Loss of autophagy causes a synthetic lethal deficiency in DNA repair.

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Loss of autophagy causes a synthetic lethal deficiency in DNA repair. is …
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scholarly articleQ13442814

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P819ADS bibcode2015PNAS..112..773L
P356DOI10.1073/PNAS.1409563112
P932PMC publication ID4311830
P698PubMed publication ID25568088
P5875ResearchGate publication ID271220170

P50authorKevin M RyanQ37834605
David A GillespieQ60976727
P2093author name stringYaou Zhang
Mathias Rosenfeldt
Florian Beaumatin
Alice D Baudot
Jim O'Prey
Jaclyn S Long
Naihan Xu
Sanket Joshi
Daniel R Croft
Margaret O'Prey
Emma Y Liu
Laurence Y Lao
Michaela Mrschtik
P2860cites workDNA Damage, Aging, and CancerQ22121931
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The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stressQ24310746
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repairQ24338781
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpointsQ24527393
XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsQ24597771
The DNA-damage response in human biology and diseaseQ24606586
DNA end resection: many nucleases make light workQ24654725
Suppression of basal autophagy in neural cells causes neurodegenerative disease in miceQ28131756
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HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stabilityQ28294885
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Autophagy gone awry in neurodegenerative diseasesQ29614849
DNA end joining becomes less efficient and more error-prone during cellular senescenceQ34336407
A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo.Q35664079
Autophagy suppresses tumor progression by limiting chromosomal instabilityQ35812219
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesisQ35855667
Etoposide, topoisomerase II and cancerQ36230274
Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouseQ36820879
DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stressQ37418404
Role of autophagy and autophagy genes in inflammatory bowel diseaseQ37608036
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DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpointsQ37742898
RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesisQ37912725
Proteasome-dependent degradation of Chk1 kinase induced by the topoisomerase II inhibitor R16 contributes to its anticancer activityQ39940713
Autophagy for the avoidance of degenerative, inflammatory, infectious, and neoplastic diseaseQ40010337
Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.Q40378903
DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cellsQ40814143
Oncogene-induced sensitization to chemotherapy-induced death requires induction as well as deregulation of E2F1.Q41462289
The comet assay: a method to measure DNA damage in individual cellsQ64388028
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectautophagyQ288322
P304page(s)773-778
P577publication date2015-01-07
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleLoss of autophagy causes a synthetic lethal deficiency in DNA repair
P478volume112