| P2093 | author name string | Angela Grimes | |
| | Sathees B C Chandra | |
| P2860 | cites work | A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy | Q74117541 |
| | Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species | Q74602438 |
| | p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts | Q80208893 |
| | p16(INK4a) translation suppressed by miR-24 | Q21092220 |
| | Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling | Q22003910 |
| | PML regulates p53 acetylation and premature senescence induced by oncogenic Ras | Q22254666 |
| | Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a | Q24324559 |
| | A biomarker that identifies senescent human cells in culture and in aging skin in vivo | Q24562644 |
| | Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence | Q24650807 |
| | Molecular dissection of formation of senescence-associated heterochromatin foci | Q24681416 |
| | Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. | Q27931258 |
| | Mortality patterns suggest lack of senescence in hydra | Q28272908 |
| | Senescence Induced by Altered Telomere State, Not Telomere Loss | Q28315731 |
| | Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors | Q29614306 |
| | A DNA damage checkpoint response in telomere-initiated senescence | Q29615919 |
| | Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas | Q29616243 |
| | Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints | Q29617405 |
| | Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication | Q29617915 |
| | Restoration of p53 function leads to tumour regression in vivo | Q29618727 |
| | BRAFE600-associated senescence-like cell cycle arrest of human naevi | Q29619550 |
| | Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence | Q29620428 |
| | Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence | Q33283342 |
| | Transcriptional networks and cellular senescence in human mammary fibroblasts | Q33763939 |
| | The cellular response to p53: the decision between life and death | Q33771774 |
| | Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging | Q33946993 |
| | Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics | Q33962085 |
| | Cellular senescence as a tumor-protection mechanism: the essential role of counting | Q34132858 |
| | Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production | Q34212784 |
| | Regulation of cellular senescence by p53. | Q34254621 |
| | Oncogenic ras and p53 cooperate to induce cellular senescence | Q34279104 |
| | DNA end joining becomes less efficient and more error-prone during cellular senescence | Q34336407 |
| | "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally | Q34369829 |
| | A test of evolutionary theories of aging. | Q34393269 |
| | Cellular senescence as a tumor-suppressor mechanism | Q34421790 |
| | A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status | Q34441492 |
| | Many ways to telomere dysfunction: in vivo studies using mouse models | Q34535647 |
| | Short telomeres limit tumor progression in vivo by inducing senescence | Q34578690 |
| | Inbreeding depression and male survivorship in Drosophila: implications for senescence theory | Q34587267 |
| | Genotype-environment interaction for quantitative trait loci affecting life span in Drosophila melanogaster | Q34608521 |
| | Cancer and ageing: rival demons? | Q35118727 |
| | Senescence of human fibroblasts induced by oncogenic Raf. | Q35210205 |
| | Senescence of immortal human fibroblasts by the introduction of normal human chromosome 6 | Q35472884 |
| | Reversal of human cellular senescence: roles of the p53 and p16 pathways | Q35561999 |
| | Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence. | Q47277811 |
| | The rate of senescence in maternal performance increases with early-life fecundity in red deer. | Q50714278 |
| | Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. | Q53334281 |
| | Tumor surveillance via the ARF-p53 pathway. | Q53430438 |
| | Bcl-2 protects against oxidative stress while inducing premature senescence. | Q53631852 |
| | Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA. | Q53851296 |
| | Adaptive variation in senescence: reproductive lifespan in a wild salmon population. | Q55072815 |
| | The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability | Q56508014 |
| | Age-dependent genetic variance in a life-history trait in the mute swan | Q56679978 |
| | Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation | Q60284598 |
| | Telomere length and the expression of natural telomeric genes in human fibroblasts | Q73424244 |
| | When cells get stressed: an integrative view of cellular senescence | Q35618961 |
| | Cellular senescence in cancer treatment: friend or foe? | Q35628579 |
| | Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases | Q35680797 |
| | Hallmarks of senescence in carcinogenesis and cancer therapy | Q35743144 |
| | Mechanisms of cellular senescence in human and mouse cells. | Q35770883 |
| | Genetic and epigenetic changes in human epithelial cells immortalized by telomerase | Q35810077 |
| | From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing. | Q35895097 |
| | p53 mediates senescence-like arrest induced by chronic replicational stress | Q35950078 |
| | Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi | Q35987307 |
| | What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? | Q36017396 |
| | The thorny path linking cellular senescence to organismal aging | Q36253779 |
| | DNA damage, cellular senescence and organismal ageing: causal or correlative? | Q36360646 |
| | p63: a new link between senescence and aging | Q36376772 |
| | The complexity of p53 stabilization and activation | Q36443523 |
| | Absence of senescence-associated beta-galactosidase activity in human melanocytic nevi in vivo | Q36538322 |
| | Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster | Q36574111 |
| | Oncogene-induced cell senescence--halting on the road to cancer | Q36587198 |
| | Cellular senescence and chromatin organisation | Q36609955 |
| | Structure-function-rescue: the diverse nature of common p53 cancer mutants | Q36777367 |
| | A theory of age-dependent mutation and senescence. | Q36837073 |
| | The guardian's little helper: microRNAs in the p53 tumor suppressor network | Q37023130 |
| | Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation | Q37082277 |
| | Age-specific inbreeding depression and components of genetic variance in relation to the evolution of senescence | Q37576258 |
| | Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. | Q37620888 |
| | Testing an 'aging gene' in long-lived drosophila strains: increased longevity depends on sex and genetic background | Q37709710 |
| | Reproductive costs of heat shock protein in transgenic Drosophila melanogaster. | Q38457798 |
| | Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence | Q40195285 |
| | Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks | Q40593721 |
| | High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human Fibroblasts | Q40620874 |
| | Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis | Q40715420 |
| | Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I--effects of proliferative senescence | Q40839462 |
| | Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts | Q40961777 |
| | Replicative senescence: implications for in vivo aging and tumor suppression | Q41003046 |
| | Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts | Q41006486 |
| | Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide. | Q41231363 |
| | Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. | Q41292286 |
| | The genetics of cellular senescence | Q41739824 |
| | Bcl-2 activates a programme of premature senescence in human carcinoma cells | Q41933470 |
| | Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence | Q42053248 |
| | DNA damage is able to induce senescence in tumor cells in vitro and in vivo. | Q43931306 |
| | Epigenetic silencing of multiple interferon pathway genes after cellular immortalization. | Q44488215 |
| | Mutation accumulation affects male virility in Drosophila selected for later reproduction | Q46633663 |
| | Oncogene-induced senescence as an initial barrier in lymphoma development | Q46634165 |
| P275 | copyright license | Creative Commons Attribution-NonCommercial 3.0 Unported | Q18810331 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 4 | |
| P921 | main subject | cellular senescence | Q9075999 |
| P304 | page(s) | 187-195 | |
| P577 | publication date | 2009-12-31 | |
| P1433 | published in | Cancer Research and Treatment | Q18411021 |
| P1476 | title | Significance of cellular senescence in aging and cancer. | |
| P478 | volume | 41 | |