| Q34395718 | Stable cellular senescence is associated with persistent DDR activation |
| Q27497212 | Stem cells, senescence, neosis and self-renewal in cancer |
| Q98467289 | Structural basis of the anti-ageing effects of polyphenolics: mitigation of oxidative stress |
| Q34400375 | Survivin and escaping in therapy-induced cellular senescence |
| Q33728894 | Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers |
| Q38749878 | Teng-Long-Bu-Zhong-Tang induces p21-dependent cell senescence in colorectal carcinoma LS174T cells via histone acetylation |
| Q41687394 | The IGF-1R/AKT pathway determines cell fate in response to p53. |
| Q42380380 | The Immortal Senescence |
| Q39018419 | The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence |
| Q34288983 | The essence of senescence |
| Q34769742 | The identification of senescence-specific genes during the induction of senescence in prostate cancer cells |
| Q26825221 | The impact of cellular senescence in cancer therapy: is it true or not? |
| Q38204520 | The implications of hyponitroxia in cancer |
| Q39820039 | The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells. |
| Q37139394 | The role of cell differentiation in controlling cell multiplication and cancer |
| Q26741736 | Therapeutic Targeting of Telomerase |
| Q27027457 | Therapeutic targeting of replicative immortality |
| Q34212773 | Therapy-Induced Senescence in Cancer |
| Q54962871 | Trabectedin modulates the senescence-associated secretory phenotype and promotes cell death in senescent tumor cells by targeting NF-κB. |
| Q33736728 | Tumor suppression by p53: making cells senescent |
| Q35378363 | Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype |
| Q40746997 | Ultraconserved region-containing Transformer 2β4 controls senescence of colon cancer cells. |
| Q30179397 | VentX trans-activates p53 and p16ink4a to regulate cellular senescence |
| Q35585808 | What has senescence got to do with cancer? |
| Q36021953 | Wnt7a is a novel inducer of β-catenin-independent tumor-suppressive cellular senescence in lung cancer |
| Q33790789 | cGAS is essential for cellular senescence |
| Q60907333 | d-amino acid oxidase promotes cellular senescence via the production of reactive oxygen species |
| Q35055094 | miR-127 regulates cell proliferation and senescence by targeting BCL6. |
| Q35551925 | miR-34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c-Myc pathway |
| Q33825111 | p35 is required for CDK5 activation in cellular senescence |
| Q88934867 | p53 Mediates Vast Gene Expression Changes That Contribute to Poor Chemotherapeutic Response in a Mouse Model of Breast Cancer |
| Q35950078 | p53 mediates senescence-like arrest induced by chronic replicational stress |
| Q39677755 | p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase |
| Q27851827 | p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. |
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