| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2004PNAS..101.7624S |
| P356 | DOI | 10.1073/PNAS.0400726101 |
| P932 | PMC publication ID | 419656 |
| P698 | PubMed publication ID | 15123826 |
| P5875 | ResearchGate publication ID | 8581401 |
| P50 | author | David A. Mittelman | Q111398813 |
| P2093 | author name string | Olivia M Pereira-Smith | |
| John H Wilson | |||
| Andrei Seluanov | |||
| Vera Gorbunova | |||
| P2860 | cites work | Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases | Q24304488 |
| A biomarker that identifies senescent human cells in culture and in aging skin in vivo | Q24562644 | ||
| Mutator phenotype of Werner syndrome is characterized by extensive deletions | Q24609670 | ||
| Biochemical evidence for Ku-independent backup pathways of NHEJ | Q24678907 | ||
| p53, the cellular gatekeeper for growth and division | Q27860990 | ||
| Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae | Q27932896 | ||
| Deletion of Ku86 causes early onset of senescence in mice | Q28144342 | ||
| The processing of Holliday junctions by BLM and WRN helicases is regulated by p53 | Q28206425 | ||
| Apoptosis in the pathogenesis and treatment of disease | Q28235731 | ||
| The clonal evolution of tumor cell populations | Q28271546 | ||
| A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis | Q28292871 | ||
| Evaluation of the co-mutagenicity of ethanol and delta 9-tetrahydrocannabinol with Trenimon | Q28316064 | ||
| Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence | Q28505334 | ||
| Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice | Q28510493 | ||
| Yeast Rad52 and Rad51 recombination proteins define a second pathway of DNA damage assessment in response to a single double-strand break | Q31023832 | ||
| Deficient DNA end joining activity in extracts from fanconi anemia fibroblasts | Q31742444 | ||
| Tubular cell senescence and expression of TGF-beta1 and p21(WAF1/CIP1) in tubulointerstitial fibrosis of aging rats | Q31917719 | ||
| Joining of linear plasmid DNA is reduced and error-prone in Bloom's syndrome cells | Q33564824 | ||
| Telomere length and replicative aging in human vascular tissues | Q33763501 | ||
| Ku86 is essential in human somatic cells | Q33894543 | ||
| Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging | Q33946993 | ||
| The age of cancer | Q34088387 | ||
| Homologous recombination resolution defect in werner syndrome | Q34150355 | ||
| Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. | Q34200511 | ||
| Neuronal cell death in nervous system development, disease, and injury (Review). | Q34213918 | ||
| Regulation of cellular senescence by p53. | Q34254621 | ||
| Base excision repair is limited by different proteins in male germ cell nuclear extracts prepared from young and old mice | Q34276065 | ||
| Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance | Q34411525 | ||
| Problems in prisons worldwide, with a particular focus on Russia | Q34497244 | ||
| DNA polymerase-beta may be the main player for defective DNA repair in aging rat neurons | Q34497433 | ||
| Through a glass, darkly: reflections of mutation from lacI transgenic mice. | Q34609797 | ||
| Sensing and repairing DNA double-strand breaks | Q34642563 | ||
| Large genome rearrangements as a primary cause of aging | Q34667124 | ||
| Impact of DNA ligase IV on the fidelity of end joining in human cells | Q34966793 | ||
| Functional characterization of global genomic DNA repair and its implications for cancer. | Q35596006 | ||
| Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged mice | Q35919383 | ||
| Elevated recombination in immortal human cells is mediated by HsRAD51 recombinase | Q36574017 | ||
| Mechanisms of nonhomologous recombination in mammalian cells | Q36894382 | ||
| Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice | Q37592150 | ||
| Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase | Q38298404 | ||
| Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA. | Q38356655 | ||
| Frequency of spontaneous chromosome aberrations in mice: effects of age. | Q38500687 | ||
| The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting | Q38508451 | ||
| DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining | Q39543261 | ||
| Double-strand break repair in Ku86- and XRCC4-deficient cells | Q39725806 | ||
| The BLM helicase is necessary for normal DNA double-strand break repair. | Q40730712 | ||
| p53 and recombination intermediates: role of tetramerization at DNA junctions in complex formation and exonucleolytic degradation | Q40738842 | ||
| Fanconi anemia C gene product plays a role in the fidelity of blunt DNA end-joining | Q41030745 | ||
| A role for p53 in DNA end rejoining by human cell extracts | Q41075503 | ||
| Abnormal processing of transfected plasmid DNA in cells from patients with ataxia telangiectasia | Q41596178 | ||
| Transgenic mouse models for studying mutations in vivo: applications in aging research | Q41628334 | ||
| Comparative levels of DNA breaks and sensitivity to oxidative stress in aged and senescent human fibroblasts: a distinctive pattern for centenarians | Q42441808 | ||
| DNA damage and repair with age in individual human lymphocytes | Q42482134 | ||
| p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts | Q42814712 | ||
| Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: potential mechanism of DNA double-strand break repair modulation. | Q53390777 | ||
| A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining. | Q53715599 | ||
| A role for both RB and p53 in the regulation of human cellular senescence | Q64378339 | ||
| DNA double-strand breaks in mouse kidney cells with age | Q64387898 | ||
| Lack of WRN results in extensive deletion at nonhomologous joining ends | Q64387933 | ||
| Age-dependent decline in rejoining of X-ray-induced DNA double-strand breaks in normal human lymphocytes | Q64390174 | ||
| Human p53 binds Holliday junctions strongly and facilitates their cleavage | Q73119545 | ||
| Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis | Q73395517 | ||
| Effect of age on the formation and repair of UV photoproducts in human skin in situ | Q73795294 | ||
| Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia | Q73930579 | ||
| Chromosome Aberrations in Liver Cells in Relation to the Somatic Mutation Theory of Aging | Q76471098 | ||
| Cellular proliferation potential during aging and caloric restriction in rhesus monkeys (Macaca mulatta) | Q77853095 | ||
| An Age-Induced Switch to a Hyper-Recombinational State | Q79087237 | ||
| P433 | issue | 20 | |
| P407 | language of work or name | English | Q1860 |
| P1104 | number of pages | 6 | |
| P304 | page(s) | 7624-7629 | |
| P577 | publication date | 2004-04-28 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | DNA end joining becomes less efficient and more error-prone during cellular senescence | |
| P478 | volume | 101 |
| Q42052679 | 53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma |
| Q91769921 | A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites |
| Q53195737 | A positive feedback signaling loop between ATM and the vitamin D receptor is critical for cancer chemoprevention by vitamin D. |
| Q37628142 | A role for XLF in DNA repair and recombination in human somatic cells |
| Q54613863 | A single-nucleotide polymorphism in the XPG gene, and tumour stage, grade, and clinical course in patients with nonmuscle-invasive neoplasms of the urinary bladder. |
| Q41913571 | ATM specifically mediates repair of double-strand breaks with blocked DNA ends |
| Q33847654 | Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging |
| Q30493825 | Age related shift in the mutation spectra of germline and somatic NF2 mutations: hypothetical role of DNA repair mechanisms |
| Q28082599 | Aging and radiation: bad companions |
| Q37678198 | Aging impairs double-strand break repair by homologous recombination in Drosophila germ cells |
| Q28384025 | Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer |
| Q42023660 | Analysis of DNA double-strand break (DSB) repair in mammalian cells. |
| Q39950377 | Assays for DNA double-strand break repair by microhomology-based end-joining repair mechanisms |
| Q42359862 | Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model |
| Q35869745 | Autophagy confers DNA damage repair pathways to protect the hematopoietic system from nuclear radiation injury |
| Q92418482 | Autophagy, Cellular Aging and Age-related Human Diseases |
| Q35641945 | Cell divisions are required for L1 retrotransposition |
| Q34697935 | Changes in DNA repair during aging. |
| Q37234989 | Changes in the level and distribution of Ku proteins during cellular senescence. |
| Q37276862 | Checkpoint kinase phosphorylation in response to endogenous oxidative DNA damage in repair-deficient stationary-phase Saccharomyces cerevisiae |
| Q34469204 | Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation |
| Q37226516 | Comparison of nonhomologous end joining and homologous recombination in human cells. |
| Q37068403 | Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence |
| Q37156490 | Copy neutral loss of heterozygosity is more frequent in older ovarian cancer patients |
| Q35044575 | Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner |
| Q37564853 | Cytogenetic perspective of ageing and longevity in men and women |
| Q36360646 | DNA damage, cellular senescence and organismal ageing: causal or correlative? |
| Q36952025 | DNA double strand break repair, aging and the chromatin connection. |
| Q35803657 | DNA double-strand break repair is impaired in presenescent Syrian hamster fibroblasts |
| Q37112251 | DNA double-strand breaks: a potential causative factor for mammalian aging? |
| Q24297891 | DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells |
| Q26775866 | DNA repair and aging: the impact of the p53 family |
| Q37229934 | DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells. |
| Q24644828 | DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells |
| Q34183328 | DNA repair deficiency in neurodegeneration. |
| Q36268064 | DNA repair pathway choice is influenced by the health of Drosophila melanogaster |
| Q36998015 | DNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease |
| Q64091697 | Delayed γH2AX foci disappearance in mammary epithelial cells from aged women reveals an age-associated DNA repair defect |
| Q24681223 | Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer |
| Q28544696 | Deregulation of DNA double-strand break repair in multiple myeloma: implications for genome stability |
| Q34539270 | Do DNA Double-Strand Breaks Drive Aging? |
| Q33974258 | Double-strand breaks repair in lymphoblastoid cell lines from sisters discordant for breast cancer from the New York site of the BCFR |
| Q35229441 | Environmental stress induces trinucleotide repeat mutagenesis in human cells |
| Q42368381 | Epigenetic Regulation of Cellular Senescence and Aging |
| Q42879413 | Evidence of an Adaptive Response Targeting DNA Nonhomologous End Joining and Its Transmission to Bystander Cells |
| Q33573646 | Exonuclease 1 is a critical mediator of survival during DNA double strand break repair in nonquiescent hematopoietic stem and progenitor cells |
| Q41417468 | Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair |
| Q40400650 | Fibromodulin gene transcription is induced by ultraviolet irradiation, and its regulation is impaired in senescent human fibroblasts. |
| Q45346807 | Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination |
| Q28545187 | GFP-based fluorescence assay for CAG repeat instability in cultured human cells |
| Q40421571 | Gene expression responses to DNA damage are altered in human aging and in Werner Syndrome. |
| Q28258404 | Genomic instability in laminopathy-based premature aging |
| Q28392173 | Growth conditions that increase or decrease lifespan in Saccharomyces cerevisiae lead to corresponding decreases or increases in rates of interstitial deletions and non-reciprocal translocations |
| Q36839039 | Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells |
| Q28595764 | High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature |
| Q64388705 | Human DNA ligase IV is able to use NAD+ as an alternative adenylation donor for DNA ends ligation |
| Q24634126 | Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich's ataxia |
| Q34533473 | Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans |
| Q36530809 | In Vitro Expansion of Bone Marrow Derived Mesenchymal Stem Cells Alters DNA Double Strand Break Repair of Etoposide Induced DNA Damage |
| Q33841800 | In search of antiaging modalities: evaluation of mTOR- and ROS/DNA damage-signaling by cytometry |
| Q28397794 | Increased mammogram-induced DNA damage in mammary epithelial cells aged in vitro |
| Q98906732 | Inhibition of non-homologous end joining of gamma ray-induced DNA double-strand breaks by cAMP signaling in lung cancer cells |
| Q57800520 | Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells |
| Q41469956 | Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons. |
| Q35978719 | Interaction of hepatitis B virus X protein with PARP1 results in inhibition of DNA repair in hepatocellular carcinoma |
| Q21144868 | Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age |
| Q21563320 | Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells |
| Q53701734 | LRH1 enhances cell resistance to chemotherapy by transcriptionally activating MDC1 expression and attenuating DNA damage in human breast cancer. |
| Q37389409 | Leukemic survival factor SALL4 contributes to defective DNA damage repair |
| Q47319367 | LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA. |
| Q38747471 | Localisation of Nup153 and SENP1 to nuclear pore complexes is required for 53BP1-mediated DNA double-strand break repair |
| Q36959663 | Long intronic GAA*TTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia |
| Q37052345 | Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer |
| Q35031397 | Loss of autophagy causes a synthetic lethal deficiency in DNA repair. |
| Q47304492 | Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability |
| Q37560972 | MAR-Mediated transgene integration into permissive chromatin and increased expression by recombination pathway engineering |
| Q37164915 | Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma |
| Q34517258 | Methylation of the nonhomologous end joining repair pathway genes does not explain the increase of translocations with aging. |
| Q42917440 | Microsatellite instability in Arabidopsis increases with plant development |
| Q36217351 | Modification of the DNA damage response by therapeutic CDK4/6 inhibition |
| Q46309715 | Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species |
| Q24599990 | Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks |
| Q40282659 | Mutagenicity of non-homologous end joining DNA repair in a resistant subset of human chronic lymphocytic leukaemia B cells |
| Q38830059 | Non-homologous end joining induced alterations in DNA methylation: A source of permanent epigenetic change. |
| Q34602683 | Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells. |
| Q91166401 | Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3 |
| Q36208555 | Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells. |
| Q37776792 | Oxidation in the nucleotide pool, the DNA damage response and cellular senescence: Defective bricks build a defective house |
| Q37297051 | P21-PARP-1 pathway is involved in cigarette smoke-induced lung DNA damage and cellular senescence |
| Q29616041 | PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways |
| Q58582587 | PARP1 is required for preserving telomeric integrity but is dispensable for A-NHEJ |
| Q47307969 | POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions |
| Q58556176 | Pathologic Replication-Independent Endogenous DNA Double-Strand Breaks Repair Defect in Chronological Aging Yeast |
| Q39101297 | Phosphorylated (pT371)TRF1 is recruited to sites of DNA damage to facilitate homologous recombination and checkpoint activation. |
| Q45974271 | Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice. |
| Q34567724 | Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling |
| Q64386960 | Preservation of genomic integrity in mouse embryonic stem cells |
| Q39889904 | Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage |
| Q92751186 | Quantitative Insights into Age-Associated DNA-Repair Inefficiency in Single Cells |
| Q47177294 | RBM45 competes with HDAC1 for binding to FUS in response to DNA damage |
| Q34425537 | RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex |
| Q40721524 | RNA binding protein RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation |
| Q35611983 | Restless genomes humans as a model organism for understanding host-retrotransposable element dynamics |
| Q40082412 | SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination. |
| Q38543012 | SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons |
| Q36035627 | SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells |
| Q34528261 | SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair. |
| Q36210354 | SPOP mutation leads to genomic instability in prostate cancer. |
| Q33564150 | SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair |
| Q34555289 | SUV39H1 downregulation induces deheterochromatinization of satellite regions and senescence after exposure to ionizing radiation |
| Q55215006 | Significance of cellular senescence in aging and cancer. |
| Q34285505 | Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence |
| Q26991467 | Sirtuins in hematological aging and malignancy |
| Q35764178 | Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End Joining |
| Q28389849 | Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors |
| Q35075792 | Suberoylanilide hydroxamic acid induces hypersensitivity to radiation therapy in acute myelogenous leukemia cells expressing constitutively active FLT3 mutants |
| Q27325200 | TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo |
| Q38739757 | TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. |
| Q47704064 | TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia |
| Q35928861 | TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. |
| Q47308626 | Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy |
| Q64061652 | Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies |
| Q89835065 | The Histone Code of Senescence |
| Q39663183 | The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining |
| Q64111860 | The RNA Processing Factor Y14 Participates in DNA Damage Response and Repair |
| Q36415420 | The distribution of constitutional and somatic mutations in the neurofibromatosis 2 gene |
| Q24306086 | The human DEK oncogene regulates DNA damage response signaling and repair |
| Q38303919 | The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/80, DNA-PKcs and XRCC4-LigIV. |
| Q37861628 | The switch from pRb/p105 to Rb2/p130 in DNA damage and cellular senescence |
| Q34461220 | Tissue-specific differences in the accumulation of sequence rearrangements with age. |
| Q41508877 | Transcriptional profiling of the age-related response to genotoxic stress points to differential DNA damage response with age. |
| Q40595329 | UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy |
| Q28596573 | USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response |
| Q34262677 | Upregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8(+) T cells sensitizing them to apoptotic cell death |
| Q30831557 | WRN regulates pathway choice between classical and alternative non-homologous end joining |
| Q33292399 | Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1. |
| Q36994681 | Yeast mother cell-specific ageing, genetic (in)stability, and the somatic mutation theory of ageing. |
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