Cyclopentenyl cytosine induces senescence in breast cancer cells through the nucleolar stress response and activation of p53.

scientific article

Cyclopentenyl cytosine induces senescence in breast cancer cells through the nucleolar stress response and activation of p53. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/MOL.110.070284
P932PMC publication ID3127532
P698PubMed publication ID21464199
P5875ResearchGate publication ID50999462

P2093author name stringMin Huang
Beverly S Mitchell
Patrick Lewicki
Patrick Whang
P2860cites workDNA damage is able to induce senescence in tumor cells in vitro and in vivo.Q43931306
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CPEC induces erythroid differentiation of human myeloid leukemia K562 cells through CTP depletion and p38 MAP kinaseQ45073108
p53 dependent cell-cycle arrest triggered by chemotherapy in xenografted breast tumors.Q46219717
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cellsQ46709814
Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1Q57562833
Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibitionQ63446341
Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugsQ73002431
p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53Q77853882
DNA topoisomerase inhibitors induce reversible senescence in normal human fibroblastsQ77905855
Functional characterization of human mesenchymal stem cell-derived adipocytesQ79236161
p53-R273H gains new function in induction of drug resistance through down-regulation of procaspase-3Q79961068
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53Q24328775
A biomarker that identifies senescent human cells in culture and in aging skin in vivoQ24562644
Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2Q24646511
Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26Q24653892
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivationQ28280958
Defining the molecular basis of Arf and Hdm2 interactionsQ28507075
Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosisQ28585867
mdm2 expression is induced by wild type p53 activityQ29618316
Dynamic sorting of nuclear components into distinct nucleolar caps during transcriptional inhibitionQ30448378
Identification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cellsQ30771484
A mutant p53 antagonizes the deregulated c-myc-mediated enhancement of apoptosis and decrease in leukemogenicityQ33861971
Cyclopentenylcytosine triphosphate. Formation and inhibition of CTP synthetase.Q34561130
Senescence as an anticancer mechanismQ34579345
Cellular senescence in cancer and agingQ34581486
Induction of senescence-associated growth inhibitors in the tumor-suppressive function of retinoidsQ35014256
Cellular senescence in cancer treatment: friend or foe?Q35628579
Depletion of guanine nucleotides leads to the Mdm2-dependent proteasomal degradation of nucleostemin.Q36057264
Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53.Q36573040
Putting a finger on growth surveillance: insight into MDM2 zinc finger-ribosomal protein interactions.Q36748093
Cyclopentenyl cytosine (CPEC): an overview of its in vitro and in vivo activityQ36907222
Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6Q39576878
Ribosomal protein S7 is both a regulator and a substrate of MDM2Q39812243
Cyclopentenyl cytosine has biological and anti-tumour activity, but does not enhance the efficacy of gemcitabine and radiation in two animal tumour models.Q39884462
Nucleoplasmic mobilization of nucleostemin stabilizes MDM2 and promotes G2-M progression and cell survivalQ39912417
Autophagic cell death, polyploidy and senescence induced in breast tumor cells by the substituted pyrrole JG-03-14, a novel microtubule poisonQ40095421
Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar disruptionQ40140550
Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1.Q40365756
Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosisQ40749705
Equilibrative-sensitive nucleoside transporter and its role in gemcitabine sensitivityQ40841473
Induction of senescence in human malignant glioma cells by p16INK4A.Q41098516
5'-Deoxy-5'-methylthioadenosine phosphorylase and p16INK4 deficiency in multiple tumor cell lines.Q41361631
Phase I clinical trial of continuous infusion cyclopentenyl cytosineQ42275991
p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosisQ42471323
P433issue1
P304page(s)40-48
P577publication date2011-04-04
P1433published inMolecular PharmacologyQ1943386
P1476titleCyclopentenyl cytosine induces senescence in breast cancer cells through the nucleolar stress response and activation of p53.
P478volume80

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cites work (P2860)
Q38705971BMH-21 inhibits viability and induces apoptosis by p53-dependent nucleolar stress responses in SKOV3 ovarian cancer cells
Q35600151Bioengineering embryonic stem cell microenvironments for the study of breast cancer
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Q35175999Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin
Q28068732Small molecule compounds that induce cellular senescence